Clinical trials: Vagus Nerve Stimulation
Irritable Bowel Syndrome (IBS)
Exercise and Vagus Nerve Stimulation in IBS
The aim of the study was to consider the possible role of exercise and vagus nerve on bowel functionality in chronic IBS and to demonstrate that exercise and transcutaneous auricular stimulation of the vagus nerve can reduce…
- Trial name
- NCT06769516
- Testing
- Auricular Vagus Nerve Stimulation (aVNS), Aerobic Exercise Therapy, Low FODMAP Diet Intervention
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Bahçeşehir University
Parkinson Disease (PD)
Synthetic Vasomotion for Glymphatic Enhancement
The goal of this pilot clinical trial is to learn whether a week-long study combining controlled breathing procedures, intermittent exposure to a low-concentration carbon dioxide gas mixture, and noninvasive vagus nerve…
- Trial name
- NCT07814534
- Testing
- Active noninvasive vagus nerve stimulation, Active intermittent hypercapnia, Guided breathing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Vagus Nerve Stimulation
Effect of Transcutaneous Electrical Auricular Stimulation of the Vagus Nerve in Kidney Transplant Recipients
Kidney transplantation entails the implantation of a live or deceased organ into a recipient. As a result of this event, there is an inflammatory response in the recipient elicited by the transplanted organ.
- Trial name
- VNS-KTx (NCT04256837)
- Testing
- Transcutaneous electrical auricular vagus nerve stimulation (VNS)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Northwell Health
Chronic Pain (Back / Neck)
Effect of Virtual Reality and Trans Auricular X-Vagus Nerve Stimulation for Anxiety and Depression in Chronic Shoulder Pain Patients
Chronic shoulder pain is a debilitating condition that significantly impacts quality of life, daily functioning, and mental well-being.
- Trial name
- VIRTAX-ADSP (NCT07198737)
- Testing
- VR and VNS
- Where
- United Kingdom
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Parkinson Disease
Balance Exercise and Vagus Nerve Stimulation on Weight-shifting Control and Ambulation in Parkinson Disease and Anxiety
Postural balance and anxiety are the two critical factors for reducing independence and quality of life in patients with Parkinson's disease (PD). Anxiety would deteriorate balance and gait dysfunction.
- Trial name
- NCT06476912
- Testing
- weight-shifting exercise
- Where
- Taiwan
- Volunteers
- 94 people
- Sponsor
- National Taiwan University Hospital
Chronic Diabetic Foot Ulcers
Pilot Study on Auricular Vagus Nerve Stimulation Effects in Chronic Diabetic Wounds
The purpose of this pilot study is to evaluate the effect of auricular autonomous nervous system stimulation on vital parameters of wound healing in diabetics.
- Trial name
- NCT02098447
- Testing
- PrimeStim
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Migraine
Non-Invasive Neurostimulation for the Prevention of Chronic Migraine
The purpose of this multi-center, prospective, double-blind, randomized, sham-controlled pilot study is to study feasibility and collect preliminary clinical data related to the safety and clinical benefits of daily use of…
- Trial name
- NCT01667250
- Testing
- GammaCore Active Device
- Where
- 6 sites in United States
- Volunteers
- 59 people
- Sponsor
- ElectroCore INC
Gastroparesis, Functional Dyspepsia
Transauricular Vagal Nerve Stimulation; Functional Dyspepsia and Gastroparesis
The goal of this study is to establish parameters of gastric myoelectrical activity and heart rate variability in healthy human subjects and compare and contrast them to those with gastroparesis and functional dyspepsia, at…
- Conditions
- Gastroparesis, Functional Dyspepsia, Healthy, Digestive System Disease
- Trial name
- AVNS (NCT05405842)
- Testing
- Transauricular Vagal Nerve Stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Stroke, Stroke, Acute
Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients
This study aims to determine whether transcutaneous vagus nerve stimulation (tVNS) via auricular or cervical branches enhances recovery when combined with task-specific training in subacute stroke patients.
- Trial name
- NCT07253870
- Testing
- Transcutaneous vagus nerve stimulation through auricular branch along with task specific exercises, Transcutaneous vagus nerve stimulation through cervical branch along with task specific exercises
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Functional Dyspepsia
Transcutaneous Auricular Vagus Nerve Stimulation Treatment on Functional Dyspepsia
Objective: To observe the effect of the treatment of transcutaneous auricular vagus nerve stimulation (taVNS) for the functional dyspepsia (FD). Methods: We accrued 94 patients at Beijing TongRen Hospital.
