Clinical trials: Urogenital Pathology
Kidney Failure, Chronic, Cardiovascular Disease
Hydroxychloroquine in Cardiovascular Disease in Patients With Chronic Kidney Disease: A Proof of Concept Study
Presence of multiple traditional and nontraditional risk factors of atherosclerosis and cardiovascular disease (CVD) including inflammation in patients with chronic kidney disease (CKD) contribute to high CVD morbidity and…
- Conditions
- Kidney Failure, Chronic, Cardiovascular Disease, Arteriosclerosis
- Trial name
- NCT01537315
- Testing
- Hydroxychloroquine
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Arkansas
HIV, Sexually Transmitted Infections
Peer-Delivered HIV Self-Testing, STI Self-Sampling and PrEP for Transgender Women in Uganda
Transgender women (TGW) are at high risk for HIV infection, and are an important, under-researched population in sub-Saharan Africa. Globally, HIV acquisition risk among TGW is 13 times higher than other adults aged 15-49 years.
- Conditions
- HIV, Sexually Transmitted Infections, PrEP, Transgender Women
- Trial name
- NCT04328025
- Testing
- Peer-delivered HIV self-testing, STI self-sampling and PrEP
- Where
- Uganda
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Makerere University
Renal Impairment
A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment
The purpose of this study is to evaluate the drug levels of mezigdomide in participants with renal impairment.
- Trial name
- NCT06318676
- Testing
- Mezigdomide
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Celgene
Stress Urinary Incontinence
Autologous Muscle Derived Cells Compared to Placebo for Urinary Sphincter Repair in Post-surgical Female Stress Incontinence
This study evaluates the efficacy and safety of Autologous Muscle Derived Cells for Urinary Sphincter Repair (AMDC-USR; generic name: iltamiocel) compared to a placebo in the reduction of stress incontinence episode frequency in…
- Trial name
- CELLEBRATE (NCT03104517)
- Testing
- AMDC-USR (iltamiocel)
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 96 people
- Sponsor
- Cook MyoSite
Syncytiotrophoblast
From Cytotrophoblast to Syncytiotrophoblast
A deeper understanding of the syncytiotrophoblast development processes and its properties may allow a better understanding of the placenta pathological process for the development of treatment models for the relevant pregnancy…
- Trial name
- NCT02368821
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Maternal-Fetal Relations, Birth, First
Effects of Pelvic Exercises on Birth and Incontinence
The Effect of Pelvic Floor Exercises During Pregnancy on Obstetric Outcomes and Urinary Incontinence: A Prospective Randomized Controlled Trial
- Conditions
- Maternal-Fetal Relations, Birth, First, Incontinence, Urinary, Pelvic Floor Disorders
- Trial name
- NCT07268014
- Testing
- Pelvic Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Septic Shock, Acute Kidney Injury
MCO Membrane Efficiency in Septic Shock Patients
This is a monocentre randomized pilot study. All patients received two consecutive RRT: CVVHD with MCO filter (Ultraflux® EMiC®2) and post-Continuous Veno-Venous Hemodiafiltration (CVVHDF) with HFF(AV1000S®) in a controlled…
- Trial name
- NCT04834921
- Testing
- Ultraflux® EMiC®2
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fiorenza Ferrari
Postpartum Hemorrhage Treated With Sulprostone
Emotional and Cardiac Impact of Postpartum Haemorrhage
To assess the impact and to identify the main risk factors for psychological and cardiac morbidity (post-traumatic stress disorder, anxiety and depression) in case of postpartum hemorrhage
- Trial name
- HELP-MOM (NCT02118038)
- Where
- France
- Volunteers
- 329 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
End Stage Renal Disease
A Study to Investigate the Influence of PTH-lowering by Etelcalcetide (Parsabiv®) on the Calcification Propensity of Serum in Dialysis Patients
This is a single-center, prospective, dose-escalation, pilot study in 15 end-stage renal disease patients on chronic hemodialysis with secondary hyperparathyroidism.
- Trial name
- NCT03795558
- Testing
- Etelcalcetide
- Where
- Austria
- Volunteers
- 37 people
- Sponsor
- Prim. Priv. Doz. Dr. Daniel Cejka
Urinary Tract Infection, Acute Pyelonephritis
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults
This is an open-label, randomized, multi-center, interventional, active-controlled Phase 4 study to evaluate the efficacy and safety of CAZ-AVI versus BAT in the treatment of infected participants with selected infection types…
- Conditions
- Urinary Tract Infection, Acute Pyelonephritis, Hospital Acquired Pneumonia, Ventilator-associated Pneumonia
- Trial name
- NCT04882085
- Testing
- Zavicefta, Ceftazidime-Avibactam, Best Available Treatment
- Where
- 37 sites in China
- Volunteers
- 60 people
- Sponsor
- Pfizer
Hyperparathyroidism, Secondary, Kidney Failure, Chronic
A Phase 2 Study of an Oral Vitamin D Compound (DP001) in Secondary Hyperparathyroidism in Patients on Hemodialysis
The goal of this study is to test a new vitamin D compound for its ability to reduce parathyroid hormone levels in patients who are on hemodialysis.
