Clinical trials: Uterine Cervical Incompetence
Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2
Cerclage for Twins With Short Cervix
A prospective randomized control trial that will compare cervical cerclage plus vaginal progesterone to vaginal progesterone along in twin pregnancies complicate by a short cervix (</= 15.0mm) between 16w0d to 25w6d.
- Conditions
- Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2, Cervical Incompetence, Cervical Shortening
- Trial name
- NCT03077633
- Testing
- Cervical Cerclage placement, Vaginal Progesterone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Cervical Insufficiency
Azithromycin for Cerclage Prophylaxis
The primary goal is to assess the effectiveness in pregnancy prolongation utilizing azithromycin at the time of transvaginal cervical cerclage placement.
- Trial name
- NCT07608562
- Testing
- Azithromycin Prophylaxis, Cefazolin, Progesterone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Cervical Insufficiency
Cerclage vs Cervical Pessary in Women With Cervical Incompetence
Cervical insufficiency (CI), responsible for 8% of preterm births (PB), is used to describe painless cervical dilation leading to recurrent second-trimester pregnancy losses/births of otherwise normal pregnancies.
- Trial name
- CEPEIC (NCT02405455)
- Testing
- Cerclage, Cervical pessary
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Female Infertility, Female Infertility Due to Ovulatory Disorder
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A"…
- Conditions
- Female Infertility, Female Infertility Due to Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome
- Trial name
- CS-EOSP-ICSI (NCT04071574)
- Testing
- Human Chorionic Gonadotropin (hCG), Gonadotropins, GNRH-A Triptorelin
- Where
- Lebanon
- Volunteers
- 200 people
- Sponsor
- Lebanese University
Preterm Birth, Cervical Length
Cervical Length Reference Range at 28-34 Weeks in Singleton Pregnancies
Cervical length, measured via transvaginal ultrasound, changes as pregnancy progresses. However, reference information for interpreting cervical length measurements during late pregnancy in Vietnam remains limited.
- Conditions
- Preterm Birth, Cervical Length, Cervical Incompetence
- Trial name
- CL-Trim3 (NCT07914595)
- Testing
- No Intervention: Observational Cohort
- Where
- Vietnam
- Volunteers
- 294 people
- Sponsor
- Mỹ Đức Hospital
Preterm Birth, Threatened Preterm Labor
Cervical Softening and the Prediction of Preterm Birth
Currently, transvaginal cervical length measurement is used to screen in asymptomatic pregnant women with a history of PTB. In symptomatic women, presenting with threatened PTB cervical length in combination with the fibronectin…
- Conditions
- Preterm Birth, Threatened Preterm Labor, Premature Birth, Premature Labor
- Trial name
- STIPP (NCT05477381)
- Testing
- Measurement of cervical stiffness by Pregnolia Device
- Where
- Netherlands
- Volunteers
- 390 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Uterine Cervical Incompetence
Cervical Occlusion for the Prevention of Preterm Birth
The aim of this study was to evaluate the effect of cervical occlusion versus no cervical occlusion in women with cervical cerclages.
- Trial name
- NCT01737788
- Testing
- Cervical occlusion
- Where
- 23 sites in Australia, Denmark and 7 more
- Volunteers
- 309 people
- Sponsor
- Niels Jørgen Secher
Cervical Insufficiency, Cervical Stiffness
Cervical Stiffness Assessment in High-risk Pregnancies for Preterm Birth
Cervical length is usually measured using ultrasound, and if it is shortened, hormone therapy (progesterone) is recommended to reduce the risk of premature birth.
- Trial name
- PilotProPre (NCT07541313)
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- Luzerner Kantonsspital
Cervical Insufficiency
Multifactorial Approach to Emergent Cerclage
Though cervical insufficiency is a common cause of second trimester pregnancy loss, the placement of an emergent cerclage in these patients is thought to improve perinatal outcomes.
- Trial name
- RECIA (NCT01114516)
- Testing
- Indomethacin and antibiotics (cefazolin or clindamycin)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Northwestern University
Breast Carcinoma, Carcinoma of Unknown Primary
Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction
This phase I trial studies the side effects and the best dose of veliparib when given together with paclitaxel and carboplatin in treating patients with solid tumors that are metastatic or cannot be removed by surgery and liver…
- Conditions
- Breast Carcinoma, Carcinoma of Unknown Primary, Endometrial Carcinoma, Esophageal Carcinoma
- Trial name
- NCT01366144
- Testing
- Carboplatin, Laboratory Biomarker Analysis, Paclitaxel
- Where
- 17 sites in United States
- Volunteers
- 94 people
- Sponsor
- National Cancer Institute (NCI)
Preterm Delivery, Cervical Cerclage
Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal
The goal of this clinical trial is to determine whether inhaled nitrous oxide can reduce pain and anxiety during cervical cerclage removal compared with standard care.
