Clinical trials: Uterine Myoma
Uterine Fibroids
Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 4)
The primary objective of this study was to show superiority of vilaprisan in the treatment of heavy menstrual bleeding (HMB) in subjects with uterine fibroids compared to placebo The secondary objectives of this study were to…
- Trial name
- NCT03400956
- Testing
- Vilaprisan (BAY1002670)
- Where
- 87 sites in United States, Czechia and 3 more
- Volunteers
- 103 people
- Sponsor
- Bayer
Fibroid, Adenomyosis
Oxytocin in MRI-HIFU
Capability of oxytocin in improving the efficacy of MRI-HIFU is studied. Patients undergoing MRI-HIFU treatment are given oxytocin during treatment and the efficacy of the treatment will be analysed by patient reported symptom…
- Trial name
- NCT03937401
- Testing
- Oxytocin
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Infertility, Abnormal Uterine Bleeding (AUB)
Evaluation of the Uterine Cavity After Operative Hysteroscopy
This study will focus on evaluation of the uterine cavity after operative hysteroscopy using three dimensional transvaginal ultrasonography and office hysteroscopy to detect and residual or recurrent abnormalities or intrauterine…
- Conditions
- Infertility, Abnormal Uterine Bleeding (AUB), Intrauterine Adhesion, Submucous Leiomyoma of Uterus
- Trial name
- NCT06924437
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Abnormal Uterine Bleeding, Unspecified, Benign Gynecological Disease
The Learning Curve of a Gynecology and Obstetrics Resident Performing Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) Hysterectomy in a University Hospital
This prospective observational study aims to evaluate the learning curve of obstetrics and gynecology residents performing Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) hysterectomy in a university hospital…
- Conditions
- Abnormal Uterine Bleeding, Unspecified, Benign Gynecological Disease, Adenomyosis of Uterus, Uterine Leiomyomas
- Trial name
- LC of V-NOTES (NCT07465822)
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Cukurova University
Uterine Myoma, Surgery, Laparoscopic
Safety and Efficacy of Using a Novel Full Visual Access Platform System in Transvaginal Hysterectomy
The modified vNOTES hysterectomy was accomplished and validated for efficacy and safety using a multi-access vaginal confinement instrument with a fully visualised vaginal access platform.
- Trial name
- NCT06658145
- Testing
- Vnotes surgery using fully visualised surgical instruments, Vnotes surgery using traditional surgical instruments
- Where
- China
- Volunteers
- 94 people
- Sponsor
- China-Japan Friendship Hospital
Endometrial Neoplasms, Uterine Cervical Neoplasms
Tissue Bank of Biological Specimens From Patients With Gynecologic Disease
The purpose of this study is to create a tissue bank of gynecologic cancers and normal tissue for the study of cancer in order to better understand the changes occurring on a molecular level (DNA, RNA, protein) that lead to the…
- Conditions
- Endometrial Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Leiomyoma
- Trial name
- NCT00299481
- Where
- 7 sites in United States
- Volunteers
- 7,000 people
- Sponsor
- U.S. Army Medical Research and Development Command
Menorrhagia, Metrorrhagia
Minimally Invasive Benign Hysterectomy
A randomised controlled trial comparing hysterectomy by minimally invasive surgical methods; robotic hysterectomy versus vaginal hysterectomy or traditional laparoscopic hysterectomy; outcome and cost analyses.
- Conditions
- Menorrhagia, Metrorrhagia, Uterine Fibroids, Cervical Dysplasia
- Trial name
- NCT01865929
- Testing
- Robotic hysterectomy, Vaginal or laparoscopic hysterectomy
- Where
- Sweden
- Volunteers
- 124 people
- Sponsor
- Region Skane
Leiomyoma of Uterus
Vaginoscopy Compared to Traditional Hysteroscopy for Hysteroscopy Morcellation in Outpatient Clinic. A Randomized Trial
This study is a randomized controlled trial take place in a fertility outpatient clinic in an academic hospital. Women between 18 and 52 years old requiring polypectomy or myomectomy by hysteroscopy morcellation for abnormal…
- Trial name
- NCT04373694
- Testing
- vaginoscopy, standard hysteroscopy
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Fibroid
Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas
Cellular leiomyomas (CLs) are described as leiomyomas that are significantly more cellular than the surrounding myometrium, often with crowding and overlapping of nuclei.
- Trial name
- NCT02361905
- Testing
- ulipristal acetate, Leuprolide acetate
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Uterine Fibroids, Heavy Menstrual Bleeding
Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids
The primary objective of this study is to demonstrate the superior efficacy versus placebo of OBE2109 alone and in combination with add-back therapy for the reduction of heavy menstrual bleeding associated with uterine fibroids…
- Trial name
- PRIMROSE 2 (NCT03070951)
- Testing
- OBE2109, Add-back
- Where
- 96 sites in United States, Bulgaria and 7 more
- Volunteers
- 511 people
- Sponsor
- ObsEva SA
Uterine Fibroids, Adenomyosis
Transvaginal Electromechanical Fragmentation and Removal of Large Uterus in a Sealed Bag: The First Group of Clinical Studies Balancing Scar - Free and Anti - Dissemination
This study evaluates the feasibility, safety, and efficiency of transvaginal in-bag electromechanical morcellation for specimen extraction in patients undergoing total laparoscopic hysterectomy for large uteri.
- Conditions
- Uterine Fibroids, Adenomyosis, Enlarged Uterus
- Trial name
- NCT07486622
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Chang Zhou
Endometriosis, Uterine Fibroids, Male Hormone-sensitive Prostate Cancer, Assisted Reproduction
A Clinical Study Evaluating the Relative Bioavailability of SHR7280 Dry Suspension and Tablets
To assess the relative bioavailability of SHR7280 dry suspension and tablets in healthy subjects. To assess the safety and tolerability of a single dose of SHR7280 dry suspension and tablets.
- Trial name
- NCT05868057
- Testing
- SHR7280 tablets, SHR7280 dry suspension
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Uterine Leiomyoma
Evaluating Serum Sestrin in Leiomyoma Patients
Leiomyomas are the most common benign neoplasms of women's reproductive system affecting 20-30% of women within the reproductive ages.
- Trial name
- NCT04819633
- Testing
- Determination of serum sestrin levels
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Leiomyoma
Superior Hypogastric Nerve Block for Pain Control Post-uterine Fibroid Embolization
Uterine fibroid embolization (UFE) is now an accepted treatment of uterine fibroids. However the procedure is often very painful and, in many centres, patients are admitted overnight with patient controlled analgesic (PCA) pumps…
- Trial name
- NCT02270255
- Testing
- Superior hypogastric nerve block, 0.75% Ropivacaine, Subcutaneous injection
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Fibroid Uterus, Leiomyoma
Safety of Treatment of Uterine Fibroids With Asoprisnil
The objective of this study is to determine the long-term safety of asoprisnil in women with symptomatic uterine fibroids who completed the 6 month Study C02-037.
- Conditions
- Fibroid Uterus, Leiomyoma, Menorrhagia, Metrorrhagia
- Trial name
- NCT00156208
- Testing
- Asoprisnil
- Volunteers
- 166 people
- Sponsor
- Abbott
Menorrhagia, Leiomyoma
Emmy Trial: Uterine Artery Embolization (UAE) Versus Hysterectomy for Uterine Fibroids
The Emmy trial is set up to evaluate the safety and efficacy of uterine artery embolization (UAE) in comparison to hysterectomy for the treatment of symptomatic uterine fibroids.
- Conditions
- Menorrhagia, Leiomyoma, Uterine Neoplasms
- Trial name
- NCT00100191
- Testing
- uterine artery embolization, hysterectomy
- Where
- 2 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Leiomyoma
Treatment of Uterine Fibroids With CDB-2914, an Experimental Selective Progesterone Receptor Antagonist
Uterine leiomyomata (fibroids) are a common benign tumor of the uterine muscle in premenopausal women. These tumors may cause bleeding, pelvic pain and pressure.
- Trial name
- NCT00044876
- Testing
- CDB-2914
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Uterine Leiomyoma
Effects of Oligo-fucoidan on Leiomyoma Patients
Uterine leiomyoma is the most common benign tumor in women, with an incidence rate of approximately 20% among women of reproductive age. Patients may experience severe abdominal pain, abnormal bleeding, and infertility.
- Trial name
- NCT06959966
- Testing
- Oligo Fucoidan
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Taipei Medical University
Fibroid
3 Dimensional Ultrasound in Comparison to Hysteroscopy in Myomas
three-dimensional saline infusion sonohysterography (3D SIS) was performed in all cases. A sterile Cuscoe speculum was passed, the cervix visualized and cleaned with sterile chlorhexidine solution.
- Trial name
- NCT04736095
- Testing
- 3D Ultrasound, Hysteroscopy
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Aljazeera Hospital
Uterine Fibroids, Polyps
HOME Study: Hysteroscopic Office Myomectomy Evaluation
The purpose of this study is to demonstrate safety and effectiveness of the MyoSure Tissue Removal System when used by community gynecologists in an office setting for the treatment of patients with symptomatic intrauterine…
- Trial name
- HOME (NCT01152112)
- Testing
- Myomectomy
- Where
- 9 sites in United States
- Volunteers
- 74 people
- Sponsor
- Hologic, Inc.