Clinical trials: Uterine Neoplasm
Vitamin D Deficiency, Leiomyoma
Correlation Between Serum Vitamin D3 and Incidence of Uterine Leiomyoma
The aim of the current study is to evaluate the association between low serum vitamin D level and incidence of uterine leiomyoma in Egyptian women as the research hypothesis that low serum vitamin D is considered a risk factor…
- Trial name
- NCT05151393
- Testing
- Measuring vitamin D3 level
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Endometrial Cancer
Collection of Endometrial Cancer-derived Organoids to Evaluate the Efficacy of PARP Inhibitors: PENDOR Pilot Study
This study comprises 3 stages: 1. Collection of tumor and blood samples. 2. Creation of organoid models based on tumor samples. 3. Development of functional tests to predict clinical response to treatment.
- Trial name
- PENDOR (NCT06603506)
- Testing
- tumour and blood samples
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Centre Francois Baclesse
Ovarian Cancer, Sarcoma
Combination Chemotherapy in Treating Patients With Sarcoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00662233
- Testing
- cyclophosphamide, doxorubicin hydrochloride, etoposide
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Cervical Cancer Stage IVB
Chemotherapy Plus Radiation Therapy in Treating Patients With Primary Stage IVB Cervical Cancer
This is a prospective, single arm, phase II trail to assess the effect of primary lesion radiotherapy in the treatment of stage IVB cervical cancer on the basis of systemic chemotherapy.
- Trial name
- NCT03175848
- Testing
- Chemotherapy,radiotherapy
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Zhejiang Cancer Hospital
Cervical Intraepithelial Neoplasia Grade 2/3
Validation of Human Papillomavirus Assays and Collection Devices for Self-samples and Urine Samples
The VALHUDES study is a Diagnostic Test Accuracy study that aims to document the clinical accuracy of hrHPV testing on urine samples, collected under standardised and optimised conditions, and on two types of vaginal self-samples…
- Trial name
- VALHUDES (NCT03064087)
- Testing
- Colli-Pee, Multi-Collect Swab, Evalyn Brush
- Where
- 5 sites in Belgium
- Volunteers
- 500 people
- Sponsor
- Marc Arbyn
HIV Infections, Cervix, Dysplasia
A Phase III Randomized Trial of Topical Vaginal Fluorouracil (5-Fluorouracil, 5-FU) Maintenance Therapy Versus Observation After Standard Treatment for High-Grade Cervical Dysplasia in HIV-Infected Women
To determine the efficacy and safety of intravaginal fluorouracil administered as prophylaxis in HIV-infected women who have received standard ablative therapy (surgery) for high-grade cervical dysplasia (pre-cancer of the…
- Trial name
- NCT00000758
- Testing
- Fluorouracil
- Where
- 21 sites in United States, Puerto Rico
- Volunteers
- 158 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervical Squamous Cell Carcinoma, Recurrent Cervical Cancer
Erlotinib in Treating Patients With Persistent or Recurrent Cancer of the Cervix
This phase II trial is studying erlotinib to see how well it works in treating patients with persistent or recurrent cancer of the cervix.
- Trial name
- NCT00031993
- Testing
- erlotinib hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer, Carcinosarcoma
ZW25 in Women With Endometrial Cancers
This study is being done to test the drug ZW25 and look at whether this drug is effective in women with HER2-overexpressed endometrial cancer or carcinosarcoma that has been treated in the past.
- Trial name
- NCT04513665
- Testing
- ZW25
- Where
- 7 sites in United States
- Volunteers
- 16 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cervical Cancer
Combination Pembrolizumab, Chemotherapy and Bevacizumab in Patients With Cervical Cancer
The investigators propose to evaluate the efficacy of the combination of standard chemotherapy with bevacizumab with Pembrolizumab in women with recurrent, persistent, or metastatic cervical cancer.
- Trial name
- NCT03367871
- Testing
- Pembrolizumab, Paclitaxel, Cisplatin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Miami
Endometrial Cancer
Investigating the Use of Fluorescence Imaging in Endometrial Cancer Surgery
The main purpose of the study is to evaluate the detection rate and accuracy of fluorescence imaging in endometrial cancer staging by sentinel node assessment.
