Clinical trials: Validation Studies, open to volunteers
Unipolar Depression, Major Depressive Disorder (MDD)
Validation of EmoDTx as a Digital Endpoint for Mood Monitoring in Adult Patients Suffering From Unipolar Depression
The aim of this study is to validate the EmoDTx as a digital tool for mood monitoring in adult patients with unipolar depression. The study is prospective, multicenter, and observational, with a single-arm approach.
- Conditions
- Unipolar Depression, Major Depressive Disorder (MDD), Depression
- Trial name
- EMC2FR (NCT06860165)
- Where
- 2 sites in France
- Volunteers
- 98 people
- Sponsor
- Emobot
Hematuria
Study on Risk Assessment for Patients With Microscopic Hematuria (Non-Visible Blood in Urine) Using a Urine Marker Test
The goal of this clinical study is to learn how well a urine test called Xpert® Bladder Cancer Detect (Xpert BC-D) can help doctors assess the risk of bladder cancer in people with non-visible blood in their urine (microscopic…
- Trial name
- UroDetect III (NCT07307300)
- Where
- Germany
- Volunteers
- 1,475 people
- Sponsor
- Christian Bolenz
HLH, Hemophagocytic Lymphohistiocytoses
Prospective Validation of the OHI Index
Hemophagocytic lymphohistiocytosis (HLH) associated with hematologic malignancies (HM-HLH) is a syndrome with an abysmal prognosis (10-30% 5 years overall survival).
- Conditions
- HLH, Hemophagocytic Lymphohistiocytoses, Hemophagocytic Syndrome, Hematologic Malignancy
- Trial name
- HLH (NCT05882175)
- Where
- 2 sites in Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Fibromyalgia, Chronic Pain
Emotional Allodynia Questionnaire (AEQ) in Fibromyalgia (PEARL)
The Emotional Allodynia Questionnaire (AEQ) is an 11-item self-report instrument that measures disproportionate emotional reactivity to low-intensity interpersonal cues(perceived unresponsiveness, exclusion, loss of reciprocity)…
- Conditions
- Fibromyalgia, Chronic Pain, Nociplastic Pain
- Trial name
- PEARL (NCT07677631)
- Where
- 5 sites in Italy
- Volunteers
- 425 people
- Sponsor
- University of Bari
Respiratory, Monitored Anaesthesia Care
The PneumoRator Study
Healthcare workers measure heart rate, blood pressure, temperature, oxygen levels and breathing rate to monitor how unwell a patient is. All these apart from breathing rate are now normally measured by machines.
- Conditions
- Respiratory, Monitored Anaesthesia Care, Perioperative
- Trial name
- NCT07293299
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Validation Studies, Psychiatric Diagnosis
Digitizing and Automating the Diagnostic Psychiatric Assessment Process
This is an observational study that will be responsible for the Spanish translation and cross-cultural adaptation, and validation of the Electronic Semi-Structured Psychiatric Interview for Children and Adolescents (EPSI-C), to…
- Trial name
- DADAP (NCT07468214)
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Irene Lopez Armenteros
Validation Studies
Validation of the Dutch Translation of the Prosthesis Evaluation Questionnaire
The aim of our research is to be able to use the questionnaire 'Prosthesis Evaluation Questionnaire' (PEQ) in Dutch. The PEQ is a validated and reliable questionnaire for research into the quality of life in adults with a lower…
- Trial name
- NCT06493890
- Testing
- Validation PEQ-DLV
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- University Medical Center Groningen
Chronic Pain
Validation of the Turkish Brief Inventory of Treatment Expectations in Chronic Pain
The purpose of this study is to conduct the Turkish cross-cultural adaptation, validity, and reliability study of the "Brief Inventory of Treatment Expectations in Chronic Pain" (BITEC) scale.
- Trial name
- BITEC-TR (NCT07673874)
- Testing
- Survey Assessment Battery
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Hacettepe University
Celiac Disease, Small Bowel Mucosal Atrophy or Lesions
AI System for Detection and Characterization of Chronic Enteropathies
Coeliac disease (CD) is an immune-mediated enteropathy leading to small intestinal mucosal atrophy. Diagnosis relies on serology and duodenal biopsies, but it can be complicated by patchy lesions and differential diagnosis with…
- Conditions
- Celiac Disease, Small Bowel Mucosal Atrophy or Lesions, Non-celiac Enteropathies
- Trial name
- NCT07387185
- Where
- Italy
- Volunteers
- 380 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Hepatocellular Carcinoma (HCC)
Biomarker Validation for Treatment Efficacy and Recurrence Prediction in Hepatocellular Carcinoma
Observational Model: Cohort Time Perspective: Other (prospective and retrospective data/sample collection) Primary Purpose: Other (biomarker validation for treatment response and recurrence prediction) Biospecimen Retention…
- Trial name
- NCT07840092
- Testing
- No investigational intervention. Participants receive standard clinical care. Clinical data, imaging/pathology information, and available biospecimens are collected for research.
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Cancer, Frailty
G8 Screening Tool Validation in Older Adults With Cancer in Portugal
The G8 screening tool is widely recommended for the identification of frailty in older adults with cancer. However, prospective validation data in the Portuguese population are currently lacking.
- Conditions
- Cancer, Frailty, Aged
- Trial name
- G8-PT (NCT07487298)
- Testing
- G8 Screening Tool, Comprehensive Geriatric Assessment
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Hospital de Braga
Thyroid Diseases, Thyroid Neoplasms
Computer Vision-Based Recognition of Parathyroid Glands and Recurrent Laryngeal Nerves in Endoscopic Surgery
This study aims to evaluate the performance of the PTAIR computer vision model for recognizing parathyroid glands and recurrent laryngeal nerves during endoscopic thyroid surgery.
- Trial name
- PTAIR (NCT07628543)
- Testing
- PTAIR Computer Vision Model Assessment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University
Anemia
NeoSpHb Study: Can a Painless Device Detect Anaemia in Babies Without Blood Tests? A Study in the Neonatal Intensive Care Unit (NICU)
The goal of this study is to evaluate the diagnostic performance and feasibility of non-invasive spectrophotometric haemoglobin (SpHb) measurement for detecting anaemia in infants admitted to the Neonatal Intensive Care Unit…
- Trial name
- NeoSpHb (NCT07788703)
- Testing
- Spectrophotometry hemoglobin
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- University of Malaya
Urothelial Carcinoma
Prospective Validation Study of High Volume Urine DNA Testing in Individuals With Suspicion of Urothelial Cancer
Urothelial cancers of the bladder and upper urinary tract account for over 200,000 deaths and 600,000 diagnoses annually worldwide.
- Trial name
- UROSCOUT-1 (NCT06310759)
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 3,000 people
- Sponsor
- Tampere University Hospital
Cervical Cancer Treated with Pelvic Radiotherapy, Cervical Cancers
Establishment and Validation of Prediction Model of Simultaneous Chemoradiotherapy for Cervical Cancer Organoids
This is a single-arm, single-center, open-label, Phase II study aimed at assessing the efficacy of organoids in predicting the response to radiotherapy and chemotherapy in cervical cancer
- Trial name
- ECCO (NCT06786780)
- Testing
- Drug: Cisplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chongqing University Cancer Hospital
Atrial Fibrillation (AF), Atrial Fibrillation With Rapid Ventricular Response
Clinical Validation of SMD-RVECG for Predicting Atrial Fibrillation With Rapid Ventricular Response Within 2 Hours
The purpose of this retrospective study is to evaluate the clinical performance of SMD-RVECG, an artificial intelligence-based medical device software that analyzes single-lead electrocardiogram data to predict the risk of atrial…
- Trial name
- AFRVR (NCT07722039)
- Testing
- SMD-RVECG
- Volunteers
- 348 people
- Sponsor
- HUINNO Co., Ltd
Bacterial Infections, Bacterial Infections and Mycoses
Large Algorithm Setting and Validation Study
In this pilot study, prospectively acquired clinician-collected and participant-collected vaginal swab specimens will be obtained from up to 1000 individuals with signs and symptoms of vaginitis to develop and validate a…
- Conditions
- Bacterial Infections, Bacterial Infections and Mycoses, Infections, Vaginitis
- Trial name
- LAVA (NCT07607470)
- Testing
- Nanopath Vaginitis Assay, BD Max™ Vaginal Panel, Cepheid Xpert® Xpress MVP
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Nanopath, Inc
Emergency Medicine, Artificial Intelligence (AI)
Diagnostic Accuracy of GPT-4o and Claude for HEART Score Calculation in Chest Pain
This prospective observational diagnostic accuracy study evaluates whether large language models (LLMs) - GPT-4o (OpenAI, gpt-4o-2024-11-20) and Claude (Anthropic, claude-sonnet-4-6) - can accurately calculate HEART scores from…
- Conditions
- Emergency Medicine, Artificial Intelligence (AI), Artificial Intelligence (AI) in Diagnosis, Chest Pain Rule Out Myocardial Infarction
- Trial name
- LLM-HEART (NCT07626060)
- Testing
- GPT-4o HEART Score Calculator, Claude HEART Score Calculator, Three-Expert Consensus HEART Score
- Where
- Turkey (Türkiye)
- Volunteers
- 690 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Prostate Cancer (Diagnosis)
Validation of a Platelet Proteomic Assay for Diagnosing and Monitoring Prostate Cancer
This is a single center study evaluating whether a new blood test based on platelet proteins rather than plasma proteins can improve detection of prostate cancer and evaluate the degree of serious disease.
- Trial name
- NCT07144228
- Testing
- HeLP TM
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Tuberculosis in HIV-infected Individuals, Drug Susceptible Pulmonary Tuberculosis
Short-Course Regimens for DS-PTB in AIDS Patients
This study adopts a multicenter, open-label, randomized controlled design, conducted across key designated AIDS diagnosis and treatment hospitals nationwide.
- Trial name
- NCT07608172
- Testing
- 2HPMZ/2HPM, 2HRZE/4HR
- Volunteers
- 148 people
- Sponsor
- Shanghai Public Health Clinical Center