Clinical trials: Vagus Nerve Stimulations
Postoperative Delirium
The Effect of Transcutaneous Electrical Acupoint Stimulation Combined With Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery
The aim of this clinical trial is to study the effect of transcutaneous electrical acupoint stimulation combined with auricular vagus nerve stimulation on postoperative delirium in elderly patients undergoing gastrointestinal…
- Trial name
- NCT07045090
- Testing
- Transcutaneous electrical acupoint stimulation, Transcutaneous electrical acupoint stimulation combined with auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Affiliated Hospital of Nantong University
Chronic Migraine
Non-Invasive Neurostimulation for the Prevention of Chronic Migraine
The purpose of this multi-center, prospective, double-blind, randomized, sham-controlled pilot study is to study feasibility and collect preliminary clinical data related to the safety and clinical benefits of daily use of…
- Trial name
- NCT01667250
- Testing
- GammaCore Active Device
- Where
- 6 sites in United States
- Volunteers
- 59 people
- Sponsor
- ElectroCore INC
Stroke, Dysphagia
Auricular Vagus Nerve Stimulation and Post-Stroke Dysphagia in Older Adults
This study investigates the effect of non-invasive transcutaneous auricular vagus nerve stimulation (tVNS-E) on swallowing rehabilitation in patients over 70 years old after stroke.
- Trial name
- SVA-DPA (NCT07428590)
- Testing
- tVNS-E active device, tVNS-E inactive device
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Fatigue, Recovery, Psychological
Effects of Transcutaneous Vagus Nerve Stimulation on Recovery
During the recovery process, the activity of the sympathetic system decreases, while the activity of the parasympathetic system increases.
- Trial name
- NCT06566118
- Testing
- Auricular Vagus Nerve Stimülation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
COVID, Corona Virus Infection
Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms
The study is a prospective, randomized, controlled investigation designed for comparison of two groups for the reduction of respiratory distress in a CoViD-19 population, using gammaCore Sapphire (nVNS) plus standard of care…
- Conditions
- COVID, Corona Virus Infection, Respiratory Failure, Respiratory Distress Syndrome, Adult
- Trial name
- SAVIORII (NCT04382391)
- Testing
- gammaCore® Sapphire (non-invasive vagus nerve stimulator), Standard of care therapies
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Meniere Disease
Transcutaneous Auricular Vagus Nerve Stimulation for Meniere Disease
Objective: To evaluate the effect of Transcutaneous auricular vagus nerve stimulation for the patients Meniere disease. Methods: We enrolled 231 patients at Beijing TongRen Hospital.
- Trial name
- NCT06544590
- Testing
- taVNS, Betahistine Mesylate tablet
- Where
- China
- Volunteers
- 77 people
- Sponsor
- Beijing Tongren Hospital
Hearing Loss
Pupillary Dilation During Post-Auricular Vagal Nerve Stimulation
The research team will evaluate pupillary dilation from vagal nerve stimulation of Arnold's Nerve, a branch of the vagus nerve, during routine cochlear implantation surgery.
- Trial name
- NCT05870527
- Testing
- Electrical stimulator
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Spinal Cord Injuries
Technology Development for Physical Rehabilitation of Patients With Upper Extremity Motor Deficits (RePlay)
Injuries and disease processes that produce upper extremity deficits are devastating to patients and their families. One potential avenue to treat these neurological disorders is through the enhancement of neural plasticity…
- Trial name
- RePlay (NCT03621969)
- Testing
- Physical exam and medical history, Assessments, Patient Instruction and use of Device (RePlay)
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Gastroparesis
Vagal Nerve Stimulation for Gastroparesis
This study is investigating a new form of treatment for a digestive disorder called gastroparesis. Gastroparesis is thought to be caused by a mix of inflammation and neural dysfunction.