- Trial name
- 2MD-7H-2B (NCT01922843)
- Testing
- DP001 softgel capsules
- Where
- 14 sites in United States
- Volunteers
- 62 people
- Sponsor
- Deltanoid Pharmaceuticals
Renal Failure Chronic, Anemia
Predictors of Response to Iron and Erythropoietin Stimulating Agents
The purpose of the study is to identify predictors of treatment response. This involves collected baseline clinical parameters and bloods for biochemical parameters prior to administering the study treatment.
- Trial name
- PRIME (NCT03658876)
- Testing
- Iron Sucrose Solution for Injection, Epoetin Beta
- Volunteers
- 197 people
- Sponsor
- Imperial College London
Enterobacteriaceae Infections, Bacteremia
Infections Caused by ESbL-Producing Enterobacteriaceae in Italy
To assess the molecular epidemiology, clinical impact, treatment outcome and risk factors for infections caused by Enterobacteriaceae producing ESBLs in Italy in a large multicenter observational survey. SPECIFIC OBJECTIVES 1.
- Conditions
- Enterobacteriaceae Infections, Bacteremia, Pneumonia, Skin Diseases
- Trial name
- NCT00404625
- Testing
- Risk factors for infections due to ESBL+ Enterobacteriaceae, Risk factors for inadequate initial antimicrobial therapy, Overall and 30-day mortality in bad first antibiotic therapy
- Where
- 6 sites in Italy
- Volunteers
- 813 people
- Sponsor
- University of Siena
Focus Chronic Kidney Disease With Hypertension
Exercise as an Adjunct Therapy to Reduce Blood Pressure in Chronic Kidney Disease
The general objective of the study is to investigate the effect of regular aerobic exercise on resting and 24-hr blood pressure levels in men and women with stage 3-4 kidney disease and hypertension.
- Trial name
- PACE (NCT02112825)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
HPV, Cervical Cancer
Multimodality Treatments of HPV-related Lesions of the Female Genital Tract
Cervical cancer is one of the most preventable types of cancer, as it develops over an extended period, and its causative agent is well-known.
- Conditions
- HPV, Cervical Cancer, Cervix Lesion, Vagina Disease
- Trial name
- NCT05938192
- Testing
- vaccination
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
End Stage Renal Disease
An Effectiveness-Implementation Trial of SPIRIT in ESRD
Despite advances in dialysis, only 50% of dialysis patients are alive 3 years after the onset of end-stage renal disease (ESRD).
- Trial name
- NCT03138564
- Testing
- SPIRIT, Comparison Condition
- Where
- 39 sites in United States
- Volunteers
- 852 people
- Sponsor
- Emory University
HIV Infection, Alcohol Use
Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV)
This study is a randomized controlled trial (RCT) to compare the effects of varenicline, cytisine, and nicotine replacement therapy (NRT) to reduce: 1) alcohol use and craving, 2) smoking; and 3) inflammation and risk for…
- Conditions
- HIV Infection, Alcohol Use, Smoking
- Trial name
- St PETER HIV (NCT02797587)
- Testing
- Varenicline, Cytisine, Nicotine Replacement Therapy
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Boston Medical Center
Anemia, Chronic Kidney Diseases
Effect of rEPO in FGF23 in ESRD Patients
Objective: To evaluate the effects of recombinant Erythropoietin (rEPO) in plasma levels of Fibroblast Growth Factor 23 (FGF23) in End-Stage Renal Disease (ESRD) patients in hemodialysis.
- Trial name
- NCT03803514
- Testing
- Recombinant EPO
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
Overactive Bladder
Educating Patients on Management of Overactive Bladder: Written Versus Verbal Instructions
Background: Overactive bladder (OAB) is a common condition among postmenopausal women, requiring a multifaceted treatment approach that requires patient retention of information given to them in clinic.
- Trial name
- NCT02197533
- Testing
- Written List
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
End-stage Kidney Disease, End-stage Renal Disease
The Optiflow Patency and Maturation Study
The objective of this study is to assess the performance and safety of the Optiflow Anastomotic Connector (Optiflow) when used to facilitate the creation of autogenous arteriovenous fistula (AVF) anastomoses.
- Trial name
- OPEN (NCT01921933)
- Testing
- Optiflow
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Bioconnect Systems, Inc
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