Clinical trials: Urolithiasis, open to volunteers
Stone, Kidney
FANS-Optimization of Irrigation and Suction Parameters in RIRS
Kidney stones are commonly treated with flexible ureteroscopy, a minimally invasive procedure in which a small scope is passed through the urinary tract to reach and treat stones in the kidney.
- Trial name
- NCT07840482
- Testing
- ClearPetra™ FANS - High-Flow Setting, ClearPetra™ FANS - Moderate-Flow Setting
- Volunteers
- 100 people
- Sponsor
- University of Kansas Medical Center
Calculous Anuria, Upper Ureteral Stone
Initial Drainage Method and Flexible Ureteroscopy Outcomes in Calculous Anuria
Calculous anuria caused by obstructing upper ureteral stones in a solitary functioning kidney is a urological emergency requiring urgent decompression.
- Conditions
- Calculous Anuria, Upper Ureteral Stone, Obstructive Uropathy, Acute Kidney Injury
- Trial name
- NCT07627880
- Testing
- Initial JJ Ureteral Stent Drainage, Initial Percutaneous Nephrostomy Drainage
- Where
- 3 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Beni-Suef University
Kidney Stones, Urolithiasis
DISON I - Directly Integrated Suction and Optics System for the Treatment of Nephrolithiasis
A single-arm, multicenter, international, prospective interventional study designed to evaluate the safety and performance of an investigational device during retrograde intrarenal surgery for the treatment of renal calculi.
- Conditions
- Kidney Stones, Urolithiasis, Nephrolithiasis
- Trial name
- DISON I (NCT07712861)
- Testing
- RIRS with Investigational Device
- Where
- 5 sites in Argentina, Canada and 3 more
- Volunteers
- 75 people
- Sponsor
- Ventaris Surgical Incorporated
Urolithiasis, Strategy Training
Real-World Study of Obstructive Upper Urinary Tract Stones and Acute Pyelonephritis
Upper urinary tract stone obstruction complicated by acute pyelonephritis is a critical urological emergency requiring urgent decompression and infection control, yet real-world clinical decisions regarding the choice between…
- Conditions
- Urolithiasis, Strategy Training, Observation, Pyelonephritis Acute
- Trial name
- NCT07816991
- Testing
- Ureteral Stent, Percutaneous Nephrostomy, Initial Medical Therapy
- Volunteers
- 1,650 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Kidney Calculi, Calcium Oxalate Kidney Stones
Bryophyllum Pinnatum Tea as a Novel Treatment for Recurrent Kidney Stone Formers
The aim of this randomized placebo-controlled double-blind crossover clinical trial is to test the ability of a traditional tea made from the leaf of the Bryophyllum pinnatum (B.
- Conditions
- Kidney Calculi, Calcium Oxalate Kidney Stones, Calcium Phosphate Kidney Stones
- Trial name
- NCT06987084
- Testing
- Bryophyllum pinnatum tea
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Indra Gupta
Renal Colic, Kidney Stones, Urolithiasis, Hypocitraturia
The Use of AR / VR in Patients Presenting to the ED With Renal Colic
Utilization of VR / AR Calming as an adjunct to pharmacologic pain management for Renal Colic in Emergency Department Patients
- Trial name
- NCT07070401
- Testing
- Commercial AR/VR Headset with Calming App, Pharmacologic Standard of Care Alone
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Community Medical Center, Toms River, NJ
Kidney Stone
Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis
The purpose of this study is to compare two variations of the mini-PCNL procedure using either a vacuum-assisted sheath or standard sheath which are both used for the surgical treatment of kidney stones.
- Trial name
- NCT05993546
- Testing
- vacuum assisted sheath, passive suction via conventional sheath
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The Cleveland Clinic
Nephrolithiasis
Is CYP24A1 Heterozygosity a Risk Factor for Nephrolithiasis?
Biallelic loss-of-function variants in CYP24A1 have been identified as a common genetic cause of autosomal recessive hypercalcemia (ARH, ORPHA 300547, 1 in 80,000 live births), characterized by low PTH (parathyroid hormone)…
- Trial name
- HETEROCYP (NCT07201701)
- Testing
- Supplementary blood samples for PBMC analysis at V2
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Hospices Civils de Lyon
Urolithiasis
Renal Stone Treatment Global Registry
This is an international prospective data registry to assess the treatment outcomes and complications of different treatment approaches for different surgical treatment of urolithiasis.
- Trial name
- NCT05297331
- Where
- 3 sites in Hong Kong
- Volunteers
- 3,000 people
- Sponsor
- Chinese University of Hong Kong
Nephrolithiasis
Tract Closure in PCNL
This is a prospective, randomized controlled trial evaluating the effect of a hemostatic agent on tract-related bleeding during percutaneous nephrolithotomy (PCNL).
