Clinical trials: Uterine Diseases
Cancer, Physical Activity
Mobile Weight Loss Intervention for Adolescent and Young Adult Cancer Survivors
The purpose of this study is to conduct a 6-month pilot randomized trial to determine the feasibility and acceptability of theory-based mobile weight loss interventions for survivors of adolescent and young adult cancer (AYAs).
- Conditions
- Cancer, Physical Activity, Cancer Survivorship, Mental Health
- Trial name
- AYAConnect (NCT06171945)
- Testing
- AYA Connect intervention, Positive Psychology (PP) intervention, Positive Psychology Plus (PP+) intervention
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
CIN 2/3, HPV Infection
Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)
This is a phase II double blind, placebo-controlled, randomized study of Artesunate vaginal inserts for the treatment of women who have cervical high grade intraepithelial neoplasia (CIN2/3).
- Conditions
- CIN 2/3, HPV Infection, Pre-Cancerous Dysplasia, Cervical Dysplasia
- Trial name
- ART-CIN_IIB (NCT04098744)
- Testing
- Artesunate vaginal insert
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- Frantz Viral Therapeutics, LLC
Solid Tumor, Solid Tumor, Adult
A Study With NKT3447 for Adults With Advanced/Metastatic Solid Tumors
The goal of the Dose Escalation phase of the study is to evaluate the safety, tolerability, and pharmacokinetics (PK) to determine the maximum tolerated dose (MTD) and/or preliminary recommended dose for expansion (RDE) of…
- Conditions
- Solid Tumor, Solid Tumor, Adult, Advanced Solid Tumor, Metastatic Tumor
- Trial name
- NCT06264921
- Testing
- NKT3447
- Where
- 8 sites in United States
- Volunteers
- 23 people
- Sponsor
- NiKang Therapeutics, Inc.
Urethritis, Cervicitis
Rapid Diagnostic Assay for Gonorrhea and Chlamydia
This study is a pilot randomized controlled trial evaluating the use of either a) rapid 30-minute desktop assay or b) point-of-care gram stain (current standard of care) to guide the clinical management of patients with…
- Conditions
- Urethritis, Cervicitis, Sexually Transmitted Infections
- Trial name
- NCT05564299
- Testing
- Rapid 30-minute Desktop Assay
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Massachusetts General Hospital
Advanced Cancer, Anal Carcinoma
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)
In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).
- Conditions
- Advanced Cancer, Anal Carcinoma, Anal Cancer, Biliary Cancer
- Trial name
- NCT02628067
- Testing
- pembrolizumab
- Volunteers
- 1,609 people
- Sponsor
- Merck Sharp & Dohme LLC
Hemorrhoidal Disease, Cervical Cancer Radiation Complications
A Clinical Study on Alleviating Hemorrhoids-related Symptoms of Pelvic Radiation Therapy
The goal of this clinical trial is to reduce the acute hemorrhoids-related symptoms for cervical cancer patients with hemorrhoids who need postoperative pelvic radiation therapy, including prolapse, local burning, bleeding…
- Trial name
- ACS-RT (NCT07175584)
- Testing
- anal canal-sparing techniques
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Endometrial Hyperplasia, Endometrial Diseases
Topical Lidocaine vs. Traditional Management in Manual Vacuum Aspiration Pain Management.
The main objective of this study is to evaluate the effect of lidocaine versus placebo according to the visual analog pain scale, during manual uterine aspiration in patients with endometrial thickening, by means of a…
- Trial name
- ENDOLID (NCT06784024)
- Testing
- Lidocaine topical, Saline solution
- Where
- Honduras
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Ricardo A Gutierrez Ramirez, MD, MSc, FACOG
Endometrial Diseases, Pain, Postoperative
Transcutaneous Electrical Nerve Stimulation During Outpatient Endometrial Biopsy
The purpose of this study is to see whether transcutaneous electrical nerve stimulation (or TENS) reduces pain during an endometrial biopsy.
- Trial name
- NCT05472740
- Testing
- TENS 7000
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Duke University
HPV Infection, Cervical Disease
Impact of HPV Vaccination on HPV Infection and Cervical Related Disease Burden in Real-World Settings (HPV-RWS)
Take AS04 adjuvanted HPV16/18 vaccine as an example to evaluate the impact of HPV vaccination on HPV infection and related disease burden in the real world based on prospective cohort and Yinzhou Regional Health Information…
- Trial name
- HPV-RWS (NCT05341284)
- Testing
- Questionnaire Survey and Cervical Cancer Screening
- Volunteers
- healthy volunteers welcome
- Sponsor
- Peking University
Cervical Cancer, Papillomavirus Infection
HPV Self-Sampling in Somali Women (Isbaar Project)
This study plans to assess the effect of implementing HPV self-sampling in primary care on uptake of cervical cancer screening in 30-65 year old Somali women who are due for cervical cancer screening.
