Clinical trials: Uterine Neoplasm
Castration-resistant Prostate Cancer, Metastatic Breast Cancer
Phase I Study of LFA102 in Patients With Prolactin Receptor-positive Castration-resistant Prostate Cancer or Prolactin Receptor-positive Metastatic Breast Cancer
The purpose of this first multi-dose study in cancer patients is to determine the maximum tolerated dose (MTD) or recommended phase II dose (RP2D), characterize the safety, tolerability and pharmacokinetics profile.
- Conditions
- Castration-resistant Prostate Cancer, Metastatic Breast Cancer, Uterine Leiomyoma
- Trial name
- NCT01338831
- Testing
- LFA102
- Where
- 9 sites in United States, Belgium and 2 more
- Volunteers
- 73 people
- Sponsor
- Novartis Pharmaceuticals
Leiomyoma, Uterine, Thrombosis
Are Uterine Fibroids Pro-thrombotic?
This study will investigate whether the presence of uterine fibroids is independently associated with a laboratory defined pro-thrombotic phenotype. VTE is associated with significant mortality and morbidity.
- Trial name
- NCT05607602
- Testing
- Comparison of blood samples between the two groups
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Heavy Menstrual Bleeding, Uterine Fibroids
A Study to Assess Patient-Reported Quality of Life and Effectiveness on Control of Bleeding in Adult Participants With Heavy Menstrual Bleeding Due to Uterine Fibroids Taking Oral Oriahnn Capsules
Uterine Fibroids (UF) are noncancerous (benign) tumors that commonly occur in up to 80% of women of reproductive age. Symptoms can include heavy menstrual bleeding (HMB), low back pain, urinary frequency and urgency…
- Trial name
- REACH (NCT05026502)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- AbbVie
Breast Cancer, Cervical Cancer
Patient Navigation in the Safety Net:CONNECTeDD
The Boston University Medical Center, funded by the National Cancer Institutes will train health workers at six of its affiliated Community Health Centers to guide patients through the cancer care system.
- Trial name
- NCT00613275
- Testing
- patient Navigation
- Where
- United States
- Volunteers
- 4,038 people
- Sponsor
- Boston Medical Center
Cervical Cancer
Molecular Markers in Cervical Cancer Screening in the Feasibility of the Mathematical Markov Model Analysis
The purpose of this study is to: 1. make p16INK4A as a cervical cancer screening of tumor markers, cytology improve existing diagnostic sensitivity, specificity, repeatability and validity, so as to effectively prompted the early…
- Trial name
- NCT00889902
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wuhan University
Cervical Carcinoma, Human Papillomavirus Infection
Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S02)
This clinical trial evaluates the use of self-collected vaginal samples for human papillomavirus (HPV) testing in patients referred for a colposcopy and/or cervical excisional procedures to improve cervical cancer prevention.
- Trial name
- NCT06611553
- Testing
- Biospecimen Collection, Cervical Biopsy, Colposcopy
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute (NCI)
Cervix Cancer, Cadonilimab
Evaluation of AK104 (Cadonilimab) Combined with Chemotherapy for Recurrent or Metastatic Small Cell Neuroendocrine Carcinoma of the Cervix
The goal of this clinical trial is to evaluate the safety and effectiveness of AK104 (Cadonilimab) combined with chemotherapy (cisplatin or carboplatin, and etoposide) for the treatment of recurrent or metastatic small cell…
- Conditions
- Cervix Cancer, Cadonilimab, Small Cell Neuroendocrine Carcinoma of the Cervix
- Trial name
- NCT06810895
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ding Ma
Cervical Cancer, Healthy Women
A Family-based Intervention to Improve Pap Test Screening Among Under-screened Chinese American Immigrant Women
The purpose of this study is to find out the impact of the involvement of an influential person(s) (e.g., spouse, partners, parents, children, friends) on Pap test screening intention and behaviors, Pap test self-efficacy, and…
- Trial name
- NCT03961412
- Testing
- family-based intervention, Participant only intervention
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Breast Cancer, Cervix Cancer
Carboplatin-cyclophosphamide Combined With Atezolizumab
This is a single centre, 3+3, dose finding, open label, phase 1b clinical study of carboplatin and cyclophosphamide, in combination with atezolizumab.
- Conditions
- Breast Cancer, Cervix Cancer, Ovarian Cancer, Endometrial Cancer
- Trial name
- PROLOG (NCT02914470)
- Testing
- carbplatin, cyclophophamide, atezolizumab
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Endometrial Cancer, Lymph Node Metastases
Sentinel Node Mapping in High Risk Endometrial Cancer
This study will evaluate the role of systematic lymphadenectomy after sentinel node (SLN) mapping in high risk endometrial cancer (high grade histologies or deep myometrial invasion).