- Trial name
- NCT07668817
- Testing
- Floseal, Surgicel, Surgiflo
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Kidney Stones, Nephrolithiasis
Effect of Complete Suction-Induced Collapse of the Renal Collecting System at the End of RIRS on Early Postoperative Outcomes
The purpose of this study is to evaluate whether actively suctioning the renal collecting system to induce a "collapse" state at the end of retrograde intrarenal surgery (RIRS) can reduce postoperative pain and infection in…
- Conditions
- Kidney Stones, Nephrolithiasis, Renal Calculi
- Trial name
- NCT07535281
- Testing
- Complete suction-induced collapse, Standard RIRS with natural drainage
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Kangdong Sacred Heart Hospital
Urolithiasis, Lithotripsy
A Study on the Application of NE Irrigation Fluid for Hemostasis in Flexible Ureteroscopic Lithotripsy: A Prospective Single-arm Interventional Study of Upper Urinary Tract Calculi.(NE: Norepinephrine)
Urinary stone disease is globally prevalent with rising incidence and recurrence, imposing heavy socioeconomic burdens. Flexible ureteroscopy has advanced stone treatment.
- Trial name
- NCT07786844
- Testing
- Using irrigation fluid with a certain concentration of norepinephrine
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Geriatric Hospital of Nanjing Medical University
Urolithiasis, Kidney Calculi
Human Voice vs AI-Cloned Voice Audio Added to Written Consent Before Ureteroscopy or Retrograde Intrarenal Surgery (AUDIO-CONSENT)
Before kidney stone surgery with a flexible or semirigid ureteroscope, patients must read and sign a written consent form, but many patients find these forms long and hard to understand.
- Conditions
- Urolithiasis, Kidney Calculi, Ureteral Calculi, Informed Consent
- Trial name
- AUDIO-CONSENT (NCT07859436)
- Testing
- Standard written informed consent, Human-voice audio consent recording, AI-cloned-voice audio consent recording
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Aydin Adnan Menderes University
Kidney Calculi, Kidney Stones
Comparison of Vacuum-Assisted and Conventional Ureteral Access Sheath in Retrograde Intrarenal Surgery
This study aims to compare the efficacy and safety, the ratio of stone-free rates, and complications of two types of access sheaths used in retrograde intrarenal surgery to treat upper urothelial stones.
- Trial name
- NCT06684756
- Testing
- Retrograde intrarenal surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Namik Kemal University
Kidney Calculi
Comparing Super Pulse Fiber Thulium Laser and Holmium Laser for Ureteral Stone Fragmentation During Ureteroscopy
The goal of this prospective, multicenter, randomized controlled trial is to objectively evaluate the clinical efficacy and safety differences between superpulse thulium fiber laser (sTFL) and holmium:YAG laser (Ho:YAG) in…
- Trial name
- NCT06667557
- Testing
- Superpulse Thulium Fiber Laser (sTFL) Treatment, Holmium:YAG Laser (Ho:YAG) Treatment
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Urologic Injuries, Kidney Disease
The Clinical Research of Traditional Chinese Medicine Formula
This study examines the efficacy and safety of Bushen Huoxue Simiao formula for tonifying the kidneys and promoting blood circulation in treating postoperative complications of upper urinary tract stones, thereby providing…
- Trial name
- NCT07746219
- Testing
- Bushen Huoxue Simiao Formula, control group
- Volunteers
- 80 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Nephrolithiasis, Kidney Stone
HoYAG vs TFL in miniPCNL With ClearPetra
Mini percutaneous nephrolithotripsy is the treatment of choice for kidney stones over 2cm. This procedure commonly uses laser energy for breaking the stones, and among possible laser platforms, Hoyag and thulium fiber laser are…
- Trial name
- NCT07087977
- Testing
- HoYAG laser, TFL laser platform
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Kansas Medical Center
Kidney Stone
Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser
In view of the positive results of the numerous studies conducted on forced diuresis after extra-corporeal lithotripsy, the investigators chose to evaluate forced diuresis by injection of Furosemide associated with intravenous…
- Trial name
- FIREStones (NCT05916963)
- Testing
- Furosemide 40 mg
- Where
- 9 sites in France
- Volunteers
- 374 people
- Sponsor
- University Hospital, Tours
Kidney Stone, Normal Controls
Oxalate and Citrate
This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.
- Trial name
- NCT05334979
- Testing
- Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Nephrolithiasis
Tissue Sensor for Semirigid Thulium Fiber Laser Ureterolithotripsy
Tissue Sensor (TS) is a technology designed to automatically deactivate laser emission when contact between the laser fiber and tissue is detected.
- Trial name
- Tissue Sensor (NCT07835113)
- Testing
- Semirigid TFL ureterolithotripsy with Tissue Sensor activated., Semirigid TFL ureterolithotripsy with Tissue Sensor deactivated.
- Volunteers
- 121 people
- Sponsor
- Botkin Hospital