- Trial name
- NCT01562106
- Testing
- Fluorescence-guided sentinel lymph node detection
- Where
- 3 sites in United States
- Volunteers
- 123 people
- Sponsor
- Swedish Medical Center
Ovarian Cancer, Endometrial Cancer
Exploring the Potential of Novel Biomarkers Based on Plasma microRNAs for a Better Management of Pelvic Gynecologic Tumors
This trial is a non-randomized, open label and multicenter study. It aims to : for endometrial cancer.:validate the 5-miR index assessed in plasma samples as a diagnostic marker to assess the risk of lymph node metastases for…
- Trial name
- GYNO-MIR (NCT03776630)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 363 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Uterine Fibroids
PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata
Phase III, multicentre, randomized, double-blind, parallel group, long-term study investigating the efficacy and safety of the 5mg and 10mg doses of PGL4001 for the treatment of uterine myoma.
- Trial name
- PEARLIV (NCT01629563)
- Testing
- PGL4001 5 mg, PGL4001 10 mg
- Where
- 49 sites in Belgium, Czechia and 9 more
- Volunteers
- 451 people
- Sponsor
- PregLem SA
Cervical Cancer, Cervical Carcinoma
Pembrolizumab and Olaparib in Cervical Cancer Patients
The study is a non-randomized, open-label phase II clinical trial to test the investigational combination of the drug pembrolizumab with the drug olaparib in patients diagnosed with advanced or recurrent cervical carcinoma after…
- Trial name
- NCT04483544
- Testing
- pembrolizumab, olaparib
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Baptist Health South Florida
Cervix Cancer, Human Papilloma Virus
Relational Agents in Cervical Cancer Education (RACE)
The goal of this clinical trial is to assess the feasibility of using interactive teaching to educate cervical cancer patients about Human papillomavirus (HPV) and HPV vaccinations.
- Conditions
- Cervix Cancer, Human Papilloma Virus, Vaginal Cancer, Vulvar Cancer
- Trial name
- RACE (NCT06537687)
- Testing
- Control, Intervention
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Radhika Gogoi
Recurrent Uterine Sarcoma, Uterine Carcinosarcoma
Temsirolimus in Treating Patients With Recurrent or Persistent Cancer of the Uterus
This phase II trial is studying how well temsirolimus works in treating patients with recurrent or persistent cancer of the uterus.
- Trial name
- NCT01061606
- Testing
- temsirolimus
- Where
- 20 sites in United States
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
Ovarian Neoplasms, Colorectal Neoplasms
An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation
Doctors will take some tissue from the tissue removed during surgery in order to study how the blood vessels of the tumor respond to radiation therapy.
- Conditions
- Ovarian Neoplasms, Colorectal Neoplasms, Melanoma, Small Cell Lung Cancer
- Trial name
- NCT00132704
- Testing
- Ionizing radiation (IR) therapy, Ionizing radiation (IR)
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ovarian Neoplasms, Endometrial Neoplasms
A Study of Sofe-M in Participants With Selected Advanced Solid Tumors
The purpose of this study is to find out whether the study drug, Sofetabart Mipitecan (LY4170156), is safe, tolerable and effective in participants with advanced solid tumors.
- Conditions
- Ovarian Neoplasms, Endometrial Neoplasms, Uterine Cervical Neoplasms, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT06400472
- Testing
- Sofe-M, bevacizumab, carboplatin
- Where
- 25 sites in United States, Australia and 5 more
- Volunteers
- 575 people
- Sponsor
- Eli Lilly and Company
Cervical Cancers
The Effect of Motivational Interviewing on HPV-DNA Testing
The aim of this randomized controlled study was to examine the effects of Health Belief Model Based Motivational Interviewing on HPV-DNA testing in women according to the Precautionary Acceptance Process.
- Trial name
- NCT06662136
- Testing
- motivasional intereview
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Muazez küçükkaya
Cervical Cancer
Rice Technologies for Cervical Cancer Screening and Diagnosis
The study aims to compare the accuracy of the lateral flow test to detect HPV at the POC with commercially available HPV test and to determine the diagnostic accuracy and reliability of a multimodal optical imaging system to…
- Trial name
- NCT05372484
- Testing
- Multimodal optical imaging
- Where
- 4 sites in United States, Mozambique
- Volunteers
- 678 people
- Sponsor
- M.D. Anderson Cancer Center
Low Grade Endometrial Stromal Sarcoma
Evaluation of Clinical Impact of Interruption VS Maintenance of AI in Patients With Locally Advanced/ Metastatic Low Grade Endometrial Stromal Sarcoma (LGESS)
The primary objective is to compare the progression-free survival (PFS) between aromatase inhibitors interruption and aromatase inhibitors maintenance strategies in patients with a locally advanced or metastatic Low Grade…
- Trial name
- BFR-ESS (NCT03624244)
- Testing
- Aromatase Inhibitors
- Where
- 22 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Leon Berard
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