Clinical trials: Urologic Diseases
Diabetic Nephropathy
Study on the Efficacy and Safety of a Novel Tripterygium Wilfordii Preparation in Reducing Proteinuria in Patients With Diabetic Nephropathy
The investigators designed a randomized parallel controlled clinical study, selected 98 cases of diabetic nephropathy patients with urinary protein > 1g, randomly assigned into the Kunxian capsule + irbesartan group or irbesartan…
- Trial name
- NCT04981613
- Testing
- Kunxian capsule
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Myocardial Infarction
Accelerated Rule Out of Myocardial Infarction
Every year > 50.000 people in Denmark are hospitalized with a suspected acute myocardial infarction (AMI). The majority has other explanations of their chest discomfort and most are discharged again without any initiation of…
- Trial name
- AROMI (NCT02666326)
- Testing
- Accelerated, combined biomarker rule-out strategy for MI
- Where
- 3 sites in Denmark
- Volunteers
- 4,516 people
- Sponsor
- Aarhus University Hospital Skejby
Multiple Organ Failure, End Stage Cardiac Failure
Timing of Acute Palliative Care Consultation in Critically Ill Patients
A prospective randomized controlled trial studying the ordering of palliative care consultations in the emergency department (Ig) versus later palliative care consultations in the hospital--ICU or hospital ward(Cg).
- Conditions
- Multiple Organ Failure, End Stage Cardiac Failure, End Stage Chronic Obstructive Airways Disease, Chronic Kidney Disease Stage 5
- Trial name
- NCT02858778
- Testing
- Early order of palliative care consultation
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Renal Cell Carcinoma
Identification and Description of Patients With High-risk Non Metastatic RCC
Renal cell carcinoma (RCC) is the 14th most common cancer worldwide. Surgery is the standard of care for localized RCC, however, the risk of recurrence varies widely among patients.
- Trial name
- HIROES (NCT07753343)
- Testing
- Cohort 1, Cohort 2, Cohort 3
- Where
- France
- Volunteers
- 6,109 people
- Sponsor
- University Hospital, Bordeaux
Reusable Underwear, Urinary Incontinence, Dispoable Pad
Randomized Controlled Crossover Comparison of Icon Underwear to Disposable Pads
This is a randomized cross over trial to compare quality of life and product performance between Icon reusable underwear versus standard disposable pad in patients with mild to moderate urinary incontinence.
- Trial name
- NCT03263676
- Testing
- Icon resuable underwear, Disposable pad
- Volunteers
- 70 people
- Sponsor
- Medstar Health Research Institute
Chronic Kidney Disease
Determinants of Muscle Strength in Chronic Kidney Disease
Aim of this study is to determine in chronic kidney disease patients: the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle…
- Trial name
- NCT02806089
- Testing
- Handheld dynamometer, Creatinine index, Electrical bioimpedance analysis
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Melanoma, Prostate Cancer
Low Dose Naltrexone for Metastatic Melanoma, Castrate Resistant Prostate Cancer and Renal Cancer
will scientifically evaluate whether Low Dose Naltrexone (LDN) has activity in refractory solid tumors within the context of a phase II clinical study
- Conditions
- Melanoma, Prostate Cancer, Renal Cancer
- Trial name
- NCT01650350
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brown University
Urinary Tract Infections, Pyelonephritis
Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis
The purpose of this study is to assess the microbiological cure rate of doripenem in the treatment of patients with complicated urinary tract infection or pyelonephritis.
- Trial name
- NCT00210990
- Testing
- doripenem
- Volunteers
- 403 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Chronic Kidney Disease
Study of an Autologous Neo-Kidney Augment in Patients With Chronic Kidney Disease
The primary purpose of this study is to assess the safety and optimal delivery of the Neo-Kidney Augment (NKA) when implanted at one site in a recipient kidney.
- Trial name
- NCT01846715
- Testing
- Implantation of SRC
- Where
- 2 sites in Sweden
- Volunteers
- 6 people
- Sponsor
- Tengion
Bladder Cancer
DURvalumab in Combination With S-488210/S-488211 vAccine in Non-muscle Invasive Bladder CancEr
DURANCE is a two part, phase Ib/II, multi-centre study to assess the safety and activity of S-488210/S-488211 in combination with durvalumab, in patients with non-muscle invasive bladder cancer (NMIBC).
