Clinical trials: Uterine Hemorrhage
Postpartum Hemorrhage
Safety, Tolerability and Pharmacokinetics (PK) Study of Oxytocin (GR121619) Administered Via an Inhaled Route in Healthy Female Volunteers
Intramuscular (IM) oxytocin is the gold standard prophylactic therapy for post partum haemorrhage (PPH). However, in resource-poor settings within the developing world, the stability and therefore effectiveness of prophylactic IM…
- Trial name
- NCT02542813
- Testing
- IM oxytocin 10 IU, IH oxytocin 50 mcg, IH oxytocin 200 mcg
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Menorrhagia
Prevalence of Heavy Menstrual Bleeding in Female Population Living in Beijing
The purpose of the study is to estimate the prevalence of heavy menstrual bleeding (HMB) in females aged between 18 and 50 years old living in Bejing.
- Trial name
- NCT02304510
- Where
- China
- Volunteers
- 2,455 people
- Sponsor
- Peking University
Uterine Hemorrhage
Aqua Therapeutics Thermal Therapy Vapor Ablation System (ATTTVAS) Abnormal Uterine Bleeding Safety Study
Abnormal uterine bleeding (AUB) is defined as "flow outside of normal volume, duration, regularity, or frequency". Acute AUB is excessive bleeding that requires immediate intervention to prevent further blood loss.
- Trial name
- AQTH-EA-22 (NCT07580560)
- Testing
- Aqua Therapeutics Thermal Therapy Vapor Ablation System (ATTTVAS)
- Where
- 3 sites in Italy, Netherlands
- Volunteers
- 10 people
- Sponsor
- Aqua Therapeutics, Inc.
Uterine Fibroids
Laparoscopic Occlusion of Uterine Vessels Compared to Uterine Fibroid Embolization for Treatment of Uterine Fibroids
Women with symptomatic uterine fibroids are treated either by Uterine Fibroid Embolization (UFE) or laparoscopic occlusion. The study hypothesis is that laparoscopic occlusion of uterine vessels and UFE have equal effect on…
- Trial name
- NCT00277680
- Testing
- Laparoscopic bilateral occlusion of uterine artery, Radiological embolization (UFE)
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Ullevaal University Hospital
Menorrhagia
Ultrasound Appearance of the Endometrium Post Radio-Frequency Ablation
The study primarily aims to evaluate the post ablative endometrium and uterus using transvaginal ultrasound to provide descriptive information as to what may be expected in the 12 months after a NovaSure ablation.
- Trial name
- NCT02584088
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Postpartum Hemorrhage, Postpartum Period
Effects of an Interaction-Based Multi-Care Program on Postpartum Hemorrhage Recovery
This study explored the impact of an interaction standard theory-based multi-care program on postpartum recovery, coping styles, psychological distress, and quality of life in women experiencing postpartum hemorrhage (PPH).
- Conditions
- Postpartum Hemorrhage, Postpartum Period, Psychological Distress, Quality of Life
- Trial name
- NCT07058142
- Testing
- Interaction Standard Theory-Based Multi-Care Program, Conventional Nursing Intervention
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Xingxing Lv
Post-partum Hemorrhage, Blood Transfusion
Risk Factors, Management and Complications of Severe Post-partum Hemorrhage
The incidence of severe post-partum hemorrhage has been increasing in developed countries. The reason for this is at least partially unknown.
- Trial name
- PPH-REG (NCT02815605)
- Where
- Finland
- Volunteers
- 9,000 people
- Sponsor
- Tampere University Hospital
Intermenstrual Bleeding
Nonsurgical Management of Cesarean Scar Niche Related Abnormal Uterine Bleeding
A study of the effect of three different nonsurgical methods for management of abnormal uterine bleeding caused by cesarean scar niche.
- Trial name
- NCT05594186
- Testing
- Tranexamic acid, Oral contraceptive pills and the Levonorgestrel-releasing intrauterine system.
- Where
- Saudi Arabia
- Volunteers
- 158 people
- Sponsor
- Saudi German Hospital - Madinah
Postpartum Hemorrhage
In-vitro Myometrial Contractility After Oxytocin Pre-exposure in Women With Advanced Maternal Age and Morbid Obesity
Women with advanced maternal age and morbid obesity, have a higher incidence of labor induction/ augmentation and cesarean section (CS), and are at a greater risk for postpartum hemorrhage (PPH).
- Trial name
- NCT01865669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization: an In-vitro Analysis of Oxytocin Receptor Expression and Signaling
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity worldwide, and is caused most commonly by poor uterine muscle contraction after delivery of the baby and placenta.
