Clinical trials: Uterine Diseases
Cervical Cancer
Phase I Pilot Study to Evaluate the Prognostic Value of Perfusion CT for Primary Cervical Cancer
The investigators hope to learn whether perfusion CT is a useful way to assess primary cervical tumor microenvironment and whether there is a relationship between pretreatment perfusion CT measurements and primary cervical tumor…
- Trial name
- NCT01805141
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Cervical Cancer
Carboplatin and Topotecan in Treating Patients With Relapsed or Metastatic Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as carboplatin and topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00807079
- Testing
- carboplatin, topotecan hydrochloride
- Where
- France
- Volunteers
- 12 people
- Sponsor
- ARCAGY/ GINECO GROUP
Postpartum Hemorrhage
Efficacy of Balloon Tamponade in Post-partum Hemorrhage Within 24 Hours After Delivery
Postpartum hemorrhage (PPH) is a major cause of maternal death, especially in developing countries like Pakistan where it accounts for up to 34% of maternal deaths.
- Trial name
- BT-PPH (NCT07845240)
- Testing
- Intrauterine Balloon Tamponade - Condom Catheter
- Where
- Pakistan
- Volunteers
- 121 people
- Sponsor
- Aziz Fatimah Medical & Dental College, Faisalabad
Adrenocortical Adenoma, Endometrial Stromal Sarcomas
Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492
To provide medical follow-up to patients exposed to BGG492 for more than 28 days in study CBGG492A2207 (NCT 01147003) and/or CBGG492A2212 (NCT 01338805).
- Trial name
- NCT02150213
- Testing
- MRI, CT or ultrasound was permitted if MRI was contraindicated, Dexamethasone Supression Test, Sonogram
- Where
- 20 sites in United States, Germany and 4 more
- Volunteers
- 59 people
- Sponsor
- Novartis Pharmaceuticals
Endometrial Cancer, Uterine Cancer
A Study of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Recurrent Epithelial Endometrial or Epithelial Ovarian Cancer or Carcinosarcoma
A Phase 2 Study Evaluating the Efficacy and Safety of DKN-01 as a Monotherapy or in Combination with Paclitaxel in Patients With Recurrent Epithelial Endometrial Cancer, Epithelial Ovarian Cancer, or Carcinosarcoma
- Conditions
- Endometrial Cancer, Uterine Cancer, Ovarian Cancer, Carcinosarcoma
- Trial name
- P204 (NCT03395080)
- Testing
- Paclitaxel, 300mg DKN-01, 600mg DKN-01
- Where
- 17 sites in United States
- Volunteers
- 111 people
- Sponsor
- Leap Therapeutics, Inc.
Cervical Cancer
Simple Versus Radical Hysterectomy for Stage I Cervical Cancer
The primary objective of this study is to assess the preferences (values and utilities) of women for complications and recurrences associated with the surgical treatment of cervical cancer.
- Trial name
- NCT00506376
- Testing
- Interview
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Endometrial Cancer
Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma
RATIONALE: Metformin and temsirolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
- Conditions
- Breast Cancer, Endometrial Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT00659568
- Testing
- metformin hydrochloride, temsirolimus
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- London Health Sciences Centre
Breast Cancer, Lung Cancer
18F-ASIS PET/CT Imaging of Tissue Factor Expression In Patients With Primary and Metastastic Cancer
The primary objective of the trial is to test the new radio tracer 18F-ASIS for PET imaging of tissue factor (TF) expression. The tracer has the potential of identifying tumors with high levels of TF expression, which is expected…
- Conditions
- Breast Cancer, Lung Cancer, Pancreatic Cancer, Ovarian Cancer
- Trial name
- NCT03790423
- Testing
- Injection of 18F-ASIS, PET/CT scan
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cancer of Cervix
Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer Patients
The propose of this study is to determine if neoadjuvant chemotherapy followed by chemoradiation is safe and effective in locally advanced cervical cancer patients.
- Trial name
- NCT02309658
- Testing
- gemcitabine, cisplatin, chemoradiation
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Endometrial Disease
Intrauterine Saline Washing for Detection Endometrial Disease in Patients With Abnormal Uterine Bleeding
Investigator will examined the diagnostic effect of the endometrial washing by saline. Because this technique more less painful and easier compared to endometrial curettage. Participants will separate into two groups.
- Trial name
- NCT02691715
- Testing
- Endometrial saline plus curettage, Endometrial curettage
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Uterine Cervical Neoplasms
Post-TRaUmatic STress Disorder Induced by Gynecological Brachytherapy
This is a multicenter, prospective study aimed at providing information on the psychological effects (including post-traumatic stress symptoms) of utero-vaginal brachytherapy in patients with cervical cancer using…
- Trial name
- TRUST-GB (NCT07204535)
- Testing
- Prospective questionnaires
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Paul Strauss
Intra-Uterine Death
Analysis of All Stillbirths in Stockholm County 2017, a Multidisciplinary Audit
All stillbirths in Stockholm during 2017 were analysed according to the primary outcomes which were preventable/non-preventable deaths and the level of delay.
- Trial name
- NCT04281368
- Testing
- Analysis of IUFD
- Where
- Sweden
- Volunteers
- 79 people
- Sponsor
- Karolinska Institutet
To Compare Efficacy Intrauterine vs Sublingual MISOPROSTOL in Addition to Oxytocin in Reducing Blood Loss of Post-cesarean Section in High Risk Women
Sublingual vs Intrauterine MISOPROSTOL Plus Oxytocin Infusion for Prevention of Post-cesarean Hemorrhage in High Risk Pregnant Women: A Double-blind Placebo RCT
Research Objective: Primary outcome -To compare efficacy Intrauterine vs Sublingual MISOPROSTOL in addition to Oxytocin in reducing blood loss of post-cesarean section in high risk women Secondary outcome -To study…
- Trial name
- NCT04560218
- Testing
- sublingual Misoprostol, Intrauterine Misoprostol
- Where
- Thailand
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Infertility
Physiotherapy Treatment for Uterine Blood Flow Improved Dimensional Ultrasound Evaluated With Angiography
Ivanovski shows that by studying the vascular impedance can calculate the optimal uterine receptivity in IVF. A reduced vascular resistance and increased blood flow rate improves the chance of pregnancy. Dr. Luis T.
- Trial name
- NCT02437435
- Testing
- Reproductive Technique Gimilio
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- University of Valencia
HIV-Associated Malignant Neoplasm, HIV Infections
Use of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AMC
This study is being done to understand how many people with HIV (PWH) present for cancer care across the AIDS Malignancy Consortium in the United States and if there are reasons that some PWH choose to participate, or not in…
- Conditions
- HIV-Associated Malignant Neoplasm, HIV Infections, Cancer, AIDS Related Lymphoma
- Trial name
- NCT05510908
- Testing
- Non-Interventional, Non-Interventional Follow-up
- Where
- 16 sites in United States, Puerto Rico
- Volunteers
- 460 people
- Sponsor
- AIDS Malignancy Consortium
Cervical Cancer
Trial to Optimally Show the Pharmacological Action of Z-100
The objective of this clinical trial is to evaluate the change of the immunological parameter levels in FIGO stage IIIB cervical cancer subjects by administration of Z-100
- Trial name
- NCT03476018
- Testing
- Z-100
- Where
- 2 sites in Vietnam
- Volunteers
- 72 people
- Sponsor
- Zeria Pharmaceutical
Postpartum Hemorrhage
Comparing Misoprostol and Oxytocin in UnijectTM for Postpartum Hemorrhage (PPH) Prevention in Mali
This is a large, community-based, cluster-randomized trial to compare routine prophylactic use of 600 mcg oral misoprostol and 10 IU oxytocin delivered by UnijectTM intramuscularly during the third stage of labor.
- Trial name
- NCT01487278
- Testing
- misprostol, UnijectTM
- Where
- Mali
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Adenomyosis, Adenomyoma of Uterus
Ultrasound-Guided Radiofrequency Ablation for Focal Adenomyosis
This single-center, single-arm, open-label study evaluates the efficacy and safety of ultrasound-guided radiofrequency ablation (RFA) in women with symptomatic focal adenomyosis who wish to preserve the uterus.
- Trial name
- RFA-ADENO-USG (NCT07906535)
- Testing
- Myoblate Radiofrequency Ablation System (Mygen V-1000 generator)
- Where
- Czechia
- Volunteers
- 41 people
- Sponsor
- University Hospital Pilsen
Cervical Cancer
Serplulimab for Locally Advanced Cervical Cancer
This study is a randomized, controlled, open-label, phase II clinical trial designed to enroll patients with previously untreated locally advanced cervical cancer.
- Trial name
- NCT07340489
- Testing
- Serplulimab, radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Hysterectomy, Benign Uterine Diseases
Effect of Posterior Colpotomy First Technique on the Vaginal Length During Total Abdominal Hysterectomy
the same surgeon performed all of the procedures using the same method. A lower midline or Pfannestiel incision is the first step in the complete abdominal hysterectomy procedure. They clamp, cut, and ligate the top pedicles.
- Trial name
- NCT07308197
- Testing
- Abdominal hysterectomy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
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