Clinical trials: Vaginal Bleeding, open to volunteers
Gynaecological Cancers, Ovarian Cancer
Methylation Profiling in Self-samples for Identification of (Epi)Genetic Biomarkers for Gynecological Cancers
The goal of the MYSSELF study is to investigate which biological markers (i.e., (epi)genetic biomarkers) found in self-collected samples, such as first-void urine and vaginal samples, are linked to the presence of endometrial…
- Conditions
- Gynaecological Cancers, Ovarian Cancer, Endometrial Cancer, Vulvar Cancer
- Trial name
- MYSSELF (NCT07902375)
- Testing
- Colli-Pee 20 mL device with UCM, Evalyn Brush
- Where
- Belgium
- Volunteers
- 730 people
- Sponsor
- Universiteit Antwerpen
Pregnancy of Unknown Location (PUL)
Expediting Pregnancy of Unknown Location Risk Stratification Using the ROM-Plus Point of Care Test
The goal of this study is to learn if the ROM-Plus bedside test can effectively triage patients who present with pregnancy of unknown location (PUL) and vaginal bleeding as high or low risk for ectopic pregnancy.
- Trial name
- NCT07519954
- Testing
- ROM-Plus bedside test
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Post Partum Hemorrhage
A Pragmatic Randomized Controlled Trial to Predict Postpartum Hemorrhage
This research project aims to enhance the safety of childbirth by using advanced computer models to predict the risk of postpartum hemorrhage (PPH). PPH is a significant concern for mothers during and after delivery.
- Trial name
- NCT06513351
- Testing
- Novel PPH Risk Prediction Model - Comparator Arm B
- Where
- United States
- Volunteers
- 12,500 people
- Sponsor
- Holly Ende
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Pelvic Organ Prolapse, Abnormal Uterine Bleeding
Evaluating Artisential Laparoscopic Instruments in Gynecologic Surgery
This study evaluates the efficacy and safety of Artisential laparoscopic instruments in minimally invasive gynecologic surgery.
- Conditions
- Pelvic Organ Prolapse, Abnormal Uterine Bleeding, Mesh Augmentation, Laparoscopic Surgery
- Trial name
- MIGS-ART (NCT06050161)
- Testing
- Articulating laparoscopic instrument, Conventional laparoscopic instrument, Robotic surgical instrument
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kern Medical Center
Post Partum Hemorrhage
Sublingual Oxytocin for the Prevention of Post-partum Hemorrhage
An open-label, randomized, single-center, dose ascending trial will be conducted to evaluate the efficacy and safety of sublingual oxytocin for the prevention of post-partum hemorrhage caused by uterine atony in term pregnant…
- Trial name
- NCT06968481
- Testing
- Oxytocin sublingual, Oxytocin IM
- Where
- Nigeria
- Volunteers
- 330 people
- Sponsor
- Insud Pharma
Menstruation Disturbances, Metrorrhagia
Transdermal Ethinyl Estradiol and Norelgestromin for Irregular Bleeding in Contraceptive Implant Users
The goal of this clinical trial is to evaluate the effectiveness of transdermal contraceptive patches in treating irregular vaginal bleeding in women over 18 years old who are using contraceptive implants and experiencing…
- Conditions
- Menstruation Disturbances, Metrorrhagia, Uterine Hemorrhage, Contraception Behavior
- Trial name
- NCT07083635
- Testing
- Transdermal Ethinyl Estradiol/Norelgestromin Patch
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Chulalongkorn University
Severe Postpartum Hemorrhage
Detection of Bleeding Disorders Diagnosed After Vaginal Delivery Complicated by Severe Postpartum Hemorrhage
A cohort study designed to detect bleeding disorders diagnosed in women who experienced severe postpartum hemorrhage after vaginal delivery
- Trial name
- DIDAPPH (NCT06970860)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Postmenopausal Bleeding
Evaluation of DNA Methylation Markers for Endometrial Cancer Risk-stratification Using Patient-collected Urine and Vaginal Samples and Clinician-collected Cervical Samples From Women With Postmenopausal Bleeding
The goal of this observational study is to investigate the clinical utility of DNA-methylation testing in urine and vaginal samples collected by patients and cervical samples collected by clinicians, to determine the risk of…
- Trial name
- NCT07400835
- Testing
- DNA-methylation testing in patient-collected urine and vaginal samples and clinician-collected cervical samples
- Where
- 3 sites in Denmark
- Volunteers
- 600 people
- Sponsor
- University of Aarhus
Uterine Fibroids (UF), Abnormal Uterine Bleeding Unrelated to Menstrual Cycle
POPQ Associated With Total Laparoscopic Hysterectomy
The goal of this observational study is to evaluate the impact of different hysterectomy (removal of the uterus) techniques on the risk of pelvic organ prolapse (situation when one or more of your pelvic organs like your bladder…
- Conditions
- Uterine Fibroids (UF), Abnormal Uterine Bleeding Unrelated to Menstrual Cycle, Endometrial Hyperplasia, Pelvic Organ Prolapse (POP)
- Trial name
- POP-LAP (NCT07137299)
- Testing
- Questionnaire and Physical Exam
- Where
- 4 sites in Poland
- Volunteers
- 2,000 people
- Sponsor
- Medical University of Silesia
Post Partum Hemorrhage
Evaluating Placental Thickness and Thickness of Uterine Muscle at Placenta Attachment in Prediction of Postpartum Blood Loss in Placenta Accreta
Aim of the Work is To determine the significance of the placental thickness and the thickness of the uterine muscle layer at placental attachment in the prediction of postpartum hemorrhage in cases of placenta previa accreta and…
- Trial name
- NCT06351969
- Where
- 2 sites in Egypt
- Volunteers
- 150 people
- Sponsor
- Benha University
Postmenopausal Women, Intrauterine Diseases
Office Hysteroscopy in Postmenopausal Women: A Randomized Trial of Cervical Preparation Strategies
The goal of this randomized controlled trial is to evaluate the effectiveness of different cervical preparation strategies before office hysteroscopy in postmenopausal women undergoing evaluation for intrauterine pathology.
- Conditions
- Postmenopausal Women, Intrauterine Diseases, Endometrial Pathology, Postmenopausal Bleeding
- Trial name
- NCT07697781
- Testing
- No Cervical Preparation, Misoprostol ( Cytotec) 200 microgram a tablet, Vaginal Estrogen (7-Day Regimen)
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Faculty of Medicine of Tunis
Postpartum Hemorrhage
Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section
Cesarean section (CS) is one of the most frequently performed operative interventions worldwide [1]. Cesarean section rates increase each year throughout the world.
- Trial name
- NCT06765473
- Testing
- Misoprostol
- Volunteers
- 400 people
- Sponsor
- Assiut University
Blood Loss
Local Tranexamic Acid During Vaginal Hysteractomy to Reduce Blood Loss
Assessing the efficiency of Prophylactic use of local tranexamic acid during vaginal hysterectomy to reduce blood loss during operation
- Trial name
- NCT04760301
- Testing
- local tranexamic acid injection, local normal saline injection to cervix
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Postpartum Complication, Postpartum Hemorrhage
Carbetocin vs Misoprostol for Postpartum Hemorrhage Prevention
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide, particularly among women with known risk factors.
- Trial name
- NCT07353281
- Testing
- Carbetocin 100 Microgram/mL Solution for Injection, Misoprostol
- Volunteers
- 146 people
- Sponsor
- Western Galilee Hospital-Nahariya
Postpartum Hemorrhage
Administration Of Calcium Gluconate for The Reduction of Blood Loss During Vaginal Delivery
Postpartum hemorrhage is one of the leading causes of maternal morbidity following childbirth. Even when excessive bleeding is not clinically recognized, some women experience a significant decrease in hemoglobin levels after…
- Trial name
- NCT07714902
- Testing
- calcium gluconate
- Where
- Israel
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Hemorrhage, Obstetric, Uterine Abnormality
Evaluation of the Non-inferiority of Resorbable Gelatin Embolization Compared to Embolization Combined With Endometrial Aspiration for the Management of Hemorrhagic Uterine Vascular Abnormalities Following Premature Termination of Pregnancy
The goal of this clinical trial is to determine the best treatment for patients who experience vaginal bleeding following a premature termination of pregnancy.
- Conditions
- Hemorrhage, Obstetric, Uterine Abnormality, Uterine Artery Embolization, Vaginal Bleeding During Pregnancy
- Trial name
- NIEMBUT (NCT07206342)
- Testing
- embolization therapy, embolization followed by aspiration
- Where
- 4 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Grenoble