Clinical trials: Uterine Hemorrhage
Post-Partum Hemorrhage
Fibrinogen in Haemorrhage of Delivery
The purpose of the study is to assess the benefits of a therapeutic strategy that associates an early administration of human fibrinogen concentrate in the management of PPH on the reduction of bleeding after the initiation of…
- Trial name
- FIDEL (NCT02155725)
- Testing
- Human Fibrinogen concentrate
- Where
- 31 sites in France, Martinique
- Volunteers
- 448 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Menorrhagia
Study in Women With Idiopathic Menorrhagia to Determine the Reduction in Menstrual Blood Loss (MBL) After Treatment With the Levonorgestrel-releasing Intrauterine System (IUS)
The purpose of this study is to determine whether the levonorgestrel-releasing intrauterine system is effective in decreasing menstrual blood loss.
- Trial name
- NCT00360490
- Testing
- Levonorgestrel IUS (Mirena, BAY86-5028), Medroxyprogesterone acetate
- Where
- 54 sites in United States, Argentina and 3 more
- Volunteers
- 165 people
- Sponsor
- Bayer
Uterine Hemorrhage, Menorrhagia
Treatment of Non-Gestational Acute Uterine Bleeding: A Randomized Trial
To determine the relative efficacy of multidose medroxyprogesterone acetate (MPA, Provera) and a multidose, monophasic combination oral contraceptive in the treatment of hemodynamically stable women with non-gestational, acute…
- Trial name
- NCT00350480
- Testing
- Provera, Combination Birth Control pills
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Kaiser Permanente
Hemorrhage, Postpartum, Placenta Previa
Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa
Many RCT(randomized controlled trial) studies reported that tranexamic acid reduced blood loss in women who had elective cesareans.
- Trial name
- TRAPP (NCT05811676)
- Testing
- Tranexamic acid, 0.9% sodium chloride
- Where
- 27 sites in China
- Volunteers
- 1,732 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Postpartum Hemorrhage
Postpartum Hemorrhage: Incidence and Risk Factors
Postpartum hemorrhage(PPH) is a major cause of maternal morbidity and mortality across the world. Incidence of PPH varies in the literature from 2 to 10%, most recent studies find around 10% of PPH and 2% of severe PPH.
- Trial name
- NCT05525143
- Testing
- Pregnant women who have given birth vaginally or by cesarean section
- Where
- Belgium
- Volunteers
- 2,402 people
- Sponsor
- Brugmann University Hospital
Abnormal Uterine Bleeding
D-chiro-inositol and AUB
Patients with AUB will undergo 6-month treatment with D-chiro-inositol and will fill in questionnaires on AUB, with the evaluation of hormonal serum levels.
- Trial name
- NCT06398145
- Testing
- D-chiro-inositol and lactalbumin (high dose), D-chiro-inositol and lactalbumin (low dose)
- Volunteers
- 20 people
- Sponsor
- University Of Perugia
Menorrhagia
Copper IUD Treatment Observation Study
Studies indicate that bleeding irregularities and dysmenorrhea are common reasons for copper IUD method discontinuation. Some evidence suggests that non-steroidal anti-inflammatory medications (NSAIDs) can help improve bleeding…
- Trial name
- CITROS (NCT02519231)
- Testing
- Naproxen
- Where
- 5 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Washington
Postpartum Hemorrhage
A Study to Evaluate the Effect of Carbetocin on the QT/QTc Interval in Healthy Subjects
Carbetocin is an oxytocin receptor agonist that selectively binds to receptors in the smooth muscle of the uterus, stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions, and raises the…
- Trial name
- NCT05924321
- Testing
- Carbetocin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Post Partum Hemorrhage
Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery
The goal of this study is to compare 2 medications that are commonly used to prevent excess uterine bleeding (postpartum hemorrhage, or PPH) following cesarean delivery (CD), oxytocin and carbetocin.
- Trial name
- NCT06333340
- Testing
- Oxytocin, Carbetocin
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Health Care Cost, Post Partum Haemorrhage
Health Economics Evaluation of the Management of Severe Postpartum Hemorrhage: Comparison of Recombinant Activated Factor VII Strategy to the Reference Strategy
The main objective of this project is to assess the average cost of the treatment of bleeding postpartum with recombinant activated factor VII (NovoSeven®) and compare it to the reference strategy.
- Trial name
- NCT02900690
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pain
Fundal Block in Pre-menopausal Women to Reduce Pain During Outpatient-based Endometrial Ablation (FUNDAL-PAIN)
The objective of this study is to assess the efficacy of a fundal block in reducing women's perception of pain during NovaSure endometrial ablation (EA) in an outpatient-based setting.
