Clinical trials: Uterus Disorder
Intraepithelial Neoplasia, Intraepithelial Neoplasm, Cervical
HRME in the Screening of Cervical Cancer Precursor Lesions in Brazil (UH3 - Brazil)
STUDY PURPOSES: This study aims to evaluate a high resolution microendoscope (HRME): 1) To assess the sensitivity and specificity of the HRME device in the detection of cervical intraepithelial neoplasia grade 2 (CIN2) or…
- Conditions
- Intraepithelial Neoplasia, Intraepithelial Neoplasm, Cervical, Cervical Cancer, Neoplasm Cervix
- Trial name
- UH3 (NCT03195218)
- Testing
- HRME examination
- Where
- Brazil
- Volunteers
- 1,780 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Cervical Intraepithelial Neoplasia
Efficacy Study of Diathermy Cone Biopsy for the Treatment of Cervical Intraepithelial Lesion
The purpose of this trial is to determine whether SWETZ (Straight Wire Excision of Transformation Zone) is a superior alternative to LLETZ cone (Large Loop Excision of Transformation Zone cone biopsy) in the management of…
- Trial name
- NCT00995020
- Testing
- Straight Wire Excision of Transformation Zone, Large Loop Excision of Transformation Zone (cone biopsy)
- Where
- 2 sites in Brazil
- Volunteers
- 103 people
- Sponsor
- Oswaldo Cruz Foundation
Prolapse, Vaginal, Stress Urinary Incontinence
Perineal Massage for Pessary Examinations
Pessaries are effective non-surgical devices for reduction of prolapse. However, use of pessaries are limited in some women due to patient discomfort.
- Conditions
- Prolapse, Vaginal, Stress Urinary Incontinence, Pessaries, Pain
- Trial name
- NCT06416982
- Testing
- Perineal massage
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Obstructive Pulmonary Disease
IN UTERO SMOKING AND PREMATURE CELLULAR SENESCENCE
Actually, there is an increasing number of arguments for a premature origin of chronic adult's diseases, as the chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01865435
- Testing
- cord blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Uterine Cervical Dysplasia
Buffered Lidocaine for Loop Electrosurgical Excision Procedures (LEEPs)
Women undergoing a LEEP procedure who receive lidocaine buffered with sodium bicarbonate for their cervical block will experience less injection pain than women who receive plain lidocaine.
- Trial name
- NCT01405768
- Testing
- sodium bicarbonate buffered lidocaine, Non-buffered lidocaine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Washington University School of Medicine
Gynecological Malignant Tumor, Solid Tumor
A Study of BL-B01D1 in Patients With Multiple Solid Tumors, Including Recurrent or Metastatic Gynecological Malignancies
A phase Ib/II clinical study to evaluate the safety, tolerability, pharmacokinetics and efficacy of BL-B01D1 for injection in patients with multiple solid tumors, including recurrent or metastatic gynecological malignancies.
- Trial name
- NCT05803018
- Testing
- BL-B01D1
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Endometriosis, Endometrioma
Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)
The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy
- Trial name
- NCT06847685
- Where
- 3 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cervical Cancer, HPV
CTCs in Cervix Cancer
This study is a validation study to confirm the ability of Telomescan OBP-401 to identify CTCs in patients with HPV 16 / 18 associated cervical cancer.
- Trial name
- NCT04064515
- Testing
- Blood Assayed for CTCs
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- NYU Langone Health
Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
The main purpose of this study is to: Learn about the safety of ubamatamab and to find out what dose of ubamatamab can be given alone or with cemiplimab to patients with ovarian cancer or cancer of the uterus The study will also…
- Conditions
- Recurrent Ovarian Cancer, Recurrent Fallopian Tube Cancer, Recurrent Primary Peritoneal Cancer, Recurrent Endometrial Cancer
- Trial name
- NCT03564340
- Testing
- Ubamatamab, Cemiplimab, Sarilumab
- Where
- 54 sites in United States, Australia and 8 more
- Volunteers
- 890 people
- Sponsor
- Regeneron Pharmaceuticals
Menstrual Pain, Dysmenorrhea
Yoga and Aerobic Exercise Training in Primary Dysmenorrhea
The aim of this study is to compare the effects of aerobic exercise and yoga exercises on menstrual pain parameters (pain severity and duration, analgesic usage), uterine artery blood flow, menstrual stress level, physical…
- Trial name
- NCT05623085
- Testing
- Aerobic exercise, Yoga exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cervical Cancer, Vulvar Cancer
Long-term Follow-up of Bivalent Human Papillomavirus (HPV) Vaccine Study in Women
This extension study aims to evaluate the long-term protection and immune response of the bivalent HPV vaccine in women aged 18-30 who participated in a previous efficacy study (311-HPV-1003).
