Clinical trials: Uterine Disease
Advanced Cancer, Ovarian Cancer
COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.
This is a Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary clinical activity of COM701 as monotherapy and in combination with nivolumab.
- Conditions
- Advanced Cancer, Ovarian Cancer, Breast Cancer, Lung Cancer
- Trial name
- NCT03667716
- Testing
- COM701, COM701 with Opdivo (Nivolumab).
- Where
- 11 sites in United States
- Volunteers
- 121 people
- Sponsor
- Compugen Ltd
Cervical Intraepithelial Neoplasia, Cervical Cancer
Lot Consistency Clinical Trial of of Recombinant HPV Bivalent Vaccine in 9 to14 Years Old Healthy Female
This study is to evaluate lot-lot consistency of Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli) .
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT05426148
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli) / Cecolin®
- Where
- China
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Xiamen Innovax Biotech Co., Ltd
Neural Tube Defects, Spina Bifida
Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele
The purpose of this study is to evaluate the feasibility of a fetoscopic surgical technique for antenatal correction of fetal myelomeningocele. Two surgical approaches will be utilized.
- Conditions
- Neural Tube Defects, Spina Bifida, Myelomeningocele, Chiari Malformation
- Trial name
- NCT03856034
- Testing
- Fetoscopy
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- USFetus
Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Neoplasms
Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer
In patients diagnosed as endometrial cancer by thorough pathologic examinations, Lynch syndromes are screened by (1)immunohistochemical staining (for MLH1, MSH2, MSH6 and PMS2), (2) tests of microsatellite instability and (3)…
- Trial name
- NCT03291106
- Testing
- immunohistochemical staining, tests of microsatellite instability, clinical criteria of Lynch syndromes
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Lei Li
Menorrhagia
Construct Validity of a Diagnostic Hysteroscopy Training Model
In a prospective case-control study, the investigators compare the Objective Structured Assessment of Technical Skills (OSATS) scores in medical students and gynecologic experts performing a hysteroscopy on a training model for…
- Trial name
- HSK-2 (NCT02475252)
- Testing
- hysteroscopy on a training model
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Breast Cancer, Endometrial Cancer
Non-Hormonal Vaginal Moisturizer in Hormone-Receptor Positive Postmenopausal Cancer Survivors Experiencing Estrogen Deprivation Symptoms on Vulvovaginal Health
The purpose of this study is to see whether it is feasible to conduct a study to determine if the use of hyaluronic acid (HLA) vaginal gel (HyaloGYN®) improves vulvovaginal health.
- Trial name
- NCT01738152
- Testing
- HLA vaginal gel (HyaloGYN®),, questionnaires
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cervical Cancer, Locally Advanced Cervical Cancer
Study on Disease Characteristics and Treatment in Locally Advanced or Recurrent / Metastatic Cervical Cancer in Italy
Multicenter, Observational, Retrospective charts review. Observational study with descriptive purpose only. Retrospective data capture in consecutive patients diagnosed with CC who attended the Oncologic Clinics from Jan 2018 to…
- Conditions
- Cervical Cancer, Locally Advanced Cervical Cancer, Recurrent Cervical Cancer, Metastatic Cervical Cancer
- Trial name
- RETRACE (NCT06771193)
- Where
- 11 sites in Italy
- Volunteers
- 200 people
- Sponsor
- MSD Italia S.r.l.
Recurrent Endometrial Carcinoma, Recurrent Endometrial Clear Cell Adenocarcinoma
Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer
This phase Ib trial tests the safety, side effects, and best dose of M1774 when given with ZEN-3694 in treating patients with ovarian and endometrial cancer that has come back (recurrent).
- Conditions
- Recurrent Endometrial Carcinoma, Recurrent Endometrial Clear Cell Adenocarcinoma, Recurrent Endometrial Endometrioid Adenocarcinoma, Recurrent Endometrial Low Grade Endometrioid Adenocarcinoma
- Trial name
- NCT05950464
- Testing
- BET Bromodomain Inhibitor ZEN-3694, Biopsy Procedure, Biospecimen Collection
- Where
- 14 sites in United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer, HIV/AIDS
Improving Cervical Cancer Screening Among HIV-Infected Women in India
Background: Cervical cancer is a major cause of cancer deaths among women. Most cases of cervical cancer are caused by the human papillomavirus (HPV). HPV is more common in women who have the human immunodeficiency virus (HIV).
