Clinical trials: VOLUME OF FLUID
Thyroidectomy, Fluid Responsiveness
Study of Stroke Volume Variation and Pleth Variability Index as Predictors of Fluid Responsiveness
Appropriate indices to guide fluid therapy are essential for effective hemodynamic management during the perioperative period. Values derived from respiratory changes in arterial pressure waveform or plethysmographic waveform…
- Trial name
- NCT02122367
- Testing
- HES 130/0.4 (VolulyteⓇ, Fresenius Kabi, Canada)
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Chung-Ang University Hospital
Cardiac Edema
A Dose-finding Study of JMKX003142 in Treatment of Cardiac Edema
To Evaluate the Safety, Efficacy, and Pharmacokinetic/Pharmacodynamics Characteristics of JMKX003142 injection Administered Randomly,Double-blind, Placebo-controlled Study in Chinese Cardiacl Edema Patients.
- Trial name
- NCT06949020
- Testing
- JMKX003142 Injection
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Jemincare
Breathing
Diagnostic Accuracy of the Central Venous Pressure (CVP) Variation to Predict Fluid Responsiveness in Spontaneously Breathing Patients
Volume expansion (VE) is often administered in intensive care (ICU)-patient to improve arterial oxygen delivery. Such effect is secondary to an increase in stroke volume and cardiac output.
- Trial name
- VPVC (NCT03780660)
- Where
- France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Lille
Volume Overload
Management of Fluid Overload in TAVR
Fluid overload (FO) puts aortic stenosis (AS) patients at risk for heart failure and death. However, conventional FO assessment, including rapid weight gain, peripheral edema, or chest radiography, is inaccurate.
- Trial name
- EASE-TAVR (NCT04556123)
- Testing
- Measurement of the hydration state and decongestive treatment according to bioimpedance spectroscopy, Measurement of the hydration state and decongestive treatment according to clinical judgement alone
- Where
- 2 sites in Austria
- Volunteers
- 232 people
- Sponsor
- Medical University of Vienna
Fasting
Effect of Drinking Carbohydrate-containing Fluids on Gastric Residual Volume in Elderly Patients
In the past, some guidelines advised no oral intake for at least 8 hours before any surgery. However, research has shown risks associated with excessive fasting, such as postoperative insulin resistance, and advantages in shorter…
- Trial name
- NCT04514380
- Testing
- Carbohydrate fluid, Non-carbohydrate fluid
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Seoul National University Bundang Hospital
Liver Transplantation, End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL) - Pilot
Hypothesis: A Canadian multicentre clinical trial is feasible. Study Design: Multicenter internal pilot parallel arm randomized controlled trial.
- Trial name
- REFIL-1 (NCT05647733)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Optimized cardiac output liberal fluid management strategy, Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 138 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Validation of PVI in Tidal Volume Challenge Test
PVI for TVC Response
Determine the ability of changes in Plethysmographic Variability Index during tidal volume challenge to predict fluid responsiveness
- Trial name
- NCT04978909
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Fluid Responsiveness
Pneumoperitoneum and Trendelenburg Position on Fluid Responsiveness
The increased intraabdominal pressure and intrathoracic pressure due to pneumoperitoneum negatively affect the cardiovascular system, relatively dynamic parameters may vary due to intraoperative fluid therapy.
- Trial name
- NCT04060069
- Testing
- Ringer Lactate
- Volunteers
- 45 people
- Sponsor
- Kocaeli University
Volume Expansion, Fluid Responsiveness
Ability of Changes in Analgesia Nociception Index to Assess the Stroke Volume Effects of a Volume Expansion of 250ml of Crystalloid in the Operating Room
Volume expansion is the cornerstone of perioperative hemodynamic optimization. The main objective of volume expansion is to increase and maximize stroke volume. Hemodynamic changes have an impact on the autonomic nervous system.
- Trial name
- REVANI (NCT04223414)
- Testing
- Analgesia Nociception Index (ANI)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Bordeaux
Periodontal Pocket
The Efficacy of Salvia Officinalis Gel in the Treatment of Periodontitis CLINICAL TRIAL
From each participant, two sites of periodontal pockets ( ≥ 5 mm ) were selected and randomly allocated to either the test site (treated with scaling and RSD with S.
- Trial name
- clinical (NCT06900517)
- Testing
- Salvia officinalis Gel
- Volunteers
- 23 people
- Sponsor
- University of Baghdad
Acute Heart Failure (AHF), Fluid Over-load
Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.
