Clinical trials: Uterine Neoplasm
Cervical Cancer, HPV DNA
Postoperative ctHPV-DNA for Recurrence Prediction and Adjuvant Treatment Decision-Making in Cervical Cancer
This prospective observational study will evaluate whether changes in circulating tumor human papillomavirus DNA (ctHPV-DNA) after radical surgery can help predict the risk of recurrence in patients with HPV-associated cervical…
- Trial name
- NCT07782697
- Where
- China
- Volunteers
- 580 people
- Sponsor
- Anhui Provincial Hospital
Leiomyoma, Uterine Fibroids
Fibroid Ablation Study
The primary objective of this study is to establish the effectiveness and confirm the safety of the VizAblate System in ablating symptomatic uterine fibroids.
- Conditions
- Leiomyoma, Uterine Fibroids, Menorrhagia
- Trial name
- FAST-EU (NCT01226290)
- Testing
- VizAblate System
- Where
- 10 sites in Mexico, Netherlands and 1 more
- Volunteers
- 51 people
- Sponsor
- Gynesonics
Cervical Cancer, Psychological Distress
Effect of Two Cognitive-Behavioral Interventions on Cervical Cancer Patients
Cancer represents the second cause of death in general population worldwide and according to statistics, it is expected to increase in the next 20 years.
- Conditions
- Cervical Cancer, Psychological Distress, Coping Skills
- Trial name
- NCT04165460
- Testing
- Psychoeducation, Relaxation, Cognitive Restructuring
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- National Institute of Cancerología
Cervical Cancers
Neoadjuvant Immunochemotherapy for Locally Advanced Cervical Cancer: a Prospective, Single-arm, Phase II Clinical Trial
This is a prospective, single-arm, Phase II clinical trial designed to evaluate the efficacy and safety of paclitaxel and carboplatin combined with PD-1/PD-L1 immune checkpoint inhibitors in the treatment of locally advanced…
- Trial name
- NCT07003620
- Testing
- Neoadjuvant immunochemotherapy
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Advanced Solid Tumors, Glioblastoma
Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors
Prospective, open-label, dose-ranging, uncontrolled phase I/II study of Lurbinectedin in combination with irinotecan. The study will be divided into two stages: a Phase I dose escalation stage and a Phase II expansion stage.
- Conditions
- Advanced Solid Tumors, Glioblastoma, Soft Tissue Sarcoma (Excluding GIST), Endometrial Carcinoma
- Trial name
- NCT02611024
- Testing
- Lurbinectedin, Irinotecan
- Where
- 23 sites in United States, France and 4 more
- Volunteers
- 316 people
- Sponsor
- PharmaMar
Endometrial Cancer, Overweight
the Effectiveness of a Weight Management Program in Patients Who Have Completed Treatment for Endometrial Cancer
The primary purpose of this study is to evaluate the effectiveness of a 12-month comprehensive weight management program on weight change in overweight/obese patients following treatment for endometrial cancer.
- Trial name
- NCT03908996
- Testing
- Profile by Sanford weight management plan
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Genital Neoplasms, Female
Intra-tumor Injection of Oncolytic Viruses H101 Combined With or Without Radiotherapy in Refractory/Recurrent Gynecological Malignancies
The purpose of this clinical trial is to evaluate the effectiveness and safety of oncolytic viruses H101 intra-tumor injection combined with or without radiotherapy in refractory or recurrent gynecological malignancies.
- Trial name
- NCT05051696
- Testing
- H101
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Liu Zi
Uterine Cervical Dysplasia
LLETZ Under Direct Colposcopic Vision
To assess the benefits of large Loop excision of the transformation Zone (LLETZ) under direct colposcopic Vision.
- Trial name
- NCT02910388
- Testing
- LLETZ with colposcopy, LLETZ without colposcopy
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Endometrial Cancer
Circulating Tumor DNA Study in Patients With Endometrial Cancer
The objective of this study is to identify a population at risk of early recurrence after oncologic resection surgery of a primary uterine tumor based on the detection of ctDNA
- Trial name
- ctDNA-endo (NCT05955079)
- Testing
- Whole blood
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cervical Cancer, Uterine Cervical Disease
A Proximity-incentive Strategy for Cervical Cancer Screening
In France, cervical cancer screening is based on a cervical smear for women aged 25 to 30 years and on High Risk- HPV (HR-HPV) testing for women aged 30 to 65 years.