- Trial name
- FUNDAL-PAIN (NCT04249063)
- Testing
- Xylocaine 1 % and Normal Saline, Normal Saline
- Where
- Canada
- Volunteers
- 288 people
- Sponsor
- Saskatchewan Health Authority - Regina Area
Vaginal Bleeding
Does Skyla Insertion Timing Impact Bleeding?
Women presenting for contraception will be offered the IUS Skyla and study participation. Daily bleeding will be collected for a total of 90 days and correlated with insertion timing and baseline endometrial thickness.
- Trial name
- NCT03074903
- Testing
- Intrauterine system
- Where
- 3 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Childbirth
Third Stage of Labor a Swedish Randomized Controlled Trial
The purpose with this study was to compare blood loss and women's experience of afterpains during the third stage when handled with active or expectant management of the third stage of labour. Hypothesis 1.
- Trial name
- NCT01221051
- Testing
- active management of the third stage of labor, expectant management of the third stage of labor
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Pre-eclampsia, Oocyte Donation
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation.
- Conditions
- Pre-eclampsia, Oocyte Donation, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia; Mild
- Trial name
- PRIOR (NCT07263490)
- Where
- 6 sites in Denmark
- Volunteers
- 462 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Uterine Fibroids, Heavy Menstrual Bleeding
Efficacy and Safety of BG2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids.
The primary objective of this study is to demonstrate the superior efficacy versus placebo of BG2109 alone and in combination with add-back therapy for the reduction of heavy menstrual bleeding associated with uterine fibroids in…
- Trial name
- NCT05620355
- Testing
- BG2109, Add-back therapy
- Where
- 29 sites in China
- Volunteers
- 312 people
- Sponsor
- Bio Genuine (Shanghai) Biotech Co., Ltd.
Menorrhagia
A Study Run at Multiple Study Sites to Test Whether the SAMANTA Questionnaire That is Used to Diagnose Heavy Menstrual Bleeding (HMB), Can Also be Used to Assess Changes of Severity of HMB in Women With HMB Who Are Treated During 12 Months With a Chronic Hormonal Treatment
A study run at multiple study sites in Spain to test whether the SAMANTA questionnaire that is used to diagnose heavy menstrual bleeding (HMB), can also be used to assess changes of severity of HMB in women with HMB who are…
- Trial name
- SAMIRA (NCT03751800)
- Testing
- Chronic hormonal treatment
- Where
- Spain
- Volunteers
- 422 people
- Sponsor
- Bayer
Post Partum Hemorrhage
A Pragmatic Randomized Controlled Trial to Predict Postpartum Hemorrhage
This research project aims to enhance the safety of childbirth by using advanced computer models to predict the risk of postpartum hemorrhage (PPH). PPH is a significant concern for mothers during and after delivery.
- Trial name
- NCT06513351
- Testing
- Novel PPH Risk Prediction Model - Comparator Arm B
- Where
- United States
- Volunteers
- 12,500 people
- Sponsor
- Holly Ende
Von Willebrand Diseases
Minimize Menorrhagia in Women With Von Willebrand Disease
This is an outpatient, 24-week Phase III prospective, randomized, crossover trial comparing recombinant von Willebrand factor (rVWF) and tranexamic acid (TA, Lysteda®) to minimize menorrhagia in women with von Willebrand disease…
- Trial name
- VWDMin (NCT02606045)
- Testing
- recombinant von Willebrand factor, tranexamic acid
- Where
- 19 sites in United States
- Volunteers
- 39 people
- Sponsor
- Margaret Ragni
Abnormal Uterine Bleeding, Analgesia
Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy
A randomized double-blind placebo controlled trial comparing the effect of a combined ketorolac and lidocaine paracervical block with a standard lidocaine paracervical block on procedure related pain with office hysteroscopies.
- Conditions
- Abnormal Uterine Bleeding, Analgesia, Paracervical Block
- Trial name
- NCT06653400
- Testing
- paracervical block, Lidocaine, ketorolac
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postpartum Hemorrhage
Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section
This randomized controlled trial aims to evaluate the efficacy of adding preoperative rectal misoprostol to standard oxytocin for reducing intraoperative and postoperative blood loss in women undergoing elective cesarean section.
- Trial name
- NCT07188207
- Testing
- Oxytocin
- Volunteers
- 282 people
- Sponsor
- Assiut University