- Trial name
- DURANCE (NCT04106115)
- Testing
- Durvalumab, S-488210/S-488211
- Where
- 7 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- University College, London
Renal and Urinary Disorders, Renal Cancer
Application of the "Off-Clamp And Sutureless" Technique in Robot-Assisted Partial Nephrectomy
The detection rate of renal masses smaller than 7 cm has significantly increased in recent years. To preserve postoperative renal function to the greatest extent possible, guidelines from the European Association of Urology…
- Conditions
- Renal and Urinary Disorders, Renal Cancer, Renal Particial
- Trial name
- NCT07141225
- Testing
- Off-Clamp Sutureless Technique
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Shao Pengfei
Retrograde Intrarenal Surgery, Renal Stones
Retrograde Intrarenal Surgery Low Risk Trial
In the treatment of kidney stones and upper ureteral stones, flexible ureteroscopic lithotripsy has become the mainstream choice due to its minimally invasive nature and high safety.
- Trial name
- NCT06741917
- Testing
- Levofloxacin, Cefmetazole (drug)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Renal Stones
Standard Versus Mini Percutaneous Nephrolithotomy for Renal Stones
Renal stone disease is a common urological condition associated with significant morbidity. Percutaneous nephrolithotomy (PCNL) is the standard treatment for renal stones larger than 2 cm.
- Trial name
- NCT07464717
- Testing
- Mini Percutaneous Nephrolithotomy, Standard Percutaneous Nephrolithotomy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Teaching Hospital
Lung Cancer, Head and Neck Cancer
First-in-human Study of S-588210 (S-488210+S-488211)
The primary objective is to evaluate the safety and tolerability of S-588210 (S-488210+S-488211) in patients with unresectable recurrent and/or metastatic solid tumors.
- Conditions
- Lung Cancer, Head and Neck Cancer, Bladder Cancer, Esophageal Cancer
- Trial name
- NCT04316689
- Testing
- S-488210, S-488211
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Shionogi
Kidney Disease
A Study of GSK4771261 in Healthy Participants Aged 25 to 55 Years of Age Inclusive
This is a first time in Asia (FTIA) study of GSK4771261 in healthy participants of Chinese, Japanese, and White/European ancestry.
- Trial name
- NCT07600450
- Testing
- GSK4771261
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Renal Insufficiency, Chronic, Hypertension
Mobile Health Technology for Chronic Kidney Disease Patients: Medication Management
Patients with complex, long-lasting conditions such as chronic kidney disease (CKD) often take multiple medications and frequently have serious medication problems, arising from poor communication between doctors and patients.
- Conditions
- Renal Insufficiency, Chronic, Hypertension, Medication Reconciliation, Mobile Applications
- Trial name
- NCT02905474
- Testing
- Usual Care, Integrated mobile medication app, Commercially available mobile medication app
- Where
- Canada
- Volunteers
- 182 people
- Sponsor
- University Health Network, Toronto
Overactive Bladder
Microorganism in Overactive Bladder Patients
The objective of this prospective study is to determine the incidence of mycoplasma in women with overactive bladder (OAB) symptoms and whether antibiotic therapy targeting these organisms is effective.
- Trial name
- NCT00883818
- Testing
- azithromycin, doxycycline
- Where
- 3 sites in South Korea
- Volunteers
- 84 people
- Sponsor
- Samsung Medical Center
Diabetic Nephropathy, Diabetes Mellitus
Soy Protein in Early Diabetic Nephropathy
Diabetic nephropathy is a frequent cause of end-stage renal disease. Reduction of dietary protein has been used to slow down renal disease progression, but patients are often unwilling to make these dietary changes.
- Trial name
- NCT00067678
- Testing
- soy protein
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Urinary Incontinence
Translating Unique Learning for Incontinence Prevention
More than one in three US women suffers from the distressing, embarrassing, and often unreported problem of urinary incontinence (UI). UI severity increases with age and the financial cost exceeds $19 billion per year .
- Trial name
- TULIP (NCT01599715)
- Testing
- Instructional DVD, Bladder Health Class
- Where
- 2 sites in United States
- Volunteers
- 647 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Acute Kidney Injury
Neutral Endopeptidase for Early Detection of Acute Kidney Injury After Cardiac Surgery
The investigators want to investigate if the urinary biomarker neprilysin can identify cardiac surgical patients suffering from postoperative AKI within 24 hours.
- Trial name
- NEPAKI-CS (NCT03854825)
- Testing
- Cardiac surgery
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
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