Clinical trials: Uterus; Scar
Infertility, Asherman's Syndrome
Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair
Patients with intrauterine adhesions (Asherman's Syndrome) and persistent thin endometrial lining in in vitro fertilization (IVF) treatment programs, particularly those resistant to standard therapies, present a significant…
- Trial name
- PRP-E (NCT02825849)
- Testing
- Intrauterine infusion of platelet rich plasma
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Magnetic Resonance Imaging, Ovarian Function
Fertility After Transvaginal Surgery or Uterine Artery Embolization Combined With Uterine Curettage in Patients With Cesarean Scar Pregnancy
To investigate the fertility in patients after treatment by transvaginal surgery or uterine artery embolization combined with uterine curettage
- Conditions
- Magnetic Resonance Imaging, Ovarian Function, Menstruation
- Trial name
- NCT02933190
- Testing
- transvaginal surgery；UAE and D&C
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Cesarean Scar Defects, Cesarean Section Complications
Diagnostic Accuracy of Saline Sonohystrography vs. 3D Transvaginal Ultrasound for Cesarean Scar Defect Assessment
To compare accuracy of three dimensional transvaginal ultrasound versus the "gold standard" saline infused sonography for assessing the characteristics, frequency and appearance of caesarean scar defects in symptomatic patients…
- Conditions
- Cesarean Scar Defects, Cesarean Section Complications, Uterine Scar Dehiscence, Vaginal Birth After Cesarean
- Trial name
- NCT05996926
- Testing
- Three-Dimensional Transvaginal Ultrasound (3D TVS), Saline-Infused Sonography (Sonohystrography)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Infertility, Polyp Uterus
HYALOBARRIER® GEL ENDO Versus no HYALOBARRIER® GEL ENDO Following Operative Hysteroscopy for Improving Reproductive Outcome in Women With Intrauterine Pathology Wishing to Become Pregnant
To compare the costs and effects of HYALOBARRIER® GEL ENDO versus no HYALOBARRIER® GEL ENDO for increasing the chance of conception leading to live birth measured at 30 weeks after randomization in women wishing to become…
- Conditions
- Infertility, Polyp Uterus, Myoma;Uterus, Adhesion
- Trial name
- AGNOHSTIC (NCT03880435)
- Testing
- Hyalobarrier® gel endo
- Where
- Belgium
- Volunteers
- 419 people
- Sponsor
- University Hospital, Ghent
Uterine Scar Defect
Suture of UTerus and Ultrasound Repair Evaluation
This study compares three techniques of uterine closure on myometrium thickness evaluated by ultrasound six months after the primary cesarean.
- Trial name
- SUTURE (NCT01860859)
- Testing
- Closure of the hysterotomy at the time of primary cesarean
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Isthmocele, Cesarean Scar Diverticula
Comparing Decidual Inclusion vs. Exclusion in Uterine Suture Techniques During Cesarean Section to Improve Scar Thickness and Reduce Isthmocele Risk in Primiparous Women
This study compares two ways of closing the uterus during cesarean delivery. In one group, the decidual layer near the uterine cavity is included in the suture. In the other group, this layer is left out.
- Trial name
- DISSUC (NCT07608874)
- Testing
- Single-Layered Non-Locked Closure with Decidual Inclusion, Single-Layered Non-Locked Closure with Decidual Sparing
- Where
- Switzerland
- Volunteers
- 374 people
- Sponsor
- Kantonsspital Baden
Recurrent Miscarriage
3D Ultrasound to Assess in Recurrent Miscarriage
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
- Trial name
- 3D-ARM (NCT06164015)
- Testing
- 3D Ultrasound scan with power Doppler angiography
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Cesarean Section; Dehiscence, Uterine Bleeding
Impact of Single- Versus Double-layer Hysterotomy Closure on Cesarean Niche Development: a Randomized Controlled Trial
The objective of this randomized monocentric study is to assess potential variations in the incidence and severity of isthmocele morbidity among women undergoing cesarean section with either single or double-layer closure of the…
- Conditions
- Cesarean Section; Dehiscence, Uterine Bleeding, Uterus; Scar, Uterus Abnormal
- Trial name
- NCT06308172
- Testing
- Hysterotomy closure
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Cesarean Section Complications, Scar Niche
A Two-Layered Simple Interrupted Myometrial Suturing Reduces Uterine Niche Formation After Primary Cesarean Section
The purpose of the study is to determine whether two-layered simple interrupted myometrial suturing is superior to double-layered continuous suturing for the prevention of uterine niche formation after primary cesarean section.
- Conditions
- Cesarean Section Complications, Scar Niche, Myometrial Remodeling, Suture Techniques
- Trial name
- NCT07229222
- Testing
- Primary Cesarean Section with two-layered simple interrupted suturing of the myometrium, Primary Cesarean Section with double-layered continuous suturing of the myometrium, Saline-infusion Sonohysterography
- Where
- Egypt
- Volunteers
- 380 people
- Sponsor
- Benha University
Isthmocele, Uterine Scar Defects
Cesarean Scar Defects After Uterine Closure by Double-layer Barbed or Smooth Suture
Late sequelae of a cesarean section related to a uterine scar defects include gynecological symptoms and obstetric complications.
- Conditions
- Isthmocele, Uterine Scar Defects, Cesarean Section Complications, Uterine Niche
- Trial name
- NCT04825821
- Testing
- Clinical and ultrasonographic assessment
- Where
- Italy
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino
Herpes Genitalis, Genital Wart
Safety and Efficacy of Laser Therapy in Gynaecology
The aim of this study is to retrospectively evaluate the effectiveness and safety of Er:YAG laser for treatment of different gynecological indication, e.g.
- Conditions
- Herpes Genitalis, Genital Wart, Lichen Sclerosus, Cervical Intraepithelial Neoplasia
- Trial name
- NCT04073082
- Where
- Slovenia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Juna d.o.o.
Termination of Pregnancy
Termination of Pregnancy in Previous Scarred Uterus: PGE1 Versus Cervical Folleys
As mentioned above, previous studies have shown variable results and the best among these two is still in debate, so there must be re-evaluation of results on this topic.
- Trial name
- NCT07604051
- Testing
- PGE1 tablet, cervical folleys
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Dr Mudassar Saeed Pansota
Scar Niche, Abnormal Uterine Bleeding
Sublingual Misoprostol Versus No Cervical Priming Before Hysteroscopic Resection of Symptomatic Uterine Niches
The purpose of the study is to evaluated whether preoperative sublingual misoprostol can enhance the effectiveness and safety of niche resection in patients with symptomatic uterine niche.
- Conditions
- Scar Niche, Abnormal Uterine Bleeding, Cesarean Section Complications
- Trial name
- NCT07271056
- Testing
- Misoprostol 200mcg Tab, Hysteroscopic resection of uterine niche, Saline-infusion Sonohysterography
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Benha University
Uterine Caesarean Scar Defect
Enhanced Reproductive Efficiency: Shorter Time to Pregnancy After Hysteroscopic-Assisted Novel Transvaginal Repair
To investigate whether a novel hysteroscopic-assisted transvaginal repair technique results in a shorter time to pregnancy and superior fertility outcomes compared to traditional transvaginal repair.
- Trial name
- NCT07169435
- Where
- China
- Volunteers
- 120 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Fluid Uterus
Intracavitary Fluid and Position of C-section-scar
Does the presence of intracavitary fluid during hormonal stimulation for IVF depends on the position of C-section-scar ?
- Trial name
- NCT03518385
- Testing
- ultrasound,transvaginal scan
- Where
- United Arab Emirates
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Cesarean Section, Dehiscence
Incidence of Uterine Cesarean Scar Niche After Cesarean Delivery
To assess the incidence of cesarean scar niche and its risk factors in a prospectively collected population.
- Trial name
- NCT05900492
- Testing
- cesarean section
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Scar; Previous Cesarean Section
Assessing the Stability of Uterine Scar Tissue in Women With Previous History of Caesarean Section Using Multimodal Analyses of the Lower Uterine Segment Including Quantitative Sonography
This prospective, clinical, observational trial compares the measured value with quantitative ultrasonic (preoperatively) Elastic modulus E (kPA) with the measured value with quantitative ultrasonic Elastic modulus E (kPA) in…
- Trial name
- QUANTUSLUS (NCT02827591)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Uterine Scar From Previous Cesarean Delivery (Diagnosis)
Uterine Niche After Cesarean Section
In the past decade several articles have described a defect that can be seen on ultrasound at the site of cesarean delivery scar, known as a 'niche' .An incompletely healed scar is a long-term complication of cesarean delivery…
- Trial name
- AMSRM (NCT03787381)
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Intermenstrual Bleeding
Nonsurgical Management of Cesarean Scar Niche Related Abnormal Uterine Bleeding
A study of the effect of three different nonsurgical methods for management of abnormal uterine bleeding caused by cesarean scar niche.
- Trial name
- NCT05594186
- Testing
- Tranexamic acid, Oral contraceptive pills and the Levonorgestrel-releasing intrauterine system.
- Where
- Saudi Arabia
- Volunteers
- 158 people
- Sponsor
- Saudi German Hospital - Madinah
Cesarean Section Complications, Scar; Deformity
Uterine Closure Techniques and Cesarean Scar Defect Risk
Cesarean operations are one of the most common obsetric operations and have an increasing trend in all over the world. However unfortunately the operation techniques have not been standardized yet.
- Trial name
- NCT05100147
- Testing
- Uterine closure during Cesarean section
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Mersin University