- Conditions
- Cervical Cancer, Uterine Cervical Disease, Human Papilloma Virus
- Trial name
- RIDECA (NCT04716127)
- Testing
- Proximity-incentive strategy based on vaginal self-sampling for women 50 to 65 years who do not participate to cervical cancer screening
- Where
- 2 sites in France
- Volunteers
- 656 people
- Sponsor
- University Hospital, Montpellier
Endometrial Cancer
HE4 is a Beneficial Biomarker in Endometrial Cancer
Evaluation of Serum level of Human Epididymis Secretory Protein 4 (HE4) in Endometrial Cancer and clinical significant it
- Trial name
- HE4 (NCT03459976)
- Testing
- evaluate serum level HE4 in endometrial cancer
- Where
- 3 sites in Egypt
- Volunteers
- 87 people
- Sponsor
- Ain Shams University
Hodgkin's Disease, Cervical Cancer
Psychosocial Impact of Cancer-Related Female Infertility
The success of cancer treatment combined with the trend to delay childbearing is increasing the numbers of women survivors whose childbearing has been interrupted by cancer. For some, treatment has resulted in infertility.
- Conditions
- Hodgkin's Disease, Cervical Cancer, Breast Cancer, Lymphoma
- Trial name
- NCT00386217
- Testing
- Telephone Survey
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer
To Evaluate the Efficacy and Safety of PEG-rhG-CSF（Jinyouli®） in Reducing Neutropenia in Patients With Cervical Cancer
A Prospective, open, randomized, controlled clinical study to evaluate the efficacy and safety of PEG-rhG-CSF(PEGylated recombinant human granulocyte stimulating factor injection) in reducing neutropenia during…
- Trial name
- NCT03206684
- Testing
- PEG-rhG-CSF, rhG-CSF
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Air Force Military Medical University, China
Cervical Intraepithelial Neoplasia
Music Listening to Reduce Pain and Anxiety During LEEP
Loop electrosurgical excision procedure (LEEP) is the primary diagnostic and therapeutic procedure employed in women with high-grade intraepithelial neoplasia of the cervix.
- Trial name
- NCT02398916
- Testing
- Music listening
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Chiang Mai University
Uterine Cervical Dysplasia
LLETZ With Videocolposcopy Versus LLETZ With Binocular Colposcopy
To assess the benefits of performing large Loop excision of the transformation Zone (LLETZ) using videocolposcopy compared to binocular colposcopy.
- Trial name
- NCT04326049
- Testing
- LLETZ with videocolposcope, LLETZ with binocular colposcope
- Where
- Germany
- Volunteers
- 227 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Solid Tumors, Neoplasms (Cancer / Tumors)
Exploratory Study on the Efficacy and Safety of Trastuzumab Rezetecan in the Treatment of HER2-Expressiong Advanced Solid Tumor
The goal of this clinical trial is to learn if Trastuzumab Rezetecan can treat advanced solid tumors with HER-2 expression in adult participants.
- Conditions
- Solid Tumors, Neoplasms (Cancer / Tumors), Advanced Malignant Solid Neoplasm, Locally Advanced Malignant Solid Neoplasm
- Trial name
- NCT07631884
- Testing
- Trastuzumab Rezetecan
- Volunteers
- 15 people
- Sponsor
- Haihua Yuan
Cervical Cancer
HPV Self-sampling in the General Population
A randomized controlled trial comparing three strategies for cervical cancer screening: direct mailing of HPV self-sampling kit ("Outreach" arm), choice between self-sampling or healthcare provider sampling ("Choice" arm), and…
- Trial name
- MIRABELLE (NCT06749847)
- Testing
- Women receive invitation letter with HPV self-sampling kit, Women receive invitation letter with choice of ordering a free self-sampling kit or visit healthcare provider
- Where
- 2 sites in France
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
HER2-positive Breast Cancer, Cervical Cancer
Tucatinib Continuation Study
The purpose of this protocol is to give continued access to tucatinib eligible participants. It also enables ongoing safety follow-up for those who continue to benefit from the study treatment.
- Conditions
- HER2-positive Breast Cancer, Cervical Cancer, Biliary Tract Neoplasms, Urothelial Cancer
- Trial name
- NCT07768358
- Testing
- tucatinib
- Volunteers
- 175 people
- Sponsor
- Pfizer
Solid Tumor
A Clinical Study of the Safety and Effectiveness of an Investigational Cell Therapy Given With and Without an Investigational RNA-based Vaccine in Patients With Organ Tumors
This is a Phase I, FIH, open-label, multi-site, dose escalation trial with expansion cohorts to evaluate safety and preliminary efficacy of claudin 6 (CLDN6) chimeric antigen receptor T cells (CAR-T) with or without CLDN6…
- Trial name
- NCT04503278
- Testing
- CLDN6 CAR-T, CLDN6 uRNA-LPX/CLDN6 modRNA-LPX
- Where
- 12 sites in Australia, Germany and 2 more
- Volunteers
- 214 people
- Sponsor
- BioNTech Cell & Gene Therapies GmbH
Endometrial Cancer, Serous Adenocarcinoma
Niraparib in High-grade Endometrial Cancer Trial
The study will investigate the effect of niraparib on tumor tissue in chemotherapy naïve, newly diagnosed, high-grade endometrial cancer patients.
- Conditions
- Endometrial Cancer, Serous Adenocarcinoma, Uterine Neoplasm
- Trial name
- NIREC (NCT05289648)
- Testing
- Niraparib oral capsule
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
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