- Trial name
- VNS (NCT03120325)
- Testing
- Vagal Nerve Stimulation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Young Adults
Noninvasive Vagus Nerve Stimulation (VNS) for Neuromotor Adaptations
The study will examine how electrical stimulation of vagus nerve (i.e. nerve around the outer ear) from the skin surface during motor training influences a brain hormone (called norepinephrine), brain activity, and motor…
- Trial name
- NCT03628976
- Testing
- tVNS, Motor training
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Parkinson Disease, Apathy
A Randomized Double-Blind Active-Controlled Crossover Trial of Respiratory-Gated Versus Non-Gated Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Motor and Non-Motor Symptoms in Parkinson's Disease
The goal of this clinical trial is to compare the effects of different modes and frequencies of transcutaneous auricular vagus nerve stimulation (taVNS) on motor and non-motor symptoms in people with Parkinson's disease.
- Conditions
- Parkinson Disease, Apathy, Sleep Disorder, Motor Disorders
- Trial name
- NCT06642454
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Anhui Medical University
Motion Sickness
Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation
The purpose of this research study is to learn how a wearable nerve stimulation device, the Spark Biomedical's Sparrow Ascent System™, impacts the development of spatial disorientation and/or motion sickness in a healthy…
- Trial name
- NCT06892340
- Testing
- Transcutaneous Auricular Neurostimulation device
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Smoking Cessation
A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation
The purpose of this study is to provide preliminary evidence for the efficacy of 12 weeks of vagal nerve stimulation (VNS) and nicotine replacement therapy (NRT) for increasing smoking abstinence rates.
- Trial name
- NCT07487818
- Testing
- Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Thyroid Disease, Recurrent Laryngeal Nerve Injury
Low-Current Stimulation for Recurrent Laryngeal Nerve Protection During Thyroid Surgery
This single-center prospective randomized interventional study evaluated whether intraoperative low-current stimulation could assist recurrent laryngeal nerve localization and reduce temporary recurrent laryngeal nerve injury…
- Trial name
- NCT07706699
- Testing
- 3 mA low-current stimulation-assisted recurrent laryngeal nerve identification, 5 mA low-current stimulation-assisted recurrent laryngeal nerve identification
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Asthma, Syncope
Vagal Nerve Stimulation Assessed by the Diving Reflex: An Investigation Into Mechanisms of Asthma Death
The investigators' hypothesis is that dysregulation of autonomic function, as revealed during a simulated dive reflex, may result in an attenuation of the heart rate response to a greater degree in asthmatics who collapse during…
- Trial name
- NCT02083029
- Testing
- Simulated dive reflex
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Breast Cancer
MindVybe tVNS/APS for Wellbeing in Breast Cancer Survivors
This study tests whether a gentle, non-invasive device called mindvybe can help improve feelings of wellbeing in people who have had breast cancer.
- Trial name
- NCT07782866
- Testing
- Transcutaneous vagus nerve and acupuncture point stimulation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The Healing Consciousness Foundation
Atrial Fibrillation
Vagal Nerve Stimulation for the Treatment of Persistent AF
The goal of this clinical trial is to answer the question whether a transcutaneous stimulation of a certain nerve (Nervus vagus) with a dedicated device reduces the recurrence of the heart rhythm disorder atrial fibrillation.
- Trial name
- VAST-AF (NCT05833373)
- Testing
- Vagal stimulation with the device tVNS from tVNS Technologies GmbH
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Krankenhaus Hetzelstift
PTSD
Non-invasive Nerve Stimulation and Sleep
People often have difficulty sleeping. Reasons are many. But, difficulty falling and staying asleep are common issues. Sleep difficulties are common in disorders such as Post Traumatic Stress Disorder.
- Trial name
- NINS (NCT04021537)
- Testing
- non-invasive nerve stimulation
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Depressive Disorder
tVNS for Depression
This is a phase II, randomized, sham controlled, clinical trial. This clinical trial has as primary objective to evaluate changes in depressive symptoms of a transcutaneous Vagus Nerve Stimulation (tVNS) treatment protocol for…
- Trial name
- NCT02562703
- Testing
- Transcutaneous Vagus Nerve Stimulation
- Volunteers
- 40 people
- Sponsor
- Santa Casa Medical School
Spinal Cord Injuries
Auricular Vagus Nerve Stimulation (aVNS) in Chronic Spinal Cord Injuries (SCI)
The purpose of this research is to test if Auricular Vagal Nerve Stimulation (aVNS) is safe in persons with spinal cord injury (SCI).
- Trial name
- NCT06588608
- Testing
- auricular nerve stimulation (aVNS)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Miami