Clinical trials: Validation Studies
Chronic Cough
Validation Study With a Non-CE Marked Medical Device (MD)
This interventional study aims to validate the cough detection device by automatically and continuously measuring the cough frequency with SIVA-MVP among chronic cough patients and in a real-world environment.
- Trial name
- NCT05689307
- Testing
- SIVA-MVP
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Siva Health AG
Gastroparesis
ABCA2 GIRMS Analytical Validation Clinical Performance Study
The purpose of this study is to collect human breath samples for use in a validation study intended to demonstrate equivalent clinical performance measures of new ABCA2 GIRMS (Automated Breath Carbon Analyzer-2 Gas Isotope Ratio…
- Trial name
- NCT04607304
- Testing
- ABCA2 GIRMS
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Cairn Diagnostics
Knee Injuries, Proprioceptive Disorders
A Validation Study of Force Sense Measurement
The term proprioception was first introduced by Sherrington in 1906, who described it as a type of feedback from the limbs to the central nervous system.
- Trial name
- NCT03852199
- Testing
- Test protocol for proprioceptive force sense in case group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Critical Illness, Muscle Atrophy
VALIDation of Bedside Ultrasound of Muscle Layer Thickness of the Quadriceps in the Critically Ill Patient
The overall objective is to evaluate the validity of bedside US of QMLT and MF-BIA by comparing measurements from US and MF-BIA to those estimates of lean body mass obtained from CT Scan of abdomen when done for clinical reasons.
- Trial name
- VALIDUM (NCT04676464)
- Testing
- Ultra- sound
- Volunteers
- 204 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Colorectal Cancer Screening
Colorectal Cancer Screening Validation Study
The purpose of this study is to evaluate the gene expression patterns from colorectal mucosal cells collected through the use of a standard anoscope and cytology brush.
- Trial name
- CRC screening (NCT00720993)
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- IntelliGeneScan, Inc.
Asthma, Parkinson's Disease
Agricultural Health Study Follow-up
Background: The Agricultural Health Study (AHS) is looking at the long-term health effects of farming exposures including pesticides, crops, and animals.
- Trial name
- NCT01399411
- Where
- 3 sites in United States
- Volunteers
- 89,656 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Pelvic Floor Dyssynergia
Reliability and Validation of 3-D Electromagnetic Tracking During Pelvic Floor Muscle (PFM) Activation - a Pilot Study
Now a days the ultrasound is seen as a valid and reliable measurement tool to test the Pelvic Floor Muscle (PFM) movement (Sherburn, Murphy, Carroll, Allen, \& Galea, 2005).
- Trial name
- NCT01590927
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Moser, Helene
Chronic Kidney Disease
Uraemic Toxins in Chronic Kidney Disease Paediatric Patients: Observational Study
Children with chronic kidney disease (CKD) suffer from one of the most devastating diseases in childhood resulting in a lifelong need for health care, and a 3 times decreased life expectancy.
- Trial name
- UToPaed_1 (NCT02624466)
- Testing
- CKD progress
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- University Hospital, Ghent
COPD, ILD
Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases
This upcoming case-control study aims to confirm the Lung Sliding Index (LSI), a new ultrasound score that measures how well the pleura moves, in various lung diseases.
- Conditions
- COPD, ILD, Bronchiectasis, Pneumothorax
- Trial name
- NCT06983366
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assiut University
Validity, Distracted Driving
Way To Drive Validation Study
Way to Drive is a smart phone-based driving telematics application. Research participants are invited to download the app, which uses phone sensors to track driving behaviors including mileage, hard breaking events, and handheld…
- Conditions
- Validity, Distracted Driving, Driving Behaviors
- Trial name
- NCT05422586
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Pennsylvania
Coronary Stenosis
Validation of a Predictive Model of Coronary Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis
Coronary fraction flow reserve (FFR), the ratio of the mean coronary pressure distal to a coronary stenosis to the mean aortic pressure during maximal coronary blood flow (hyperemia), defines the hemodynamic significance of…
- Trial name
- FFRB (NCT03054324)
- Testing
- Fractional Flow Reserve
- Where
- 2 sites in Singapore
- Volunteers
- 132 people
- Sponsor
- National Heart Centre Singapore
Non-Communicable Chronic Diseases, Survey and Questionnaire
Evaluation of Validity and Reliability of the Turkish Translation of the Digital Health Readiness Questionaire in Different Chronic Diseases
The World Health Organization (WHO) defines digital health as the field of knowledge and application related to any aspect of the adoption of digital technology in the stages of improvement.
- Conditions
- Non-Communicable Chronic Diseases, Survey and Questionnaire, Validation Studies, Digital Health
- Trial name
- NCT06581770
- Testing
- Survey using a questionnaire.
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul Galata University
Chronic Myeloid Leukemia
Phase IV EORTC Quality of Life Module for Patients With Chronic Myeloid Leukemia
The objective of this study is to test the scale structure, reliability, validity and responsiveness to change of the QLQ-CML24 in conjuction with the QLQ-C30 for patients diagnosed with CML, and to investigate longitudinal…
- Trial name
- NCT03075969
- Where
- 32 sites in United States, Austria and 7 more
- Volunteers
- 337 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Deglutition Disorders
Diagnostic Accuracy of Aerodigestive Ultrasound for Predicting Swallowing Disorders
Swallowing disorders management requires an accurate recognition of implicated anatomical structures and pathways. The usual clinical assessment of swallowing disorders lacks reliability and accuracy.
- Trial name
- DARC-VADOC (NCT04800783)
- Testing
- Swallowing ultrasound
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Hopital Forcilles
Type 1 Diabetes Mellitus
T Cell Validation Study Using Blood Samples From Subjects With Recent Onset Type 1 Diabetes Mellitus
Type 1 diabetes is a condition that is caused in part by an abnormality of the immune system which occurs when T cells, which are part of the immune system, damage the insulin secreting cells (islet cells) in the pancreas.
- Trial name
- NCT00212329
- Testing
- T Cell Proliferation and Autoreactivity Assays, Cellular Immunoblot Assays, Tetramer Studies
- Where
- 14 sites in United States, United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Aortic Aneurysm
Validation of a Software and the Follow-up of Anteropoterior Migration of Stent
The treatment of aortic aneurysms is today based on different indicators (diameters, lengths, angles, volumes of the arteries) measured on CT scan images. Several indicators are time consuming and complicatated to measure.
- Trial name
- ASMOT (NCT05287828)
- Testing
- Surgeons CT scan analysis, PRAEVAorta CT scan analysis
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Nurea
Acute Respiratory Distress Syndrome (ARDS), Ventilated Patient in Intensive Care
Comparison of Dynamic Mechanical Power Formula With Geometric Method in Pressure- and Volume-Controlled Ventilation: A Validation Study
This prospective observational study aims to validate the dynamic mechanical power (MPdyn) formula by comparing it with the gold-standard geometric method (MPgeo) in patients with acute respiratory distress syndrome (ARDS) who…
- Trial name
- NCT07099729
- Testing
- Volume-Controlled Ventilation (VCV) with inspiratory-to-expiratory (I:E) ratio of 1:2., Volume-Controlled Ventilation (VCV) with inspiratory-to-expiratory (I:E) ratio of 1:1., Pressure-Controlled Ventilation (PCV) with inspiratory-to-expiratory (I:E) ratio of 1:2.
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
OSA
Prospective Study for the Clinical Validation of the Soundi Wearable Medical Device
This is a pre-marketing, single-centre, prospective clinical trial with the aim of comparison the effectiveness and safety of the SOUNDI medical device compared to polysomnography in detecting parameters for the diagnosis of…
- Trial name
- SOUNDI (NCT06320795)
- Testing
- SOUNDI
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Biocubica srl
Pulse Oximetry, Oxygen Measurements, SpO2
SpO2 Validation Study-Philips Optimus
Validation study to validate the SpO2 accuracy performance of the Sponsor's SpO2 sensors over the range of 70-100% SaO2 during non-motion conditions assessed by CO-Oximetry
- Trial name
- NCT07215429
- Testing
- No intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Decompensated Liver Cirrhosis, Primary Biliary Cholangitis
LEOPARD Prospective Validation Cohort 1
Intro: The present clinical research protocol is part of the LEOPARD European project (Grant n° 101080964 Horizon Europe) which aims to design and validate new predictive models of mortality among liver transplantation (LT)…
- Conditions
- Decompensated Liver Cirrhosis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Hepato-cellular Carcinoma
- Trial name
- LEOPARD PVC1 (NCT06723275)
- Testing
- Standardized assessments, guided tumor biopsy and biobanking, Standardized assessments and biobanking
- Where
- 8 sites in Belgium, France and 3 more
- Volunteers
- 630 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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