Clinical trials: Uterine Hemorrhage
Uterine Fibroid, Heavy Menstrual Bleeding
Ulipristal Acetate in Symptomatic Uterine Fibroid
This study evaluates the effectiveness and safety of ulipristal acetae (UPA) in women with symptomatic uterine fibroids. Those who fulfilled inclusion/exclusion criteria will be treated UPA at daily dose of 5mg.
- Trial name
- NCT04132349
- Testing
- Ulipristal Acetate 5 mg
- Where
- Vietnam
- Volunteers
- 25 people
- Sponsor
- Mỹ Đức Hospital
Uterine Bleeding, Uterine Neoplasms
Anterior Quadratus Lumborum Block as a Component of Multimodal Analgesia for Abdominal Hysterectomies
The main goal of this randomised double-blinded controlled trial is to assess whether adding anterior quadratus lumborum block preoperatively can reduce intraoperative and postoperative opioid consumption, reduce pain after…
- Conditions
- Uterine Bleeding, Uterine Neoplasms, Uterine Diseases, Uterine Fibroids
- Trial name
- NCT07046949
- Testing
- ANTERİOR QUADRATUS LUMBORUM BLOCK, Parenteral administration of analgesics, General Anesthesia (GA)
- Where
- Ukraine
- Volunteers
- 56 people
- Sponsor
- Yuri Semenyuk Rivne Regional Clinical Hospital
Placenta Previa With Hemorrhage - Delivered, Placenta Accreta
A.Chohan Continuous Squeezing Suture (ACCSS) for Placenta Previa / Accreta
Placenta praevia and accreta spectrum disorders are rising in incidence due to increased rate of repeat caesarean sections. Peripartum hysterectomy remains the only definitive treatment of massive postpartum haemorrhage related…
- Trial name
- ACCSS (NCT04660578)
- Testing
- ACCSS
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- King Edward Medical University
Abnormal Uterine Bleeding, Cesarean Section Complications
Oral Contraceptive Pills Versus Levonorgestrel-Releasing Intrauterine System for Niche-Related Abnormal Uterine Bleeding
The purpose of the study is to compare the clinical efficacy and niche morphological changes following treatment with combined oral contraceptive pills (OCPs) versus a levonorgestrel-releasing intrauterine system (LNG-IUS) in…
- Conditions
- Abnormal Uterine Bleeding, Cesarean Section Complications, Uterine Scar
- Trial name
- NCT07229209
- Testing
- transvaginal ultrasonography, monophasic combined oral contraceptive pill, 52 mg levonorgestrel-releasing intrauterine system
- Where
- Egypt
- Volunteers
- 166 people
- Sponsor
- Benha University
Uterine Hemorrhage
A Study of Severe Uterine Bleeding Following Exposure to Direct Oral Anticoagulants
The purpose of this study is assess the: (a) incidence of severe uterine bleeding (SUB) following exposure to individual direct oral anticoagulant (DOACs) (rivaroxaban, apixaban, dabigatran) and warfarin, (b) individual DOACs…
- Trial name
- NCT04394234
- Testing
- Direct oral anticoagulant (DOACs), Warfarin
- Where
- United States
- Volunteers
- 961,985 people
- Sponsor
- Janssen Research & Development, LLC
Uterine Fibroids, Polyps
HOME Study: Hysteroscopic Office Myomectomy Evaluation
The purpose of this study is to demonstrate safety and effectiveness of the MyoSure Tissue Removal System when used by community gynecologists in an office setting for the treatment of patients with symptomatic intrauterine…
- Trial name
- HOME (NCT01152112)
- Testing
- Myomectomy
- Where
- 9 sites in United States
- Volunteers
- 74 people
- Sponsor
- Hologic, Inc.
Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children
Clinical Spectrum and Management of Von Willebrand Disease Among Children in Assiut Governorate
Von Willebrand disease (VWD) is the most common inherited bleeding disorder in children. It occurs due to a deficiency or dysfunction of von Willebrand factor, a protein that plays an essential role in blood clotting.
- Conditions
- Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children, Pediatric Hemostatic Disorders
- Trial name
- VWD-ASSIUT (NCT07410130)
- Testing
- Tranexamic Acid, Von Willebrand Factor-Containing Concentrates
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Assiut University
Postpartum Hemorrhage
Management of Postpartum Haemorrhage and Effect of Geographic Region
Background: Maternal deaths occur universally and are largely avoidable. Postpartum haemorrhage accounts for a disproportionate amount of maternal deaths.
