Clinical trials: VZV
Glioblastoma (GBM)
Efficacy of Zoster Vaccination in Glioblastoma Patients
In modern practice a trimodality treatment has emerged as standard of care for histologically confirmed glioblastoma. We hypothesize that the additional vaccination against herpes zoster, after surgical resection followed by…
- Trial name
- STARGATE (NCT07546669)
- Testing
- Additional vaccination against shingles (herpes zoster), Standard of care treatment without additional vaccination
- Volunteers
- 230 people
- Sponsor
- University Hospital, Essen
Herpes Zoster, Herpes Zoster Vaccine
Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ/su) Vaccine in Adults With Solid Tumours Receiving Chemotherapy
The purpose of this study is to evaluate the immunogenicity and safety of GSK Biologicals' HZ/su vaccine in adults with solid tumours undergoing chemotherapy.
- Trial name
- NCT01798056
- Testing
- GSK 1437173A
- Where
- 28 sites in Canada, Czechia and 4 more
- Volunteers
- 237 people
- Sponsor
- GlaxoSmithKline
Post Herpetic Neuralgia
Acupuncture as Treatment of Post-herpetic Neuralgia: A RCT A Double-blinded Randomized Clinical Trial.
The aim of this study is to perform the first RCT investigating the possible effect of superficial dry-needling (SDN) - a special kind of acupuncture used for PHN. The participants will be divided into two groups.
- Trial name
- NCT03974438
- Testing
- Superficial dry needling / Acupunture
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Odense University Hospital
Herpes Zoster Pain
The Efficacy of High-frequency Short-time Spinal Cord Stimulation in the Treatment of Herpes Zoster-associated Neuralgia
Zoster-associated neuralgia (ZAN) is a type of neuropathic pain caused by the reactivation of the varicella-zoster virus (VZV). The global annual incidence is approximately 3-5 per 1,000 individuals, and in China, the incidence…
- Trial name
- NCT06942806
- Testing
- HF-SCS parameter settings: Frequency 1000 Hz, pulse width 60-180 μs, amplitude 0.5-3.0 V, LH-SCS parameter settings: Frequency 30-100 Hz, pulse width 100-300 μs, amplitude 0.5-5.0 V
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Li Zhao
Acute Herpes Zoster
Efficacy of Electroacupuncture for Acute Herpes Zoster-Associated Pain and Biomarker Evaluation
Background: Herpes zoster (HZ) is an acute dermatological condition caused by the varicella-zoster virus. Its onset is characterized by severe pain, imposing significant physical and psychological burdens on patients.
- Trial name
- NCT07515885
- Testing
- Acupuncture, Valacyclovir, pregabalin and mecobalamin
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Dexiong Han
Measles, Mumps
Immune Responses to Two Dose Varivax +/- MMR-II
This study will test the safety and how well the body's immune system responds to a live, but weakened varicella (chickenpox) vaccine, known as Varivax, given with and without ProQuad, another measles, mumps, rubella, and…
- Conditions
- Measles, Mumps, Rubella, Varicella
- Trial name
- NCT00258726
- Testing
- MMR-II, Pro-Quad, Varivax
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Sclerosis, Hypogammaglobulinemia
Rituximab-Induced Hypogammaglobulinemia in Multiple Sclerosis
B cells are considered major contributors to multiple sclerosis (MS) pathogenesis, a role that has taken on renewed importance with the advent of B-cell-depleting therapies.
- Trial name
- NCT04283747
- Testing
- Serum immunoglobulin titer
- Where
- Iran
- Volunteers
- 170 people
- Sponsor
- Mazandaran University of Medical Sciences
Varicocele
Analysis on AEFI Surveillance Data for Live Attenuated Varicella Vaccine
The purpose of this study is to observe the occurrence of adverse events of live attenuated varicella vaccine.
- Trial name
- NCT02983656
- Testing
- live attenuated varicella vaccine
- Volunteers
- 394 people
- Sponsor
- Zhejiang Provincial Center for Disease Control and Prevention
Prevention of : Herpes-Zoster
Immunogenicity and Safety of a 1-dose Regimen of a Zoster Vaccine Versus Different 2-dose Regimens in Participants ≥ 70 Years of Age. (V211-043)
Primary objective: Immunogenicity To demonstrate that a second dose of ZOSTAVAX® elicits higher varicella-zoster virus (VZV) antibody titres than a first dose of ZOSTAVAX® whether given as a 0-1 month schedule or as a 0-3 month…
- Trial name
- NCT00561080
- Testing
- Zostavax
- Volunteers
- 759 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Herpes Zoster, Local Infiltration
Clinical Efficacy and Safety of Tender Point Infiltration (TPI) for Acute and Subacute Zoster Associated Pain
Herpes zoster (HZ) is a skin infection disease which cause severe zoster-associated pain (ZAP) along sensory nerve in the corresponding segment.
