Clinical trials: Urolithiasis, active
Urolithiasis
Renal Stone Treatment Global Registry
This is an international prospective data registry to assess the treatment outcomes and complications of different treatment approaches for different surgical treatment of urolithiasis.
- Trial name
- NCT05297331
- Where
- 3 sites in Hong Kong
- Volunteers
- 3,000 people
- Sponsor
- Chinese University of Hong Kong
Acupressure, Urinary Calculi
Acupressure as Complementary Analgesia in Shock Wave Lithotripsy
This study aims to evaluate the efficacy of acupressure applied to the LI4 (Hegu) and Qiu points before Extracorporeal Shock Wave Lithotripsy (ESWL) in patients with kidney or proximal ureteral stones.
- Conditions
- Acupressure, Urinary Calculi, Urolithiasis, ESWL
- Trial name
- NCT07885696
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Medipol University
Kidney Calculi, Kidney Diseases
Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure
Stone disease is a common condition, affecting approximately 9% of Americans in 2007. It causes great morbidity and is also a costly condition, estimated to cost the US healthcare system approximately 3.79 billion dollars in…
- Conditions
- Kidney Calculi, Kidney Diseases, Nephrolithiasis, Urolithiasis
- Trial name
- NCT05100017
- Testing
- Methocarbamol, Oxybutynin
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Northwestern University
Kidney Stone, Kidney Calculi
O. Formigenes Colonization in Calcium Oxalate Kidney Stone Disease
The goal of this trial is to test if colonization with the gut bacteria Oxalobacter formigenes leads to a reduction in urinary oxalate excretion in patients with calcium oxalate kidney stone disease.
- Conditions
- Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06330246
- Testing
- Low oxalate fixed diets pre-colonization, Moderately high oxalate fixed diets pre-colonization, Colonization with Oxalobacter formigenes
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Kidney Stone, Kidney Calculi
Gut Oxalate Absorption in Calcium Oxalate Stone Disease
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate.
- Conditions
- Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06331546
- Testing
- Low-oxalate diet, High-oxalate diet, soluble oxalate gut absorption test
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Renal Stone
Supervised Endoscopic Tele-controlled Intelligent Lithotripsy
This is a phase I feasibility study to investigate the use of a novel intelligent robotic retrograde intrarenal surgery (RIRS) platform.
- Trial name
- SENTINEL-1 (NCT07411391)
- Testing
- RIRS using the TaloStone T1000 RIRS platform
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- Chinese University of Hong Kong
Urolithiasis
Comparison of Two Versus Four Weeks of Ureteral Stenting Prior to Ureteroscopy After Failed Primary Ureteral Access
This study proposes a non-randomized controlled trial comparing 2 weeks versus 4 weeks of DJ ureteral stenting in patients whose primary ureteral access failed during an initial attempt at FURS.
- Trial name
- NCT07868874
- Testing
- Preoperative DJ Ureteral Stenting
- Where
- Pakistan
- Volunteers
- 198 people
- Sponsor
- PAEC General Hospital, Islamabad
Urolithiasis, Kidney Calculi
Human Voice vs AI-Cloned Voice Audio Added to Written Consent Before Ureteroscopy or Retrograde Intrarenal Surgery (AUDIO-CONSENT)
Before kidney stone surgery with a flexible or semirigid ureteroscope, patients must read and sign a written consent form, but many patients find these forms long and hard to understand.
- Conditions
- Urolithiasis, Kidney Calculi, Ureteral Calculi, Informed Consent
- Trial name
- AUDIO-CONSENT (NCT07859436)
- Testing
- Standard written informed consent, Human-voice audio consent recording, AI-cloned-voice audio consent recording
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Aydin Adnan Menderes University
Urolithiasis
Assessment of Urinary Microplastic Concentration in Patients With Urolithiasis: A Prospective Case-Control Study
This prospective observational case-control study aims to evaluate the presence and burden of microplastic particles in urine samples from patients with kidney and ureteral stones and to compare these findings with healthy…
- Trial name
- Microplastics (NCT07841834)
- Testing
- No Intervention
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Kidney Stones, Urolithiasis, Hypocitraturia, Living Kidney Donation
Long-Term Risk of Kidney Stones in Living Kidney Donors
Using a population-based, matched, retrospective cohort approach, this study will evaluate the long-term risk of kidney stones among living kidney donors compared with matched healthy nondonors.
