Clinical trials: Urologic Diseases
Acute Kidney Injury
Strategy for Uptake of Processes for Recognizing and Responding to Acute Kidney Injury
Acute kidney injury (AKI) is common and costly complication of major surgery. AKI can lead to prolonged hospitalization and a higher likelihood of dialysis, chronic kidney disease and death.
- Trial name
- SUPPORT AKI (NCT03564314)
- Testing
- SUPPORT AKI Clinical Decision Support
- Where
- 4 sites in Canada
- Volunteers
- 2,135 people
- Sponsor
- University of Calgary
Uremia, Uremic Osteodystrophy
Multi-center Clinical Study on Hemoperfusion of KHA80
To evaluate the decreasing rate of blood IL-6, β2-MG and PTH in maintenance hemodialysis patients in the 52nd week compared with routine hemodialysis.
- Conditions
- Uremia, Uremic Osteodystrophy, Dialysis Related Complication
- Trial name
- NCT06233838
- Testing
- KHA80 hemoperfusion treatment
- Where
- China
- Volunteers
- 394 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Gitelman Syndrome, Potassium Depletion
Monocentric STUDY, Randomised Double Blinded (Healthy Subjects, or Transversal (Patients With Gitelman Syndrome)
Progesterone is needed to permit adaptation of the kidney to limit potassium loss in the urines. The investigators wonder whether progesterone or other adrenal hormon play the same role.
- Trial name
- DEPROGE (NCT02297048)
- Testing
- Potassium depletion
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
IgA Nephropathy
Correlation of Microbiome and Metabonomics With IgA Nephropathy
IgAN is the most prevalent primary glomerulonephritis in China, is characterized by the deposition of IgA1 (particularly, galactose-deficient IgA1) in the glomerular mesangium.
- Trial name
- NCT05190848
- Where
- 5 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Overactive Bladder (OAB), Overactive Bladder Syndrome
Real-world Experiences and Voices Exploring the Actual Lived Burden of OAB: A Mixed-methods Multi-country PROMs Study on OAB Patients' Quality of Life
The main goal is to understand what it is truly like to live with OAB from the patient's perspective, including how it affects: daily activities, emotional wellbeing and mental health, social life and relationships, work and…
- Trial name
- REVEAL-OAB (NCT07545148)
- Volunteers
- 2,000 people
- Sponsor
- European Association of Urology Research Foundation
Acute Kidney Injury
Impact of a Treatment With Angiotensin Receptor Blocker on Outcome After Acute Kidney Injury in Patients Discharged From the ICU.
The patients discharged from intensive care units (ICU) have a high incidence of cardiovascular events and mortality rate during the year following ICU discharge.
- Trial name
- START-or-NOT (NCT05272878)
- Testing
- IRBESARTAN, tablet, 150 mg
- Where
- France
- Volunteers
- 508 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
End Stage Renal Disease and Cognitive Impairment
Blood-Brain Barrier Evaluation In Nephrology (BREIN)
Patients with Chronic Kidney Disease (CKD) have impaired psycho-cognitive functions in parallel with deteriorating kidney function.
- Trial name
- BREIN (NCT04328415)
- Testing
- Cerebral scintigraphy
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Kidney Disease With High Proteinuria
Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)
This is a Phase III, randomised, multicentre, double-blinded study to evaluate efficacy, safety and tolerability of treatment with zibotentan/dapagliflozin and dapagliflozin alone in participants with chronic kidney disease (CKD)…
- Trial name
- NCT06087835
- Testing
- Zibotentan/Dapagliflozin, Dapagliflozin
- Where
- 296 sites in United States, Argentina and 28 more
- Volunteers
- 1,835 people
- Sponsor
- AstraZeneca
Carcinoma, Hepatocellular, Colorectal Neoplasms
Early Biomarkers of Tumor Response in High Dose Hypofractionated Radiotherapy Word Package 3 : Immune Response
This study will follow-up immune cell populations, secreted factors and released nanovesicles in the blood before, during and after high dose radiation therapy which should give new information of the efficacy of the…
- Conditions
- Carcinoma, Hepatocellular, Colorectal Neoplasms, Melanoma, Kidney Neoplasms
- Trial name
- NCT02439008
- Testing
- Blood samples collection before radiotherapy, Blood samples collection during radiotherapy, Blood samples collection after radiotherapy
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Oscar Lambret
Kidney Failure
Phosphorus and Calcium Removal During Long Hemodialysis Treatment Sessions
The purpose of this sudy is to determined the effect of dialysate volume and treatment time on phosphate and calcium removal in stage V chronickidney disease patients treated by hemodialysis using the System One (NxStage Medical…
- Trial name
- hemodialysis (NCT00633308)
- Testing
- NxStage System One (NxStage Medical, Lawrence, MA)
- Sponsor
- Indiana University
Renal Insufficiency, Chronic
Educational Programme Impact on Serum Phosphate Control
Background: In Chronic Kidney Disease patients, it is crucial to begin treatment as soon as possible in order to minimize the complication-related risks.
