Clinical trials: Uveitis
Uveitis
Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography
Optical Coherence Tomography (OCT) is routinely used in ophthalmic clinical practice. It uses infrared light to image patient's eyes.
- Trial name
- NCT02907814
- Testing
- Optical Coherence Tomography (OCT), Eye Exam
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Non-infectious Intermediate and Posterior Uveitis
Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate
BACKGROUND: Uveitis comprises of a group of diseases associated with inflammation of the eye that can lead to vision loss. Some people with uveitis also have macular edema (swelling of the retina at the back of the eye).
- Trial name
- MEXX (NCT01314417)
- Testing
- Methotrexate
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Eye Institute (NEI)
Uveitis
Abatacept in the Treatment of Uveitis
The purpose of this study is to assess the safety and efficacy of abatacept in the treatment of uveitis.
- Trial name
- NCT01279954
- Testing
- Abatacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Juvenile Idiopathic Arthritis Associated Uveitis
Tocilizumab in the Management of Juvenile Idiopathic Arthritis Associated Uveitis
The investigators are doing this research study to see if tocilizumab (Actemra) is safe and effective when used for severe or refractory non-infectious uveitis.
- Trial name
- NCT01603355
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Eric B. Suhler
Macular Edema, Uveitis
PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial
To evaluate the relative efficacy of three commonly utilized regional corticosteroids for the regional treatment of uveitic macular edema: periocular triamcinolone acetonide; intravitreal triamcinolone acetonide; intravitreal…
- Trial name
- POINT (NCT02374060)
- Testing
- Periocular triamcinolone 40 mg, Intravitreal triamcinolone 4 mg, Dexamethasone intravitreal implant
- Where
- 26 sites in United States, Australia and 2 more
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- JHSPH Center for Clinical Trials
Uveitis
Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis
Uveitis is an acute or chronic inflammatory condition of unknown etiology. Although uveitis often responds adequately to topical corticosteroids, there are many patients for which this treatment is either inadequate or not…
- Trial name
- NCT02769702
- Testing
- Acthar
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Uveitis
Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis
Background: Uveitis is a serious inflammatory condition in which the body's immune system attacks parts of the eye, often causing vision loss.
- Trial name
- NCT01195948
- Testing
- B27PD
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Eye Institute (NEI)
Uveitis, Intermediate Uveitis
Sirolimus as Therapeutic Approach to Uveitis
The purpose of this study is to find out about the safety and effectiveness of the study drug, sirolimus, in patients with uveitis and to utilize the potential effectiveness of sirolimus, and yet to avoid the potential…
- Conditions
- Uveitis, Intermediate Uveitis, Posterior Uveitis, Panuveitis
- Trial name
- SAVE (NCT00908466)
- Testing
- Sirolimus (rapamycin)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Uveitis
Microplasmin Intravitreal Administration in Participants With Uveitic Macular Edema
The objective of this study is to investigate the safety and efficacy of microplasmin as a treatment for uveitic macular edema.
- Trial name
- MIME (NCT01194674)
- Testing
- Microplasmin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Acute Anterior Uveitis
Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis
The purpose of the study is to determine whether topical ocular administration of LME636 60 mg/mL is efficacious in resolving the ocular inflammation in the anterior chamber (AC) associated with acute anterior uveitis (AAU).
- Trial name
- NCT02482129
- Testing
- LME636 60 mg/mL ophthalmic solution, Dexamethasone 0.1% ophthalmic solution, LME636 Vehicle
- Volunteers
- 45 people
- Sponsor
- Alcon Research
Uveitis, Anterior Uveitis
Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients
Uveitis represents a heterogeneous group of diseases that results from ocular inflammatory reaction involving ocular tissue and vasculature. The inflammation usually causes pain, redness, photophobia and blurred vision.
- Conditions
- Uveitis, Anterior Uveitis, Intermediate Uveitis, Posterior Uveitis
- Trial name
- NCT02764697
- Testing
- H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Tampa Bay Uveitis Center, LLC
Anterior Uveitis, Iritis
PEMF: an Adjunct Therapy for Anterior Uveitis
The purpose of this study is to determine if a medical device (ActiPatch) that emits a low frequency pulsed electromagnetic field (PEMF) will benefit patients with anterior uveitis.
- Trial name
- PEMF (NCT01154010)
- Testing
- PEMF
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Uveitis, Cytoid Macular Edema
Lucentis for Inflammatory Macular Edema Trial
Uveitis is an inflammation (swelling and irritation) inside the eye, affecting the uvea. The uvea is the layer of the eye between the sclera and the retina and provides most of the blood supply to the retina.
- Trial name
- LIME (NCT00498355)
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Francisco
Non-infectious Uveitis
Safety and Efficacy of AIN457 in Noninfectious Uveitis
This study was performed to evaluate the efficacy and safety of AIN457 for patients with active uveitis that requires systemic immunosuppression.
- Trial name
- NCT00685399
- Testing
- AIN457, AIN 457
- Where
- 23 sites in United States, Germany
- Volunteers
- 76 people
- Sponsor
- Novartis Pharmaceuticals
Uveitis
Phase II Study to Analyze Sarilumab in Non-Infectious Uveitis
Primary Objective: To evaluate the efficacy of sarilumab at Week 16 in participants with non-infectious uveitis (NIU). Secondary Objectives: To evaluate the change in best corrected visual acuity (BCVA).
- Trial name
- SARILNIUSATURN (NCT01900431)
- Testing
- Sarilumab, Prednisone, Methotrexate
- Where
- 20 sites in United States, Czechia and 4 more
- Volunteers
- 58 people
- Sponsor
- Sanofi
Autoimmune Connective Tissue Disorder, Immune System Diseases
Anakinra for Behcet s Disease
Background: Behcet's disease (BD) is an autoimmune disease where the immune system attacks the body. People with BD may develop oral or genital ulcers, skin problems, and eye disease.
- Trial name
- NCT01441076
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Uveitis, Iritis
Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
Retinal optical coherence tomography (OCT) is an established technology which enables a detailed cross-sectional visualization of the retinal micro-anatomy, and an objective measurement of its thickness in-vivo.
- Conditions
- Uveitis, Iritis, Iridocyclitis, Anterior Uveitis
- Trial name
- NCT00476593
- Testing
- Diclofenac, Dexamethasone
- Where
- 2 sites in Norway
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Anterior Uveitis, Arthritis, Juvenile Idiopathic
Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis
This study will examine the safety and effectiveness of a monoclonal antibody called humanized anti-Tac (HAT, also called daclizumab) to treat children and adolescents with uveitis (chronic inflammatory eye disease) associated…
- Conditions
- Anterior Uveitis, Arthritis, Juvenile Idiopathic, Iritis, Immunosuppression
- Trial name
- NCT00130637
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Eye Institute (NEI)
Uveitis
Multicenter Uveitis Steroid Treatment (MUST) Trial
The purpose of this study is to compare the effectiveness of standardized systemic therapy versus fluocinolone acetonide implant therapy for the treatment of severe cases of non-infectious intermediate uveitis, posterior uveitis…
- Trial name
- MUST (NCT00132691)
- Testing
- fluocinolone acetonide intraocular implant, oral corticosteroid with immunosuppressive agents as needed
- Where
- 23 sites in United States, Australia and 1 more
- Volunteers
- 255 people
- Sponsor
- JHSPH Center for Clinical Trials
Uveitis
First-line Antimetabolites as Steroid-sparing Treatment Uveitis Pilot Trial
The proposed study is a masked trial, with stratified block randomization by site, designed to determine which treatment, methotrexate or mycophenolate mofetil, is more effective as first-line steroid-sparing treatment for…
- Trial name
- FAST (NCT01232920)
- Testing
- Methotrexate, Mycophenolate mofetil
- Where
- 2 sites in India
- Volunteers
- 80 people
- Sponsor
- University of California, San Francisco