Clinical trials: Uterine Neoplasms
Advanced Solid Tumor, Melanoma
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This is a proof-of-concept study designed to investigate HER3-DXd monotherapy in locally advanced unresectable or metastatic solid tumors.
- Conditions
- Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer
- Trial name
- NCT06172478
- Testing
- HER3-DXd
- Where
- 96 sites in United States, Australia and 14 more
- Volunteers
- 740 people
- Sponsor
- Daiichi Sankyo
Endometrial Carcinoma
Elemene Liposomes in Endometrial Cancer
The goal of this clinical trial is to learn if Elemene Liposomes, combined with carboplatin and paclitaxel (TC) chemotherapy can improve prognosis in patients with advanced or recurrent endometrial cancer.
- Trial name
- NCT07738315
- Testing
- Elemene Injection/Elemene Oral Emulsion, Carboplatin-Paclitaxel chemotherapy
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Uterine Myoma
Intracorporeal Versus Extracorporeal Morcellation: Clinical Efficacy and Safety Outcomes
The aim of this study protocol will be to compare the technique of intracorporeal morcellation using reusable electronic device (standard technique) with a technique of removal "protected" by endobag and extracorporeal myoma…
- Trial name
- IEME (NCT02086435)
- Testing
- Extracorporeal morcellation, Intracorporeal morcellation
- Where
- Italy
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Cervical Intraepithelial Neoplasia Grade 2/3, Carcinoma Cervix
Extended VALidation of HUman Papillomavirus Assays and Collection DEvices for HPV Testing on Self-samples
The "Extended VALHUDES" study is a Clinical Performance / Diagnostic Test Accuracy Study that aims to extend validation, achieved as part of the "Belgian VALHUDES", of HPV testing using BD Onclarity on samples collected using…
- Trial name
- Ext-VALHUDES (NCT04788849)
- Testing
- BD Onclarity™ HPV assay
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Milano Bicocca
Endometrial Cancer, Endometrial Neoplasms
Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy?
Aim: Assess accuracy of histological diagnosis using ultrasound guided biopsy for women with suspected endometrial cancer (as an alternative to hysteroscopy guided biopsy).
- Conditions
- Endometrial Cancer, Endometrial Neoplasms, Endometrial Hyperplasia, Endometrial Polyp
- Trial name
- NCT03207126
- Testing
- Ultrasound guided biopsy
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Imperial College London
Ovarian Cancer, Endometrial Cancer
Docetaxel and PTK787 in Metastatic Breast Cancer Patients and Gynecological Cancer Patients
The main purpose of this study is to see if the study drug, PTK787, is safe and to find the highest dose that can be given safely without causing serious side effects.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Cervical Cancer, Fallopian Tube Cancer
- Trial name
- NCT00268918
- Testing
- Docetaxel, PTK787
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Dana-Farber Cancer Institute
Cervical Cancer
FDG-PET and Circulating HPV in Patients With Cervical Cancer Treated With Definitive Chemoradiation (II)
Nearly all cervical cancers are caused by the human papilloma virus (HPV), which can be detected in cancer tissue by laboratory tests.
- Trial name
- HPVDNA02 (NCT03853915)
- Testing
- [18-F]- FDG - PET
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University Health Network, Toronto
Endometrial Cancer, Immune Checkpoint Inhibitors
DETERMINANTS OF IMMUNOTHERAPY EFFICACY IN ENDOMETRIAL CANCER
In recent years, the introduction of immune checkpoint inhibitors (ICI) in combination with chemotherapy has significantly changed the management of advanced and recurrent Endometrial Cancer (EC).
- Trial name
- iDEA (NCT07690540)
- Testing
- Prospective exploratory cohort
- Where
- Italy
- Volunteers
- 510 people
- Sponsor
- European Institute of Oncology
Cervical Cancer, Immune Checkpoint Inhibitor
Tislelizumab Combing Chemoradiotherapy in Recurrent Cervical Cancer
Tislelizumab combined with chemoradiotherapy in the treatment of recurrent/ metastasis cervical cancer: a single arm,single center， phase ii and observational clinical study
- Conditions
- Cervical Cancer, Immune Checkpoint Inhibitor, Chemoradiotherapy
- Trial name
- NCT05863260
- Testing
- Treatment Group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Cervical Cancer
HPV Self-test to Increase Cervical Cancer Screening in Asian Women
The study was to pilot test the feability of using HPV self-sampling testing to increase cervical cancer screening among under-served Asian women through engaging community-based organizations in the greater Philadelphia and New…
- Trial name
- NCT04612660
- Testing
- Education on cervical cancer prevetnion, Dynamic group interaction, Physician engagement
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Temple University
Mayer-Rokitansky-Kuster Syndrome, Asherson's Syndrome
INvestigational Study Into Transplantation of the Uterus
Observational study on cohort of 10 women undergoing uterine transplantation using deceased donors
- Conditions
- Mayer-Rokitansky-Kuster Syndrome, Asherson's Syndrome, Postpartum Hemorrhage, Cervical Cancer
- Trial name
- INSITU (NCT04244409)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Womb Transplant UK
Leiomyoma, Uterine Fibroids
Fibroid Ablation Study - Large Fibroids
The purpose of this study is to establish the effectiveness and confirm the safety of the VizAblate System in the ablation of large (> 5 cm) symptomatic uterine fibroids.
