Clinical trials: Vagal Nerve Stimulation
Anxiety
Is Auriculotherapy Responsible for Improvements on Anxiety Students' Prior and After Examinations?
As the investigators have shown before, there was a tendency for a reduction of anxiety levels on university students after 30 minutes, with auriculotherapy treatment before examinations have started.
- Trial name
- NCT05042778
- Testing
- Auriculotherapy
- Where
- Portugal
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Vagus Nerve Stimulation in Reward Learning
Pulsed tVNS Protocol and Reinforcement Learning
The aim of this study is to investigate the potential of a phasic taVNS stimulation protocol for reinforcement learning. The investigators will disentangle its effects on learning actions and outcomes through the administration…
- Trial name
- NCT06205108
- Testing
- taVNS stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Healthy
Mapping Auricular Vagus Nerve Circuitry
This study will determine how noninvasive nerve stimulation affects human brain, stomach, and autonomic activity.
- Trial name
- NCT00200889
- Testing
- active TEAS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myocardial Injury
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Myocardial Injury in Elderly Patients Undergoing Thoracoscopic Surgery: a Prospective, Randomized Controlled Study
This research group plans to design a prospective, double-blind, randomized controlled study to explore the effect of taVNS on hs-cTnT in elderly patients undergoing thoracoscopic surgery, and to evaluate the effect on…
- Trial name
- NCT06759818
- Testing
- transcutaneous vagus nerve stimulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Jiaxing University
Acute Ischemic Stroke
Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions…
- Trial name
- NUVISTA (NCT05390580)
- Testing
- transcutaneous auricular vagal nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Motion Sickness
Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation
The purpose of this research study is to learn how a wearable nerve stimulation device, the Spark Biomedical's Sparrow Ascent System™, impacts the development of spatial disorientation and/or motion sickness in a healthy…
- Trial name
- NCT06892340
- Testing
- Transcutaneous Auricular Neurostimulation device
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Healthy Young Adults
Noninvasive Vagus Nerve Stimulation (VNS) for Neuromotor Adaptations
The study will examine how electrical stimulation of vagus nerve (i.e. nerve around the outer ear) from the skin surface during motor training influences a brain hormone (called norepinephrine), brain activity, and motor…
- Trial name
- NCT03628976
- Testing
- tVNS, Motor training
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Intracerebral Hemorrhage
Auricular VNS Following Intracerebral Hemorrhage
This study will evaluate whether non-invasive auricular vagal nerve stimulation lowers inflammatory markers, and improves outcomes following intracerebral hemorrhage.
- Trial name
- NCT06799390
- Testing
- Auricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Treatment Resistant Depression
A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
The primary objective of this study is to assess short, mid and long-term clinical outcomes in patients with difficult to treat depression (such as patients with treatment resistant depression) treated with Vagus Nerve…
- Trial name
- RESTORE-LIFE (NCT03320304)
- Testing
- Vagal Nerve Simulation (VNS) Therapy
- Where
- 18 sites in Austria, Belgium and 2 more
- Volunteers
- 500 people
- Sponsor
- LivaNova
Alcohol Use Disorder (AUD)
Research on the Heart-Brain Coupling Mechanisms and Interventions for Emotional Inhibitory Control Deficits in Individuals With Alcohol Use Disorder
The goal of this clinical trial is to understand whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with mindfulness training can improve emotional inhibitory control in adults with Alcohol Use Disorder…
- Trial name
- NCT07036055
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Mindfulness Training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Obesity & Overweight
Transcutaneous Auricular Vagus Nerve Stimulation for Poor Weight-Loss Response to Lifestyle Intervention
This single-center, randomized, single-blind, sham-controlled pilot study aims to evaluate the adjunctive effect of transcutaneous auricular vagus nerve stimulation (taVNS) in overweight/obese patients who show a poor weight loss…
- Trial name
- NCT07630597
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Neonatal Opioid Withdrawal Syndrome, Neonatal Abstinence Syndrome
Neurostimulation to Improve NOWS Outcomes
The objective of this study is to determine if tAN therapy can reduce the median number of days of oral morphine administered to an infant after start of treatment.
- Trial name
- SPROUT (NCT05129020)
- Testing
- Sparrow Fledging Therapy System
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- Spark Biomedical, Inc.
Generalized Anxiety Disorder
Transcutaneous Vagus Nerve Stimulation for Generalized Anxiety Disorder
This is a randomized, double-blind, parallel-controlled study of patients with generalized anxiety disorder, who will be randomly assigned to either drug-combined transcutaneous vagus nerve stimulation (tVNS) group or…
- Trial name
- NCT06134323
- Testing
- medication-combined transcutaneous vagus nerve stimulation
- Where
- 2 sites in China
- Volunteers
- 82 people
- Sponsor
- Xijing Hospital
Cluster Headache
A Randomized Multicentre Study for the Acute Relief of Episodic and Chronic Cluster Headache.
The study will look at a non-invasive treatment for people suffering with chronic and episodic headaches. Study subjects will be randomized to an active treatment or an in-active treatment for 2 weeks.
- Trial name
- NCT01958125
- Testing
- gammaCore
- Where
- 9 sites in Denmark, Germany and 2 more
- Volunteers
- 102 people
- Sponsor
- ElectroCore INC
Cognitive Function
The Effect of Transcutaneous Vagus Nerve Stimulation on Cognitive Function
Cognitive health is generally considered a key component of quality of life. Current evidence indicates that a large number of individuals are at a high risk for cognitive impairment from many causes as they age.
- Trial name
- NCT04070547
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- Czechia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Ostrava
Vestibular Diseases, Vestibular Vertigo
Investigation of the Efficacy of Non-Invasive Vagus Nerve Stimulation and Physiotherapy in Unilateral Vestibular Hypofunction Patients
The purpose of this study: To investigate the effectiveness of non-invasive vagus nerve stimulation and vestibular rehabilitation applications in patients diagnosed with Unilateral Vestibular Hypofunction (UVH).
- Conditions
- Vestibular Diseases, Vestibular Vertigo, Vertigo
- Trial name
- NCT06332326
- Testing
- non-invasive vagus nerve stimulation, vestibular rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Parkinson Disease, Idiopathic, Constipation
Ameliorating Effects and Mechanisms of TaVNS on Constipation in PD Patients.
The investigators intend to conduct a randomized, double-blind, sham-stimulation-controlled experiment, incorporating various clinical scales, gastrointestinal electrogram, and high-resolution anorectal manometry (HRAM), to…
- Trial name
- NCT06623591
- Testing
- active Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 30 people
- Sponsor
- Kezhong Zhang
Depressive Symptoms in Patients With Epilepsy
Efficacy of taVNS Versus Sham Stimulation in Reduing Depressive Symptoms in Patients With Epilepsy: a Multi-center, Double-blinded, Randomized, 20-week, Parallel-arm, Superiority Study
The purpose of this study is to compare the efficacy of taVNS versus sham stimulation in reduing depressive symptoms in patients with epilepsy.
- Trial name
- TIDES (NCT06794034)
- Testing
- Intervention
- Where
- 5 sites in China
- Volunteers
- 158 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
VNS-induced Corticospinal Plasticity
The goal of this study is to learn more about the connections between the brain, spinal cord, and muscles and how these connections can be strengthened after neurological injury.
- Trial name
- NCT04088565
- Testing
- Paired-Associative Stimulation (PAS), Vagus Nerve Stimulation (VNS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Burn Injury
Effect of Non-Invasive Vagus Nerve Stimulation in Burn Patients
This study will evaluate the effects of non-invasive vagus nerve stimulation (nVNS) in adults with burn injuries. Burn patients may experience anxiety, poor sleep quality, pain, itching, and changes in autonomic nervous system…
- Trial name
- NCT07566871
- Testing
- Non-Invasive Vagus Nerve Stimulation, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fenerbahce University