Clinical trials: Vaginal Microbiome
Healthy
Pubic Hair and the Urinary and Vaginal Microbiome
This research study seeks to find if there is a connection between the presence of pubic hair and the type of bacteria that live in the vagina and bladder.
- Trial name
- NCT03272204
- Testing
- No pubic hair, Pubic Hair
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Margaret Mueller
Menopause
Satavari and Ashoka for Menopause (SAM) Study
This 12-week randomized, placebo-controlled clinical trial will evaluate the efficacy and safety of a daily oral supplement containing Ashoka Bark and Shatavari in women experiencing menopausal symptoms.
- Trial name
- SAM (NCT07861295)
- Testing
- Ashoka Bark and Shatavari
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vidya USA Corporation
Menopause
Estrogen and the Urogenital Microbiome in GSM
This is a study of how local estrogen treatment affects the microbiome of the vagina and bladder in postmenopausal women experiencing symptoms as part of "Genitourinary Syndrome of Menopause." The goal is to understand more about…
- Trial name
- NCT03336437
- Testing
- Estradiol vaginal ring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Bacterial Vaginosis, HIV Infections
Effect of Bacterial Vaginosis on HIV Susceptibility and Female Genital Immunology
A non-randomized, interventional, longitudinal clinical study to quantify the impact of bacterial vaginosis treatment on HIV susceptibility and genital immunology in Kenyan women.
- Trial name
- NCT02527941
- Testing
- Metronidazole
- Where
- Kenya
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Recurrent Bacterial Vaginitis
Vaginal Flora for Treatment of Bacterial Vaginosis
Bacterial vaginosis (BV) is the most common vaginal infection in women. It is caused by a vaginal bacterial imbalance. Treatment with antibiotics is the standard of care but there is a high rate of recurrence.
- Trial name
- VFT (NCT02236429)
- Testing
- vaginal flora transplant
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Vaginal Microbiome
Longitudinal Analysis of the Vaginal Microbiome
This is a longitudinal, observational study with the goal of understanding vaginal microbiome changes both within a single day and across a menstrual cycle.
- Trial name
- NCT05383326
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Viome
Urinary Tract Infections
Effects of Flourish on Recurrent Urinary Tract Infection
An over-the-counter vaginal care system is being tested to see if it may be effective in preventing recurrence of symptomatic urinary tract infection (UTI) in women who have had multiple UTIs within the past year.
- Trial name
- NCT05397782
- Testing
- BioNourish, a component of Flourish HEC
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Vaginal Biome Science
Bacterial Vaginosis
Flourish HEC to Prevent Recurrence of BV
In a population of women with heightened vulvovaginal sensitivity and recurrent bacterial vaginosis (BV), the use of the Flourish HEC Vaginal Care System is being tested for prevention of BV recurrence over six months of use.
- Trial name
- NCT05386147
- Testing
- Flourish HEC Vaginal Care System (contains a class II medical device plus other unregulated components)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vaginal Biome Science
Sexually Transmitted Infections (Not HIV or Hepatitis), Premature Birth
Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa
This cohort study plans to investigate associations between the presence of multiple lower genital tract microorganisms in pregnancy and gestational age at birth.
- Conditions
- Sexually Transmitted Infections (Not HIV or Hepatitis), Premature Birth, Pregnancy; Infection, Microbial Colonization
- Trial name
- NCT06131749
- Testing
- No intervention
- Where
- South Africa
- Volunteers
- 603 people
- Sponsor
- University of Bern
Vaginal Flora Imbalance
FB101 Intervention in Women Screened to Have Vaginal Dysbiosis (Dyscover-3)
This study will explore and map the potential shifts in vaginal microbiomes as a consequence of a microbial intervention with product FB101 in healthy, asymptomatic volunteer women screened to have vaginal dysbiosis based on…
- Trial name
- Dyscover-3 (NCT05850078)
- Testing
- FB101
- Where
- Ireland
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Freya Biosciences ApS
Implantation Failure
Vaginal Microbiome Influence on the Results of Assisted Reproduction Techniques
The objective of the present study to analyze the vaginal microbiome in patients who have not achieved gestation after oocyte donation treatment and after probiotic administration.
- Trial name
- RIFMicrobiome (NCT03153787)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 69 people
- Sponsor
- Instituto Bernabeu
Pregnancy
The Effect of Under-nutrition on the Human Microbiota
The purpose of this study is to determine whether a difference exists in the gut, oral, vaginal and human milk microbiome of under-nourished pregnant women as compared to healthy and obese pregnant women.
- Trial name
- NCT02021799
- Testing
- Moringa and Lactobacillus rhamnosus GR-1
- Where
- Tanzania
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Implantation Failure, Infertility, Female
Modulating the Vaginal Microbiome After Implantation Failure
Vaginal microbiome has in studies shown a link with the outcome of fertility treatment. The investigators wish to determine if it is possible to change an unfavorable vaginal microbiome using lactobacilli loaded vaginal…
- Conditions
- Implantation Failure, Infertility, Female, Vaginal Flora Imbalance
- Trial name
- NCT03843112
- Testing
- Vivag Plus
- Where
- Denmark
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Bacterial Vaginosis, Microbial Colonization
The Genital Microbiome of Male Partners of Women With Recurrent BV Undergoing Vaginal Microbiome Transplantation
There is strong observational evidence that sexual activity plays a key role in Bacterial Vaginosis (BV) acquisition and recurrence.
- Trial name
- NCT05963711
- Testing
- chlorhexidine gluconate 4%
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Vaginal Flora Imbalance
Chlorhexidine Gluconate Versus Povidone-iodine
A hysterectomy, or removal of the uterus, is a common surgery performed for a variety of reasons. During this surgery, to prevent infection, the vagina is thoroughly prepped with a cleansing solution, most commonly chlorhexidine…
- Trial name
- CHDvPI (NCT04658355)
- Testing
- Chlorhexidine Gluconate, Povidone-iodine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Vaginal Microbiome
Influence of Probiotics on the Vaginal Microbiota
The study aims to assess the influence of a probiotic supplement (OMNi-BiOTiC® FLORA plus +) on the vaginal microbiome composition of women suffering from infertility.
- Trial name
- NCT04471116
- Testing
- OMNi-BiOTiC® FLORA plus+
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Kinderwunsch Institut GmbH