- Conditions
- Herpes Zoster, Local Infiltration, Acute Pain
- Trial name
- NCT06344403
- Testing
- analgesic, Tender point infiltration
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Beijing Tiantan Hospital
Herpes Zoster, Shingles
A Study of FV-100 Versus Valacyclovir in Patients With Herpes Zoster
The purpose of this study is to compare the safety and efficacy of two doses of FV-100 to valacyclovir in patients with herpes zoster, or shingles.
- Trial name
- NCT00900783
- Testing
- valacyclovir, FV-100
- Volunteers
- 350 people
- Sponsor
- Bristol-Myers Squibb
Autoimmune Rheumatic Diseases
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases Under Immunomodulators
This interventional phase IV clinical trial will evaluate the efficacy, immunogenicity and safety of the adjuvanted recombinant herpes zoster vaccine (RZV) in adults with autoimmune rheumatic diseases (ARDs) receiving…
- Trial name
- IMUNO-RZV (NCT07280741)
- Testing
- Recombinant Zoster Vaccine (RZV)
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo General Hospital
Follicular Lymphoma
Prospective Biological Study to Evaluate the Persistence of COVID-19 Vaccine and Other Vaccines'-Induced Immune Responses in Follicular Lymphoma Patients Undergoing Frontline Induction Immuno-chemotherapy and Anti-CD20 Maintenance
This is a prospective biological study evaluating the persistence of COVID-19 vaccine and other vaccines' (zoster, diphtheria and tetanus)-induced immunity in a subgroup patient affected by Follicular Lymphoma requiring treatment…
- Trial name
- FIL_FollVax22 (NCT06070961)
- Testing
- Cellular immunity vs SARS-CoV-2, Humoral immunity vs SARS-CoV-2, Cellular immunity vs Varicella Zoster Virus
- Where
- 14 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Lung Cancer
Observational Study on the Impact of Herpes Zoster Vaccine on the Incidence of Herpes Zoster and Survival in Lung Cancer Patients
To evaluate the impact of herpes zoster vaccine on the incidence of herpes zoster and survival in lung cancer patients, and to explore its preventive effect and safety.
- Trial name
- NCT07170059
- Testing
- herpes zoster vaccine
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Post Herpetic Neuralgia
Predictive Models for the Treatment of Recurrent Herpes Zoster Neuralgia Following Spinal Cord Electrical Stimulation.
Shingles is a neuropathic disease caused by varicella-herpes virus(VZV) invading nerves and accompanying pain.Currently, the treatment of postherpetic neuralgia (PHN) includes medication and minimally invasive interventional…
- Trial name
- NCT06410222
- Testing
- Recurrence after undergo spinal cord stimulation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Feng Gao
Achalasia
VZV in the Enteric Nervous System: Pathogenesis and Consequences
Varicella zoster virus (VZV) is the cause of chickenpox and shingles, but it also infects, becomes latent, and reactivates in nerve cells of the bowel to cause a gastrointestinal disorder ("enteric shingles").
- Trial name
- NCT05550194
- Testing
- ValACYclovir 1000 MG, Shingrix
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Shingles, Herpes Zoster
Safety and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix® in Healthy Adults 50 Years of Age and Over
This is a randomized, active-controlled, observer-blinded, dose-escalation multi-center trial of 2 doses of an investigational HZ vaccine (Z-1018) in approximately 764 healthy adults.
- Conditions
- Shingles, Herpes Zoster, Vaccine-Preventable Diseases
- Trial name
- NCT06569823
- Testing
- Z-1018, Shingrix
- Where
- 16 sites in Australia, New Zealand
- Volunteers
- 764 people, healthy volunteers welcome
- Sponsor
- Dynavax Technologies Corporation
Acute Herpes Zoster Pain Managment
Ultrasound-Guided Erectro Spinae Plane Block Versus Stellate Ganglion Block for Patients With Upper Limb Acute Herpes Zoster Pain.
Herpes zoster (HZ) is a painful, eruptive, viral condition results from reactivation of the latent varicella zoster virus after the primary infection.
- Trial name
- NCT06307444
- Testing
- Ultrasound-Guided Stellate Ganglion Block, T2 T3 (High Thorathic) ESP Block
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Tanta University
Atrophic Varicella Scar
Efficacy of TCA Effect on Varicella Atrophic Scars
This study aims to determine the efficacy of 70% trichloroacetic acid on atrophic scars of varicella
- Trial name
- NCT00422539
- Testing
- 70% trichloroacetic acid
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Varicella, Rubella
Immunogenicity, Safety of Measles-mumps-rubella-varicella Vaccine (MeMuRu-OKA) Compared to Priorix™ Given With Varilrix™
As measles-mumps-rubella (MMR) vaccination is established as routine childhood practice in most industrialised countries and varicella vaccination is now being introduced in many countries during the second year of life, a…
- Conditions
- Varicella, Rubella, Measles, Mumps
- Trial name
- NCT00353288
- Testing
- MeMuRu-OKA (study vacc), MMR, Varicella vacc (control)
- Where
- 39 sites in France, Germany and 1 more
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline