Clinical trials: Vagus Nerve Stimulation
Insomnia
A Study of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Insomnia During Pregnancy
The goal of this clinical trial is to learn whether transcutaneous auricular vagus nerve stimulation (taVNS) can treat insomnia during pregnancy. It will also learn about the safety of taVNS for pregnant women and their fetuses.
- Trial name
- NCT07730762
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital
Post COVID Syndrome, Fatigue
Vagal Nerve Stimulation for Post COVID Fatigue
The purpose of this study is to evaluate the impact of vagal nerve stimulation on patients with post COVID syndrome who have fatigue and headache.
- Conditions
- Post COVID Syndrome, Fatigue, Headache
- Trial name
- NCT05445427
- Testing
- vagal nerve stimulator
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Diabetic Peripheral Neuropathy
Effect of Non-invasive Vagus Nerve Stimulation on Cognitive Functions in Diabetic Polyneuropathy Patients
Diabetic peripheral neuropathy (DPN) occurs due to long standing hyperglycemia and associated metabolic derangements. Cognitive impairment is a common complication in diabetes mellitus.
- Trial name
- NCT06048653
- Testing
- A computer based cognitive rehabilitation program (Rehacom system), Vagus nerve stimulation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- heba ahmed khalifa
Diabetes Mellitus, Diabetic Neuropathies
Use of taVNS for Painful Diabetic Neuropathy: 12-Week Randomized, Sham-Controlled Trial
This 12-week, randomized, double-blind, sham-controlled, parallel-group trial will evaluate the analgesic and mechanistic effects of home-based transcutaneous auricular vagus nerve stimulation (taVNS) in adults with painful…
- Conditions
- Diabetes Mellitus, Diabetic Neuropathies, Type2diabetes, Neuropathic Pain
- Trial name
- PAK-VAGUS (NCT06292962)
- Testing
- non-invasive transcutaneous vagal nerve stimulation (tVNS)
- Where
- Pakistan
- Volunteers
- 185 people
- Sponsor
- Saima Abass Tahammal
Heavy Drinking
Exploring the Effects of Brief Mindfulness Training With Vagal Nerve Stimulation on Alcohol Cue Reactivity Among Young Adult Heavy Drinkers
The present study will assess the acceptability and feasibility of a brief intervention designed to help young heavy drinkers reduce their alcohol consumption.
- Trial name
- NCT07516873
- Testing
- Active RAVANS, Brief Mindfulness-Based Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cambridge Health Alliance
Depression, Postoperative
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Breast Cancer Surgery Patients
A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of a single session of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on perioperative negative emotions (anxiety…
- Conditions
- Depression, Postoperative, Anxiety, Breast Surgery
- Trial name
- NCT07458646
- Testing
- Active taVNS
- Where
- 2 sites in China
- Volunteers
- 232 people
- Sponsor
- Chinese PLA General Hospital
Dysmenorrhea Primary
Pain Relief From Dysmenorrhea Employing taVNS
The goal of this clinical trial is to determine if transauricular vagal nerve stimulation (taVNS) is effective in treating moderate dysmenorrhea.
- Trial name
- taVNS-DYSM (NCT06912386)
- Testing
- taVNS
- Where
- China
- Volunteers
- 20 people
- Sponsor
- University of Electronic Science and Technology of China
Sepsis
Transcutaneous Auricular Vagus Nerve Stimulation as Adjuvant Treatment for Sepsis Patients
The goals of this randomized clinical trial are to investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) combined with standard intensive care on systemic organ function in septic patients, and…
- Trial name
- TaVNS-Sepsis (NCT07051694)
- Testing
- taVNS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Military Medical University
Obesity, Craving
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Food Craving in Obese Individuals.
Background: Obesity is one of the most important diseases around the globe; with a continuous increase and public health concern. Current treatments present some limitations.
- Trial name
- taVNS (NCT03217929)
- Testing
- Active-taVNS
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
COVID-19
Transcranial Non-invasive Electrical Stimulation of the Vagus Nerve in Hospitalized Moderate-to-severe COVID-19 Patients
Subtle Pulse Electro-biological Recovery Apparatus (SPERA) is an innovative device which delivers digital subliminal pulse stimulation trans cranially to auricular branches of the central nervous system and modulates the…
- Trial name
- NCT06767241
- Testing
- Non-invasive auricular vagus nerve stimulation, Standard Medical Therapy
- Where
- Romania
- Volunteers
- 83 people
- Sponsor
- University of Medicine and Pharmacy "Victor Babes" Timisoara
Drug-Resistant Epilepsy, Epilepsy
Ultrasound-Guided Intermediate Cervical Plexus Block for Postoperative Analgesia in Vagus Nerve Stimulation Surgery
This retrospective cohort study evaluated the medical records of adult patients who underwent vagus nerve stimulator (VNS) implantation under general anesthesia for drug-resistant epilepsy at Fırat University Hospital between…
- Conditions
- Drug-Resistant Epilepsy, Epilepsy, Postoperative Pain
- Trial name
- NCT07689617
- Testing
- Ultrasound-guided intermediate cervical plexus block, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Firat University
Autism Spectrum Disorder
Non-invasive Auricular Fiber Vagus Nerve Stimulation (afVNS) for Treatment of Autism Spectrum Disorder
Non-invasive vagus nerve stimulation for the symptomatic improvements in Autism Spectrum Disorder
- Trial name
- NCT06473623
- Testing
- vagus nerve stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Neuropix
Rheumatoid Arthritis (RA)
Treatment With Auricular Vagus Nerve Stimulation in Rheumatoid Arthritis - the TRAVAGA Study
Purpose and aim The overall aim is to investigate efficacy and safety of a newly developed non-invasive auricular investigational device that electrically stimulates the auricular branch of the vagus nerve to activate the…
- Trial name
- TRAVAGA (NCT06779123)
- Testing
- Transauricular vagus nerve stimulation., transauricular vagus nerve non-stimulation
- Where
- 6 sites in Sweden
- Volunteers
- 128 people
- Sponsor
- taVNS AB
Crohn Disease
Long Term Observational Study of a Vagal Nerve Stimulation Device in Crohn's Disease
This will be an open label multicenter study of the safety and efficacy of an active implantable VNS device in patients with Crohn's Disease.
- Trial name
- NCT02951650
- Testing
- Cyberonics VNS
- Where
- 4 sites in Croatia, Italy and 2 more
- Volunteers
- 15 people
- Sponsor
- SetPoint Medical Corporation
Tinnitus, Subjective, Vagus Nerve Stimulation
Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus
This clinical study is a prospective, multicenter, randomized, controlled, double-blind clinical study. Sun Yat Sen Memorial Hospital of Sun Yat sen University was the central unit, and Nanjing First Hospital, Sun Yat Sen…
- Conditions
- Tinnitus, Subjective, Vagus Nerve Stimulation, Music Therapy, Double-Blind Method
- Trial name
- NCT05417711
- Testing
- Transcutaneous Vagus Nerve Stimulation Paired with Tailor-Made Notched Music Therapy, Tailor-made Notched Music Training
- Volunteers
- 388 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Upper Limb Deficit, Stroke Gait Rehabilitation
Impact of VNS With Rehab on Gait Post-Stroke
This is a prospective, double-blinded, randomized controlled study to evaluate the impact of Vagus Nerve Stimulation (VNS) therapy on lower limb function.
- Conditions
- Upper Limb Deficit, Stroke Gait Rehabilitation, Stroke
- Trial name
- NCT07643337
- Testing
- Vagus Nerve Stimulation Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- State University of New York at Buffalo
Chronic Dizziness, Persistent Postural Perceptual Dizziness
A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness
The purpose of this study is to measure the change in dizziness, as measured by change in Dizziness Handicap Inventory (DHI) score, following a 4-week treatment period with auricular transcutaneous vagus nerve stimulation (aTVNS).
- Trial name
- NCT07420803
- Testing
- Auricular transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Vaping
Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study
The purpose of this study is to assess the effects of non-invasive vagus nerve stimulation (nNVS) on cognitive functioning in the users of e-cigarettes or vaping products.
- Trial name
- nVNS (NCT06804109)
- Testing
- Active nVNS, Control nVNS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Temple University
Transcutaneous Vagus Nerve Stimulation, Diabetic Peripheral Neuropathy
Low Level Laser VS Transcutaneous Vagus Nerve Stimulation on Vascular Changes in Patients With Diabetic Polyneuropathy
To compare the effect of both low-level laser versus transcutaneous vagus nerve stimulation on vascular changes in patients with diabetic polyneuropathy
- Trial name
- NCT07078058
- Testing
- Low level laser, Transcutaneous auricular Vagus nerve stimulation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Horus University
Experimental Pain in Healthy Human Subjects
Tonic Pain and Transauricular Vagal Nerve Stimulation
This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception.
- Trial name
- NCT07325058
- Testing
- taVNS, Earlobe Stimulation
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Aalborg University