Clinical trials: Vaccines Adverse Reaction
COVID-19 Vaccine Adverse Reaction
Detoxification From the Lipid Tract
Apart from electroencephalogram biofeedback and electrical brain stimulation adopted for maintenance treatment, the study utilizes ultra-low frequency transcranial magnetic stimulation (ULF-TMS) for initial γ-aminobutyric acid…
- Trial name
- NCT06357104
- Testing
- electroencephalogram biofeedback, electrical brain stimulation, ultra-low frequency transcranial magnetic stimulation
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Pachankis, Yang I., M.D.
Influenza, Vaccines Adverse Reaction
Surveillance for Adverse Events Following Influenza Immunization
Influenza vaccines are continuously modified to adjust to the virus antigenic shifts or drifts, and its safety profile may vary.
- Trial name
- NCT01318876
- Where
- 7 sites in Canada
- Volunteers
- 7,645 people, healthy volunteers welcome
- Sponsor
- PHAC/CIHR Influenza Research Network
SARS-CoV Infection, Coronavirus Infection
Evaluate the Impact, Safety, Tolerability and Immunogenicity of the Coronavac Vaccine in Kidney Transplant Recipients
Since the beginning of the SARS-CoV-2 pandemic, 1031 (8.7%) of the 11875 kidney transplant recipients being followed up at Hospital do Rim have been infected.
- Conditions
- SARS-CoV Infection, Coronavirus Infection, Vaccine Adverse Reaction
- Trial name
- TXCoronavac (NCT04801667)
- Testing
- Coronavac
- Where
- Brazil
- Volunteers
- 3,371 people
- Sponsor
- Hospital do Rim e Hipertensão
COVID-19 Respiratory Infection, COVID-19 Vaccine Adverse Reaction
A Randomized, Phase I Study of DNA Vaccine OC-007 as a Booster Dose of COVID-19 Vaccine
This is a randomized, placebo-controlled, double-blinded phase I study, designed to evaluate the safety including reactogenicity and immunogenicity of this investigational DNA vaccine delivered intramuscularly by in vivo EP in…
- Trial name
- OpenCorona1 (NCT05685953)
- Testing
- DNA vaccine OC-007
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Matti Sällberg
Vaccination; Complications, Vaccine Adverse Reaction
Effectiveness of CARD for Improving School-Based Immunizations
Vaccination is estimated to have saved more lives in Canada than any other single intervention and is considered one of the most important advances in the prevention of disease.
- Conditions
- Vaccination; Complications, Vaccine Adverse Reaction, Fear
- Trial name
- NCT03966391
- Testing
- Multi-faceted knowledge translation intervention
- Where
- Canada
- Volunteers
- 8,839 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Rabies Vaccine Adverse Reaction
A Clinical Trial of Freeze-dried Human Rabies Vaccine (MRC-5 Cells)
This trial is a randomized, blind, similar vaccine controlled, single center, non-inferiority design phase III clinical trial, with a study population of 10 to 60 years old, conducted in two stages.Phase 1 and Phase 2
- Trial name
- NCT06078423
- Testing
- Freeze-dried human rabies vaccine (MRC-5 cells) Zhifeilongkoma - 5-dose program, Freeze-dried human rabies vaccine (MRC-5 cells) Zhifeilongkoma - 4-dose program, Freeze-dried human rabies vaccine (MRC-5 cells) Kanghua - 5-dose program
- Where
- China
- Volunteers
- 1,880 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Influenza, Obesity
Effectiveness and Tolerability of Influenza Vaccine in Patients at Risk for Severe and Complicated Influenza
The aim of the study is to evaluate simultaneously the immunological and clinical efficacy and tolerability of an influenza vaccine, inactivated, quadrivalent, with cleaved virus, in patients at risk for severe and complicated…
- Conditions
- Influenza, Obesity, Pregnancy; Infection, Elderly Infection
- Trial name
- NCT06286488
- Testing
- Vaxigrip
- Where
- Poland
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Vaccine Adverse Reaction
Reactogenicity, Safety and Immunogenicity of a LAIV А/17/Hong Kong/2017/75108 H7N9 Influenza Vaccine
This is a single center phase I, double-blind placebo-controlled study to assess reactogenicity, safety and immunogenicity of a live monovalent A/17/Hong Kong/2017/75108 (H7N9) influenza vaccine in healthy male and female adults…
- Trial name
- NCT03739229
- Testing
- H7N9 LAIV
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Research Institute of Influenza, Russia
COVID-19, Vaccine Immune Response
COVID-19 Vaccine Reactogenicity and Immunogenicity
Analysis of antibody kinetics after vaccination with mRNA-1273 and factors influencing the vaccine immunogenicity
- Conditions
- COVID-19, Vaccine Immune Response, Vaccine Adverse Reaction
- Trial name
- NCT05258708
- Testing
- mRNA-1273 COVID-19 vaccine
- Where
- 5 sites in South Korea
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Smallpox Vaccine Adverse Reaction
VA-006 Vaccinia Vaccine (ACAM2000) for the Production of VIGIV
The purpose of this study is to vaccinate plasma donors with ACAM2000 smallpox vaccine for collection of plasma to be used in the manufacturing of Vaccinia Immune Globulin Intravenous (VIGIV).
- Trial name
- NCT01158157
- Testing
- ACAM2000
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Heterologous Immunity, Infant Morbidity
Comparing Morbidity and Mortality Effects of Two Different Strains of BCG
Background: Investigators at Bandim Health Project (BHP, www.bandim.org) in Guinea-Bissau have shown in several randomized trials that the Bacille-Calmette-Guérin (BCG) vaccine against tuberculosis (TB) is associated with reduced…
- Conditions
- Heterologous Immunity, Infant Morbidity, Infant Mortality, Trained Immunity
- Trial name
- NCT03400878
- Testing
- BCG-Japan, BCG-Russia
- Where
- 2 sites in Guinea-Bissau
- Volunteers
- 17,505 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Diseases, Chronic, Covid19
Safety and Immune Response of COVID-19 Vaccination in Patients With Basic Disease
On 11 February 2020, the International Committee for the Classification of Viruses named the disease caused by SAＲS-CoV-2 infection in humans as the new coronavirus pneumonia (coronavirus disease 2019, COVID-19).Due to the…
- Conditions
- Diseases, Chronic, Covid19, Adverse Reaction to Vaccine
- Trial name
- SIM-PBD (NCT05043246)
- Testing
- SARS-COV-2 VACCINE
- Where
- China
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Adverse Reaction to Cholera Vaccine, Cholera Vaccination Reaction
Extended Dose Intervals With Oral Cholera Vaccine in Cameroon
The primary aim of this project is to determine changes in the vibriocidal geometric mean titers (GMT) in subjects who receive the second dose of oral cholera vaccine (OCV) at different intervals: 2 weeks, 6 months, or 11 months…
- Trial name
- NCT03719066
- Testing
- killed whole cell oral cholera vaccine
- Where
- Cameroon
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Covid19, Vaccine Adverse Reaction
Study of Sputnik V COVID-19 Vaccination in Adults in Kazakhstan
This study will assess the safety, reactogenicity, and immunogenicity of Gam-COVID-Vac (Sputnik V) vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing…
- Trial name
- NCT04871841
- Testing
- Sputnik V
- Where
- Kazakhstan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Karaganda Medical University
Vaccine Reaction, Vaccine Adverse Reaction
Immunogenicity and Safety Following In-House Recombinant Hepatitis B Vaccine in Indonesian Population (Phase III)
This is a phase 3, experimental, randomized, observer-blind, lot to lot consistency study. The primary objective of this study is to assess the protectivity of In-House Recombinant Hepatitis B vaccine 28 days after 3 doses…
- Trial name
- NCT05482295
- Testing
- In-House Recombinant Hepatitis B (Bio Farma) vaccine, Registered Hepatitis B vaccine recombinant (Engerix-B)
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Adverse Reaction to Vaccine, COVID19 Vaccine
COVID-19 Vaccines Safety Tracking (CoVaST)
This project aims to monitor the side effects of COVID-19 vaccines worldwide actively. The primary objectives of the project include a) to estimate the prevalence of each local and systemic side effect of each COVID-19 vaccine…
- Trial name
- NCT04834869
- Testing
- BNT162b2, mRNA-1273, AZD1222
- Where
- 14 sites in United States, Canada and 12 more
- Volunteers
- 30,000 people
- Sponsor
- Masaryk University
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Vaccine Reaction, Vaccine Adverse Reaction
Safety and Immunogenicity of SARS-CoV-2 Protein Subunit Recombinant Vaccine in Healthy Children
A Phase III, Observer-blind, randomized, active-controlled prospective intervention study
- Trial name
- NCT05546502
- Testing
- SARS-CoV-2 Protein Subunit Recombinant Vaccine, Active Comparator
- Where
- 10 sites in Indonesia
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
mRNA Based-Covid-19 Vaccine Effects on Blood Glucose Levels
To determine if patients with a history of Diabetes Mellitus Type I or II developed a change in blood glucose levels as reported on Continuous glucose monitoring devices (CGMS) within the first week following administration of…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Hyperglycemia, Vaccine Adverse Reaction
- Trial name
- NCT04923386
- Testing
- None (not interventional)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Levenson, David I., M.D.
Adverse Reaction to Drug
Explore Active Surveillance Mode of the Community's Adverse Event Following Immunization(AEFI)
The investigators would remind the guardians of observation after immunization via sending short message and collect the information of AEFI by two ways, short message/telephone and website questionnaire.
- Trial name
- AEFI (NCT01830257)
- Testing
- sending message
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Center for Disease Control and Prevention