- Conditions
- Cervical Cancer, Vulvar Cancer, Vaginal Cancer, CIN - Cervical Intraepithelial Neoplasia
- Trial name
- NCT06776055
- Testing
- HPV-16/18 vaccine
- Where
- 9 sites in China
- Volunteers
- 5,372 people, healthy volunteers welcome
- Sponsor
- Shanghai Zerun Biotechnology Co.,Ltd
Postpartum Hemorrhage
TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA
Several randomized, controlled trials, mostly involving women undergoing cesarean delivery, have shown that the prophylactic intravenous administration of 1 g of tranexamic acid after childbirth reduced blood loss.
- Trial name
- TRAAPrevia (NCT04304625)
- Testing
- Tranexamic Acid / Sodium chloride
- Where
- France
- Volunteers
- 1,380 people
- Sponsor
- University Hospital, Bordeaux
Endometrial Cancer
Uterine Manipulator in Endometrial Cancer Surgery: Pro MUCEI Study
The uterine manipulator is a device commonly used in minimally invasive hysterectomy surgery for endometrial cancer. However, without substantial evidence to support its use, surgeons are required to make decisions about its use…
- Trial name
- proMUCEI (NCT05242276)
- Testing
- USE OF UTERINE MANIPULATOR DURING THE HYSTERECTOMY
- Where
- Spain
- Volunteers
- 1,200 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Female Infertility, Female Infertility Due to Ovulatory Disorder
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A"…
- Conditions
- Female Infertility, Female Infertility Due to Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome
- Trial name
- CS-EOSP-ICSI (NCT04071574)
- Testing
- Human Chorionic Gonadotropin (hCG), Gonadotropins, GNRH-A Triptorelin
- Where
- Lebanon
- Volunteers
- 200 people
- Sponsor
- Lebanese University
Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified
Human Papilloma Virus (HPV) Circulating Tumor DNA (ctDNA) in Cervical Cancer
This study collects blood samples to determine if the DNA of HPV that causes cervical cancer can be detected in patients with cervical cancer that is new (primary), has come back (recurrent), or has spread to other places in the…
- Conditions
- Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Infiltrating Cervical Carcinoma, Metastatic Cervical Carcinoma
- Trial name
- NCT04574635
- Testing
- Biospecimen Collection
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Postpartum Hemorrhage
Intrauterine Balloon (Bakri©) Versus Uterine Tamponade With Chitosan Gauze (Celox PPH©) in the Management of Postpartum Hemorrhage Refractory to Medical Treatmen
Postpartum hemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide, particularly in low- and middle-income countries.
- Trial name
- NCT06996808
- Testing
- Bakri Baloon, Celox gauze
- Volunteers
- 196 people
- Sponsor
- University of Roma La Sapienza
Cancer Harboring BRAF Alterations, HGG
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with BRAF altered (BRAF V600E or BRAF fusions) locally advanced or metastatic solid tumors, or recurrent or progressive…
- Conditions
- Cancer Harboring BRAF Alterations, HGG, LGG, Solid Tumors
- Trial name
- NCT05503797
- Testing
- Plixorafenib
- Where
- 70 sites in United States, Australia and 10 more
- Volunteers
- 254 people
- Sponsor
- Fore Biotherapeutics
Uterine Myoma
GnRH Agonist Pretreatment in Hysteroscopic Myomectomy
The primary outcome of this study is to assess if the GnRHa administration before cold loop hysteroscopic myomectomy contributes to accomplish the treatment in only one surgical procedure.
- Trial name
- NCT01873378
- Testing
- Triptorelin 3.75 mg
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Cervical Cancer, Endometrial Cancer
Value of Diffusion Weighted Magnetic Resonance Imaging in Detection of Recurrent Disease in Surgically Treated Cervical and Endometrial Cancer Patients
Endometrial and cervical cancers are one of the most common malignancies seen in females. Identification of recurrent disease in early phases of treatment carries a primary importance on the outcome of patients.
- Trial name
- NCT01710085
- Testing
- Diffusion weighted MRI (DW- MRI)- Philips Achieva 3.0T X, Netherlands, 2011
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Uludag University
Cervical Cancer
Bintrafusp Alfa Combination Therapy in Participants With Cervical Cancer (INTR@PID 046)
This study was to evaluate the safety and tolerability of bintrafusp alfa in combination with other anti-cancer therapies in participants with locally advanced or advanced cervical cancer.
- Trial name
- NCT04551950
- Testing
- M7824, Carboplatin, Paclitaxel
- Where
- 13 sites in United States, Japan and 1 more
- Volunteers
- 25 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.