- Conditions
- Cervical Cancer, Papillomavirus Infection, Uterine Diseases, Uterine Cervical Disease
- Trial name
- Isbaar (NCT05453006)
- Testing
- COPAN 552c.80 FLOQSwab
- Where
- United States
- Volunteers
- 3,367 people
- Sponsor
- University of Minnesota
Papillomavirus Infections, Uterine Cervical Neoplasms
HPV Infection and Genital Microecology of Childbearing-age Female in China: A Cohort and Multicenter Study
The purpose of this study to access the relations between genital microecology, HPV infection and cervical intraepithelial neoplasia of childbearing-age female in China
- Conditions
- Papillomavirus Infections, Uterine Cervical Neoplasms, Sexual Transmitted Disease
- Trial name
- NCT04694495
- Testing
- 16S rRNA gene sequencing of cervical secretions
- Where
- 42 sites in China
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Cervical Cancer, Uterine Cervical Neoplasm
Effect of an Anti-inflammatory Diet on Patients With Cervical Cancer
During radiation therapy (RT) to pelvic tumors, the small intestine, colon and rectum are inevitably included in the radiation field and are healthy tissues that suffer damage as an adverse effect.
- Conditions
- Cervical Cancer, Uterine Cervical Neoplasm, Pelvic Inflammatory Disease, Radiation Toxicity
- Trial name
- NCT03994055
- Testing
- Omega-3 fatty acids, Antioxidants, Soluble fiber
- Where
- Mexico
- Volunteers
- 136 people
- Sponsor
- National Institute of Cancerología
Cancer, Leukemia
Early Ageing During Therapy in AYA Cancer Patients
Longitudinal cohort study; measurements before start of systemic therapy and one year later.
- Conditions
- Cancer, Leukemia, Hodgkin Lymphoma, Testicular Cancer
- Trial name
- NCT05062707
- Testing
- Blood sampling
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- University Medical Center Groningen
HPV, Cervical Cancer
Multimodality Treatments of HPV-related Lesions of the Female Genital Tract
Cervical cancer is one of the most preventable types of cancer, as it develops over an extended period, and its causative agent is well-known.
- Conditions
- HPV, Cervical Cancer, Cervix Lesion, Vagina Disease
- Trial name
- NCT05938192
- Testing
- vaccination
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
HPV, HPV Vaccination
Impact of Catch-up HPV Vaccination
Each year in France, more than 6000 new cases of HPV inducted cancers are recorded. The vaccinal cover stays insufficient since less than 30% of the french population is vaccinated.
- Conditions
- HPV, HPV Vaccination, Vaccine Preventable Disease, Cervical Lesion
- Trial name
- HPVAC2 (NCT05462249)
- Where
- France
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Solid Tumors
Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of escalating doses of RMC-5552 monotherapy in adult participants with relapsed/refractory solid tumors…
- Trial name
- NCT04774952
- Testing
- RMC-5552
- Where
- 8 sites in United States
- Volunteers
- 58 people
- Sponsor
- Revolution Medicines, Inc.
Adenopathy, Uterine Fibroids
A Clinical Study on the Feasibility and Safety of Abdominal Endoscopic Single-port Surgery System to Assist Gynecological Day Surgery
In this study, a prospective study is used to select patients who will undergo intra-abdominal endoscopic single-port surgery system for benign gynecological diseases from February 2025 to December 2026 in the Second Affiliated…
- Conditions
- Adenopathy, Uterine Fibroids, Ovarian Cysts, Adnexal Mass
- Trial name
- NCT06828419
- Testing
- Domestic single-port laparoscopic surgery system
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
ALS, Amyotrophic Lateral Sclerosis
NYSCF Scientific Discovery Biobank
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells…
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Alzheimer Disease, Alzheimer Disease, Early Onset
- Trial name
- NCT06203106
- Testing
- Biological Sample Collection
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- New York Stem Cell Foundation Research Institute
Breast Cancer, Benign Breast Disease
Evaluating Scaleup of an Adapted Breast Cancer Early Diagnosis Program in Rwanda
Breast cancer incidence is increasing in low- and middle-income countries (LMICs) and breast cancer mortality is high in these regions largely due to late stage diagnoses.
- Conditions
- Breast Cancer, Benign Breast Disease, Cervix Cancer
- Trial name
- NCT05364138
- Where
- Rwanda
- Volunteers
- 2,357 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Gynecologic Disease, Gynecologic Cancer
Evaluation of Salivary RNA in Subjects Scheduled for Surgery for a Gynecologic Pathology
GynRAN is an international, multicentre, transversal, diagnostic and non-interventional study carried out in gynecology-obstetrics/gynecological oncology departments that aims to identify a diagnostic signature for gynecological…
- Conditions
- Gynecologic Disease, Gynecologic Cancer, Endometriosis, Ovarian Cancer
- Trial name
- GynRNA (NCT06392997)
- Testing
- Saliva sample
- Where
- 13 sites in France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- ZIWIG