Clinical trials: Uterine Synechiae
Intrauterine Adhesion
Intrauterine Balloon Dilatation Therapy in the Prevention of Adhesion Formation After Hysteroscopic Myomectomy
Transcervical resection of submucous myomas (TCRM) is nowadays considered necessary if it is associated with infertility or miscarriage or menorrhagia.
- Trial name
- NCT03169478
- Testing
- multiple myoma IUB dilatation group
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Infertility, Polyp Uterus
HYALOBARRIER® GEL ENDO Versus no HYALOBARRIER® GEL ENDO Following Operative Hysteroscopy for Improving Reproductive Outcome in Women With Intrauterine Pathology Wishing to Become Pregnant
To compare the costs and effects of HYALOBARRIER® GEL ENDO versus no HYALOBARRIER® GEL ENDO for increasing the chance of conception leading to live birth measured at 30 weeks after randomization in women wishing to become…
- Conditions
- Infertility, Polyp Uterus, Myoma;Uterus, Adhesion
- Trial name
- AGNOHSTIC (NCT03880435)
- Testing
- Hyalobarrier® gel endo
- Where
- Belgium
- Volunteers
- 419 people
- Sponsor
- University Hospital, Ghent
Intrauterine Adhesion
Human Amniotic Epithelial Stem Cell in Treatment of Refractory Severe Intrauterine Adhesion
This project will investigate the safety and effectiveness of human amniotic epithelial stem cells for treatment of severe refractory Asherman's syndrome.
- Trial name
- NCT03381807
- Testing
- hAESCs
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Asherman Syndrome
CURENDO (Cord-blood Uterine Regeneration Endometrium): Platelet-rich Plasma Therapy Derived From Umbilical Cord Blood for the Treatment of Endometrial Pathologies (Asherman Syndrome / Endometrial Atrophy / Thin Endometrium)
In recent years, platelet-rich plasma (PRP) has emerged as a promising alternative for treating endometrial pathologies that affect the endometrial lining.
- Trial name
- CURENDO (NCT07697924)
- Testing
- Umbilical cord platelet-rich plasma (hUC-PRP)
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Fundación IVI
Asherman Syndrome
Estrogen in the Prevention of Adhesion Reformation
Asherman syndrome, which occurs after trauma to the basalis layer of the endometrium.It seems that the role of postoperative estrogen therapy in the prevention of recurrence of IU adhesions is still controversial.
- Trial name
- NCT03620929
- Testing
- Estradiol Valerate
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Myoma;Uterus
Prevalence of Intrauterine Adhesions After Myomectomy
This prospective, multicenter, observational study evaluated the prevalence of intrauterine adhesions after laparoscopic or laparotomic myomectomy and investigated clinical and surgical factors associated with their occurrence.
- Trial name
- NCT04030273
- Testing
- Diagnostic hysteroscopy
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- Università degli Studi dell'Insubria
Intrauterine Adhesion
The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility.
- Trial name
- NCT03330873
- Testing
- disposable balloon uterine stent, Foley catheter
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Asherman Syndrome
Effects of Platelet Rich Plasma on Endometrium
Intrauterine platelet rich plasma will be injected in the endometrial region via the vaginal route after the cessation of menstrual period.
- Trial name
- NCT04424160
- Testing
- PRP injection in the endometrium
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Acibadem University
Infertility, Female, Intrauterine Adhesion
HMG Stimulation Versus HRT for Endometrial Preparation Prior to Blastocyst Transfer in Moderate to Severe IUA Patients
Evaluation of endometrial preparation using either human menopausal gonadotrophin (HMG) stimulation and hormone replacement therapy (HRT) prior to blastocyst transfer in patients with moderate to severe intrauterine adhesion…
- Trial name
- NCT03578172
- Testing
- human menopausal gonadotrophin, hormone replacement therapy
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Asherman Syndrome, Endometrial Atrophy
Umbilical Cord Plasma for Treating Endometrial Pathologies (Thin Endometrium / Asherman's Syndrome/ Endometria Atrophy)
In the last years, platelet-rich plasma (PRP) has emerged as a promising alternative to treat endometrial pathologies affecting the endometrial lining.
