Clinical trials: Uterine Diseases
Post Partum Hemorrhage
Mostafa Maged Maneuveur to Prevent and Control Post-partum Haemorrhage During Normal Vaginal Delivery
PPH is commonly defined as blood loss exceeding 1000 milliliters after vaginal birth or cesarean section.1 PPH is often classified as primary/immediate/early (occurring within 24 hours of birth) or secondary/delayed/late…
- Trial name
- NCT05288322
- Testing
- Mostafa Maged maneuver
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Fayoum University
Breast Cancer, Lung Cancer
Sample Collection for Ongoing Research and Product Evaluation Study
The SCORE study is a prospective, multi-site clinical trial designed to collect blood and tissue samples, along with relevant clinical data, from participants diagnosed with various solid tumors.
- Conditions
- Breast Cancer, Lung Cancer, Muscle Invasive Bladder Cancer, Rectal Cancer
- Trial name
- SCORE (NCT07318051)
- Where
- United States
- Volunteers
- 9,600 people
- Sponsor
- Natera, Inc.
Advanced Cancer, Metastatic Cervical Cancer
Balstilimab Versus Investigator Choice Chemotherapy in Patients With Recurrent Cervical Cancer (BRAVA)
This Phase 3 trial is an open-label, randomized study with single-agent Balstilimab (BAL) or Investigator Choice (IC) chemotherapy (single-agent gemcitabine, irinotecan, pemetrexed, vinorelbine, or topotecan) in patients with…
- Trial name
- NCT04943627
- Testing
- Balstilimab (BAL), Topotecan, Vinorelbine
- Where
- 3 sites in United States, Armenia
- Sponsor
- Agenus Inc.
Anomaly Uterus
Retrospective Study of 110 Cases of Uterine Rupture to Determine Obstetric and Neonatal Complications
This study has for objective to collect medical data from patients with uterine rupture at the childbirth.
- Trial name
- RUVO (NCT03052686)
- Testing
- Childbirth with uterine rupture
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Hôpital NOVO
Cervical Cancer
Clinical and Pathological Characteristics as Prognostic Factors in Locally Advanced Cervical Cancer
Locally advanced cervical cáncer continues to be a public health problem in emergent economies, even though treatment is very well standardized, recurrence rate is still high, making necessary to evaluate prognostic clinical and…
- Trial name
- NCT04537273
- Testing
- Descriptive and analytical
- Volunteers
- 1,954 people
- Sponsor
- National Institute of Cancerología
Cervical Cancer, Gynecologic Cancer
Spatially Fractionated Radiation Treatment for Gynaecological Cancers
This is a prospective study to evaluate in-field disease control, survival and late toxicity in patients with cervical cancer or pelvic recurrence treated with spatially fractionated RT.
- Conditions
- Cervical Cancer, Gynecologic Cancer, Recurrent Cancer
- Trial name
- NCT06644846
- Testing
- Spatially fractionated radiation therapy
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Tata Memorial Hospital
Postpartum Hemorrhage
Routine Bilateral Uterine Artery Ligation During the Cesarean Delivery of Multiple Gestation
Multiple pregnancy is well defined to be associated with a greater risk of postpartum blood loss . Interventions to control PPH generally stepped from less to more invasive and including compression maneuvers , drugs , and…
- Trial name
- NCT05670886
- Testing
- uterine artery ligation
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Cairo University
Uterine Cervical Dysplasia
LLETZ Under Direct Colposcopic Vision
To assess the benefits of large Loop excision of the transformation Zone (LLETZ) under direct colposcopic Vision.
- Trial name
- NCT02910388
- Testing
- LLETZ with colposcopy, LLETZ without colposcopy
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
HPV, Cervical Cancers
Self-sampling for HPV Screening
To offer large-scale HPV self-sampling in Québec, it is essential to first demonstrate the most effective pathway for patient recruitment, proper sample collection, and safe continuity of care.
- Trial name
- HPVselftest (NCT07273383)
- Testing
- HPV self-sampling test
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cervical Cancer, Genital Wart
Phase III Study Comparing the Immunogenicity of 9-valent HPV Recombinant Vaccine and Gardasil-9
This study will evaluate the immunogenicity and safety of Zerun 9-valent HPV recombinant vaccine in healthy female 16-26 years of age by comparing with GARDASIL®9.