- Trial name
- ALICE (NCT03366051)
- Testing
- Sentinel Node Mapping, Lymphadenectomy
- Where
- 5 sites in Brazil
- Volunteers
- 178 people
- Sponsor
- AC Camargo Cancer Center
Prostate Cancer, Uterine Cancer
COQ10 and Vitamin E for Off-Target Radiation Toxicity
The goal of this supportive care study is to learn if high-dose Vitamin E and CoQ10 in combination can reduce the negative sub-acute and chronic side effects of radiation to the pelvis in adults treated for prostate, uterine…
- Conditions
- Prostate Cancer, Uterine Cancer, Cervical Cancer, Anal Cancer
- Trial name
- NCT07668284
- Testing
- Coenzyme Q10 Cap/Tab, Vitamin E Cap/Tab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Nebraska
Carcinoma, Endometrioid, Fertility Preservation
Fertility Sparing Therapy for Patients With Stage IA G2 Endometrial Cancer
Endometrial cancer (EC) is a prevalent gynecological cancer with an escalating global incidence and a decreasing age of onset. In the era of precision medicine, there is an increasing emphasis on tailoring treatments to different…
- Trial name
- NCT06468215
- Testing
- Treatment Option 1 is a single-drug regimen, with oral medroxyprogesterone acetate (MPA) 500mg/d or MA 320mg/d.
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Peking University People's Hospital
Cervical Cancer
VIBE - Virtual Image Guided Brachytherapy Emulation for Locally Advanced Cervical Cancer (LACC)
This study will evaluate the role of SBRT with the aim to reproduce high dose rate brachytherapy (HDR BT) dose distribution by means of external beam radiotherapy in the radical treatment in patients with LACC.
- Trial name
- VIBE (NCT06394297)
- Testing
- SBRT
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Fundacao Champalimaud
Cervical Carcinoma, Dyspareunia
Fractional CO2 Laser Therapy in Minimizing Genitourinary Syndrome of Menopause in Gynecological Cancer Survivors
This randomized pilot trial studies how well fractional carbon dioxide (CO2) laser therapy works in minimizing genitourinary syndrome of menopause (GSM) in gynecological cancer survivors.
- Conditions
- Cervical Carcinoma, Dyspareunia, Endometrial Carcinoma, Ovarian Carcinoma
- Trial name
- NCT03372720
- Testing
- Laser Therapy, Questionnaire Administration
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Uterine Fibroids
Efficacy and Safety of TAK-385 in the Treatment of Uterine Fibroids
The purpose of this study is to determine the efficacy and safety of TAK-385, once daily (QD), for 12 weeks in women with uterine fibroids.
- Trial name
- NCT01452659
- Testing
- TAK-385
- Where
- 27 sites in Japan
- Volunteers
- 216 people
- Sponsor
- Takeda
Uterine Fibroids, Menorrhagia, Endometriosis
Study Comparing Conventional vs. Robotic-assisted Laparoscopic Hysterectomy
The purpose of this study is to compare two ways of performing laparoscopic hysterectomy - robotic-assisted vs. conventional laparoscopy.
- Trial name
- NCT00485355
- Testing
- conventional laparoscopic hysterectomy, robotic assisted laparoscopic hysterectomy
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Endometrial Cancer
A Study of Multiparametric Ultrasound Imaging (mpUS) for People With Endometrial Cancer
The researchers are doing this study to see how well multiparametric ultrasound (mpUS) imaging can evaluate vaginal tissue before and after IVRT.
- Trial name
- NCT07318415
- Testing
- Multiparametric Ultrasound Imaging, The vaginal assessment score (VAS)
- Where
- 7 sites in United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Uterine Neoplasms
Evaluation of Toxicity and Outcomes of Different Therapeutic Strategies in Patients With Uterine Neoplasms
The single-center observational study aims to collect data related to the radiation treatment of uterine neoplasms. The purpose of the study is to systematically gather data on radiation treatment in uterine neoplasms in order to…
- Trial name
- NCT06774482
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Endometrial Cancer, Endometrial Intraepithelial Neoplasia
Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer
The goal of this study is to determine the anti-proliferative effect of tirzepatide on the endometrium of patients with endometrial intra-epithelial neoplasia (EIN) and Grade 1 endometrial cancer (EC), by comparing archival…
- Conditions
- Endometrial Cancer, Endometrial Intraepithelial Neoplasia, Grade 1 Endometrial Endometrioid Carcinoma
- Trial name
- NCT07078838
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cervical Cancer
Multidisciplinary Assesssment of Structured Report for Cervical Cancer Staging
This study aims to validate a structured report for cervical cancer anchored to the FIGO staging system. A structured report is hypothesized to aid in uniformly applying FIGO staging, reducing staging discrepancies and improving…
- Trial name
- STRECC (NCT06260358)
- Testing
- Survey
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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