Clinical trials: Uterine Neoplasm
Breast Neoplasms
Prevalence of Genetic Polymorphisms in Genes Coding for Tamoxifen Metabolising Enzymes
CYPTAM-BRUT 3 is a prospective, multicentric study in Belgium within the CYPTAM study of the Leiden University Medical Center (NTR1509) including postmenopausal women receiving tamoxifen for estrogen-receptor positive breast…
- Trial name
- CYPTAMBRUT-3 (NCT00966043)
- Where
- 11 sites in Belgium
- Volunteers
- 158 people
- Sponsor
- Vlaamse Vereniging voor Obstetrie en Gynaecologie
Recurrent Cervical Cancer, Metastatic Cervical Cancer
A Study of SHR-A2102 Versus Investigator's Choice of Chemotherapy in Patients With Platinum-based Chemotherapy and PD-(L)1 Inhibitor Treatment Failed Recurrent or Metastatic Cervical Cancer
The main objective of this study is to evaluate the efficacy of SHR-A2102 versus investigator's choice of chemotherapy in patients with platinum-based chemotherapy and PD-(L)1 inhibitor treatment failed recurrent or metastatic…
- Trial name
- NCT07418749
- Testing
- SHR-A2102 for Injection, Pemetrexed Disodium for Injection, Gemcitabine Hydrochloride for Injection
- Where
- China
- Volunteers
- 398 people
- Sponsor
- Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Uterine Cervical Neoplasms, Uterine Neoplasms
Sentinel Node Mapping in Women With Cervical and Endometrial Cancer
This study aims to evaluate the effect of SLN mapping on the incidence and severity of lymphedema in women with early stage cervical and endometrial cancer.
- Trial name
- SENTIREC I (NCT02825355)
- Where
- 3 sites in Denmark
- Volunteers
- 512 people
- Sponsor
- University of Southern Denmark
Cervical Cancer, Condylomata Acuminata
Broad Spectrum HPV Vaccine Tolerability, Immunogenicity, and Efficacy Study (V502-003)
This study is to evaluate an investigational vaccine with the following objectives: (1) To demonstrate prevention of cervical, vulvar, and vaginal cancers and related precancers, external genital lesions, and persistent infection…
- Trial name
- NCT00365443
- Testing
- V502
- Volunteers
- healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cervical Cancer, Head and Neck Squamous Cell Carcinoma
ITIL-168 in Advanced Solid Tumors
DELTA-2 is a phase 1 clinical trial to evaluate the safety, feasibility, and preliminary efficacy of ITIL-168 with pembrolizumab in participants with advanced cancer whose disease has progressed after standard therapy.
- Conditions
- Cervical Cancer, Head and Neck Squamous Cell Carcinoma, Non-small Cell Lung Cancer
- Trial name
- DELTA-2 (NCT05393635)
- Testing
- ITIL-168
- Sponsor
- Instil Bio
Leiomyoma, Uterine
FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea
The objective of this study is to determine the effect of low caffeine green tea extract containing 45% epigallocatechin gallate (EGCG) on fibroids and subsequent pregnancy and live births in women seeking fertility treatment.
- Trial name
- FRIEND (NCT05364008)
- Testing
- Green Tea Extract
- Where
- 4 sites in United States
- Volunteers
- 33 people
- Sponsor
- Yale University
Uterine Sarcoma, Vulvar Cancer
UNDERSTANDING the RAREST GYNECOLOGICAL CANCERS: a MULTI -OMICS PLATFORM for IMPROVED PATIENTS MANAGEMENT
Rare gynecological cancers including uterine sarcomas, vulvar and non-epithelial ovarian cancers, are under-studied diseases and the absence of standardized diagnostic and therapeutic approaches or tailored clinical guidelines…
- Conditions
- Uterine Sarcoma, Vulvar Cancer, Non Epithelial Ovarian Cancers (NEOC)
- Trial name
- ROAR (NCT06582108)
- Testing
- DNA, RNA, ctDNA, metabolomics
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Intraepithelial Neoplasia
DC Vaccines Targeting HPV16/18 E6/E7 Protein to Regress CINI/CIN2
To establish therapeutic dendritic cell (DC) vaccines targeting HPV 16/18 E6/E7 protein to block the progression of CIN1/CIN2 to cervical cancer and evaluate the safety and efficacy of the vaccines.
- Trial name
- NCT03870113
- Testing
- Vaccinated group
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shenzhen People's Hospital
Uterine Bleeding, Uterine Fibroids
What Are we Missing? Diagnosing Uterine Adenomyosis Using Ultrasound Elastography
To improve the clinical care of women with pelvic pain and abnormal uterine bleeding due to benign uterine conditions including leiomyomas (uterine fibroids) and adenomyosis by evaluating the accuracy of radiology diagnostic…
- Conditions
- Uterine Bleeding, Uterine Fibroids, Adenomyosis
- Trial name
- NCT01992718
- Testing
- Evaluation of MRI, US for pelvic and uterine conditions, Patient preference between MRI and Ultrasound
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Michigan
Lymphedema, Stage 0 Cervical Cancer
Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer
This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how well it works compared with standard home maintenance therapy in treating patients with lower-extremity lymphedema caused by treatment…
- Conditions
- Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer
- Trial name
- NCT00577317
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gynecologic Oncology Group
Cervical Cancer, Cervical Dysplasia
HPVPro Study: Comparison of HPV Detection in Clinician-collected Cervical Swabs and Self-sampled Cervicovaginal Swabs
Comparison of the detection of human papillomavirus DNA in paired physician-obtained cervical swabs and self-sampled cervicovaginal swabs and evaluation of HPV prevalence in Czech women screening population.
- Conditions
- Cervical Cancer, Cervical Dysplasia, Human Papillomavirus Infection
- Trial name
- HPVPro (NCT04133610)
- Testing
- Self-sampling using digene HC2 DNA Collection Device, Self-sampling using Evalyn Brush
- Where
- 3 sites in Czechia
- Volunteers
- 1,044 people, healthy volunteers welcome
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Epidemiology
Perceptions of Cervical Cancer Among Asian Americans
The goal of this research study is to learn about the beliefs, practices, and knowledge about cervical cancer among Asian American young adults.
- Trial name
- NCT00518388
- Testing
- Focus Group, Questionnaire
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cervix Cancer
Phase II Study , Association of Cisplatine Topotecan and Cetuximab in Patients Whith Late or in Progress Epithelial Cancer of the Cervix
The efficacy of chimiotherapy in cervix epithelial cancer is low even with the association cisplatine - topotecan . News thérapeutics are needed in the goal of increase the survival and quality of life in patients with cervix…
- Trial name
- ERBUS (NCT00518193)
- Testing
- ERBITUX
- Where
- 4 sites in France
- Volunteers
- 44 people
- Sponsor
- ARCAGY/ GINECO GROUP
Fetal Conditions, Maternal; Procedure
A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures
In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery.
- Conditions
- Fetal Conditions, Maternal; Procedure, Pregnancy Related, Twin to Twin Transfusion Syndrome
- Trial name
- NCT06056635
- Testing
- Karl Storz Curved Scope, Karl Storz Straight Scope
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Male Breast Cancer, Recurrent Breast Cancer
Interleukin-12, Paclitaxel, and Trastuzumab in Treating Patients With Solid Tumors
Phase I trial to study the effectiveness of interleukin-12, paclitaxel, and trastuzumab in treating patients who have solid tumors.
- Conditions
- Male Breast Cancer, Recurrent Breast Cancer, Recurrent Endometrial Carcinoma, Recurrent Gastric Cancer
- Trial name
- NCT00028535
- Testing
- trastuzumab, paclitaxel, recombinant interleukin-12
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer
Cervical Carcinoma in Shatby University Hospital and Its Relation to Human Papilloma Virus
incidence of detection of carcinogenic types of human papilloma virus in 60 cases of cervical cancer
- Trial name
- NCT05539274
- Testing
- human papilloma virus testing and genotyping in cervical cancer cases
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Hossam Hassan Aly Hassan El Sokkary
Endometrial Hyperplasia
Management of Endometrial Hyperplasia With a LNG-IUS: Multicenter Study: KGOG2006
A prospective multicenter trial has been started in Korea to investigate the treatment efficacy of Levonorgestrel-releasing intrauterine system (LNG-IUS) in endometrial hyperplasia (EH) patients.
- Trial name
- KGOG2006 (NCT01234818)
- Testing
- Mirena (LNG-IUS)
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Korean Gynecologic Oncology Group
Human Papillomavirus-16 Positive, Human Papillomavirus-18 Positive
DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers
This phase II trial studies how well deoxyribonucleic acid (DNA) plasmid-encoding interleukin-12/human papillomavirus (HPV) DNA plasmids therapeutic vaccine INO-3112 and durvalumab work in treating patients with human…
- Conditions
- Human Papillomavirus-16 Positive, Human Papillomavirus-18 Positive, Metastatic Malignant Neoplasm, Recurrent Anal Canal Carcinoma
- Trial name
- NCT03439085
- Testing
- DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457, Durvalumab
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer, Radiotherapy Side Effect
Application of KANG FU PEN in Radical Concurrent Radiotherapy and Chemotherapy for Cervical Cancer to Prevent and Treat Radiation-induced Rectal Injury
A total of 520 cases will be randomly divided into Kang Fu Pen (liquid dressing) enema intervention group (experimental group) and non-enema intervention group (control group), according to the ratio of 1:1.
- Conditions
- Cervical Cancer, Radiotherapy Side Effect, Radiotherapy; Complications
- Trial name
- NCT04819685
- Testing
- KANG FU PEN
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Peking Union Medical College Hospital
Blood Loss, Surgical, Uterine Myoma
Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy
A total of 200 women for elective abdominal myomectomy were randomly allocated into two groups. 100 women in experimental group were administered 400ug Misoprostol (2 tablets of Prosotec®) through the rectal route prior to…
- Trial name
- NCT05108597
- Testing
- Misoprostol
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
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