- Conditions
- Leiomyoma, Uterine Fibroids, Menorrhagia
- Trial name
- FAST-L (NCT01539187)
- Testing
- VizAblate System
- Where
- 10 sites in Mexico, Netherlands and 1 more
- Volunteers
- 6 people
- Sponsor
- Gynesonics
Locally Advanced Cervical Cancer, Uterine Carcinoma
Clinical Feasibility of the ARCHITECT Applicator in Cervical Cancer Brachytherapy
This prospective, non-randomised, single centre, phase I trial assesses the clinical feasibility of the use of the patient-tailored ARCHITECT applicator in locally advanced cervical cancer brachytherapy.
- Trial name
- ARCHITECT (NCT07435987)
- Testing
- ARCHITECT applicator
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Erasmus Medical Center
HPV-induced Cancers
Cisplatin-based Chemotherapy Combined With P16_37-63 Peptide Vaccination in Patients With HPV-positive Cancers
The study will include 10 patients with HPV-associated ano-genital cancer (cervical, vulvar, vaginal, penile, anal) or HPV-associated head and neck cancer, who are planned to receive a cisplatin-based chemotherapy (alternatively…
- Trial name
- VICORYX-2 (NCT02526316)
- Testing
- P16_37-63 peptide combined with Montanide® ISA-51 VG, P16_37-63 peptide without Montanide® ISA-51 VG
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Oryx GmbH & Co. KG
Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma
Determine the Utility of Liquid Biopsies and Tumor Molecular Profiling in Predicting Recurrence in Endometrial Cancers
This study is to find out how well liquid biopsies work as a non-invasive alternative to other methods of finding cancer cells (such as a tissue biopsy) in patients with endometrial cancer.
- Conditions
- Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Mucinous Adenocarcinoma, Endometrial Serous Adenocarcinoma
- Trial name
- NCT05049538
- Testing
- Biospecimen Collection, Liquid Biopsy, Pap Smear
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- M.D. Anderson Cancer Center
Endometrial Cancer, Sentinel Lymph Node Detection
Indocyanine Green and Near-infrared Fluorescence Imaging to Detect Sentinel Lymph Nodes in Patients With Endometrial Cancer
Patients with endometrial cancer who have planned robotic laparoscopic hysterectomy and full bilateral pelvic and para-aortic lymphadenectomy will receive injections of a fluorescent dye, Indocyanine green (ICG).
- Trial name
- NCT02131558
- Testing
- ICG Dye
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Lahey Clinic
Cervical Cancer, Cervical Intraepithelial Neoplasia
V501 Safety and Efficacy Study in Japanese Women Aged 16 to 26 Years (V501-110)
This study evaluated the long-term safety of quadrivalent Human Papillomavirus (HPV) types 6, 11, 16, 18 vaccine and its effectiveness in the prevention of cervical intraepithelial neoplasia (CIN), adenocarcinoma in situ, and…
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasia, Adenocarcinoma in Situ
- Trial name
- NCT01544478
- Testing
- V501
- Volunteers
- 1,030 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Non-Small Cell Lung Cancer, Small Cell Lung Cancer
QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
QUILT-3.055 is a Phase 2b, open-label, multicohort study investigating combination immunotherapies in patients with advanced solid tumors who have previously been treated with PD-1/PD-L1 checkpoint inhibitors.
- Conditions
- Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Urothelial Carcinoma, Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT03228667
- Testing
- N-803 + Pembrolizumab, N-803 + Nivolumab, N-803 + Atezolizumab
- Where
- 35 sites in United States
- Volunteers
- 40 people
- Sponsor
- ImmunityBio, Inc.
Stage IVB Cervical Cancer, Recurrent Cervical Cancer
First-line Treatment With Camrelizumab + Apatinib Versus Chemotherapy + Bevacizumab in Advanced Cervical Cancer
Cervical cancer is the second-most common cancer in the world and is a leading cause of cancer death among women in developing countries.
- Conditions
- Stage IVB Cervical Cancer, Recurrent Cervical Cancer, Persistent Cervical Cancer
- Trial name
- NCT04974944
- Testing
- Camrelizumab, Apatinib, Paclitaxel
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Sun Yat-Sen University Cancer Center
Uterine Fibroids, Arterial Embolization
Uterine Fibroid Embolization- Long Term Follow up and Technical Perspectives
The purpose of this prospective non-randomised study is to examine whether two different microspheres (Bead-Block and Embosphere) are equally effective in the treatment of the uterine fibroid controlled with contrast-enhanced MR…
- Trial name
- NCT01852734
- Testing
- embolizations ,uterine fibroid, embolizations
- Where
- 2 sites in Denmark
- Volunteers
- 52 people
- Sponsor
- Odense University Hospital