- Conditions
- Preterm Delivery, Cervical Cerclage, Cervical Insufficiency
- Trial name
- NCT07491874
- Testing
- Inhaled nitrous oxide
- Where
- 4 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Kaplan Medical Center
Adverse Reaction to Spinal Anesthetic, Maternal Care for Cervical Incompetence
Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)
This study aims to determine whether or not spinal anesthesia with the local anesthetic drug, chloroprocaine, wears off faster than the local anesthetic drug, bupivacaine, and results in faster discharge from the post-anesthesia…
- Trial name
- NCT02862912
- Testing
- Chloroprocaine, Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Columbia University
Preterm Labor
Use of Pessary in Case of Cervical Insufficiency and Short Cervix
Prematurity is the most important cause of obstetric morbidity and mortality. Health centers and obstetricians are trying to reduce the preterm birth rate by taking into account the permanent effects of premature birth on human…
- Trial name
- NCT03096691
- Testing
- cervical pessary
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Cerclage, Cervical, Cervical Insufficiency
Effectiveness of Cervico-isthmic Cerclage
This study compares the rate of live births before and after cervico-isthmic cerclage in 3 hospitals in the last 10 years. The hypothesis is that cerclage significantly increases the rate of live births in women with cervical…
- Trial name
- CERCEI LB (NCT04722536)
- Testing
- Cervico-isthmic cerclage
- Where
- 3 sites in France
- Volunteers
- 45 people
- Sponsor
- Hospices Civils de Lyon
Cervical Insufficiency, Preterm Birth
Investigation Into the Microorganisms in Pregnant Women
Pregnant women with short cervical length (<25 mm) in second-trimester ultrasonographic assessment are at high risk for preterm birth, a major cause of perinatal mortality and morbidity worldwide.
- Trial name
- NCT04688866
- Testing
- Sequencing
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cervical Cancer
Protecting Young Special Risk Females From Cervical Cancer Through Human Papilloma Virus (HPV) Vaccination
A research project is currently being undertaken looking at Human Papilloma Virus (HPV) vaccination in special risk groups. It aims to see if young women with a chronic illness respond well to the HPV vaccine or whether they may…
- Trial name
- HPV (NCT00964210)
- Testing
- Licensed quadrivalent HPV vaccine, Gardasil
- Where
- Australia
- Volunteers
- 240 people
- Sponsor
- Murdoch Childrens Research Institute
Cerclage, Cervical, Cervical Insufficiency
Long-Term Patient-Reported Maternal Outcomes Following Abdominal Cerclage for the Prevention of Preterm Birth
This study aims to explore the maternal patient reported outcomes on pelvic pain sexual health anxiety and depression bladder discomfort foreign body sensation trust in the cerclage, and how these parameters affect the general…
- Trial name
- NCT06875401
- Testing
- Abdominal cerclage (open or laparoscopic)
- Where
- Denmark
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cervical Incompetence (Complicating Pregnancy)
Pregnancy Outcomes According to Cervical Cerclage Indications and Factors Affecting Pregnancy Duration and Outcomes
This study aimed to asses predictive factors associated with successful cervical cerclage and poor pregnancy outcomes in all indications.129 pregnant women who underwent cerclage at 12-25 weeks gestation in a perinatal medical…
- Trial name
- CCERCIAFAO (NCT06443112)
- Testing
- transvaginal cervical cerclage by Mc Donald technique
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Cervix Cancer
Alendronate to Reduce Pelvic Insufficiency Fractures in Cervical Cancer Patients Undergoing Chemoradiation
Primary Objective Proof of concept: To evaluate the efficacy of alendronate in preventing pelvic insufficiency fractures (PIFs) in cervical cancer patients treated with chemo-radiotherapy over the short and long term.
- Trial name
- NCT07245381
- Testing
- Alendronate 70mg weekly
- Volunteers
- 65 people
- Sponsor
- Dr. Itay GoorAryeh