Clinical trials: Validation
Chronic Liver Disease
Validation of the Second Generation of the Controlled Attenuation Parameter (CAP) Using the MRI-PDFF as Reference
Chronic liver diseases (CLDs) represent a major worldwide public health burden. Worldwide estimations show that 844 million people have CLDs, a lot more than other chronic diseases such as diabetes or cardiovascular diseases.
- Trial name
- NCT03704792
- Testing
- FibroScan 530 Compact
- Where
- 5 sites in France
- Volunteers
- 207 people
- Sponsor
- Echosens
Insulin Sensitivity/Resistance
Assessment of Insulin Sensitivity in Healthy Adults by a 13C-glucose Breath Test : Method Development and Validation
The current research project aims to assess the insulin resistance (less sensitivity), from measures of insulin and glucose in response to a standard oral intake of glucose (standardized oral glucose tolerance test).
- Trial name
- NCT06766617
- Testing
- 75 gr Glucose
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Cancer, Biomarker Discovery and Validation
Biomarkers for Cancer Treatment
Circulating biomarkers, such as miRNAs and proteomics, undergo identifiable and measurable changes during and following treatment for cancer, compared to pre-treatment baseline.
- Trial name
- NCT07803289
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Pulmonary Disease, Copd
Validation and Characterization of Signal Decrease on an Oximeter in COPD (They Have Chronic Obstructive Pulmonary Disease) Patients During Deep Inhalation (
The objective is to verify that there is a decrease in the pulsed oxygen saturation with the digital sensor. That is, the drop in oxygen saturation in COPD patients during inhalation is real and not due to an artifact of the…
- Trial name
- OXYMETRE (NCT03966196)
- Testing
- Measurements of oxygen saturation and finger pressure during deep inspiration
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Atrial Fibrillation
WIBOFA - Validation of SCT02 With ECG-App for Detection of AF
The aim of the study is to evaluate the performance of Withings SCT02 with embedded Withings ECG-app in the automatic detection of atrial fibrillation
- Trial name
- WIBOFA (NCT06351761)
- Testing
- Investigational Device (Withings SCT02) 30 second Electrocardiogram recording, Reference Device (Schiller Cardiovit FT-1) 30 second Electrocardiogram recording
- Where
- 4 sites in United States, France
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- Withings
Dental Caries, Caries Risk
Validation of a Digital Caries Risk Assessment Questionnaire Against the CAMBRA Protocol in an Egyptian Adult Population
This study is designed as a cross-sectional diagnostic agreement study conducted in accordance with the Standards for Reporting Diagnostic Accuracy Studies (STARD 2015) and the Guidelines for Reporting Agreement and Precision of…
- Trial name
- NCT07716254
- Testing
- Digital Caries Risk Assessment
- Where
- Egypt
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Chronic Kidney Diseases
External Validation of Clinical Prediction Tools for Estimating Salt and Potassium Intake in Nephrology Patients.
There is no validated self-questionnaire to assess salt and potassium intake in nephrology patients. Using Bayesian models, researchers developed clinical prediction tools to estimate salt and potassium intake in nephrology…
- Trial name
- UniverSel (NCT05783960)
- Testing
- administration questionary
- Where
- 5 sites in France
- Volunteers
- 629 people
- Sponsor
- Hospices Civils de Lyon
AI (Artificial Intelligence)
Scientific Validity Assessment and Optimization of AI-Generated A3/A4 Type Questions for the Chinese Medical Licensing Examination
This is a cross-sectional study that primarily employs quantitative analysis, supplemented by qualitative assessment. The research is conducted in two stages: Phase I consists of a model performance comparison experiment, and…
- Trial name
- NCT07505862
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Colorectal Cancer Stage III, Liver Metastasis Colon Cancer
GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Colorectal Cancer
Improving personalized cancer treatments and finding the best strategies to treat each patient relies on using new diagnostic technologies.
- Trial name
- NCT06111105
- Where
- 15 sites in Austria, Denmark and 3 more
- Volunteers
- 590 people
- Sponsor
- Claus Lindbjerg Andersen
Healthy
The Influence of Personality on Two Aspects of Cognitive Performance: Processing Speed, and Accuracy.
Recently, a lot of evidence for a relation between measures of cognitive performance and personality characteristics has been collected.
- Trial name
- NCT00729820
- Volunteers
- 30 people
- Sponsor
- BeerYaakov Mental Health Center
Bowel Dysfunction, Dysmotility
Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children
The goal of this clinical trial is to learn if the new non-invasive device (Body Surface Colonic Mapping) works to accurately assess colonic movement and function in children.The main questions it aims to answer are: Are Body…
- Conditions
- Bowel Dysfunction, Dysmotility, Hirschsprung Disease, Anorectal Malformations
- Trial name
- NCT07789782
- Testing
- Body Surface Colonic Mapping
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Murdoch Childrens Research Institute
Stroke
Reliability and Validity of Modified Postural Assessment Scale for Stroke Patients and the Application of This Scale on Early Detection of Patients With Stroke at High Risk of Falls
The purposes of this study are to investigate the reliability and validity of the modified Postural Assessment Scale for Stroke Patients (mPASS) and its applications in early detection of fall-prone patients.
- Trial name
- NCT00166959
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Hyperoxaluria
Validation Testing for Plasma Oxalate Levels in the Biochemical Laboratory at the Galilee Medical Center, in Collaboration With the Biochemistry Laboratory at CHARITE Hospital in Berlin, and Testing the Relationship Between Oxalate Levels and Vitamin C Levels in Plasma
Background: Elevated plasma oxalate levels in various conditions, including: primary hyperoxaluria due to increased production in the liver, renal failure due to decreased renal excretion, intestinal diseases with fatty diarrhea…
- Trial name
- NCT06578754
- Testing
- This is an non-interventional study
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Fragile X Syndrome
Validation of Saliva in the Esoterix Genetic Laboratories Fragile X Assay
The purpose of this research is to determine if saliva samples can be used as an alternate sample type to test for fragile X. By using saliva instead of blood, it would be easier for patients to have fragile X testing.
- Trial name
- NCT01616589
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Esoterix Genetic Laboratories, LLC
Psychological Distress
Validation of the Spanish Version of the Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) in Chile
AIM: study the psychometric properties of the Spanish version of the Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM), an instrument that measures psychological distress, in the Chilean population.
- Trial name
- NCT04122079
- Where
- Chile
- Volunteers
- 1,120 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Mental Health
Intervention in Groups of Family Caregivers in Primary Health Care
Although Primary Health Care (PHC) Teams are used to deal with prevention and treatment of sanitary problems in adults with chronic diseases, they usually have a lack of experience in development of psychotherapeutic…
- Trial name
- IGFC (NCT01177696)
- Testing
- Psychotherapeutic intervention
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Skin Cancer, Actinic Keratoses
Validation of SHADE a Mobile Technology for Monitoring of Ultraviolet Exposure
This study will evaluate the safety and effectiveness of Shade for the management of UV-induced skin complications and data collected from this study will be used to support the proposed indications for use.
- Conditions
- Skin Cancer, Actinic Keratoses, Ultraviolet-Induced Change in Normal Skin, Behavior, Health
- Trial name
- NCT03315286
- Testing
- SHADE Ultraviolet Sensor, Standard of care counseling
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Weill Medical College of Cornell University
HCC - Hepatocellular Carcinoma, Cirrhosis
Non-invasive Assessment for Outcome Prediction in Patients With Hepatocellular Carcinoma
This is a single-centre, prospective cohort study. Consecutive patients with compensated liver disease and hepatocellular carcinoma (HCC) for curative-intent treatment will be invited to this study.
- Trial name
- NCT07036874
- Testing
- transient elastography and oesophagogastroduodenoscopy
- Where
- Hong Kong
- Volunteers
- 159 people
- Sponsor
- Chinese University of Hong Kong
Breast Cancer, Breast - Female
Improving Combined PET/CT and MRI of the Breast Using Dedicated Breast Positioning and Image Registration
The goal of this clinical trial is to improve the combined use of PET/CT and MRI for imaging of the breast. PET/CT and MRI are usually performed in different body positions, which can change the shape and position of the breast…
- Trial name
- REPOSE-Breast (NCT07883460)
- Testing
- Prone Breast PET/CT Acquisition
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Universität Münster
Stroke
A Randomised Controlled Trial Comparing the Impact of Virtual Reality, Paper and Pencil and Conventional Methods on Stroke Rehabilitation
Virtual Reality allows the integration of both cognitive and motor rehabilitation in a more ecologically valid context. The purpose of this study is to determine whether this methodology has more impact on stroke rehabilitation…
- Trial name
- NCT02857803
- Testing
- Virtual Reality, Paper and Pencil, Conventional Therapy
- Where
- Portugal
- Volunteers
- 42 people
- Sponsor
- Universidade da Madeira