Clinical trials: Uterine Myoma
Leiomyoma, Uterine Fibroids
Fibroid Ablation Study - Large Fibroids
The purpose of this study is to establish the effectiveness and confirm the safety of the VizAblate System in the ablation of large (> 5 cm) symptomatic uterine fibroids.
- Conditions
- Leiomyoma, Uterine Fibroids, Menorrhagia
- Trial name
- FAST-L (NCT01539187)
- Testing
- VizAblate System
- Where
- 10 sites in Mexico, Netherlands and 1 more
- Volunteers
- 6 people
- Sponsor
- Gynesonics
Uterine Myomas
PGL4001 Versus Placebo in Uterine Myomas
This trial will assess the efficacy and safety of PGL4001 with concomitant iron administration versus placebo with concomitant iron administration, over a 3-month period for the pre-operative treatment of pre-menopausal women…
- Trial name
- PEARLI (NCT00755755)
- Testing
- PGL4001 (ulipristal) and iron
- Where
- 38 sites in Czechia, Hungary and 4 more
- Volunteers
- 241 people
- Sponsor
- PregLem SA
Fibroids, Uterine, Fluid Deficit
Effect of Misoprostol on Fluid Deficit Volume in Hysteroscopic Myomectomy
The goal of this double blinded randomized control trial is to evaluate the impact of misoprostol on fluid deficit during hysteroscopic myomectomies.
- Conditions
- Fibroids, Uterine, Fluid Deficit, Hysteroscopy / Methods
- Trial name
- NCT07286188
- Testing
- Misoprostol Tabets
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Uterine Fibroids
PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata
Phase III, multicentre, randomized, double-blind, parallel group, long-term study investigating the efficacy and safety of the 5mg and 10mg doses of PGL4001 for the treatment of uterine myoma.
- Trial name
- PEARLIV (NCT01629563)
- Testing
- PGL4001 5 mg, PGL4001 10 mg
- Where
- 49 sites in Belgium, Czechia and 9 more
- Volunteers
- 451 people
- Sponsor
- PregLem SA
Uterine Fibroids (UF)
Artificial Intelligence for the Intra-procedural Assessment of Uterine Artery Embolization
Uterine artery embolization is a minimally invasive treatment for symptomatic uterine fibroids, but intra-procedural assessment of embolization adequacy currently relies on subjective angiographic criteria.
- Trial name
- AI-EMBO (NCT07230444)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Emanuele Barabino
Uterine Fibroids With Menorrhagia
A Phase II/III Study of Efficacy and Safety of SHR7280 Tablets in Subjects With Menorrhagia With Uterine Fibroids
Phase II:To explore the optimal effective dose of SHR7280 tablets in subjects with menorrhagia with uterine fibroids as a phase III treatment dose.
- Trial name
- NCT05442827
- Testing
- SHR7280 tablets
- Where
- China
- Volunteers
- 357 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Leiomyoma, Uterine Fibroids
Pilot of Letrozole for Uterine Myomas
PLUM evaluates the drug letrozole as a treatment for uterine fibroids. This study is a randomized, blinded, placebo-controlled trial of oral letrozole among premenopausal women with symptomatic uterine fibroids.
- Trial name
- PLUM (NCT02470741)
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Leiomyoma of Uterus
Vaginoscopy Compared to Traditional Hysteroscopy for Hysteroscopy Morcellation in Outpatient Clinic. A Randomized Trial
This study is a randomized controlled trial take place in a fertility outpatient clinic in an academic hospital. Women between 18 and 52 years old requiring polypectomy or myomectomy by hysteroscopy morcellation for abnormal…
- Trial name
- NCT04373694
- Testing
- vaginoscopy, standard hysteroscopy
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Uterine Fibroids, Uterine Leiomyomata
Pilot Study of MRI-Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids
Uterine fibroids (leiomyomas) are a common cause of heavy uterine bleeding and pain in reproductive aged women and are the most common cause of hysterectomy in the United States.
- Trial name
- NCT00837161
- Testing
- Philips MR guided HIFU system
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Philips Healthcare
Uterine Fibroids
Study of Proellex in Pre-menopausal Women With Symptomatic Uterine Fibroids
Two (2) dose levels of Proellex or placebo will be administered once-daily for up to 91 days. Following screening and a pre-treatment endometrial biopsy, subjects will be followed monthly for the three month treatment phase.
- Trial name
- NCT00882258
- Testing
- 12.5 mg Proellex, 25 mg Proellex
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- Repros Therapeutics Inc.