- Conditions
- Cervical Cancer, HIV/AIDS, HPV, Cervical Intraepithelial Neoplasia
- Trial name
- NCT02247999
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Carcinoma Cervix
Concurrent Chemoradiotherapy With Weekly Cisplatin Versus Concurrent Chemoradiotherapy With Weekly Cisplatin and Paclitaxel in Locally Advanced Carcinoma Cervix
The purpose of this study is to check whether addition of paclitaxel to cisplatin and radiation therapy will improve the outcome in locally advanced carcinoma cervix.
- Trial name
- NCT01593306
- Testing
- Paclitaxel, Cisplatin, Cisplatin
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Indira Gandhi Medical College, Shimla
Endometrial Cancer
Racial Disparity in Endometrial Cancer
The objectives for this study: 1. Investigate some of the causes for the racial disparity of endometrial cancer survival rates among black and white women 2.
- Trial name
- NCT00375804
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Louisville
Cervical Cancer
FDG-PET and Circulating HPV in Patients With Cervical Cancer
The addition of concurrent chemotherapy to definitive radiation has improved the 5-year survival of women with locally advanced cervical cancer to 58%.
- Trial name
- NCT02388698
- Testing
- Cervical swab, PET-CT, Plasma HPV
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cervical Cancer
Folate and Protection Against Cervical Cancer
This is a randomised double-blind placebo-controlled trial to see whether giving a low dose of the vitamins folic acid and riboflavin is beneficial to women who have very low grade abnormalities of the cervical cells.
- Trial name
- NCT00220532
- Testing
- Folic acid with riboflavin
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Anemia, Cervix Neoplasms
Will Radiation/Chemotherapy Treatment of Cervical Cancer Work Better With Medication That May Improve Anemia?
This is a clinical trial (a type of research study) designed to describe the efficacy (effectiveness) and toxicity (safety) of a new medical treatment, NESP (Novel Erythropoiesis Stimulating Protein).
- Trial name
- NCT00039884
- Testing
- NESP - Novel Erythropoiesis Stimulating Protein
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mirhashemi, Ramin, M.D.
Intra-Uterine Death
Analysis of All Stillbirths in Stockholm County 2017, a Multidisciplinary Audit
All stillbirths in Stockholm during 2017 were analysed according to the primary outcomes which were preventable/non-preventable deaths and the level of delay.
- Trial name
- NCT04281368
- Testing
- Analysis of IUFD
- Where
- Sweden
- Volunteers
- 79 people
- Sponsor
- Karolinska Institutet
Human Papilloma Virus
Zinc Sulfate for Human Papillomavirus (HPV)
The Human Papillomavirus (HPV) is well established as the primary causative agent in both warts and cervical cancer. Although cervical high risk HPV (hrHPV) infections have a high rate of spontaneous resolution this takes time…
- Trial name
- NCT03404310
- Testing
- Zinc Sulfate
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Corewell Health West
Cervical Adenosarcoma
Surgical Handling of Fertility-preserving Treatments for Cervical Adenocarcinomas
Despite a growing body of literature on the subject, there is still uncertainty regarding direct comparisons between different conservative surgical techniques for cervical adenocarcinomas.
- Trial name
- SHAFT (NCT07394413)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Uterine Hemorrhage
Aqua Therapeutics Thermal Therapy Vapor Ablation System (ATTTVAS) Abnormal Uterine Bleeding Safety Study
Abnormal uterine bleeding (AUB) is defined as "flow outside of normal volume, duration, regularity, or frequency". Acute AUB is excessive bleeding that requires immediate intervention to prevent further blood loss.
- Trial name
- AQTH-EA-22 (NCT07580560)
- Testing
- Aqua Therapeutics Thermal Therapy Vapor Ablation System (ATTTVAS)
- Where
- 3 sites in Italy, Netherlands
- Volunteers
- 10 people
- Sponsor
- Aqua Therapeutics, Inc.
Uterine Cervical Neoplasms
Oncological Outcome After Completing or Abandoning (Radical) Hysterectomy in Patients With Cervical Cancer and Intraoperative Detection of LN Positivity
The ABRAX trial is multicentre retrospective cohort study. Included are patients with negative LN in clinical staging, in whom LN involvement is detected intraoperatively.
- Trial name
- ABRAX (NCT04037124)
- Testing
- Cervical procedure
- Where
- Czechia
- Volunteers
- 718 people
- Sponsor
- General University Hospital, Prague
Cervical Cancer
Sexual Health Empowerment for Cervical Health Literacy and Cancer Prevention
The purpose of this study is to learn if a cervical health literacy program is a practical and helpful way of improving women's cervical health knowledge and improving cancer screening behaviors, and ultimately preventing…
- Trial name
- SHE Project (NCT02128659)
- Testing
- SHE Project
- Where
- 3 sites in United States
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Megha Ramaswamy, PhD, MPH
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