Clinical trials: Uterine Myoma
Uterine Leiomyomata
A Study of Progenta (CDB-4124) in Pre-menopausal Women With Symptomatic Leiomyomata
A study of 3 doses of Progenta versus placebo versus Lucron Depot for treatment of leiomyomata.
- Trial name
- NCT01069094
- Testing
- Progenta, Lucron Depot
- Where
- Poland
- Volunteers
- 29 people
- Sponsor
- Repros Therapeutics Inc.
Uterine Myomas, Adenomyosis
Single-port Access Laparoscopic-assisted Vaginal Hysterectomy
Minimally invasive surgery has become the standard treatment for many gynecologic disease processes. In the last decade, numerous studies have demonstrated that laparoscopic approaches to various gynecologic oncology…
- Trial name
- NCT01048931
- Testing
- single-port LAVH
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Uterine Fibroid, Embolization
Uterine Fibroid Embolization (UFE) for Symptomatic Fibroids: Comparison of Gel-Bead to Commonly Used Embolic Agents.
The purpose of this post-market study is to evaluate UFE agents for the treatment of symptomatic uterine fibroids, using Gel-Bead compared to four other commonly used embolic agents.
- Conditions
- Uterine Fibroid, Embolization, Symptoms
- Trial name
- NCT03072446
- Testing
- Gel-Beads embolic material
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Uterine Fibroids
Study of Proellex in Pre-menopausal Women With Symptomatic Uterine Fibroids
Two (2) dose levels of Proellex or placebo will be administered once-daily for up to 91 days. Following screening and a pre-treatment endometrial biopsy, subjects will be followed monthly for the three month treatment phase.
- Trial name
- NCT00882258
- Testing
- 12.5 mg Proellex, 25 mg Proellex
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- Repros Therapeutics Inc.
Leiomyoma, Uterine, Liver Injury
Liver Safety Assessment During Ulipristal Acetate Treatment for Uterine Fibroids (LISA)
Uterine fibroids are are the most common gynecological tumor. Among the pharmacological treatment options, ulipristal acetate (UPA) has proven to be effective in control of bleeding and reduction of size of fibroids.
- Conditions
- Leiomyoma, Uterine, Liver Injury, Treatment Side Effects
- Trial name
- LISA (NCT04004884)
- Testing
- Ulipristal Acetate
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Uterine Fibroids
Pharmacokinetics, Safety and Efficacy Study of Proellex in Pre-menopausal Women With Symptomatic Uterine Fibroids
PK of 25 mg and 50 mg Proellex® administered once daily (QD) over a 4-month period.
- Trial name
- NCT00683917
- Testing
- Proellex 25 mg, Proellex 50 mg, Lupron Depot
- Where
- 4 sites in United States, Mexico
- Volunteers
- 10 people
- Sponsor
- Repros Therapeutics Inc.
Uterine Artery Embolization for Uterine Leiomyomata
Patient-Controlled Epidural Analgesia After Uterine Artery Embolization
Uterine artery embolization (UAE) is commonly used to treat symptomatic uterine leiomyomata through induction of infarction and subsequent hyaline degeneration.
- Trial name
- NCT02236585
- Testing
- Patient-controlled epidural analgesia, Continuous epidural analgesia
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Uterine Fibroids
Safety of 25 and 50 mg Proellex® in the Treatment of Women With Symptomatic Uterine Fibroids
Safety and efficacy study of 25 and 50 mg doses of Proellex
- Trial name
- NCT01069120
- Testing
- Proellex
- Where
- 4 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Uterine Fibroids
Uterine Leiomyoma Treatment With Radiofrequency Ablation
The ULTRA study is a single-arm trial of 100 premenopausal women with symptomatic uterine fibroids who undergo treatment with the Acessa device.
- Trial name
- ULTRA (NCT01840124)
- Testing
- Radiofrequency ablation of fibroids
- Where
- 5 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Leiomyoma, Uterine Fibroids
Fibroid Ablation Study
The primary objective of this study is to establish the effectiveness and confirm the safety of the VizAblate System in ablating symptomatic uterine fibroids.
- Conditions
- Leiomyoma, Uterine Fibroids, Menorrhagia
- Trial name
- FAST-EU (NCT01226290)
- Testing
- VizAblate System
- Where
- 10 sites in Mexico, Netherlands and 1 more
- Volunteers
- 51 people
- Sponsor
- Gynesonics
Fibroid
Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma
The uterine leiomyoma is the most common female benign disease. Submucosal fibroid are about 10%, they distort the endometrial cavity causing heavy and/or irregular bleeding (AUB) and infertility.
- Trial name
- NCT02361879
- Testing
- ulipristal acetate, Leuprolide acetate
- Where
- Italy
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Leiomyomas
Somatic Stem Cells in Leiomyomas?
The purpose of this study is to identify and characterize the Somatic Stem Cell (SSC) responsible for the formation and growth of leiomyomas using the Side Population method.
- Trial name
- NCT01592903
- Testing
- Laparoscopic myomectomy. Following analysis and proliferation of cells isolated from removed human leiomyoma.
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Igenomix
Endometrial Polyp Benign, Retained Products of Conception
The Use of a Morcellator in Operative Hysteroscopy for Benign Intracavitary Lesions: a Feasibility Study
Polyps, intracavitary myomas and retained products of conception (RPOC) are common benign intracavitary lesions of the uterus and frequently cause abnormal uterine bleeding or pain.
- Conditions
- Endometrial Polyp Benign, Retained Products of Conception, Myoma;Uterus
- Trial name
- NCT05811286
- Testing
- Hysteroscopic morcellation 19 Fr. intrauterine BIGATTI Shaver for uterine intracavitary lesions
- Where
- 2 sites in Belgium
- Volunteers
- 56 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Leiomyoma, Uterine
FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea
The objective of this study is to determine the effect of low caffeine green tea extract containing 45% epigallocatechin gallate (EGCG) on fibroids and subsequent pregnancy and live births in women seeking fertility treatment.
- Trial name
- FRIEND (NCT05364008)
- Testing
- Green Tea Extract
- Where
- 4 sites in United States
- Volunteers
- 33 people
- Sponsor
- Yale University
Uterine Fibroids, Adhesions
Evaluation of Uterine Patency Following Sonography-guided Transcervical Ablation of Fibroids
This study is designed to observe the presence or absence of intrauterine adhesions at 6 weeks after treatment with the Sonata® System through hysteroscopic evaluation by third party readers.
- Trial name
- OPEN (NCT02844920)
- Testing
- Intrauterine ultrasound guided radio-frequency ablation
- Where
- 6 sites in Germany, Netherlands and 2 more
- Volunteers
- 37 people
- Sponsor
- Gynesonics
Heavy Menstrual Bleeding, Menorrhagia
Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids
This is a randomized controlled trial (RCT) to assess the comparative effectiveness of Levonorgestrel Intrauterine System (LNG-IUS) to Tranexamic Acid (TA) for the treatment of heavy menstrual bleeding (HMB) in women with…
- Conditions
- Heavy Menstrual Bleeding, Menorrhagia, Uterine Fibroids
- Trial name
- NCT03317795
- Testing
- Levonorgestrel IUS, Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Shannon K. Laughlin-Tommaso
Abnormal Uterine Bleeding, Postmenopausal Bleeding
Use of Nitrous Oxide During Office Hysteroscopy
The goal of this clinical trial is to assess the use of inhaled nitrous oxide during office hysteroscopy. The main questions it aims to answer are: Does it reduce pain during the procedure? Does it increase the success rate? Does…
- Conditions
- Abnormal Uterine Bleeding, Postmenopausal Bleeding, Endometrial Polyps, Retained Products of Conception
- Trial name
- NCT07074795
- Testing
- Inhalation of Nitrous Oxide (N₂O) during Office Operative Hysteroscopy, inhalation of ambient air during office hysteroscopy
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Maaynei Hayesha Medical Center
Myoma of Uterus
Analgesic Effect of Trigger Point Injection and EMLA for Shoulder Pain in Laparoscopic Hysterectomy
Laparoscopic operative procedures have revolutionized gynecological surgery. These have several advantages: a smaller and more cosmetic incision, reduced blood loss and shorter postoperative stay, which cuts down on hospital…
- Trial name
- NCT01845532
- Testing
- TPI, EMLA cream
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Yonsei University
Myoma;Uterus, Blood Loss
Reducing Blood Loss During Myomectomy:Uterine Artery Ligation Vs Pericervical Tourniquet
The goal of this clinical trial is to compare two surgical techniques for reducing blood loss during transabdominal myomectomy in women with symptomatic uterine fibroids.
- Trial name
- NCT07526311
- Testing
- Bilateral Uterine Artery Ligation, Pericervical Mechanical Tourniquet Application
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Uterine Fibroids
PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata
Phase III, multicentre, randomized, double-blind, parallel group, long-term study investigating the efficacy and safety of the 5mg and 10mg doses of PGL4001 for the treatment of uterine myoma.
- Trial name
- PEARLIV (NCT01629563)
- Testing
- PGL4001 5 mg, PGL4001 10 mg
- Where
- 49 sites in Belgium, Czechia and 9 more
- Volunteers
- 451 people
- Sponsor
- PregLem SA