Clinical trials: Uterine Cervical Dysplasia
Cervical Intraepithelial Neoplasia, Cervix Uteri Cancer
Incidence of Cervical Cancer in HPV-positive Women With Low-grade Cytological Abnormalities
The goal of this observational study is to assess the five-year incidence of histologically confirmed cervical cancer among women who test positive for human papillomavirus (HPV) with low-grade cytological abnormalities, to…
- Conditions
- Cervical Intraepithelial Neoplasia, Cervix Uteri Cancer, Human Papilloma Virus, Cervix Carcinoma
- Trial name
- NCT07259616
- Volunteers
- 46,079 people
- Sponsor
- Gynaecologisch Oncologisch Centrum Zuid
Atypical Squamous Cell of Undetermined Significance, ASC-US
Comparison Of Cytology And Molecular Screening For Detecting Cervical Reactive Cellular Changes In General Population
This study compares the efficacy of cytology (Pap smear) with the molecular screening in their ability to detect reactive cellular changes in the cervix among an open population
- Conditions
- Atypical Squamous Cell of Undetermined Significance, ASC-US, Atypical Glandular Cells of Uncertain Significance, AGUS
- Trial name
- NCT07211204
- Testing
- Physical examination, Liquid-based cytology, Molecular screening
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Timser SAPI de CV
CIN - Cervical Intraepithelial Neoplasia, HPV
Multiple Human Papillomavirus Infections in the Development of CIN
Multiple infections of high-risk genotypes of Human Papillomavirus (HR-HPV) in patients with abnormal cervical cytological or histological findings are detectable in a percentage ranging from 20% to 50% of cases.
- Conditions
- CIN - Cervical Intraepithelial Neoplasia, HPV, HPV Vaccines
- Trial name
- HPV dysplasia (NCT06862102)
- Testing
- HPV vaccine
- Where
- Italy
- Volunteers
- 152 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cervical Cancer, Cervical Dysplasia
Coughing at Time of Cervical Biopsy
To investigate the effect of coughing as an intervention to reduce pain in colposcopy guided biopsy.
- Conditions
- Cervical Cancer, Cervical Dysplasia, Colposcopy, Pain Sensation
- Trial name
- NCT06149598
- Testing
- Coughing at the time of biopsy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Uterine Cervical Dysplasia, Uterine Cervical Intraepithelial Neoplasia
Clinical Trial for the Use of a Novel Cell Collector Device to Retrieve Cells From the Uterine Cervix
This study tested the safety and performance of a new cell collector device and compared the results to those obtained with the current existing device that are being used routinely
- Conditions
- Uterine Cervical Dysplasia, Uterine Cervical Intraepithelial Neoplasia, Uterine Cervical Neoplasia, Uterine Cervical Cancer
- Trial name
- NCT00266084
- Volunteers
- 85 people
- Sponsor
- University Hospitals Cleveland Medical Center
Cervical Intraepithelial Neoplasia, Cervical Cancer
A Bridging Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls
This is a bridging trial of the recombinant HPV 16/18 bivalent vaccine manufactured by Xiamen Innovax Biotech CO., LTD.The primary objective of this study is to evaluate the immunogenicity (type specific IgG antibody) and safety…
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT02562508
- Testing
- 3 doses of HPV 16/18 bivalent vaccine, 2 doses of HPV 16/18 bivalent vaccine
- Where
- China
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- Jun Zhang
Cervical Cancer, Cervical Intraepithelial Neoplasm
The Role of Blood Perfusion in Cervical Cancer, Cervical Intraepithelial Neoplasm and Ovarian Cancer Patients
This study will elucidate the role of 3D transvaginal ultrasound in assessing (1) cervical vascularity and blood flow in patients with cervical cancer and cervical intraepithelial neoplasm, and (2) tumor vascularity and blood…
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasm, Ovarian Cancer
- Trial name
- NCT07385976
- Testing
- Doppler ultrasound
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Cervical Precancer, Cervical Intraepithelial Neoplasia
Point of Care - Triage and Treatment for Cervical Pre-cancer
This study evaluates a modified two-probe thermal ablation protocol using the IRIS™ device and retrospectively assesses an AI-based Automated Visual Evaluation (AVE) triage algorithm among HPV-positive women in El Salvador.
- Conditions
- Cervical Precancer, Cervical Intraepithelial Neoplasia, Human Papillomavirus Infection
- Trial name
- POC (NCT07461818)
- Testing
- IRIS™ Thermal Ablation Device
- Where
- El Salvador
- Volunteers
- 5,000 people
- Sponsor
- Basic Health International, Inc.
High-grade Squamous Intraepithelial Lesions (HSIL), Cervical Conization
Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation
The goal of this multicenter, observational study is to evaluate whether methylation testing of paired box gene 1 (PAX1) can better predict and diagnose recurrence or persistent disease in patients with positive margins after…
- Trial name
- NCT06713655
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Cervical Intraepithelial Neoplasia
Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Plasmid DNA Therapeutic Vaccine(GX-188E)
The purpose of this study is to access the efficacy and safety of GX-188E according the protocol in patients with Cervical Intraepithelial Neoplasia 2, 2/3 or 3 (CIN3)
- Trial name
- NCT02596243
- Testing
- GX-188E
- Where
- 16 sites in Estonia, South Korea and 1 more
- Volunteers
- 134 people
- Sponsor
- Genexine, Inc.
Cervical Intraepithelial Neoplasia, Uterine Artery Hemodynamics
Changes in Uterine Artery Resistance Index Following Cervical Conization
The objective of this prospective study is to evaluate the hemodynamic impact of cervical conization on uterine artery blood flow by focusing on the Resistance Index (RI) as a direct indicator of distal vascular resistance.
- Trial name
- NCT07653191
- Testing
- Cervical Conization
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adana City Training and Research Hospital
Uterine Cervical Dysplasia
Fischer Cone Biopsy Excisor Versus Loop Excision Procedure for Conization
In a randomized clinical trial of 160 women undergoing conization for cervical dysplasia, two electrosurgical excision methods, Fischer Cone Biopsy Excison vs. Loop Excision Procedure, will be compared.
- Trial name
- NCT02515162
- Testing
- Fischer Cone Biopsy Excisor, Loop Excision Procedure
- Where
- Germany
- Volunteers
- 178 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Cervical Cancer
First-void Urine Samples for the Follow-up of Women Treated for High-grade Cervical Intraepithelial Neoplasia (CIN)
The aim of this study is to analyse biomarkers in first-void urine for improved follow-up of women treated for high grade cervical intraepithelial neoplasia (CIN).
- Trial name
- NCT03542513
- Testing
- Colli-Pee, Qvintip
- Where
- Belgium
- Volunteers
- 65 people
- Sponsor
- Universiteit Antwerpen
Cervical Intraepithelial Neoplasia
Cryotherapy vs. LEEP to Treat Cervical Intraepithelial Neoplasia (CIN) 2/3 Among HIV-positive Women
The purpose of this study is to compare the rate of recurrence of cervical intraepithelial neoplasia among HIV-positive women receiving cryotherapy versus LEEP over 2 years of follow-up and to compare the shedding of HIV-1 from…
- Trial name
- PHE-LEEP (NCT01298596)
- Testing
- Loop Electrosurgical Excision Procedure (LEEP), Cryotherapy
- Where
- Kenya
- Volunteers
- 400 people
- Sponsor
- University of Washington
Cervical Intraepithelial Neoplasia (CIN), Cervical Cancer
Correlation Between Selenium Levels in Human Tissues and HPV-related Cervical Lesions and Outcomes
This study investigates the relationship between selenium levels in human tissues and the persistence of HPV (human papillomavirus) infection, particularly focusing on cervical-related lesions.
- Conditions
- Cervical Intraepithelial Neoplasia (CIN), Cervical Cancer, Persistent HPV Infection
- Trial name
- SeHPV (NCT06665841)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Cervical Intraepithelial Neoplasia
A Clinical Trial of PepCan to Two Therapy Arms for Treating Cervical High-Grade Squamous Intraepithelial Lesions
This is a Phase II study to evaluate the efficacy and safety of a human papilloma virus (HPV) therapeutic vaccine called PepCan (HPV 16 E6 peptides combined with Candida skin testing reagent called Candin®) in adult females over…
- Trial name
- NCT02481414
- Testing
- PepCan, Candin®
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Arkansas
Cervical Intraepithelial Neoplasia
Efficacy and Safety Study of BLS_ILB_E710c for the Fertile Women With Cervical Intraepithelial Neoplasia(CIN3)
The purpose of this study is to determine the efficacy and the safety of BLS-ILB-E710c for the the fertile women with Cervical Intraepithelial Neoplasia (CIN3).
- Trial name
- NCT02195089
- Testing
- BLS_ILS_E710c 500mg, BLS_ILB_710c 1000mg, BLS_ILS_E710c 1500mg
- Where
- 5 sites in South Korea
- Volunteers
- 19 people
- Sponsor
- BioLeaders Corporation
Cervical Cancer
Carotenoid Rich Diet in Treating Cervical Dysplasia
RATIONALE: A diet rich in carotenoids may be an effective treatment for cervical dysplasia. PURPOSE: Randomized phase II trial to study the effectiveness of a carotenoid rich diet in treating patients with cervical dysplasia.
- Trial name
- NCT00003094
- Testing
- preventative dietary intervention
- Where
- United States
- Sponsor
- University of California, San Diego
Cervical Carcinoma, Cervical Dysplasia
Can Text Reminders Improve Uptake of Cervical Screening?
Cervical cancer is the most common cancer in women under 35 years and is a major public health concern. Fortunately, the natural history of this malignancy can be beneficially improved through cytological screening.
- Trial name
- NCT02363088
- Testing
- Neutral text message reminder, Messenger text message reminder, Social Norms A reminder
- Where
- United Kingdom
- Volunteers
- 14,597 people, healthy volunteers welcome
- Sponsor
- Sarah Huf
Cervical Intraepithelial Neoplasia, Cervical Cancer
Efficacy, Immunogenicity and Safety Study of Recombinant Human Papillomavirus Vaccine(6,11,16,18,31,33,45,52,58 Type)(E.Coli)
This phase III clinical study was designed to evaluate the efficacy,immunogenicity and safety of Recombinant Human Papillomavirus Vaccine (6,11,16,18,31,33,45,52,58 Type)(E.Coli) manufactured by Xiamen Innovax Biotech CO., LTD.…
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Condylomata Acuminata
- Trial name
- NCT04537156
- Testing
- Nonavalent HPV vaccine, Bivalent HPV vaccine
- Where
- 2 sites in China
- Volunteers
- 9,327 people, healthy volunteers welcome
- Sponsor
- Xiamen University