This randomized controlled trial evaluates the effectiveness of two training approaches (in-person versus remote) for teaching medical residents to apply the Venous Excess Ultrasound (VExUS) score for bedside volume assessment in…
- Conditions
- Acute Heart Failure (AHF), Fluid Over-load, Congestion, Congestion, Venous
- Trial name
- NCT07541768
- Testing
- In-person VExUS Training Program, Remote VExUS Training Program, No intervention
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Urothelial Carcinoma
Prospective Validation Study of High Volume Urine DNA Testing in Individuals With Suspicion of Urothelial Cancer
Urothelial cancers of the bladder and upper urinary tract account for over 200,000 deaths and 600,000 diagnoses annually worldwide.
- Trial name
- UROSCOUT-1 (NCT06310759)
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 3,000 people
- Sponsor
- Tampere University Hospital
Blood Volume Expansion
Ability of Changes in End Tidal Carbon Dioxide to Assess the Stroke Volume Effects of a Volume Expansion of 250ml of Crystalloid in the Operating Room
Volume expansion is the cornerstone of perioperative hemodynamic optimization. The main objective of volume expansion is to increase and to maximize stroke volume.
- Trial name
- REVCO2 (NCT03635307)
- Testing
- End Tidal Carbon Dioxide measure
- Where
- France
- Volunteers
- 115 people
- Sponsor
- University Hospital, Bordeaux
Volume Expander
Ultrasound and Clinical Approach for the Dynamic Assessment of Fluid Tolerance in the Intensive Care Unit
A major cause of admission to intensive care is acute circulatory failure resulting from organ hypoperfusion due to factors such as hypotension and myocardial dysfunction.
- Trial name
- FLUID-REACT (NCT06415916)
- Testing
- Cardiac ultrasound, Lung ultrasound
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Intestinal Cancer, Diverticulitis
Using Electrical Bioimpedance Assessments to Estimate Perioperative Total Body Water and Postoperative Fluid Need
Being able to accurately monitor patient bodily fluid levels during and after surgery is very important, as there are a number of complications that can arise if a patient's fluid levels become unbalanced, such as swelling within…
- Conditions
- Intestinal Cancer, Diverticulitis, Pancreatic Cancer, Gastroesophageal Reflux Disease
- Trial name
- NCT02200055
- Testing
- Bodystat Quadscan 4000
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- United States Naval Medical Center, Portsmouth
Obstructive Sleep Apnea, Spinal Cord Injuries
Overnight Upper Airway Infiltration in Spinal Cord Injury
Obstructive Sleep Apnea (OSA), a common disorder resulting from repetitive pharyngeal collapse during sleep, is multifactorial. Usually, OSA is considered primarily a problem of upper airway anatomy, with the craniofacial…
- Trial name
- OUI-SCI (NCT05391308)
- Testing
- Pre-polysomnography mesurement, Polysomnography measure, Post-polysomnography measurements
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fluid Challenge, Hemodynamic Monitoring
Tidal Volume Challenge and Lung Recruitment Maneuver (TIDALREC): the Reliability of Pulse Pression Variation or Stroke Volume Variation on Fluid Responsiveness.
In order to predict fluid responsiveness in the operating room and therefore benefit of performing fluid administration to improve patient's hemodynamic status, it will test two ventilation strategies : the Tidal Volume Challenge…
- Trial name
- TIDALEC (NCT04535115)
- Testing
- Starting LRM (Lung Recruitment Maneuver), Starting VtC (Tidal Volume Challenge)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Lille
Coronary Surgery
Uncalibrated Pulse Contour to Assess Fluid Responsiveness in Off Pump Cardiac Surgery
The goal of this observational study is to Compare the performance of uncalibrated pulse wave contour analysis compared with transesophageal echocardiography (TEE) to assess response to a vascular filling test during…
- Trial name
- UPC-OPCS (NCT06822361)
- Where
- Reunion
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Severe Sepsis, Septic Shock
Volume Replacement With Albumin in Severe Sepsis
BACKGROUND The association between mortality and hypoalbuminemia has been observed in several diseases. Nonetheless, the efficacy of albumin on survival in critically ill patients is controversial.
- Trial name
- ALBIOS (NCT00707122)
- Testing
- Albumin and Crystalloids, Crystalloids
- Where
- Italy
- Volunteers
- 1,818 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Fluid Assessment by Doppler us Changes
Assessment of Volume Status by Doppler US
Fluid are used to increase cardiac output (CO) and blood pressure in patients admitted to the intensive care unit (ICU) .Fluid is an important line of therapy that needed in shocked patient, hypovolemic and following surgery to…
- Trial name
- NCT05115539
- Testing
- doppler US of portal vein, hepatic veins, intrarenal veins
- Volunteers
- 100 people
- Sponsor
- Assiut University