- Trial name
- NCT03166839
- Testing
- Experiencing PPH
- Volunteers
- 20,060 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Menorrhagia
The Effect of Post Ablation Medroxyprogesterone Acetate on Endometrial Amenorrhea Rates
Heavy menstrual bleeding are a common reason for consultation in gynecology and are defined by International Federation of Gynecology and Obstetrics as the perception of menstrual volume increased regardless of the frequency…
- Trial name
- MPA postAE (NCT02449161)
- Testing
- MPA
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Guy Waddell
Delivery Delayed, Mode of Delivery
Early Versus Delayed Oxytocin Infusion Following Amniotomy in Nulliparous Women
In UKM Medical Centre (UKMMC), delayed oxytocin augmentation at two hours following amniotomy is the routine obstetric practice in spontaneous or induced labour with intact membranes.
- Conditions
- Delivery Delayed, Mode of Delivery, Post Partum Hemorrhage, Uterine Hyperstimulation
- Trial name
- NCT04200599
- Testing
- duration of initiation of oxytocin
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Placenta Accreta
Internal Iliac Artery Occlusion in Placenta Accreta
This is a randomized study to assess the efficacy of prophylactic bilateral internal iliac artery occlusion performed prior to planned surgical management for placenta accreta spectrum (PAS).
- Trial name
- NCT04423263
- Testing
- Bilateral internal iliac artery balloon occlusion, Control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Voon Hian Yan
Postpartum Hemorrhage
Misoprostol for Treatment of Postpartum Hemorrhage at Community-level Births in Egypt
This randomized controlled community-based trial will assess the effectiveness of administration of 800 mcg sublingual misoprostol with standard of care vs.
- Trial name
- NCT01619072
- Testing
- Misoprostol + referral
- Where
- Egypt
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Von Willebrand Disease (VWD), Heavy Menstrual Bleeding (HMB)
HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB
The purpose of this study is to evaluate the safety, tolerability, efficacy, and pharmacodynamics (PD) of multiple doses of ALN-6400 in adult and adolescent patients with VWD and HMB
- Trial name
- HMBeacon (NCT07575308)
- Testing
- ALN-6400
- Where
- 21 sites in United States, Netherlands and 3 more
- Volunteers
- 24 people
- Sponsor
- Alnylam Pharmaceuticals
Pregnancy Related, Cesarean Section; Complications
Haemodynamic Effects of Oxytocin and Carbetocin
The purpose of this study is to evaluate the immediate effects of carbetocin and oxytocin on maternal hemodynamic parameters (heart rate and blood pressure) in a non-invasive setup (TaskeForce®-Monitor) during primary Caesarean…
- Conditions
- Pregnancy Related, Cesarean Section; Complications, Adverse Reaction to Oxytocic Agents
- Trial name
- NCT01277978
- Where
- Austria
- Volunteers
- 84 people
- Sponsor
- Medical University of Graz
Postpartum Hemorrhage
Misoprostol in the Prevention of Postpartum Haemorrhage
Postpartum haemorrhage is a major contributor to maternal mortality in the developing world. The incidence is between 5 and 12% in Jamaica and varies depending on the route of delivery.
- Trial name
- NCT04044287
- Testing
- 200 micrograms of misoprostol
- Where
- Jamaica
- Volunteers
- 1,496 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Postpartum Hemorrhage
Carbetocin Versus Ergometrin in the Prevention of Postpartum Hemorrhage
In the present study will be compared Carbetocin with ergometrin in the prevention of postpartum haemorrhage (PPH) in parturients that are undergoing caesarean section and are not presenting risk factors for PPH.
- Trial name
- NCT04300452
- Testing
- Carbetocin, Ergometrine Maleate
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Uterine Bleeding
Laparoscopic Versus Vaginal Hysterectomy in Women With Abnormal Uterine Bleeding Using Bipolar Vessel Sealer
This study will be a randomized clinical trial to evaluate the surgical performance and outcome of total laparoscopic hysterectomy compared to non-descent vaginal hysterectomy ,using bipolar vessel sealer,in cases of abnormal…
- Trial name
- NCT04237558
- Testing
- Vaginal hysterectomy, Laparoscopic hysterectomy
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Mansoura University
Uterine Myoma
Single or Triple Uterine Tourniquet at Myomectomy
The aim of study is to compare triple tourniquet vs. single tourniquet to reduce blood loss at open myomectomy.
- Trial name
- NCT02392585
- Testing
- Single tourniquet, Triple tourniquet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ragıp Atakan Al
Postpartum Hemorrhage, Hyperfibrinolysis
Haemostasis and Tranexamic Acid in Caesarean Delivery
The aim of the study is to evaluate haemostasis and fibrinolysis in peripartum of caesarean delivery and the effect of tranexamic acid (TXA) given in prevention of post-partum haemorrhage (PPH).
- Trial name
- BIO-TRAAP (NCT03742947)
- Testing
- peripartum haemostasis
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Bordeaux
Post Partum Hemorrhage
Recombinant Factor VII for Intractable Postpartum Haemorrhage
Postpartum haemorrhage remains at the top of the causes of maternal deaths in both developed and developing countries .
- Trial name
- NCT05298826
- Testing
- recombinant factor VIIa
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Aljazeera Hospital