- Trial name
- NCT02762669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Oxytocin Maintenance Infusion in Labouring Women Undergoing Cesarean Delivery: an Up-down Sequential Allocation Study
This study is designed to determine the minimal effective oxytocin maintenance infusion required in labouring women undergoing cesarean delivery to achieve the best effect.
- Trial name
- NCT05290129
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage, Neonatal Asphyxia
Saving Lives at Birth in Uganda: Building and Sustaining Capacity of Frontline Health Workers - A Program Evaluation
The study aims are to evaluate the impact of supportive follow-up strategies for a novel twinned training and capacity-sustaining program among frontline health workers (providers) attending facility-based births in remote and…
- Trial name
- NCT03254628
- Testing
- Helping Mothers Survive - Bleeding After Birth training, Helping Babies Breathe, Mentor
- Volunteers
- 3,440 people
- Sponsor
- Jhpiego
Infertility Unexplained, Abnormal Uterine Bleeding
Diagnostics of Chronic Endometritis in Infertility
Chronic endometritis (CE) is characterized by the presence of atypical plasma cell infiltrates (CD138 positive) in the endometrial stroma.
- Conditions
- Infertility Unexplained, Abnormal Uterine Bleeding, Intrauterine Disorder
- Trial name
- NCT05946655
- Testing
- Ofloxacin + Metronidazole
- Where
- Poland
- Volunteers
- 102 people
- Sponsor
- Jagiellonian University
Postpartum Hemorrhage (Primary), Hemorrhage
U-CaVIT Versus Standard of Care for Prevention of Atonic Postpartum Hemorrhage After Cesarean Section in High-risk Women.
This pilot study aims to assess performance, safety and feasibility of U-CaVIT method (Uro-Catheter Vacuum Induced Tamponade), using the Rüsch® Brillant Silicone Balloon Catheter, an urological catheter, for the prevention of…
- Conditions
- Postpartum Hemorrhage (Primary), Hemorrhage, Postpartum Complication, Delivery ,Complications,Maternal
- Trial name
- UCaVIT Pilot (NCT07019623)
- Testing
- Rüsch® Balloon Catheter Ch. 24, Ultrasonography
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Christian Haslinger
Postpartum Hemorrhage
The Use of Oxytocin, Carbetocin and Buccal Misoprostol in Patients Undergoing Elective Cesarean Section (CS)
The use of Oxytocin, Carbetocin and buccal misoprostol in patients undergoing elective Cesarean Section
- Trial name
- NCT02053922
- Testing
- Syntocinon, Carbetocin, Misoprostol
- Where
- Egypt
- Volunteers
- 270 people
- Sponsor
- Ain Shams University
Heavy Menstrual Bleeding
Quality of Life Outcomes for Ulipristal Acetate and Tranexamic Acid in the Management of Heavy Menstrual Bleeding
This study compares two treatments for the management of heavy menstrual bleeding, ulipristal acetate (UPA) and tranexamic acid (TEA), on health-related quality of life.
- Trial name
- NCT03027973
- Testing
- UPA, TEA
- Where
- Canada
- Sponsor
- University of Saskatchewan
Postpartum Hemorrhage
The Influence of Prenatal Factors on Maternal Hemorrhage
This research evaluates the effects of prenatal factors on adverse pregnancy outcomes, the general demographic information, the level of maternal exposure to air pollution, the environmental condition, pregnancy-related…
- Trial name
- TIOPFOMH (NCT04517617)
- Testing
- The level of air pollution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Menorrhagia, Uterine Fibroids
Doppler-Guided Uterine Artery Occlusion (DUAO) Device for Fibroid Related Bleeding
The objective of this study is to evaluate the safety and effectiveness of Doppler guided uterine artery occlusion (D-UAO) for the reduction of fibroid associated bleeding.
- Trial name
- DUAO (NCT00496080)
- Testing
- Doppler-Guided Uterine Artery Occlusion Device (DUAO)
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 87 people
- Sponsor
- Ethicon, Inc.
Post Partum Hemorrhage, Anemia of Pregnancy
Hemoglobin Testing in Pregnant Patients
The project is a prospective observational study aimed to assess and to validate the use of point-of-care hemoglobin testing in pregnancy.
- Trial name
- AnemiaPOC (NCT05977686)
- Testing
- Masimo Root Radical 7 Pulse CO-Oximeter, HemoCue Hb 801
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Postpartum Hemorrhage, Obesity
Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With BMI ≥ 40kg/m2
Postpartum hemorrhage (PPH) due to uterine atony is a major cause of maternal morbidity and mortality. Uterotonic drugs are used to improve the muscle tone of the uterus after birth, and these are effective at reducing the…
- Trial name
- NCT03957083
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital