Clinical trials: Uterine Contraction
Infertility
Atosiban in Women With Previous Implantation Failure and Abnormal Uterine Contractions
This study aims to evaluate the efficacy of atosiban in patients with previous pregnancy failure and abnormal uterine contractions during the peri-embryo transfer period in assisted reproductive technology.
- Trial name
- NCT07185230
- Testing
- Atosiban
- Where
- China
- Volunteers
- 792 people
- Sponsor
- Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Fetal Heartbeat Tracings
Comparing Two Methods of Contractions Monitoring for Clinical Decision Making Regarding Treatment Among Pregnant Women With Preterm Contractions.
Background: Identification and measurement of uterine contractions throughout pregnancy and labor is crucial to the well being of both mother and fetus.
- Trial name
- NCT02875418
- Testing
- EUM, Tocodynamometry
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Labor Pain
VR Scenario for Labor Pain Control
The present study aims to evaluate Virtual Reality analgesic interventions for active labor with biofeedback-based Virtual Reality technologies synchronized to uterine activity.
- Trial name
- NCT05879848
- Testing
- VR
- Where
- Italy
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Federico II University
Postpartum Hemorrhage
Investigating the Effect of Pulsatile Administration of Oxytocin on the Desensitization of Human Myometrium In-vitro
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide and is caused most commonly by poor uterine muscle (myometrium) tone after delivery.
- Trial name
- NCT02338089
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Uterine Contraction, Oxytocin
The Influence of Oxytocin on Intrapartum Fetal Well-being and Delivery Outcomes in Patients Receiving Epidural Analgesia
The aim of this study is to determine the influence of oxytocin on fetal well-being during labor in patients receiving epidural analgesia (ELA) with the use of cardiotocography (CTG) and doppler ultrasonography.
- Conditions
- Uterine Contraction, Oxytocin, Labor Progress, Fetal Doppler
- Trial name
- NCT06403982
- Testing
- Continuation of oxytocin after ELA, Discontinuation of oxytocin after ELA
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Postpartum Hemorrhage
In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol
The rates of cesarean deliveries (CD) and postpartum hemorrhage (PPH) are on the rise, with failed induction and augmentation of labor as major contributing factors.
- Trial name
- NCT03434444
- Testing
- Oxytocin, Propranolol
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Uterine Contraction, Pregnancy
Comparative Study of the Propagation of Uterine Electrical Activity (EHG) in Pregnant Women During Pregnancy and During Labour
The original aspect of the methodology proposed for this study concerns the use of as many as 16 electrodes to study the propagation and coordination (or synchronization) of uterine contraction.
- Conditions
- Uterine Contraction, Pregnancy, Delivery, Obstetric
- Trial name
- PropEHG (NCT02814344)
- Testing
- Electrohysterography
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cervical Assessment, Focal Myometrial Contractions
Focal Myometrial Contractions: Impact on Cervical Assessment and Association With Voiding
Focal myometrial (uterine) contractions occur in a substantial number of vaginal ultrasound examinations and can impede accurate cervical length measurement and placental location determination.
- Trial name
- NCT01513395
- Testing
- Interval bladder emptying
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Postpartum Hemorrhage
In Vitro Evaluation of Spontaneous and Oxytocin-induced Contractility of Pregnant Human Myometrium During Exposure to Dexmedetomidine
Postpartum hemorrhage (PPH) remains to be one of the leading causes of maternal morbidity and mortality. It has been noted that an increasing number of PPH is attributed to the increased incidence of uterine atony.
- Trial name
- NCT05511415
- Testing
- Oxytocin, Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization: an In-vitro Analysis of Oxytocin Receptor Expression and Signaling
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity worldwide, and is caused most commonly by poor uterine muscle contraction after delivery of the baby and placenta.
- Trial name
- NCT02762669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Contraction
Noninvasive Monitoring of Uterine Electrical Activity and Fetal Heart Rate: A New External Monitoring Device
The EUM (electrical uterine myography) (OB Tools, Israel) was tested and found to be reliable as a non-invasive method for evaluating uterine contractions and the fetal heart rate.
- Trial name
- EUM (NCT02993354)
- Testing
- The EUM300 (electrical uterine myography)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Obstetrical Complications, Monitoring Injury of Scalp of Newborn
Maternal-Fetal Monitoring by Connected Abdominal Patch - MOMA
During a previous clinical trial (RCF-abdo: 2018-A01194-51), trans-abdominal signals were collected in 90 patients at the maternity Jeanne de Flandre.
- Trial name
- MOMA (NCT05263427)
- Testing
- TOCONAUTE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Lille
Epidural Anesthesia in Labor and Delivery, Doppler Ultrasound
EPidural's Impact on Contractions and Fetal REsponse
This prospective observational study aims to assess the impact of epidural analgesia (ELA) on uterine contractility, cardiotocography (CTG) patterns, and maternal-fetal hemodynamics in term pregnancies.
- Conditions
- Epidural Anesthesia in Labor and Delivery, Doppler Ultrasound, Uterine Contraction
- Trial name
- EPI-CARE (NCT06860854)
- Testing
- Epidural Analgesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Postpartum Hemorrhage
Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
The goal of this study is to learn about how medication that is used to help treat low blood pressure during a Cesarean delivery (CD) can cause changes to the uterine muscle tissue and its ability to contract, in patients with…
- Trial name
- NCT06285396
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pregnancy
Measuring Uterine Electrical Activity Throughout Pregnancy and Labor Measuring Uterine Electrical Activity Throughout Pregnancy and Labor
The EUM100pro (Electrical Uterine Monitor)is a uterine contraction monitor which measures uterine contractions based on the electrical activity of the uterine muscle.The study will compare the EUM100pro measurements to the…
- Trial name
- NCT01165879
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- OB-Tools Ltd.
In Vitro Fertilisation (IVF) Treatment
Effect of Oxytocin Antagonist on Reduction of Uterine Contractions
The main purpose of this clinical research trial was to evaluate the effects of barusiban compared to placebo on uterine contractions on luteal phase uterine contractions in oocyte donors supplemented with progesterone.
- Trial name
- EFFORT (NCT01043120)
- Testing
- Barusiban
- Where
- 5 sites in Belgium, Czechia and 1 more
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Lactate Values During Labour in Women Receiving Neuraxial Anaesthesia
Lactate Values During Labour and Their Correlation With Maternal and Foetal Outcome
Postpartum haemorrhage (PPH) represents a significant cause of morbidity in the obstetric population, with a mortality rate of 140,000 women per year, and the predominant cause of PPH (70%) is uterine atony.
- Trial name
- NCT06807255
- Testing
- Lactate levels were assessed via a venous blood gas test utilising an IV cannula already placed in the woman's limb upon admission
- Where
- Italy
- Volunteers
- 303 people
- Sponsor
- Papa Giovanni XXIII Hospital
Postpartum Hemorrhage
Impact of Uterotonic Agents on Isolated Human Myometrium
The purpose of this study is to compare the ability of a sample of uterine muscle tissue to contract in the presence of various drugs.
- Trial name
- NCT00989027
- Testing
- Oxytocin, Ergonovine, Carboprost
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
The Relaxant Effect of Nitroglycerin on Oxytocin Desensitized Human Myometrium
Oxytocin causes myometrial contraction via the oxytocin receptor (OTR). Desensitization of the OTR after exposure to oxytocin has been demonstrated in previous studies.
- Trial name
- NCT03408054
- Testing
- Oxytocin, Nitroglycerin
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Preterm Labor, Preterm Contractions
Screening To Obviate Preterm Birth
Our objective is to investigate the predictive value of a panel of biomarkers associated with two biologically plausible pathways of preterm birth: membrane breakdown and cervical remodeling.
- Conditions
- Preterm Labor, Preterm Contractions, Abdominal Cramping, Back Pain
- Trial name
- STOP (NCT01868308)
- Where
- United States
- Volunteers
- 589 people
- Sponsor
- University of Pennsylvania