- Conditions
- Cervical Cancer, Genital Wart, CIN, VIN
- Trial name
- NCT05580341
- Testing
- Zerun HPV-9, GARDASIL ®9
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Zerun Biotechnology Co.,Ltd
Cesarean Section Complications, Uterine Bleeding
Surgical Incision Closure Method to Prevent Niche Formation After Cesarean Section- Randomized Controlled Trial
In the last decade we have been exposed to the complication of a caesarean section called a "niche". A niche is an anaerobic defect in the location of the cesarean section, which represents the discontinuity of the endometrium…
- Trial name
- NCT04766073
- Testing
- Niche prevention suture
- Where
- Israel
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Endometrium Cancer
PET/CT in the Management of Patients With Early Stage Endometrial Cancer
Endometrial cancer (EC) is the most common gynecologic malignancy in the developed countries and is the fifth most common cancer among women worldwide.
- Trial name
- ENCA-1 (NCT03570866)
- Testing
- Positron emission tomography and computed tomography, Surgical treatment
- Volunteers
- 40 people
- Sponsor
- Università degli Studi dell'Insubria
Endometrial Cancer, Cervical Cancer
Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer
The overarching objective of this project is to develop a pan-gynecologic cancer detection test using gynecologic (unique endometrial, cervical, and ovarian cancer) cancer-specific methylated DNA markers and high-risk human…
- Conditions
- Endometrial Cancer, Cervical Cancer, Atypical Endometrial Hyperplasia, Cervical Dysplasia
- Trial name
- ECHO (NCT05051722)
- Testing
- Vaginal Fluid Collection, Blood Collection
- Where
- 25 sites in United States
- Volunteers
- 3,110 people
- Sponsor
- Mayo Clinic
Cervical Cancer, Uterine Endometrial Cancer
Implementation of a Rapid Recovery Program in Gynecologic Oncology Surgery: A Pilot Study
Over 600,000 hysterectomies are performed annually in the United States. Despite increasing use of less invasive approaches, the majority of hysterectomies are still performed via traditional laparotomy, which can be associated…
- Conditions
- Cervical Cancer, Uterine Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT01705288
- Testing
- Laparotomy, intravenous narcotics, standard anesthesia
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Biopsy
Hysteroscopic Guided Endometrial Sampling: Prospective Comparison Between 5Fr and 7Fr Biopsy Forceps (HYSTEROBIO)
Indication for hysteroscopic guided biopsy compared to blind biopsy have been little evaluated. However, this kind of biopsy is usually performed in many centre.
- Trial name
- HYSTEROBIO (NCT04519554)
- Testing
- Endometrial sampling
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cervical Cancer, HPV Infection
Clinic or Self-Sampling for Cervical Cancer Screening
Objective: The aim of this project was to determine the effect of clinic or self-sampling on attendance, attitudes, and anxiety in cervical cancer screening.
- Trial name
- NCT06177236
- Testing
- cervical cancer screening
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Endometrial Cancer
Durvalumab and Lenvatinib in Participants With Advanced and Recurrent Endometrial Carcinoma
This study will evaluate the safety and efficacy of durvalumab in combination with lenvatinib in participants with advanced and recurrent endometrial carcinoma.The primary hypothesis of this study are that patients with advanced…
- Trial name
- Dulect2020-2 (NCT04444193)
- Testing
- Durvalumab, Lenvatinib Oral Product
- Volunteers
- 20 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Uterine Cervical Neoplasms, Endometrial Neoplasms
MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005)
The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of pembrolizumab/vibostolimab co-formulation (MK-7684A) with or without other anticancer therapies in participants with selected…
- Conditions
- Uterine Cervical Neoplasms, Endometrial Neoplasms, Squamous Cell Carcinoma of Head and Neck, Gallbladder Neoplasms
- Trial name
- NCT05007106
- Testing
- Pembrolizumab/Vibostolimab Co-Formulation, Pembrolizumab, Lenvatinib
- Where
- 73 sites in United States, Canada and 13 more
- Volunteers
- 611 people
- Sponsor
- Merck Sharp & Dohme LLC
Cancer
Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for Cancer
RATIONALE: Learning about the amount of information on fertility and infertility by patients before they received treatment for cancer in a comprehensive cancer center may help doctors plan the best treatment.
- Trial name
- NCT01295463
- Testing
- questionnaire administration, study of socioeconomic and demographic variables, assessment of therapy complications
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Institut Català d'Oncologia
Carcinoma Cervix
Concurrent Chemoradiotherapy With Weekly Cisplatin Versus Concurrent Chemoradiotherapy With Weekly Cisplatin and Paclitaxel in Locally Advanced Carcinoma Cervix
The purpose of this study is to check whether addition of paclitaxel to cisplatin and radiation therapy will improve the outcome in locally advanced carcinoma cervix.
- Trial name
- NCT01593306
- Testing
- Paclitaxel, Cisplatin, Cisplatin
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Indira Gandhi Medical College, Shimla
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