Clinical trials: Valve Disease, Aortic
Hypertrophic Obstructive Cardiomyopathy
The Effect of TASH in Patients With HOCM
To examine patients with hypertrophic obstructive cardiomyopathy (HOCM) before and after septal alcohol ablation, to investigate the effect of the treatment in regards to changes in myocardial function, perfusion, invasive…
- Trial name
- Post-TASH (NCT04066777)
- Testing
- alcohol septal ablation
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steen Hvitfeldt Poulsen
Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation
CoreValve™ Evolut R™ 34 mm System Registry (CoreValve34)
With the introduction of the CoreValve™ Evolut R™ 34mm (Medtronic™) prosthesis, patients with severe symptomatic aortic stenosis (AS) and large aortic annulus have become eligible for transcatheter aortic valve implantation…
- Trial name
- TAVI34mm (NCT03621709)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Transcatheter Aortic Valve Replacement, Coronary Artery Disease
Coronary Artery Disease Assessment Strategies in TAVI Patients
Coronary artery disease (CAD) and aortic stenosis frequently coincide. Before valve intervention, invasive coronary angiography is routinely performed to assess coronary status.
- Conditions
- Transcatheter Aortic Valve Replacement, Coronary Artery Disease, Heart Disease Risk Factors
- Trial name
- CAT (NCT06559332)
- Testing
- Risk-based CAD management, Invasive coronary angiography
- Where
- Switzerland
- Volunteers
- 546 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation)
Dilation Optimisation for Uniform Bioprosthetic Leaflet Expansion
The goal of this clinical trial is to discover if routine 'double tap' balloon post-dilation improves valve expansion and clinical outcomes in adults undergoing Transcatheter Aortic Valve Implantation (TAVI) with the SAPIEN…
- Trial name
- ACE-DOUBLE (NCT07430267)
- Testing
- 'Double tap' balloon post-dilation
- Where
- 3 sites in Australia
- Volunteers
- 250 people
- Sponsor
- The Alfred
Aortic Stenosis, Chemotherapy Induced Systolic Dysfunction
Fibrosis in Chronic and Delayed Myocardial Infarction
In this study the investigators aim to examine the role that fibrosis plays in heart conditions such as aortic stenosis , chemotherapy-induced cardiotoxicity and carcinoid syndrome .
- Conditions
- Aortic Stenosis, Chemotherapy Induced Systolic Dysfunction, Carcinoid Syndrome
- Trial name
- FCDMI (NCT05756608)
- Testing
- 68Ga-FAPI and 18F-AlF-FAPI PET-MR
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Williams Beuren Syndrome, Autism Spectrum Disorder
Molecular Characterization of Patients Affected by Williams Syndrome and Autism.
Williams Beuren syndrome (WBS) is a multiple malformations/intellectual disability (ID) syndrome caused by 7q11.23 microdeletion and clinically characterized by a typical neurocognitive profile including excessive talkativeness…
- Trial name
- WBA (NCT04095585)
- Testing
- chromosomal microarray analysis (CMA) and whole exome sequencing (WES)
- Volunteers
- 6 people
- Sponsor
- Hospices Civils de Lyon
Aortic Valve Stenosis
ASAN Medical Center Aortic Valve Replacement Registry
This study evaluates the effectiveness and safety of surgical aortic valve replacement and transcatheter aortic valve replacement in aortic Stenosis.
- Trial name
- ASAN-AVR (NCT03298178)
- Testing
- TAVR, SAVR
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Ho-Jin Kim
Heart Valve Disease, Ventricular Function
Magnetic Resonance Imaging and Fibrosis
Aortic valve disease causes impaired let ventricular function (LVF) due to hypertrophy, dilatation and diffuse myocardial fibrosis yet the prognostic effect of fibrosis, waiting time for operation and postoperative exercise…
- Conditions
- Heart Valve Disease, Ventricular Function, Fibrosis
- Trial name
- MRF (NCT02790008)
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Linkoeping University
Aortic Valve Stenosis
Can Rehabilitation After TAVI Precipitate Recovery and Improve Prognosis
Many patients we encounter a month post TAVI, still complain of having symptoms limiting their daily activity. The investigators set out to study whether rehabilitation strategy early after the procedure contributes to reduction…
- Trial name
- NCT02855099
- Testing
- Rehabilitation
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cardiac Surgery, Coronary Artery Bypass Grafting
Pharmacokinetics of AP214 Acetate in Patients Undergoing Cardiac Surgery
The purpose of the present research study is to investigate the pharmacokinetics, as well as safety, tolerability and pharmacodynamics of different ascending dosing regimens of AP214 in patients undergoing cardiac surgery.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Valve Surgery, Aortic Root or Ascending Aortic Aneurysm Repair Surgery
- Trial name
- NCT00903604
- Testing
- AP214
- Where
- 2 sites in Denmark
- Volunteers
- 42 people
- Sponsor
- Action Pharma A/S
Chest Pain, Severe Aortic Stenosis
Myocardial Flow Reserve in Severe AS Without Obstructive Coronary Artery Disease
Exertional angina is common symptom in patients with severe aortic stenosis (AS) without obstructive coronary artery disease (CAD).
- Trial name
- NCT02575768
- Testing
- Adenosine-stress cardiac magnetic resonance imaging
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Congenital Heart Disease, Coarctation of Aorta
An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Disease
The purpose of this two-way cohort study was to explore whether an integrated prenatal and postnatal treatment model for neonates with critical congenital heart disease (CCHD) could be effective in avoiding preoperative…
- Conditions
- Congenital Heart Disease, Coarctation of Aorta, Aortic Stenosis, Pulmonary Atresia
- Trial name
- NCT06768008
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Stenosis, Right Bundle-Branch Block
Prophylactic Permanent Pacemaker in Patients With Right Bundle Branch Block Undergoing Transcatheter Aortic Valve Implantation
The goal of this clinical trial is to learn about the safety and outcome of prophylactic pacemaker implantation in patients with right bundle-branch block undergoing trans-catheter aortic valve (TAVI) implantation in patients…
- Trial name
- TAVI-PACE (NCT05889208)
- Testing
- Prophylactic pacemaker implantation
- Volunteers
- 320 people
- Sponsor
- Aalborg University Hospital
Moderate Aortic Valve Stenosis
Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study
The purpose of this study is to evaluate if ataciguat slows the progression of moderate calcific aortic valve stenosis in adults.
- Trial name
- KATALYST-AV (NCT07001800)
- Testing
- Ataciguat
- Where
- 74 sites in United States, Canada
- Volunteers
- 1,276 people
- Sponsor
- Kardigan, Inc.
Delirium, Post-Op Complication
Impact of Anesthesia Technique on Post-operative Delirium After Transcatheter Aortic Valve Implantation
Aortic stenosis is a frequent valvulopathy in Europe and North America. It occurs mainly over 65 years (2-7% of the population over 65 years). Treatment of symptomatic stenosis is an indication of aortic valve replacement.
- Conditions
- Delirium, Post-Op Complication, Anesthesia, Aortic Valve Disease
- Trial name
- DELIRIUMTAVI (NCT03323619)
- Testing
- anesthesia type
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Aortic Stenosis, Gut Microbiome
Impact of Transcatheter Aortic Valve Implantation (TAVI) on the Gut Microbiota in Patients With Aortic Valve Stenosis
This study investigates the impact of transcatheter aortic valve implantation (TAVI) on the composition and function of the gut microbiota in patients with severe aortic valve stenosis.
- Conditions
- Aortic Stenosis, Gut Microbiome, Gut Microbiota, TAVI
- Trial name
- GUT-TAVI (NCT07052071)
- Testing
- TAVI
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Hippocration General Hospital
Aortic Stenosis
Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR)
This is a multi-centric, open-label, randomized trial to evaluate the safety and efficacy of temporary discontinuation of beta-blocker treatment in patients undergoing transcatheter aortic valve replacement.
- Trial name
- NCT06472934
- Testing
- Transcatheter aortic valve replacement in the absence of B-blocker treatment, Transcatheter aortic valve replacement
- Where
- 11 sites in Austria, Germany and 1 more
- Volunteers
- 498 people
- Sponsor
- University Hospital, Basel, Switzerland
Rare Diseases, Fabry Disease
Evaluation of HEArt invoLvement in Patients With FABRY Disease
This study evaluates predictors for the incidence of arrhythmias and sudden cardiac death as well as terminal heart failure in patients with Fabry disease.
- Conditions
- Rare Diseases, Fabry Disease, Fabry Disease, Cardiac Variant, Hypertrophic Cardiomyopathy
- Trial name
- HEAL-FABRY (NCT03362164)
- Where
- Germany
- Volunteers
- 650 people
- Sponsor
- Wuerzburg University Hospital
Aortic Valve Disease, Aortic Valve Stenosis
Myeloid Cells in Aortic Valve Stenosis
Investigators plan to characterize systemic inflammation and circulating immune cells in participants with moderate and severe calcific aortic valve disease and matched healthy controls.
- Trial name
- MIRACLE (NCT04717219)
- Testing
- Blood drawing
- Where
- 3 sites in Netherlands
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Aortic Stenosis
Loss of Y Chromosome in Aortic Stenosis
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body.
- Trial name
- NCT06595407
- Testing
- Blood analysis for loss-of-Y chromosome
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Virginia
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