Clinical trials: Vaginosis, Bacterial
Recurrent Bacterial Vaginosis
Vaginal Microbiota Transplant
This is a randomized trial of vaginal microbiome transplant vs. saline placebo to restore a Lactobacillus dominant vaginal microbial community in women with recurrent bacterial vaginosis.
- Trial name
- MOTIF (NCT04046900)
- Testing
- Vaginal microbiome transplant, Oral Metronidazole, Sterile saline
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Douglas Kwon
Invasive Candidiasis, Mucocutaneous Candidiasis
Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment
This is a multicenter, open label, non-comparator, single arm study to evaluate the efficacy and safety of ibrexafungerp (SCY-078) in patients ≥ 18 years of age with a documented fungal disease that has been intolerant or…
- Conditions
- Invasive Candidiasis, Mucocutaneous Candidiasis, Coccidioidomycosis, Histoplasmosis
- Trial name
- FURI (NCT03059992)
- Testing
- Ibrexafungerp
- Where
- 37 sites in United States, Austria and 6 more
- Volunteers
- 233 people
- Sponsor
- Scynexis, Inc.
Sexual Transmitted Disease, Vaginosis, Bacterial
Impact of Internal Menstrual Protections on Immunity and Vaginal Microbiota
The availability, effectiveness, and safety of menstrual protection represent a key public health issue. However, research on women's menstrual and sexual health remains extremely limited.
- Conditions
- Sexual Transmitted Disease, Vaginosis, Bacterial, Mycosis, Urogenital Disease
- Trial name
- CUPS2 (NCT07199998)
- Testing
- Samples collection (whole blood, urine, vaginal and cervical cells)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre National de la Recherche Scientifique, France
Vaginal Candidiasis
Postbiotic as Adjunct Treatment for Vaginal Candidiasis
This project aims to study the efficacy of oral administration of postbiotic at 1g/day as an adjunct treatment against vaginal candidiasis in women for 4-weeks compared to placebo.
- Trial name
- NCT06474247
- Testing
- Postbiotic
- Where
- 2 sites in India, Malaysia
- Volunteers
- 99 people
- Sponsor
- Min-Tze LIONG
Vaginal Dysbiosis, Vaginal Disease
Feasibility of an Oral Intervention for Sexual Health in Transgender Men
Transgender men (TGM) have a high incidence of sexually transmitted infected (STIs), including HIV, HPV and bacterial N. gonorrhea and C. trachomatis.
- Conditions
- Vaginal Dysbiosis, Vaginal Disease, Molecular-bacterial Vaginosis
- Trial name
- TEST-F (NCT06470906)
- Testing
- Probiotic Group
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pregnancy, Prematurity
Clindamycin to Reduce Preterm Birth in a Low Resource Setting
Preterm birth has been linked to certain types of vaginal infections. The goal of this study is to determine if giving women pregnant between 13-20 weeks with an elavated vaginal pH(evidence of this type of infection)Oral…
- Conditions
- Pregnancy, Prematurity, Preterm Birth, Bacterial Vaginosis
- Trial name
- NCT01800825
- Testing
- Clindamycin
- Where
- India
- Volunteers
- 1,726 people
- Sponsor
- Christiana Care Health Services
Bacterial Vaginosis
Treatment of Bacterial Vaginosis
We are trying to determine if longer duration of therapy with metronidazole or combination therapy of metronidazole plus azithromycin results in better cure rates for BV
- Trial name
- NCT00324818
- Testing
- metronidazole and azithromycin
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Bacterial Vaginosis
A Phase 3 Study of SPL7013 Gel (VivaGel) for the Treatment of Bacterial Vaginosis
The primary objective of the study is to assess the efficacy of 1% SPL7013 Gel compared to placebo gel for the treatment of bacterial vaginosis (BV).
- Trial name
- NCT01577238
- Testing
- 1% SPL7013 Gel
- Volunteers
- 250 people
- Sponsor
- Starpharma Pty Ltd
Bacterial Vaginosis
Safety and Efficacy of Vaginal Microbiota Transplant (VMT) in Women With Bacterial Vaginosis (BV)
The composition of a woman's vaginal microbiota has a significant impact on her reproductive tract health and general quality of life.
- Trial name
- NCT03769688
- Testing
- Cervicovaginal secretions, Metronidazole gel, Screening tests
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Vulvovaginal Candidiasis, Vaginal Yeast Infections
Zinc-containing Vaginal Gel and Oral Fluconazole for Vulvovaginal Candidiasis.
Vaginitis is one of the most common gynecological problems in women. Candida albicans is responsible for more than 85% of vaginal fungal infections and reinfection after standard treatment is quite common.
- Trial name
- NCT05895162
- Testing
- JUVIA zinc containing vaginal gel treatment, Fluconazole 150Mg Tab
- Where
- Hungary
- Volunteers
- 64 people
- Sponsor
- FEMPHARMA Kft.
