Clinical trials: Urogenital Pathology
Stress Urinary Incontinence, Ultrasound
Urethral Vascularization and Urodynamics
The urethra plays a crucial role in maintaining urinary continence. Its complex blood supply is still not well understood. Particularly in the context of urethral pressure.
- Conditions
- Stress Urinary Incontinence, Ultrasound, Vascularisation, Urodynamic Exam
- Trial name
- UVASC (NCT07185698)
- Testing
- 3D Ultrasound
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Menstrual Migraines, Menstrual Bleeding
Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives.
This study will examine the combined effects of a continuous oral contraceptive (OC) regimen with supplemental estradiol therapy on headache severity and occurrence in subjects with documented Menstrually Associated Migraines…
- Conditions
- Menstrual Migraines, Menstrual Bleeding, Menstrual Spotting
- Trial name
- Estradiol/MAM (NCT01251263)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Stress Urinary Incontinence
Testosterone Replacement in Postmenopausal Women With Stress Urinary Incontinence
The overall objective of this study is to establish if testosterone replacement in post-menopausal women with low testosterone levels and stress urinary incontinence (SUI) will lead to improvement in symptoms of SUI.
- Trial name
- NCT03116087
- Testing
- Testosterone patch
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Charles Drew University of Medicine and Science
Chronic Kidney Disease
Study of the Influence of Liver Function on Blood Concentrations of Runcaciguat in Participants With Different Degrees of Liver Impairment
Researchers are looking for a better way to treat people with chronic kidney diseases. Before a treatment can be approved for patients to take, researchers do clinical studies to better understand its safety and what happens to…
- Trial name
- NCT04820621
- Testing
- Runcaciguat (BAY1101042)
- Where
- Germany
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Bayer
Urinary Stress Incontinence
Randomized, Multicenter Trial Comparing TVT With TVT-O for Treatment of Female Urinary Incontinence
The Tensionfree Vaginal Tape (TVT) procedure is a minimally invasive surgical procedure for treatment of female urinary stress incontinence.
- Trial name
- NCT00379314
- Testing
- TVT and TVT-O minimally invasive surgical procedures, Surgery for female stress urinary incontinence
- Where
- Finland
- Volunteers
- 260 people
- Sponsor
- University of Helsinki
HIV Infections, HIV Wasting Syndrome
A Comparison of Two Caloric Supplements in the Prevention of Weight Loss in Patients With AIDS Who Take Daily Multivitamin and Mineral Supplements
To compare a caloric supplement containing peptides and medium-chain triglycerides, a caloric supplement containing whole protein and long-chain triglycerides, and no caloric supplement for the prevention of weight loss in…
- Trial name
- NCT00001077
- Testing
- Multivitamin and mineral supplements, Peptamen, NuBasics
- Where
- 17 sites in United States
- Volunteers
- 536 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Kidney Diseases
Effects of a Brief Hope Intervention to the Decision Making
Introduction A Hong Kong study found that more than half of the chronic kidney disease (CKD) patients declined peritoneal dialysis (PD) and preferred receiving palliative care, although PD is vital for early preservation of…
- Trial name
- NCT03378700
- Testing
- Brief Hope Intervention, Pre-dialysis Education Group
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Polycystic Ovary Syndrome, c Type Natriuretic Peptide
Comparison of Serum C Type Natriuretic Peptide Levels Between Polycystic Ovary Syndrome Patients and Healthy Women
Recent studies have shown that C natriuretic peptide is produced from granulosa cells, increasing cumulative guanosine monophosphate (cGMP) production by affecting cumulus cells through natriuretic peptide receptors.
- Conditions
- Polycystic Ovary Syndrome, c Type Natriuretic Peptide, Menstrual Irregularity, Hyperandrogenism
- Trial name
- CNP (NCT04006171)
- Testing
- C type natriuretic peptide
- Where
- Cyprus
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Urinary Calculi, Emergency Service, Hospital
Analysis the Relationship Between the Abdomen CT and Outcomes in Acute Urinary Stone Patients
This is an observational study based on retrospectively collected data of ureter stone patients between 2011 and 2014. Aim of study is to determine radiologic findings of non-contrast abdominal computerized tomography as…
- Trial name
- NCT02983409
- Testing
- Pstone
- Volunteers
- 862 people
- Sponsor
- Konkuk University Medical Center
Menorrhagia
The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders
Many women have heavy periods and this can be associated with low blood, tiredness and inability to carry out normal activities. Approximately 10-30% of these women will have an underlying bleeding disorder.
- Trial name
- NCT00904709
- Testing
- tranexamic acid
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- K. Sue Robinson
End Stage Renal Disease
Effects of Extended Haemodialysis Treatment Duration in Patients With End-stage Renal Disease
Design: Prospective randomised cross-over study. Fifty-two eligible patients will be randomised to a treatment time of either 6 hours or 4 hours for a period of 24 weeks and following a washout period of 4 weeks, switch to the…
- Trial name
- NCT01721421
- Testing
- extended treatment time, Standard treatment time
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- Imperial College London
Prostatic Neoplasms, Neoplasm Metastasis
Local Treatment With RP for Newly-diagnosed mPCa
The objective of this study is to evaluate the role of local treatment with radical prostatectomy in patients with newly-diagnosed metastatic hormone-sensitive prostate cancer.
- Trial name
- LoMP (NCT02138721)
- Testing
- Radical Prostatectomy (RP)
- Where
- 5 sites in Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Urinary Retention, Urinary Bladder, Neurogenic
A Prospective Evaluation of the Catheter Science C3 "Umbrella Catheter."
The Catheter Science C3 "Umbrella Catheter" has been developed for management of urinary retention in patients who are either using a Foley or Self Intermittent Catheter.
- Conditions
- Urinary Retention, Urinary Bladder, Neurogenic, Intermittent Catheterization
- Trial name
- NCT03353571
- Testing
- C3 "UMBRELLA CATHETER"
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dr. Gaines W. Hammond Jr. MD FACS
Fabry Disease
Open Label Extension of 2 mg/kg Pegunigalsidase Alfa (PRX-102) Every 4 Weeks in Adult Fabry Disease Patients
The objective of CLI-06657AA1-03 (formerly PB-102-F51) is to evaluate the long-term safety, tolerability, and efficacy of 2 mg/kg pegunigalsidase alfa administered intravenously every four weeks in adult Fabry patients who have…
- Trial name
- NCT03614234
- Testing
- pegunigalsidase alfa
- Where
- 14 sites in United States, Belgium and 5 more
- Volunteers
- 29 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Hypertension Treated With Antihypertensive Drugs, Chronic Kidney Disease, 3B and 4
LOw DosE Spironolactone, chlorThAlidone oR Combination in CKD Trial
The purpose of this research is to gather information on the safety and effectiveness of spironolactone and chlorthalidone for treatment of high blood pressure in patients with moderate to advanced CKD.
- Trial name
- LODESTAR (NCT07645300)
- Testing
- phase 2A Chlorthalidone, phase 2A Spironolactone, phase 2A Chlorthalidone + Spironolactone
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
Renal Failure Chronic
Patients With Acute Renal Failure During Severe COVID-19
The occurrence of renal failure during severe forms of COVID-19 is common (20-35% of patients treated in intensive care) and associated with an unfavorable short-term prognosis, but the medium-term renal outcome is not is not…
- Trial name
- IR-EST-POSTCOV (NCT05077163)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Overactive Bladder(OAB)
The Safety and PK Characteristics of the Co-administration of JLP-2002 and Comparator in Healthy Volunteers
A randomized, open-label, single-dose, replicate crossover study to compare the pharmacokinetics and safety in healthy adult volunteers following oral administration of JLP-2002
- Trial name
- NCT04914221
- Testing
- JLP-2002, Comparator
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Chronic Kidney Diseases
Chronic Kidney Disease: Determinants of Progression and Cardiovascular Risk
Chronic kidney disease has become an important Public Health issue in most developed and developing countries, with increasing incidence and prevalence rates.
- Trial name
- PROGREDIR (NCT03393663)
- Testing
- CKD-related outcomes
- Volunteers
- 454 people
- Sponsor
- University of Sao Paulo
Renal Insufficiency, Chronic
Catheter System Feasibility Clinical Trial
Feasibility clinical study to evaluate the safety and effectiveness of the catheter system for the percutaneous creation of an arteriovenous fistula for patients with end stage renal disease requiring dialysis access.
- Trial name
- NCT02816398
- Testing
- Percutaneous creation of an arteriovenous fistula
- Volunteers
- 26 people
- Sponsor
- Medtronic Endovascular
Prostate Cancer
Immediate Versus Deferred Androgen Deprivation Therapy,Goserelin for Recurrent Prostate Cancer After Radical Radiotherapy
This is a prospective, multicentre, open-labelled, randomized controlled trial comparing the efficacy of immediate versus deferred androgen deprivation therapy (ADT) using goserelin (Zoladex®) in men with recurrent prostate…
- Trial name
- ELAAT (NCT00439751)
- Testing
- Goserelin Acetate
- Where
- 11 sites in Canada
- Volunteers
- 79 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
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