Clinical trials: Vagus Nerve Stimulations
Endometriosis
Treatment of Chronic Pelvic Pain Due to Endometriosis by Transcutaneous Auricular Vagus Nerve Stimulation
6-10% of women of childbearing age suffer from endometriosis, which is mainly manifested by dysmenorrhea, non-menstrual pelvic pain and dyspareunia.
- Trial name
- Stim-Endom (NCT04177511)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Hopital Foch
Post-Treatment Lyme Disease
taVNS for Persistent Symptoms From Lyme Disease
This study is one of the first studies to investigate a non-antibiotic approach to the treatment of symptoms that persist after antibiotic treatment for Lyme disease (PTLS).
- Trial name
- NCT05776251
- Testing
- taVNS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Columbia University
Borderline Personality Disorder
Transcutaneous Vagus Nerve Stimulation (tVNS) for Borderline Personality Disorder (tVNS-BPD)
The goal of this clinical trial is to test the efficacy of transcutaneous vagus nerve stimulation (tVNS) in borderline personality disorder.
- Trial name
- tVNS-BPD (NCT05892900)
- Testing
- Transcutaneous vagus nerve stimulation (tVNS)
- Where
- Sweden
- Volunteers
- 42 people
- Sponsor
- Sahlgrenska University Hospital
fMRI, Transcutaneous Vagal Nerve Stimulation (tVNS)
Neural Correlates of tVNS
Transcutaneous vagal nerve stimulation (tVNS) has been applied to a number of disease areas including visceral pain, depression, cluster headache and Alzheimer's disease.
- Conditions
- fMRI, Transcutaneous Vagal Nerve Stimulation (tVNS), Nucleus of the Solitary Tract (NTS)
- Trial name
- NCT04810234
- Testing
- transcutaneous vagal nerve stimulation (tVNS)
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Autonomic Dysfunction, Autonomic Imbalance
Non-Invasive Bioelectronic Analytics
Biomarkers can be evaluated to provide information about disease presence or intensity and treatment efficacy. By recording these biomarkers through noninvasive clinical techniques, it is possible to gain information about the…
- Conditions
- Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
- Trial name
- NIBA (NCT04100486)
- Testing
- Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Neck Pain, Heart Rate Variability
Compare the Effects of Different AVNS Parameters on Neck Pain, HRV, Balance in Collegiate Atheletes
This study looks at how auricular vagus nerve stimulation (AVNS) affects neck pain, heart rate variability, and balance in college athletes, additionally, if different settings of auricular vagus nerve stimulation (AVNS) affect…
- Conditions
- Neck Pain, Heart Rate Variability, Balance
- Trial name
- NCT06450483
- Testing
- Auricular vagus nerve stimulation
- Where
- United Arab Emirates
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Cancer-related Fatigue
Feasibility and Expansion Trial of Transcutaneous Vagus Nerve Stimulation (tVNS) for Immune-Related Fatigue in Patients Receiving Immune Checkpoint Inhibitors
This study evaluates whether a non-invasive device called transcutaneous vagus nerve stimulation (tVNS) can be safely and feasibly used to help reduce fatigue in patients receiving immunotherapy for cancer.
- Trial name
- NCT07529431
- Testing
- Participants will self-administer transcutaneous vagus nerve stimulation (tVNS) at home using a non-invasive auricular stimulation device for 60 minutes per day over a 6-week period. Participants will
- Volunteers
- 13 people
- Sponsor
- University of Vermont Medical Center
Generalized Anxiety Disorder
Transcutaneous Vagus Nerve Stimulation for Generalized Anxiety Disorder
This is a randomized, double-blind, parallel-controlled study of patients with generalized anxiety disorder, who will be randomly assigned to either drug-combined transcutaneous vagus nerve stimulation (tVNS) group or…
- Trial name
- NCT06134323
- Testing
- medication-combined transcutaneous vagus nerve stimulation
- Where
- 2 sites in China
- Volunteers
- 82 people
- Sponsor
- Xijing Hospital
Emergence Agitation, Emergence Delirium
Transcutaneous Auricular Vagus Nerve Stimulation for Prevention of Emergence Agitation and Delirium in Children Undergoing Tonsillectomy and Adenoidectomy
Brief Summary This study is designed to find out whether transcutaneous auricular vagus nerve stimulation (taVNS) can safely reduce restlessness and confusion when children wake up from anesthesia after tonsillectomy and…
- Trial name
- NCT07394647
- Testing
- Active taVNS Group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Ischemic Stroke, Upper Extremity Paresis
A Trial of Rehabilitation Paired With VNS for Motor Function in Patients With Stroke (Repair Study)
The goal of this clinical trial is to investigate the efficacy and safety of vagus nerve stimulation (VNS) paired with rehabilitation for enhancing upper extremity motor function after ischemic stroke.
- Trial name
- NCT06722677
- Testing
- VNS, Rehabilitation
- Where
- 13 sites in China
- Volunteers
- 99 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Autonomic Nervous System Modulation, Pain Perception
Pain Perception and the Autonomic Nervous System
In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.
- Conditions
- Autonomic Nervous System Modulation, Pain Perception, Pain Sensitivity, Central Sensitization
- Trial name
- NCT06667895
- Testing
- respiratory gated taVNS, random burst stimulation, continuous stimulation
- Where
- Switzerland
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Alzheimer Disease (AD)
Alzheimer's Disease Treated With Vagus Nerve Stimulation
The goal of this clinical trial is to evaluate the safety and efficacy of vagus nerve stimulation (VNS) for treating Alzheimer's disease (AD) in patients aged 50-80 years with mild cognitive impairment to moderate Alzheimer's…
- Trial name
- Advant (NCT06923007)
- Testing
- Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Beijing Municipal Administration of Hospitals
Refractory Epilepsy
Acute and Long Term Effects of VNS on Memory in Patients With Refractory Epilepsy
Refractory epilepsy patients implanted with a vagus nerve stimulator perform a memory test at baseline in three conditions: invasive vagus nerve stimulation (VNS), transcutaneous vagus nerve stimulation (taVNS) and sham…
- Trial name
- NCT05031208
- Testing
- Memory task
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University Hospital, Ghent
Inflammatory Response
The Effect of Vagus Nerve Stimulation on the Inflammatory Response After Lung Lobectomy
Systemic inflammation is a potentially debilitating complication of thoracic surgeries that can result in significant physical and economic morbidity for afflicted patients.
- Trial name
- NCT03204968
- Testing
- Vagus nerve stimulation
- Where
- Austria
- Volunteers
- 130 people
- Sponsor
- Otto Wagner Hospital
Arthritis, Rheumatoid
The Reboot Study: A Safety Study of Abdominal Vagus Nerve Stimulation for Moderate to Severe Drug Refractory Rheumatoid Arthritis
This open label clinical trial aims to assess the safety of abdominal vagus nerve stimulation (aVNS) for moderate to severe, adult-onset rheumatoid arthritis (RA) that has not responded to medication.
- Trial name
- Reboot (NCT07017686)
- Testing
- abdominal vagus nerve stimulation (aVNS)
- Where
- 3 sites in Australia
- Volunteers
- 5 people
- Sponsor
- The Bionics Institute of Australia