Bacterial Vaginosis
Bacterial Vaginosis Carriage in Early Pregnancy and Preterm Delivery in Martinique, F.W.I
Preterm delivery is a public health priority in Martinique, a French oversees territory located in the Caribbean, with a rate of 10,5% substantially higher than in Continental France (7,5%).
- Trial name
- VaMap (NCT03303859)
- Testing
- Bacterial vaginosis
- Volunteers
- 511 people
- Sponsor
- University Hospital Center of Martinique
Vulvovaginal Candidiasis (VVC), Yeast Vaginitis
Clinical Study of a Vaginal Cooling Device for the Treatment of Vulvovaginal Candidiasis (VVC)
The objective of this study is to determine clinical cure rate and safety of a proprietary Vaginal Cooling Device (VCD) in women with VCC.
- Trial name
- NCT06983041
- Testing
- vaginal cooling device
- Where
- 10 sites in United States
- Volunteers
- 55 people
- Sponsor
- Coologics, Inc
Bacterial Vaginosis
A Clinical Study to Determine the Safety and Efficacy of an Oral Probiotic Supplementation to Improve Bacterial Vaginosis in Females
A Preliminary Investigation of the Safety and Effectiveness of Oral Probiotics Supplementation for Enhancing Vaginal Health in Females with Mild to Moderate Bacterial Vaginosis: An Open-Label, Single-Arm, Prospective…
- Trial name
- NCT06486103
- Testing
- MetSheFlora - Vaginal Health
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Bacterial Vaginosis
Will Lactobacillus Increase Cure Rate After Treatment of Bacterial Vaginosis and Chronic Vulvovaginal Candida
From the earlier studies the investigators have treated women with bacterial vaginosis and cronic vulvovaginal candida. The investigators have then treated them with laktobacilli 10 days for 2 month.
- Trial name
- NCT02295579
- Testing
- lactobacillus (EcoVag)
- Where
- 2 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Skaraborg Hospital
Premature Birth, Bacterial Vaginosis
Effect of Probiotic Lactobacilli on Vaginal Flora of Pregnant Women at High Risk for Preterm Delivery
Purpose of the study is to determine the effect of probiotic lactobacilli on the vaginal flora and cytokine profile during pregnancy, and the incidence of preterm labour in women at high risk for preterm birth.
- Trial name
- NCT00217308
- Testing
- Lactobacilli GR-1 and RC-14
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Bacterial Vaginosis
A Phase 2 Study of SYM-1219 to Treat Bacterial Vaginosis
The purpose of this research study is to test the safety and effectiveness of the oral investigational new drug, SYM-1219, for the treatment of bacterial vaginosis.
- Trial name
- NCT02147899
- Testing
- SYM-1219
- Where
- 16 sites in United States
- Volunteers
- 215 people
- Sponsor
- Symbiomix Therapeutics
Bacterial Vaginosis, Candidiasis
Topical Metronidazole and Miconazole Co-formulated Vaginal Suppositories for Preventing Vaginal Infections in HIV-seronegative Women
This research study is about vaginal infections such as bacterial vaginosis, yeast infections, and trichomoniasis. Usually, these infections can be treated with medication, but sometimes they come back after treatment.
- Conditions
- Bacterial Vaginosis, Candidiasis, Trichomoniasis
- Trial name
- NCT01230814
- Testing
- Neo-Penotran® Forte (active ingredient Metronidazole & Miconazole Nitrate)
- Where
- 4 sites in United States, Kenya
- Volunteers
- 234 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Vaginosis, Herpes Simplex Virus Type II
Valacyclovir Suppression to Improve the Stability of Vaginal Flora Among HSV-2 Seropositive Women
We will be examining the effects of suppressive valacyclovir therapy on the stability of vaginal flora in women who are seropositive for HSV-2.
- Trial name
- NCT00682721
- Testing
- Valacyclovir
- Where
- United States
- Sponsor
- University of Pittsburgh
Pregnancy Malaria, Bacterial Vaginoses
The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract
Malaria in pregnancy has devastating consequences for mother and foetus. WHO recommends intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) for asymptomatic women, but high-level parasite…
- Conditions
- Pregnancy Malaria, Bacterial Vaginoses, Trichomonas Vaginitis
- Trial name
- NCT04189744
- Testing
- IPTp-sulphadoxine-pyrimethamine plus metronidazole, IPTp-dihydroartemisinin-piperaquine plus metronidazole, IPTp-sulphadoxine-pyrimethamine
- Where
- Zambia
- Volunteers
- 5,436 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Recurrent Vulvovaginal Candidiasis
Study of Lactobacillus in Adjuvant Treatment of RVVC
We are trying to determine if Clotrimazole vaginal tablets with oral Lactobacillus is better than Clotrimazole vaginal tablets in Preventing the Recurrence of vulvovaginalcandidiasis
- Trial name
- NCT04699240
- Testing
- clotrimazole vaginal tablets, Clotrimazole vaginal tablets+ Lactobacillus
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Peking University Shenzhen Hospital