- Conditions
- Kidney Stones, Urolithiasis, Hypocitraturia, Living Kidney Donation, Living Kidney Donor
- Trial name
- NCT07611500
- Testing
- Living kidney donation
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Urolithiasis, Strategy Training
Real-World Study of Obstructive Upper Urinary Tract Stones and Acute Pyelonephritis
Upper urinary tract stone obstruction complicated by acute pyelonephritis is a critical urological emergency requiring urgent decompression and infection control, yet real-world clinical decisions regarding the choice between…
- Conditions
- Urolithiasis, Strategy Training, Observation, Pyelonephritis Acute
- Trial name
- NCT07816991
- Testing
- Ureteral Stent, Percutaneous Nephrostomy, Initial Medical Therapy
- Volunteers
- 1,650 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Urinary Bladder Calculi, Bladder Calculi
Transurethral Versus Percutaneous Cystolithotripsy for Bladder Stones in Adults
This study evaluates and compares two minimally invasive surgical approaches for treating bladder stones in adult patients: transurethral cystolithotripsy (TUCL) and percutaneous cystolithotripsy (PCCL).
- Conditions
- Urinary Bladder Calculi, Bladder Calculi, Urolithiasis
- Trial name
- NCT07810582
- Testing
- Transurethral Cystolithotripsy, Percutaneous Cystolithotripsy
- Volunteers
- 50 people
- Sponsor
- Assiut University
Kidney Stone, Urolithiasis, Calcium Oxalate
Heterozygous Individuals for AGXT and Kidney Stones
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production.
- Trial name
- NCT04430426
- Testing
- Controlled Diet
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Healthy
Renal Metabolism of Glycolate to Oxalate
This study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled diet.
- Trial name
- NCT04437225
- Testing
- Low oxalate controlled Diet, Primed, continuous intravenous infusion of 13C2-Glycolate, Bolus intravenous infusion of 13C2-Glycolate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kidney Stones, Kidney Calculi
Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate.
- Conditions
- Kidney Stones, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06989320
- Testing
- Low-oxalate diet and glycolate dosing, Oral glycolate dosing, Oral 13C- ascorbic acid dosing
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Urolithiasis, Lithotripsy
A Study on the Application of NE Irrigation Fluid for Hemostasis in Flexible Ureteroscopic Lithotripsy: A Prospective Single-arm Interventional Study of Upper Urinary Tract Calculi.(NE: Norepinephrine)
Urinary stone disease is globally prevalent with rising incidence and recurrence, imposing heavy socioeconomic burdens. Flexible ureteroscopy has advanced stone treatment.
- Trial name
- NCT07786844
- Testing
- Using irrigation fluid with a certain concentration of norepinephrine
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Geriatric Hospital of Nanjing Medical University
Urolithiasis
Clinical Evaluation of the Pelvic Floor Fatigue Index (PFFI)
Background: Ureteral stent-related symptoms vary considerably among patients despite similar surgical procedures and stent characteristics.
- Trial name
- PFFI (NCT07763613)
- Testing
- Ureteroscopy / Retrograde Intrarenal Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Renal Stone Disease, Ureteral Stricture
Long-term Safety of UAS-assisted vs Sheathless RIRS in Non-prestented Patients
This retrospective comparative cohort study will include adult patients who underwent primary RIRS for renal stones ≤20 mm at Al-Azhar University Hospitals between January 2020 and December 2025.
- Conditions
- Renal Stone Disease, Ureteral Stricture, Hydronephrosis, Urolithiasis
- Trial name
- NCT07767773
- Testing
- Ureteral access sheath-assisted RIRS, Sheathless RIRS
- Where
- Egypt
- Volunteers
- 1,200 people
- Sponsor
- Al-Azhar University
Urolithiasis, Kidney Stones
Pain Control During ESWL Using Non-Opioid Analgesics
This prospective randomized controlled trial aims to compare the analgesic efficacy of three non-opioid analgesics (ibuprofen, paracetamol, and tenoxicam) during extracorporeal shock wave lithotripsy (ESWL).
- Conditions
- Urolithiasis, Kidney Stones, Ureteral Stones
- Trial name
- ESWL-PAIN (NCT07512297)
- Testing
- Ibuprofen (Brufen®), Paracetamol (drug), Tenoxicam
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- University of Gaziantep
Urolithiasis
Efficacy of Neorenal Forte for the Complete Elimination of Residual Fragments
The purpose of this study is to evaluate the efficacy of a specialized formula of phytotherapeutic extracts (Neorenal Forte) aiding the complete elimination of residual fragments after fURS in adults.
- Trial name
- NERFA (NCT06651294)
- Testing
- Neorenal Forte
- Where
- 9 sites in Bulgaria
- Volunteers
- 120 people
- Sponsor
- Neopharm Bulgaria Ltd.