- Trial name
- NCT04706871
- Testing
- taVNS, tnVNS
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing Tongren Hospital
Ischemic Stroke
Combined taVNS and tDCS in Subacute Stroke Patients
Ischemic stroke, the most prevalent neurological disorder, is treated with medication and thrombectomy but with limited success, especially in chronic stages where traditional rehabilitation is the primary option.
- Trial name
- NCT06244914
- Testing
- tDCS stimulation, taVNS stimulation
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Cheng-Kung University Hospital
Healthy
How Does the Type of Waveform Affect Tolerability With Transcutaneous Auricular Vagus Nerve Stimulation?
The purpose of this research study is to investigate the effects of different forms of a gentle form of electrical stimulation applied to the ear, known as transcutaneous auricular vagus nerve stimulation (taVNS).
- Trial name
- NCT06614933
- Testing
- Biphasic transcutaneous auricular vagus nerve stimulation, Monophasic transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Healthy Adults
Does Transcutaneous Vagal Nerve Stimulation Improves Fear Extinction in Humans
A recent study with rats showed that electrical stimulation of the vagus nerve (VNS) facilitates extinction of fear (Pena, Engineer, \& McIntyre, Biological Psychiatry, 2013).
- Trial name
- t-VNSext (NCT02113306)
- Testing
- t-VNS
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Visually Induced Motion Sickness in Healthy Volunteers
Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Visually Induced Motion Sickness in Healthy Volunteers
Nausea is a common and distressing experience that often precedes vomiting. Amongst symptoms emanating from the gastrointestinal (GI) tract nausea can be considered somewhat unique, as on one hand it represents a normal, highly…
- Trial name
- NCT02177890
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wingate Institute of Neurogastroenterology
Parkinson Disease, Idiopathic, Constipation
Ameliorating Effects and Mechanisms of TaVNS on Constipation in PD Patients.
The investigators intend to conduct a randomized, double-blind, sham-stimulation-controlled experiment, incorporating various clinical scales, gastrointestinal electrogram, and high-resolution anorectal manometry (HRAM), to…
- Trial name
- NCT06623591
- Testing
- active Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 30 people
- Sponsor
- Kezhong Zhang
PostTraumatic Stress Disorder
Closed Loop Vagal Nerve Stimulation for Patients With Posttraumatic Stress Disorder
The tasks of the project are to map the potency and kinetics of the neurologic, autonomic peripheral, inflammatory, and behavioral responses to vagal nerve stimulation (VNS) vs.
- Trial name
- NCT02992899
- Testing
- GammaCore/electroCore non-invasive VNS device, O-15 water
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Emory University
Vagus Nerve Stimulations
Comparison of the Acute Effects of Auricular Vagus Nerve Stimulation and Deep Breathing Exercise
The goal of this clinical trial is to investigate whether vagus stimulation and breathing exercises are more effective in healthy adults.
- Trial name
- NCT06740032
- Testing
- Transcutaneous vagus nerve stimulation, Deep breath exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Parkinson Disease, Idiopathic
Neuroprotective Effects of Long-term TaVNS in Early Parkinson's Disease Patients
This study is a randomized, double-blind, controlled trial exploring the effects of long-term taVNS intervention in patients with early-stage Parkinson's disease.
- Trial name
- NLTVNSPD (NCT06665113)
- Testing
- taVNS real stimulation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Kezhong Zhang
Stroke, Ischemic, Hemiplegia
Evaluation of Noninvasive Vagus Nerve Stimulation on Functional Status in Ischemic Stroke
In this study, the effectiveness of vagus nerve stimulation in patients with right and left hemiparesis will be compared with each other and with the sham application.
- Conditions
- Stroke, Ischemic, Hemiplegia, Hemiparesis;Poststroke/CVA
- Trial name
- NCT05809037
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Stroke, Stroke Treatment
Effects of Vagus Nerve Stimulation on Motor Function, Respiratory Muscle Strength, and Quality of Life in Stroke Patients
Stroke is one of the leading causes of death and permanent disability worldwide. Loss of upper extremity (UE) function after stroke significantly reduces independence and quality of life.
- Trial name
- NCT07259577
- Testing
- Robotics Assisted Education + taVNS
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa