Clinical trials: Valve
Aortic Dissection
Nordic Consortium for Acute Type A Aortic Dissection-2
The Nordic Consortium for Acute Type A Aortic Dissection-2 (NORCAAD-2) is a multicenter research collaboration involving up to 19 units in the Nordic countries and one in The Netherlands.
- Trial name
- NORCAAD-2 (NCT06862583)
- Testing
- surgery, endovascular intervention
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Karolinska Institutet
Aortic Stenosis
Impact of Aortic Annulus Calcification on Long-Term Outcomes Following Transcatheter Aortic Valve Replacement: SAINT-TAVR Calcium Registry
The goal of this observational study is to learn about the long-term effects of aortic valve annular calcification in patients undergoing transcatheter aortic valve replacement (TAVR).
- Trial name
- SAINT-TAVR Ca (NCT06722066)
- Testing
- Transcatheter aortic valve replacement with ballon-expandable or self-expandable valves
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Eunpyeong St. Mary's Hospital
Hypertrophic Cardiomyopathy
New Diagnostic Strategy in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease characterized by unexplained hypertrophy of the left ventricle, often with predominant involvement of the interventricular septum, and characterized by myocyte…
- Trial name
- HYPERGEN (NCT02520856)
- Testing
- blood sample
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Age Problem, Aortic Valve Disease
Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders
In Italy, life expectancy at birth has reached 80 years in men and 85 in women; in about 50 years, life expectancy at the age of 80 has increased by an extraordinary 61% and 55%, respectively, due to more effective therapies and…
- Conditions
- Age Problem, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- FRASER-VD (NCT03365453)
- Testing
- frailty evaluation
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- University Hospital of Ferrara
Tricuspid Regurgitation Functional, Tricuspid Regurgitation
The STTAR-US Study: A Pivotal Study of Transcatheter Tricuspid Annular Repair in the US
Purpose of this clinical study is to demonstrate the safety and efficacy of MIA-T system in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR grade ≥3) despite optimal medical therapy…
- Conditions
- Tricuspid Regurgitation Functional, Tricuspid Regurgitation, Severe Tricuspid Valve Regurgitation
- Trial name
- STTAR-US (NCT06700239)
- Testing
- MIA_T Device
- Volunteers
- 600 people
- Sponsor
- Micro Interventional Devices
Williams Syndrome, Angelman Syndrome
Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes
OBJECTIVES: I. Investigate phenotype and genotype correlations in patients with Smith-Magenis syndrome (SMS) associated with del(17p11.2). II.
- Conditions
- Williams Syndrome, Angelman Syndrome, Prader-Willi Syndrome, Shprintzen Syndrome
- Trial name
- NCT00004351
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mitral Valve Insufficiency
To Evaluate the Efficacy and Safety of the Transfemoral Mitral Valve Repair System in the Treatment of Patients With Moderately Severe and Severe Functional Mitral Regurgitation(FMR) Who Remained Clinically Symptomatic After Guideline-directed Medical Treatment
To confirm the effectiveness and safety of the transcatheter mitral valve repair system for the treatment of chronic moderate to severe (3+) or severe (4+) functional mitral regurgitation (FMR) who remained clinically symptomatic…
- Trial name
- NCT05508438
- Testing
- Transfemoral mitral-valve repair
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Pan Xiangbin
Aortic Valve Stenosis
MYVAL Transcatheter Heart Valve System - Prospective German Multicenter Registry
Rational of the Myval THV - Prospective German Multicenter Registry is to evaluate the performance of this relatively new but very promising TAVR valve in a consecutive real-word, all-comers registry and to assess the long-term…
- Trial name
- German MYVAL S (NCT06804148)
- Testing
- Myval Transcatheter Heart Valve
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Prof. Dr. med. Ingo Eitel
Aortic Valve Stenosis
IcoSApent ethyL to Slow Down Aortic VAlve Stenosis proGrEssion
This study invastigates the effect of icosapent ethyl in patients with aortic valve stenosis.
- Trial name
- SALVAGE (NCT06466278)
- Testing
- Icosapent ethyl
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Severe Symptomatic Aortic Stenosis
Evaluation of Length of Stay After TF-TAVI
Transcatheter aortic valve implantation (TAVI) has been rapidly adopted worldwide since the first-in-man TAVI performed in 2002.
- Trial name
- FAST-TAVI (NCT02956915)
- Testing
- Transfemoral Transcatheter aortic valve implantation
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Rouen
Aortic Stenosis, Severe
Exercise CMR in (p)LF-LG AS
Patient with paradoxical or conventional low-flow low-gradient aortic stenosis on echocardiographic assessment will undergo physiological exercise-stress CMR in addition to guideline recommended surveys prior to TAVR.
- Trial name
- NCT06129799
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Göttingen
Coronary Artery Disease, Mitral Valve Regurgitation
Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol
The purpose of the study is to demonstrate the long term safety and effectiveness of the Carpentier-Edwards® PERIMOUNT Magna Mitral Valves in patients undergoing mitral valve replacement with or without concomitant procedures…
- Conditions
- Coronary Artery Disease, Mitral Valve Regurgitation, Mitral Valve Incompetence, Heart Failure
- Trial name
- NCT00853632
- Testing
- CEP MAGNA MITRAL PERICARDIAL BIOPROSTHESES
- Where
- 15 sites in United States, Austria and 2 more
- Volunteers
- 329 people
- Sponsor
- Edwards Lifesciences
Cardiac Disease
Beta Blockers and Angiotensin Receptor Blockers in Bicuspid Aortic Valve Disease Aortopathy (BAV Study)
The purpose of this study is to determine whether long-term treatment with a beta-blocker (BB) such as atenolol and/or an angiotensin receptor blocker (ARB) such as telmisartan, given to adult patients with bicuspid aortic valve…
- Trial name
- BAV (NCT01202721)
- Testing
- Atenolol, Telmisartan
- Where
- 13 sites in Canada
- Volunteers
- 85 people
- Sponsor
- Hamilton Health Sciences Corporation
Aortic Stenosis
Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: The DETECT AS Trial
The DETECT AS Trial is a randomized clinical trial and quality improvement initiative that seeks to investigate the impact of electronic provider notification of severe aortic stenosis (AS) on its management, on the utilization…
- Trial name
- DETECT AS (NCT05230225)
- Testing
- Physician Notification Letter
- Where
- United States
- Volunteers
- 940 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation and Flutter, Mechanical Mitral Valve Prosthesis
Impact of Education Level on Clinical Outcomes in Self-INR Managed Patients
Oral anticoagulation (OAC) is indicated in a wide variety of clinical conditions including atrial fibrillation (AF), mechanical valve prosthesis (MVP), deep vein thrombosis and pulmonary embolism.
- Trial name
- NCT06187155
- Testing
- INR self-management
- Where
- Egypt
- Volunteers
- 586 people
- Sponsor
- Cairo University
IHD, Valve Heart Disease
Role of Chest Ultrasound in Detection of Post-operative Pulmonary Complications After Cardiothoracic Surgery
assess feasibility of detecting pulmonary complications postoperative using chest ultrasound compared to chest x-ray measure time lag between using ultrasound and using chest x-ray to detect pulmonary complications postoperative
- Conditions
- IHD, Valve Heart Disease, Surgery--Complications
- Trial name
- NCT04118621
- Testing
- chest ultrasound
- Volunteers
- 100 people
- Sponsor
- Assiut University
Valvular Heart Disease
Diagnostic Study of Structural Heart Disease Based on Cardiac Electromechanical Signals
Study participants will be prospectively recruited from consecutive outpatient and inpatient populations presenting to the Cardiology and Cardiac Surgery Departments of the following participating institutions: The First…
- Trial name
- NCT07603115
- Testing
- Transthoracic Echocardiography
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Heart Valve Diseases, Cardiopulmonary Bypass
Acupuncture Improves Sleep in Patients Undergoing Cardiopulmonary Bypass
Due to various causes, such as brain impairment, environment changes, anxious,et al. patients, who undergo cardiopulmonary bypass, often suffer from poor quality of sleep.
- Trial name
- NCT01231776
- Testing
- electronic acupuncture
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Hypertrophic Cardiomyopathy
Mitral Valve Management During Septal Myectomy
Objective of the study: to evaluate whether alfieri technique improves clinical and hemodynamic results compared to transaortic mitral valve secondary cord cutting in patients scheduled to septal myectomy for severely symptomatic…
- Trial name
- MVMSM (NCT03906734)
- Testing
- Septal myectomy, alfieri stich, Subvalvular intervention
- Where
- Russia
- Volunteers
- 48 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Aortic Regurgitation
Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome
This observational study aims to evaluate risk factors of progress and adverse outcome of aortic regurgitation
- Trial name
- NCT07104968
- Where
- Sweden
- Volunteers
- 35,000 people
- Sponsor
- Uppsala University
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