Clinical trials: Urologic Diseases
Chronic Kidney Disease
Chat-based Instant Messaging Support Health Education Program
The purpose of this study is to explore the effectiveness of a CKD-specific chatbot-based instant messaging support health education (CIM-SHE) program and determine its user evaluation by CKD patients.
- Trial name
- NCT05665517
- Testing
- Chatbot Little K Nurse
- Where
- Taiwan
- Volunteers
- 55 people
- Sponsor
- National Taiwan Normal University
Acute Kidney Injury
IMPROVE AKI Cluster-Randomized Trial
When a person has an imaging procedure that uses radio-contrast dye, there is a possibility of damage to that person's kidneys, which could result in being on dialysis or early death.
- Trial name
- IMPROVE-AKI (NCT03556293)
- Testing
- AKI Prevention Toolkit, Technical Assistance (TA), Virtual Learning Collaborative (VLC)
- Where
- 2 sites in United States
- Volunteers
- 10,252 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Acute Kidney Injury, Chronic Kidney Diseases
Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices (NEPHROCT)
Kidney biopsy play a key role for the investigation of either acute kidney injury or chronic kidney disease. Despite possible complications due to the invasive nature of the biopsy, such procedure is still essential in a number…
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Tomography, Optical Coherence
- Trial name
- NEPHROCT (NCT05728216)
- Testing
- Dynamic full-field optical coherence tomography analysis of kidney biopsy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier William Morey - Chalon sur Saône
Diabetes, Hypercholesterolemia
Baromètre Santé Adulte 2021-2022
In 2021-2022, Agence Sanitaire et Sociale Nouvelle Calédonie (ASSNC) is undertaking the "Baromètre Santé Adulte" for the third time.
- Conditions
- Diabetes, Hypercholesterolemia, Renal Failure, Dengue Fever
- Trial name
- NCT05218304
- Testing
- Blood sample
- Where
- New Caledonia
- Volunteers
- 5,471 people, healthy volunteers welcome
- Sponsor
- Agence Sanitaire et Sociale de Nouvelle Calédonie
Overactive Bladder, Constipation
Dysfunctional Voiding and Lower Urinary Tract Symptoms With Baclofen
Dysfunctional voiding is often associated with constipation. The association of constipation with urologic pathologic processes has previously been described since the 1950's, but it was only over the past decade that clinicians…
- Conditions
- Overactive Bladder, Constipation, Lower Urinary Tract Symptoms
- Trial name
- NCT01003249
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Renal Cell Carcinoma, Brain Metastasis
Study of Lenvatinib Plus Pembrolizumab in IO Refractory mRCC Patients With Brain Metastases
This is a multi-center, open-label phase II study evaluating the efficacy and safety of pembrolizumab in combination with lenvatinib in patients with renal cell carcinoma (RCC) and brain metastasis who were previously treated…
- Trial name
- NCT07011849
- Testing
- Pembrolizumab, Lenvatinib
- Sponsor
- M.D. Anderson Cancer Center
Urinary Incontinence, Stress
Treatment of Stress Urinary Incontinence by Injection of Autologous Muscle Fibers Into the Urethral Sphincter.
This pilot study examines safety and efficacy of a simple procedure for treatment of stress urinary incontinence. A muscle biopsy is taken from the thigh, minced and injected into the urethral sphincter.
- Trial name
- NCT01323426
- Testing
- Periurethral injection
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital at Herlev
Kidney Disease, Chronic, Diabetic Kidney Disease (DKD)
Mesenchymal Stem Cells for Chronic Kidney Diseases
This study will evaluate the effect of intravenous injection of umbilical cord tissue derived mesenchymal stem cells (UMSCs) on the improvement of renal function in patients with chronic kidney disease (CKD) at stage 3 or 4, with…
- Conditions
- Kidney Disease, Chronic, Diabetic Kidney Disease (DKD), Hypertensive Nephropathy
- Trial name
- NCT07240987
- Testing
- 0.9% sodium chloride, MSCs
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital of Air Force Medical University
Urolithiasis, Nephrolithiasis
Effect of Furosemide on ESWL Outcomes for Renal and Ureteral Calculi
The minimally-invasive extracorporeal shockwave lithotripsy (ESWL) procedure is generally considered the best first-line treatment option for most adults and children with nephrolithiasis, especially when the calculi are smaller…
- Conditions
- Urolithiasis, Nephrolithiasis, Urinary Calculi, Ureterolithiasis
- Trial name
- NCT05270421
- Testing
- Furosemide 40 mg, Conventional Treatment
- Where
- Iran
- Volunteers
- 500 people
- Sponsor
- Shiraz University of Medical Sciences
Metastatic Bladder Cancer, Metastatic Urothelial Carcinoma
A Study to Compare the Results of FGFR Testing by Either ctDNA Blood Testing or Standard Tumor Tissue Testing
A new drug, erdafitinib, became available for some patients with bladder cancer that has spread to other organs. To qualify, patients must have specific genetic changes in their tumors.
- Trial name
- NCT06129084
- Testing
- FGFR Testing
- Where
- 7 sites in Canada
- Volunteers
- 260 people
- Sponsor
- Bernie Eigl
Solid Tumor, Colorectal Cancer
A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors
The main purpose of this study is to establish the safety and the recommended dose of TRK-950 in combination with FOLFIRI, Gemcitabine / Cisplatin, Gemcitabine / Carboplatin, Ramucirumab / Paclitaxel, PD1 inhibitors (Nivolumab or…
- Conditions
- Solid Tumor, Colorectal Cancer, Cholangiocarcinoma, Bladder Cancer
- Trial name
- NCT03872947
- Testing
- TRK-950, Irinotecan, Leucovorin
- Where
- 14 sites in United States, France
- Volunteers
- 138 people
- Sponsor
- Toray Industries, Inc
ccRCC, Clear Cell Renal Cell Carcinoma
Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc)
The goal of the Lead-in phase of the study is to evaluate the safety, efficacy, pharmacokinetics (PK) and determine recommended dose for expansion (RDE) of NKT2152 in combination with palbociclib (Doublet) and with palbociclib…
- Conditions
- ccRCC, Clear Cell Renal Cell Carcinoma, Kidney Cancer, Kidney Neoplasms
- Trial name
- NCT05935748
- Testing
- NKT2152, palbociclib, sasanlimab
- Where
- 8 sites in United States
- Volunteers
- 18 people
- Sponsor
- NiKang Therapeutics, Inc.
Interstitial Cystitis
Relationship of Interstitial Cystitis to Vulvodynia
This study is important in urologic nursing since many patients have interstitial cystitis (IC), a condition of frequency, urgency and pain affecting more than 1 million women in the United States.
- Trial name
- NCT00546858
- Testing
- Physical Examination
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Corewell Health East
Kidney Stone
LithoVue Single Use Disposable Ureteroscope
Most flexible ureteroscopes that are used to treat kidney stones have been reusable. Recently, advances in technology have resulted in single-use (disposable) ureteroscopes to become available.
- Trial name
- NCT03419091
- Testing
- single-use flexible digital ureteroscope, Reusable Ureteroscope
- Where
- 2 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Interstitial Cystitis, Levator Spasm
A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain
The goal of this clinical trial is to compare two different treatment patterns in patients with chronic bladder pain. The main questions the investigators are seeking to answer is if bladder pain improves before and after…
- Conditions
- Interstitial Cystitis, Levator Spasm, Bladder Pain Syndrome
- Trial name
- NCT05658874
- Testing
- Multimodal Bundle Drugs, Operative Cystoscopy, Behavioral health consultation/therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Jocelyn Fitzgerald
End-stage Renal Disease
Ellipsys Vascular Access System Registry
Ellipsys Vascular Access System Registry will enroll up to 100 patients to evaluate the use and performance of the Ellipsys Vascular Access System when it is used within its intended use in accordance with standard of care in a…
- Trial name
- NCT03454113
- Testing
- Ellipsys Vascular Access
- Where
- 5 sites in Germany
- Volunteers
- 17 people
- Sponsor
- Medtronic Endovascular
Kidney Diseases
Renasight Clinical Application, Review and Evaluation (RenaCARE) Study
This study is an open-label, multi-center study evaluating the clinical utility of Renasight in the diagnosis and management of kidney disease.
- Trial name
- RenaCARE (NCT05846113)
- Testing
- Renasight
- Where
- 31 sites in United States
- Volunteers
- 1,720 people
- Sponsor
- Natera, Inc.
Sepsis, Surgery
Inflammatory Mediators of Acute Kidney Injury in Intensive Care
Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality.
- Conditions
- Sepsis, Surgery, Acute Kidney Injury
- Trial name
- PronMed (NCT03720860)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Chronic Kidney Disease, Pain, Procedural
Comparing Mirror and Music for Dialysis Needle Pain
Inserting needles into the vascular access (fistula) is a major source of pain and anxiety for many hemodialysis patients. This study compared two simple, non-drug techniques to reduce this pain: listening to music and looking…
- Conditions
- Chronic Kidney Disease, Pain, Procedural, Arteriovenous Fistula
- Trial name
- MIRROR-MUSIC (NCT07320859)
- Testing
- Mirror Therapy (Visual Illusion Therapy), Music Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Izmir Kavram Vocational School
Recurrent Childhood Kidney Neoplasm, Stage I Kidney Wilms Tumor
Gene Analysis in Studying Susceptibility to Wilms Tumor
This clinical trial studies gene analysis in studying susceptibility to Wilms tumor. Finding genetic markers for Wilms tumor may help identify patients who are at risk of relapse.
- Conditions
- Recurrent Childhood Kidney Neoplasm, Stage I Kidney Wilms Tumor, Stage II Kidney Wilms Tumor, Stage III Kidney Wilms Tumor
- Trial name
- NCT01808079
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Oncology Group
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