- Trial name
- EPIC (NCT02626676)
- Testing
- Educational Programme
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- University of Sao Paulo
Moxibustion, Hematopoietic Stem Cell Transplantation
Moxibustion for the Prevention of Hemorrhagic Cystitis After Allo-HSCT
This study was a prospective, multicenter, randomized controlled clinical study planned to recruit 266 hematological patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT), who were randomly divided into two…
- Conditions
- Moxibustion, Hematopoietic Stem Cell Transplantation, Hemorrhagic Cystitis, Prevention
- Trial name
- NCT06198517
- Testing
- Moxibustion, Symptomatic treatment
- Where
- 4 sites in China
- Volunteers
- 303 people
- Sponsor
- Yi Zhang
Urinary Incontinence,Stress, Stress Urinary Incontinence
Synchronized Core-Pelvic Floor Activation in Urinary Incontinence
This study aims to investigate whether co-activation of the pelvic floor and core muscles improves treatment outcomes in individuals with urinary incontinence.
- Conditions
- Urinary Incontinence,Stress, Stress Urinary Incontinence, Mixed Incontinence Due to Prolapse of Female Genital Organ, Urinary Incontinence
- Trial name
- NCT07387640
- Testing
- Conventional Pelvic Floor Muscle Training, Pelvic Floor and Core Muscle Co-activation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
X-Linked Hypophosphatemia
Study of the Safety, Pharmacodynamics (PD) and Efficacy of KRN23 in Children From 1 to 4 Years Old With X-linked Hypophosphatemia (XLH)
The primary objectives of the study are to: Establish the safety profile of KRN23 for the treatment of XLH in children between 1 and 4 years old Determine the PD effects of KRN23 treatment on serum phosphorus and other PD markers…
- Trial name
- NCT02750618
- Testing
- Burosumab
- Where
- 3 sites in United States
- Volunteers
- 13 people
- Sponsor
- Kyowa Kirin, Inc.
Child, Only, Chronic Renal Failure in Children
The Effect of a Mobile Game Application on Children With CRF
The aim of this study was to investigate the effect of a mobile game application developed for children with Chronic Renal Failure (CRF) on disease management. The study was a randomized controlled trial.
- Conditions
- Child, Only, Chronic Renal Failure in Children, Gambling, Disease
- Trial name
- NCT07162220
- Testing
- The clinic's routine education program, Mobile game app
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Akdeniz University
Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery
Near Infrared Spectroscopy for the Detection of Acute Kidney Injury in Children Following Cardiac Surgery
One in a hundred children is born with a heart defect. Some children require heart surgery within the first few days of life, while others can wait until they are older.
- Conditions
- Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery, Children
- Trial name
- NCT01382758
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Bladder Cancer, Urothelial Carcinoma
Bladder Cancer Screening Trial
There is currently no accepted screening strategy for patients at high risk of developing bladder cancer. This study will ask patients to complete a urine test every 6 months for 2 years to help assess if routine screening helps…
- Conditions
- Bladder Cancer, Urothelial Carcinoma, Hematuria, Smoking Cessation
- Trial name
- NCT05646485
- Testing
- Urinalysis
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Renal Cell Carcinoma
Clinical Study With Axitinib In Advanced Kidney Cancer, Who Have Failed First Line Treatment
This is a single arm study with axitinib in patients with advanced kidney cancer (clear cell variant), who have failed first line therapy.
- Trial name
- NCT01473043
- Testing
- Axitinib
- Where
- 4 sites in Australia, Canada
- Sponsor
- Pfizer
Kidney Diseases
Cell-based Therapy for the Treatment of Kidney Disease
Endothelial progenitor cells derived from and delivered to the renal vasculature may be stimulated to initiate differentiation programs during episodes of injury.
- Trial name
- CTKD (NCT04187625)
- Testing
- endothelial progenitor cell
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Spinal Anesthesia, Nursing
The Effect of Local Dry Heat Applıcatıon and Half Shower on The Development of Urinary Retentıon and Paın
Urinary retention is defined as the inability to empty the bladder spontaneously even though the bladder is full. Although urinary retention is seen in two forms as acute and chronic, acute urinary retention is defined by the…
- Conditions
- Spinal Anesthesia, Nursing, Bladder Retention, Dry Heat Application
- Trial name
- NCT05580289
- Testing
- half-shower and hot pack
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Duzce University
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