Clinical trials: Valve
Aortic Valve Stenosis
Hamburg AoRtic Valve cOhoRt
The primary aim of the study is to identify the optimal treatment modality for patients with aortic valve disease, incorporating the individual patient's risk profile and anticipated clinical outcomes.
- Trial name
- HARbOR (NCT04227002)
- Where
- Germany
- Volunteers
- 15,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Sports Accident, Athletes Heart
Lithuanian Atletes' Aortic Diameter
Recent developments in football have seen the sudden death of young football player due to aortic rupture hence reinforcing the controversy of football as a field with substantial risk for sudden cardiac arrest and death.
- Trial name
- NCT03656861
- Testing
- Physical load
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Agne Slapsinskaite
Hypertrophic Cardiomyopathy, Myocardial Perfusion Imaging
Presentations of Hypertrophic Cardiomyopathy on Myocardial Perfusion Imaging
Chest pain and myocardial ischemia are prevailing features in patients with hypertrophic cardiomyopathy (HCM). Recently introduced single-photon emission computed tomography (SPECT) cameras with solid-state cadmium-zinc-telluride…
- Trial name
- NCT03150342
- Testing
- myocardial perfusion imaging
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Danon Disease
Gene Therapy for Male Patients With Danon Disease (DD) Using RP-A501; AAV9.LAMP2B
This is a non-randomized open-label Phase 1 study to evaluate the safety and toxicity of gene therapy using a recombinant adeno-associated virus serotype 9 (AAV9) containing the human lysosome-associated membrane protein 2…
- Trial name
- NCT03882437
- Testing
- RP-A501
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Cardiac Valve Disease
Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery
The aim of the study is to clarify whether the perioperative release of the cardiac biomarkers troponin I, troponin T and CK-MB consistently correlate with visualizable myocardial damage, and to what extent these biomarkers are…
- Trial name
- RORSCHACH (NCT06066970)
- Where
- 5 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Valve Heart Disease
Post-surgical Aortic Hemodynamics After Aortic Valve Replacement
The purpose of this pilot study is to obtain both near valve and downstream flow characteristics, using 3D transthoracic echocardiography and 4D flow MRI respectively, in an existing patient population at Northwestern Memorial…
- Trial name
- NCT03347851
- Testing
- MRI, Transthoracic echocardiography exam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- CryoLife, Inc.
Hypertrophic Cardiomyopathy, Coronary Artery Disease
Hypertrophic Cardiomyopathy Pilot Study
This study evaluates mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from…
- Trial name
- NCT02806479
- Testing
- Observational: Arrhythmogenic Substrate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Aortic Valve Insufficiency, Aortic Valve Stenosis
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4/X4S Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.
- Trial name
- NCT05172973
- Testing
- SAPIEN X4/X4S THV
- Where
- 37 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Edwards Lifesciences
Transcutaneous Valve Therapies
STS & ACC Foundation's Transcutaneous Valve Therapy (TVT) Registry Foundation's Transcutaneous Valve Therapy (TVT) Registry
The TVT Registry was designed to support a national surveillance system to assess the characteristics, treatments, and outcomes of patients receiving transcutaneous valve therapies.
- Trial name
- TVT (NCT04167579)
- Testing
- Transcutaneous Valve Therapy
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Hoag Memorial Hospital Presbyterian
Prostheses and Implants, Stroke
Rivaroxaban vs Warfarin in Patients With Metallic Prosthesis
Mechanical heart valves (MHV) demand lifelong anticoagulation with vitamin K antagonists (VKA) due to the high thrombogenicity of the prosthesis.
- Conditions
- Prostheses and Implants, Stroke, Valve Heart Disease, Anticoagulants and Bleeding Disorders
- Trial name
- RIWA (NCT03566303)
- Testing
- Rivaroxaban 15 mg, Warfarin
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Geral Roberto Santos
Heart Diseases, Heart Failure
Echocardiography in Nursing Home
The study seeks to explore the implementation characteristics (acceptability, appropriateness, feasibility, adoption, fidelity, penetration, implementation cost and sustainability) of systematic echocardiography in nursing homes…
- Conditions
- Heart Diseases, Heart Failure, Heart Valve Diseases
- Trial name
- ECHOGER (NCT06445231)
- Testing
- Implementation of echocardiography in nursing homes
- Where
- France
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Endocarditis
Interest of Parametric Positron Emission Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis
The objective of this study is to determine if early parametric positron emission computed tomography is useful to diagnose cardiac prosthetic valve infections.
- Trial name
- PARAVA (NCT05146180)
- Testing
- Parametric positron emission computed tomography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Atrial Fibrillation, Valvular Heart Disease
Prolongation of the Interval Between Prothrombin Time Tests in Stable Patients II
More than 2 million patients in North America are treated with warfarin - a "blood thinner" - to prevent blood clots in arteries or veins.
- Conditions
- Atrial Fibrillation, Valvular Heart Disease, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- PRINT-II (NCT01654042)
- Testing
- Prolonged interval between PT testing
- Where
- Canada
- Sponsor
- McMaster University
Hypoparathyroidism, Tetralogy of Fallot
Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects
OBJECTIVES: I. Identify latent hypoparathyroidism in normocalcemic adult survivors with repaired conotruncal cardiac defects, by evaluating parathyroid gland secretory function after induced hypocalcemia. II.
- Conditions
- Hypoparathyroidism, Tetralogy of Fallot, Pulmonary Valve Stenosis, Conotruncal Cardiac Defects
- Trial name
- NCT00004361
- Testing
- calcium gluconate, sodium citrate
- Volunteers
- 150 people
- Sponsor
- National Center for Research Resources (NCRR)
Aortic Valve, Bicuspid
Follow-up of a Cohort of Patients With Aortic Valve Bicuspidia
The aortic valve bicuspidia (BVA) is a congenital condition corresponding to the presence of 2 sigmoids instead of 3. This is the most common cardiac congenital anomaly affecting 0.5 to 2% of the population The general rule.
- Trial name
- NCT03139786
- Testing
- Study the natural history of bicuspid
- Where
- France
- Volunteers
- 232 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Mechanical Ventilation Pressure High
Effect of Airseal System Valve-less Trocar on the Ventilatory Parameters During Robotic-assisted Radical Cystectomy
The aim of the investigators' study is to investigate if the use of the AirSeal insufflation system impairs ventilatory parameters of patients less than a conventional system in patients undergoing robot-assisted laparoscopic…
- Trial name
- NCT02506270
- Testing
- Airseal Trocar, conventional trocar
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Regina Elena Cancer Institute
Cardiac Surgical Procedures
The REPLICCAR Registry and The Statewide Quality Improvement Initiative
Cardiovascular diseases remain the leading cause of death for the healthcare system and cardiac surgery has an important impact on their resolubility.
- Trial name
- REPLICCAR (NCT05363696)
- Testing
- Coronary artery bypass grafting (CABG), Heart valve surgery
- Where
- 2 sites in Brazil
- Volunteers
- 9,723 people
- Sponsor
- University of Sao Paulo General Hospital
Tricuspid Regurgitation, Right Ventricular Dilatation
Pharmacological Reduction of Right Ventricular Enlargement
Functional tricuspid regurgitation (TR) has been regarded as a secondary phenomenon of heart failure (HF), mitral valve (MV) disease or atrial fibrillation.
- Trial name
- PROVE (NCT04345796)
- Testing
- Carvedilol+Empagliflozin, Carvedilol, Empagliflozin
- Where
- 3 sites in South Korea
- Volunteers
- 56 people
- Sponsor
- Asan Medical Center
Mitral Regurgitation
Cardiovalve Transfemoral System - FIM Study
The Cardiovalve system is a replacement valve delivered through a transfemoral access and transseptal approach and is intended for symptomatic patients with Mitral regurgitation for whom surgical options are not feasible.
- Trial name
- NCT03958773
- Testing
- Cardiovalve transfemoral Mitral valve system
- Where
- Lithuania
- Volunteers
- 10 people
- Sponsor
- Cardiovalve Ltd.
Aortic Stenosis, Heart Failure
TMAO in Patients With Severe Aortic Stenosis
Trimethylamine N-oxide (TMAO) has recently gained increasing scientific interest in the field of cardiovascular disease, including its role in cell protection against osmotic and hydrostatic stress.
- Trial name
- TASTE (NCT04406805)
- Testing
- Measurement of plasma and urine trimethylamine-N-oxide concentration
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Warsaw
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