- Trial name
- hSCU-PRP (NCT05095597)
- Testing
- Injection of hUC-PRP by hysteroscopy, Oestraclin, Umbilical cord blood collection
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundación IVI
Intrauterine Adhesions
hBMSC Uterine Artery Infusion for Severe IUA-Related Infertility
The goal of this clinical trial is to test a new approach: delivering human bone marrow mesenchymal stem cells (hBMSCs) via the uterine artery to treat infertility caused by severe intrauterine adhesions (IUA).
- Trial name
- NCT07176143
- Testing
- Delivering human bone marrow mesenchymal stem cells via the uterine artery
- Volunteers
- 60 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Intra-uterine Adhesions
Platelet Rich Plasma Following Hysteroscopic Adhesolysis
Platelet Rich Plasma Following Hysteroscopic Adhesolysis: A Randomized Clinical Trial
- Trial name
- NCT03881215
- Testing
- Platelet Rich Plasma, intra-uterine balloon
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Ain Shams University
Asherman's Syndrome, Endometrium; Atrophy, Cervix
Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy
The purpose of this study is to determine whether Bone Marrow Stem Cell transplantation may improve Assisted Reproduction Techniques (ART) outcomes in refractive Asherman's Syndrome or Atrophic Endometrium.
- Trial name
- BMSCT (NCT02144987)
- Testing
- Bone Marrow CD133+ Stem Cell Transplantation
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Myoma
Intrauterine Adhesion Rate After Hysteroscopic Myomectomy and Application of HYALOBARRIER Gel
The purpose of this study is to evaluate the intrauterine adhesion rate after the application of HYALOBARRIER Gel at the end of hysteroscopic myomectomy. Secondary endpoints were tolerance and side effect and subsequent fertility.
- Trial name
- HYGEM (NCT01412489)
- Testing
- HYALOBARRIER Gel
- Where
- France
- Volunteers
- 189 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thin Endometrium, Intrauterine Adhesion
Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium
This is a non-blind self-control trial. We mainly compare the changes of endometrial thickness，changes in menstrual flow, and improvement in pregnancy before and after stem cell treatment in patients with thin endometrium.
- Trial name
- NCT03724617
- Testing
- umbilical cord mesenchymal stem cells combined with collagen scaffold
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Sir Run Run Shaw Hospital
Intrauterine Adhesion
Autologous Platelet-Rich Plasma in the Management of Asherman Syndrome
The aim of the study is to find out the benefit of the platelet-rich plasma in preventing reformation of intrauterine adhesions after adhesiolysis in cases of Asherman syndrome
- Trial name
- NCT04308811
- Testing
- platelet rich plasma, amniotic membrane graft group, Intrauterine balloon
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrauterine Polyp, Intrauterine Synechiae
Study on the Effective Dose and Safety of Esketamine in Hysteroscopic Surgery Under Monitored Anesthesia Care
Cervical dilation-induced somatic responses remain a critical challenge in ambulatory hysteroscopic surgery. Esketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, exhibits unique analgesic and sedative properties that…
- Trial name
- NCT07034963
- Testing
- Determine the ED50 and ED95 of esketamine, Intravenous the dose of esketamine ED95, Intravenous remifentanil 1μg∙kg-1
- Where
- China
- Volunteers
- 95 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Uterine Septum
Intrauterine Balloon and Postoperative Estrogen Therapy in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
Patients who want to go TCRS will randomly divided 3 groups. In Group 1(100 patients), women received postoperative estrogen therapy.
- Trial name
- NCT02617108
- Testing
- Foley balloon
- Volunteers
- 310 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Pregnancy Complications
Study on the Effect of Combined Estrogen and Progestogen Therapy on Endometrial Repair After Induced Abortion
Induced abortion is a common method to terminate pregnancy, but during the operation, it is necessary to dilate the cervix and aspirate the uterine cavity.
- Trial name
- NCT06546397
- Testing
- 17β-estradiol/dydrogesterone tablets
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Asherman Syndrome
Pre-Surgical Grading System of Asherman Syndrome
Utilising a novel pre-surgical grading system to class cases of asherman syndrome into 3 groups based on expected difficulty of surgery and potential prognostic outcomes.
- Trial name
- NCT05901948
- Testing
- Classification
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Ebtesama Hospital