Uterine Fibroids
Uterine Artery Embolization(UAE) Versus High-Intensity-Focused-Ultrasound(HIFU) for Treatment of Uterine Fibroids
This study aimed to evaluate the clinical effectiveness and adverse effects of Uterine Artery Embolization (UAE), High-Intensity-Focused-Ultrasound (HIFU) in treating patients with uterine fibroid.
- Trial name
- NCT01834703
- Testing
- UAE, HIFU
- Where
- 2 sites in Hong Kong
- Volunteers
- 85 people
- Sponsor
- Chinese University of Hong Kong
Leiomyoma
Questionnaire Study to Assess Quality of Life After Treatment of Fibroids
The purpose of this study is to determine the change in symptoms and health-related quality of life in patients undergoing treatment for fibroids.
- Trial name
- NCT00390494
- Testing
- Hysterectomy, Myomectomy, Uterine Fibroid Embolization
- Where
- 4 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Uterine Fibroids With Menorrhagia
Phase II Study of CMS-D002 Capsule for Uterine Fibroids With Menorrhagia
Objective This study evaluates whether CMS-D002 capsules are effective in treating menorrhagia in participants with uterine fibroids associated with menorrhagia.
- Trial name
- NCT07402369
- Testing
- CMS-D002 Capsules 10 mg, CMS-D002 Capsules 25 mg, CMS-D002 Capsules 50 mg
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenzhen Kangzhe Biotechnology Co., Ltd.
Intrauterine Adhesions
Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy
Seprafilm is an FDA-approved temporary bioresorbable barrier that physically separates opposing tissue surfaces. The physical presence of the membrane separates adhesiogenic tissue while the normal tissue repair process takes…
- Trial name
- Seprafilm (NCT01632202)
- Testing
- Seprafilm, Sterile Saline Solution
- Where
- 2 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Leiomyoma
Impact of Misoprostol on Blood Loss In Myomectomy Operations
The aim of this research work is to assess the effect of using single preoperative dose of rectal misoprostol in abdominal myomectomy operations on blood loss, duration of the operation and possible operative complications
- Trial name
- NCT02061657
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Exposure to Magnetic Field, Uterine Leiomyoma
Predictive Factors of Pelvic Magnetic Resonance in the Response of Arterial Embolization of Uterine Leiomyoma
The purpose of this study is to determine predictive factors in the pelvic magnetic resonance in the response of arterial embolization of uterine leiomyoma.
- Trial name
- NCT01468402
- Testing
- Magnetic Resonance Image
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Israelita Albert Einstein
Uterine Fibroids, Hysteroscopic Myomectomy
Preoperative Administration of EGCG, Vitamin D and DCI Prior Hysteroscopic Myomectomy
The administration of Epigallocatechin gallate (EGCG), Vitamin D and D-Chiro-Inositol (DCI) are effective in reducing the volume of fibroids and improving the symptoms of uterine fibroids.
- Conditions
- Uterine Fibroids, Hysteroscopic Myomectomy, Treatment Compliance, Patient Compliance
- Trial name
- PREHYSMYOM (NCT06768086)
- Testing
- Hysteroscopic myomectomy
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centro di Ricerca Clinica Salentino
Myoma;Uterus
Intraoperative Carbetocin to Decrease Blood Loss During Hysteroscopic Myomectomy
Submucous myomas represent one of the main indications of operative hysteroscopy. Since 1976 when Neuwirth and Amin reported the first five cases of excision of submucous myomas , several techniques have been developed in order…
- Trial name
- NCT04482959
- Testing
- Carbetocin, Sodium chloride 0.9%
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Hospital
Uterine Myomas
Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators
To date, laparoscopic approach may apply to several gynecologic diseases. Among the recent advances in laparoscopy an important role was assumed by the methods of tissue extraction.
- Trial name
- NCT00743080
- Testing
- Laparoscopic myomectomy and supracervical hysterectomy with GYNECARE MORCELLEX, Laparoscopic myomectomy and supracervical hysterectomy with ROTOCUT G1
- Where
- Italy
- Sponsor
- University Magna Graecia
Uterine Fibroid
Microwave Ablation for Leiomyoma
This prospective observational study aims to evaluate the effectiveness and acceptability of percutaneous or vaginal ultrasound guided microwave ablation for the treatment of symptoms related to uterine fibroids.
- Trial name
- MYOMIC2 (NCT04240262)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet