Clinical trials: Vagal Nerve Stimulation
Stroke, Cerebrovascular Accident (CVA)
Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke
The purpose of this study is to evaluate if multiple therapy sessions of Transcutaneous Vagus Nerve Stimulation (tVNS) combined with robotic arm therapy lead to a greater functional recovery in upper limb mobility after stroke…
- Conditions
- Stroke, Cerebrovascular Accident (CVA), Hemiparesis
- Trial name
- tVNS (NCT03592745)
- Testing
- Transcutaneous Vagus Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Northwell Health
Stroke, Rehabilitation
Neuromodulation for Functional Recovery After Stroke
This study used a multicenter, double-blind, randomized controlled design. The trial protocol was jointly designed by the principal investigator and an executive committee composed of experts in functional neurosurgery…
- Conditions
- Stroke, Rehabilitation, Vagus Nerve Stimulations
- Trial name
- VNS-EARLY (NCT07841431)
- Testing
- active VNS (0.8 mA), Control VNS (0.0 mA)
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Fibromyalgia
Vagus Nerve Stimulation for Treating Adults With Severe Fibromyalgia
Fibromyalgia syndrome (FMS) is a long-term disorder that is characterized by widespread body pain and tender points in joints, muscles, tendons, and other soft tissues.
- Trial name
- NCT00294281
- Testing
- Vagus Nerve Stimulation (VNS) Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Prader-Willi Syndrome
A Clinical Evaluation of Non-Invasive Vagus Nerve Stimulation for Temper Outbursts in People With PWS
The goal of the VNS4PWS clinical study is to test the efficacy, safety, and acceptability of transcutaneous vagus nerve stimulation (tVNS) treatment in people with PWS.
- Trial name
- VNS4PWS (NCT06144645)
- Testing
- tVNS, intermittent stimulation, tVNS, continuous stimulation
- Where
- 18 sites in United States
- Volunteers
- 102 people
- Sponsor
- Foundation for Prader-Willi Research
Stroke, Upper Extremity Motor Function
Invasive Vagus Nerve Stimulation Paired With Rehabilitation After Stroke
This study evaluated the feasibility, safety, and preliminary functional outcomes of invasive vagus nerve stimulation (iVNS) paired with upper-limb rehabilitation in participants with chronic stroke-related upper-limb motor…
- Conditions
- Stroke, Upper Extremity Motor Function, Intracerebral Hemorrhage
- Trial name
- VNS-Stroke (NCT07736573)
- Testing
- Invasive Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Beijing Chao Yang Hospital
Experimental Pain in Healthy Human Subjects
Tonic Pain and Transauricular Vagal Nerve Stimulation
This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception.
- Trial name
- NCT07325058
- Testing
- taVNS, Earlobe Stimulation
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Vagus Nerve Stimulation
Examining Transcutaneous Vagal Nerve Stimulation as a Facilitator of Social Bonding
This study aims to understand the role of the vagus nerve in promoting social bonding by using a non-invasive stimulation technique called transcutaneous vagal nerve stimulation (tVNS).
- Trial name
- CtVNS (NCT05899413)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Functional Gastrointestinal Disorders
Transcutaneous Electric Nerve Stimulation (TENS) for Vagal Modulation
This study is to determine if the auricular microstimulator produces the expected increase in HRV.
- Trial name
- NCT05987813
- Testing
- TENS Unit
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Partial Epilepsy, Surgery
Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy
The main objective of the study is twofold: 1. Assess the clinical efficacy of DBS on epilepsy according to their number and severity at 1 year follow up. 2.
- Trial name
- FRANCE (NCT02076698)
- Testing
- AN-DBS, Usual treatment
- Where
- 12 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Grenoble
Transcutaneous Vagal Nerve Stimulation (tVNS), Prader-Willi Syndrome
Proof of Concept Study of Vagus Nerve Stimulation
The investigator's recent pilot study of vagus nerve stimulation (VNS) from a surgically implanted medical device to control the excess eating behaviour characteristic of Prader-Willi Syndrome (PWS) found that it was safe and…
- Trial name
- NCT03689621
- Testing
- Transcutaneous vagus nerve stimulation (tVNS)
- Volunteers
- 9 people
- Sponsor
- Jessica Beresford-Webb
Mild Cognitive Impairment, Neurocardiogenic Syncope
VINCI-AD: An Investigation of Transcutaneous Vagus Nerve Stimulation in Mild Cognitive Impairment.
The VINCI-AD study will investigate the impact of non-invasive vagus nerve stimulation (VNS) on memory in participants with existing mild memory impairment. VNS is a safe, existing treatment, licensed in epilepsy and depression.
- Conditions
- Mild Cognitive Impairment, Neurocardiogenic Syncope, Memory Impairment, Inflammatory Response
- Trial name
- NCT05514756
- Testing
- Active t-VNS, Baseline assessments
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Tallaght University Hospital
Obesity and Diabetes Mellitus, Type 2
Effect of Tvns in Obesity
Avoid unhealthy foods, walk every day for at least 15 min , sleep well, he should take sessions at its time, family should Avoid disturbances, keep quiet as much as possible, make Analysis recoired before and after interaction.
- Trial name
- TVNS EFFECTS (NCT07334951)
- Testing
- Trans vagus nerve stimulation electrical device.
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Stroke, Cerebrovascular Accident
Effects of tVNS and mCIMT in Chronic Stroke
Stroke is a leading cause of death and disability worldwide, resulting in significant physical and cognitive impairments. Arm weakness is most common after stroke and its treatment is recognized as an area of considerable need.
- Trial name
- NCT07272239
- Testing
- Transcutaneous Vagus Nerve Stimulation, Modified Constraint Induced Movement Therapy with Routine Physical Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Psychosocial Well-being, Neurocognitive Function
taVNS + CCT for Neurocognitive Rehab
The purpose of this study is to investigate whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training might help improve thinking abilities and mood.
- Conditions
- Psychosocial Well-being, Neurocognitive Function, Cognitive Complaint, Cognitive Dysfunction
- Trial name
- NeuroHUB (NCT07517237)
- Testing
- taVNS, Computerized Cognitive Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Efficacy, Self, Fatigue; Muscle, Heart
Neuromodulation of the Autonomic Nervous System in Athletes
There are few studies in the literature that have evaluated the effects of using percutaneous stimulation of the auricular branch of the vagus nerve for sports purposes (to accelerate recovery after physical exertion).
- Conditions
- Efficacy, Self, Fatigue; Muscle, Heart, Fatigue, Mental, Fatigue; Combat
- Trial name
- NANSA (NCT06281795)
- Testing
- tVNS
- Where
- Russia
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Parkinson Disease
Balance Exercise and Vagus Nerve Stimulation on Weight-shifting Control and Ambulation in Parkinson Disease and Anxiety
Postural balance and anxiety are the two critical factors for reducing independence and quality of life in patients with Parkinson's disease (PD). Anxiety would deteriorate balance and gait dysfunction.
- Trial name
- NCT06476912
- Testing
- weight-shifting exercise
- Where
- Taiwan
- Volunteers
- 94 people
- Sponsor
- National Taiwan University Hospital
Nephrotic Syndrome in Children, Minimal Change Disease
taVNS for FRNS in Children
Children with frequently relapsing nephrotic syndrome (FRNS) are exposed to prolonged courses of steroids and other immunosuppressant medications.
- Conditions
- Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis
- Trial name
- kidNEY-VNS (NCT05588063)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Inflammatory Bowel Diseases (IBD), Remission of IBD
VIBRANT-IBD: Brain Effects of Non-Invasive Vagus Nerve Stimulation in IBD Remission
The VIBRANT-IBD study is a pilot, prospective, single-arm feasibility study investigating the effects of non-invasive vagus nerve stimulation (nVNS) in adults with inflammatory bowel disease (IBD) in clinical remission.
- Conditions
- Inflammatory Bowel Diseases (IBD), Remission of IBD, In Adults, Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
- Trial name
- VIBRANT-IBD (NCT07636304)
- Testing
- Non-invasive vagus nerve stimulation (nVNS)
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- University of Gdansk
Tinnitus
Vagus Nerve Stimulation (VNS) Paired With Tones for Tinnitus
Assess the safety and efficacy of VNS paired with tones for tinnitus using a randomized, controlled, parallel study design.
- Trial name
- NCT01962558
- Testing
- VNS Treatment, VNS Control
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- MicroTransponder Inc.
Epilepsy
Vagus Nerve Stimulation Clinical Outcomes Measured Prospectively in Patients Stimulated
Vagus Nerve Stimulation (VNS) Therapy has been approved marked for the treatment of epilepsy since 1994. This post-market study is designed to follow the clinical course and outcomes for patients with refractory seizures treated…
- Trial name
- V-COMPAS (NCT01281293)
- Where
- 20 sites in United States, Belgium and 3 more
- Volunteers
- 124 people
- Sponsor
- Cyberonics, Inc.