Clinical trials: Valve Disease, Aortic
Aortic Valve Replacement
Innovative Device for Pain Management by Millimeter Band Radiation: Electronic-Pain Killer
The objective of this study is to evaluate a new medical device in the management of pain. The principle of this new treatment is based on the emission of electromagnetic radiation in millimeter band.
- Trial name
- EPIKARD (NCT03889288)
- Testing
- Medical device - electronic-pain killer
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Grenoble
Aortic Valve Disease
Safety and Feasibility of TRISKELE in Severe AS
This clinical study is a prospective、single arm and exploratory study, to explore the feasibility and safety of MitrAssist TRISKELE® transcatheter aortic valve system in the treatment of patients with severe aortic stenosis.
- Trial name
- NCT05391191
- Testing
- MitrAssist TRISKELE® transcatheter aortic valve system
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Shanghai Zhongshan Hospital
Severe Aortic Valve Stenosis, Cardiovascular Diseases
Pilot Study to Evaluate a Noninvasive Electrocardiographic Monitoring Strategy Associated With Early Discharge in Patients With Conduction Disorders Following TAVI Implantation (IMPROVE Study)
Study to evaluate the efficacy and safety of a non-invasive electrocardiographic monitoring strategy associated with early discharge in patients with conduction disorder after transfemoral TAVI implantation, and its potential…
- Trial name
- IMPROVE (NCT07456280)
- Testing
- Standard care, PhysioMem PM 100 4G ambulatory monitoring system
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hypertrophic Cardiomyopathy, Left Ventricular Hypertrophy
Factors Contributing to Increased Left Ventricle Size in Patients With Abnormally Enlarged Hearts
The human heart is divided into four chambers. One of the four chambers, the left ventricle, is the chamber mainly responsible for pumping blood out of the heart into the circulation.
- Trial name
- NCT00001878
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Valve Stenosis
Pacing the Atrium to Confirm or Exclude Pacemaker Indication in TAVI
The current observational registry aims to evaluate in patients undergoing TAVI implantation: 1. the positive and negative predictive value for PPM post TAVI of Wenckebach phenomenona (WB) during RAP during the TAVI procedure, 2.
- Trial name
- PACE-TAVI (NCT05278585)
- Testing
- RAP TAVI
- Where
- 12 sites in Belgium
- Volunteers
- 500 people
- Sponsor
- AZ Sint-Jan AV
Heart Valve Disease
On-X Heart Valve - 17mm Aortic and 23mm Mitral
This study examines the hemodynamic and hemolytic properties of two additional smaller size valves to the On-X line of valves already approved by FDA.
- Trial name
- NCT01812174
- Testing
- 17mm aortic valve (On-X ), 23mm mitral valve (On-X)
- Where
- 10 sites in United States, Puerto Rico and 1 more
- Volunteers
- 20 people
- Sponsor
- On-X Life Technologies, Inc.
Aortic Valve Stenosis
Long Term Follow-up of the 23mm Portico™ Aortic Valve Implant and the St. Jude Medical Transfemoral Delivery System
Collect and evaluate the long term safety data.
- Trial name
- NCT01497418
- Where
- 2 sites in Canada
- Volunteers
- 2 people
- Sponsor
- Abbott Medical Devices
Valvular Heart Disease, Mitral Valve Disease
Prevalence Study of Cardiovascular Diseases in a Population ≥ 65 Years in Italy
This registry is a large-scale epidemiological study (PREVASC) aimed at estimating the prevalence of symptomatic and asymptomatic valvular hear disease in men and women aged over 65 years randomly selected in Italy.
- Conditions
- Valvular Heart Disease, Mitral Valve Disease, Aortic Valve Stenosis, Aortic Valve Insufficiency
- Trial name
- PREVASC (NCT05892588)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Aortic Stenosis, Ascending Aortic Dilatation
Comparison of Self- and Balloon-expandable Valves in Patients With Ascending Aortic Dilation Undergoing Transcatheter Aortic Valve Replacement: The AAD-CHOICE
This study aimed at comparing the performance of self-expandable valves versus balloon-expandable valves in patients with ascending aortic dilation undergoing transcatheter aortic valve replacement.
- Trial name
- NCT06009588
- Testing
- self-expandable valves, balloon-expandable valves
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Dental Caries
Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations
This study will examine the clinical performance of Class II restorations over a three year period with 3 composite resins - a conventional composite resin, a flowable composite resin and a bulk placed and cured composite resin.
- Trial name
- NCT02889835
- Testing
- Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Aortic Stenosis
Anatomical Determinants and Outcomes of Small Annulus Patients Undergoing TAVR in Different ASIAN Ethnicity
Transcatheter aortic valve implantation (TAVI) presents unique challenges for Asian patients compared to Caucasians, largely due to the prevalence of small aortic annulus (SAA) defined based on Caucasians' data (430 mm²)…
- Trial name
- NCT07240025
- Where
- Hong Kong
- Volunteers
- 31 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
Cardiac Biomarkers in Pediatric Cardiomyopathy (PCM Biomarkers)
Cardiomyopathy is a disease of the heart muscle. It is rare, but it can be serious. Cardiomyopathy in children can result in death, disability, heart transplantation or serious heart rhythm disorders.
- Trial name
- NCT01873976
- Where
- 13 sites in United States, Canada
- Volunteers
- 288 people
- Sponsor
- Wayne State University
Hypertrophic Obstructive Cardiomyopathy (HOCM)
CArdiac Desynchronization In Obstructive HCM, CARDIO-HCM
The purpose of this study is to evaluate the benefit of the optimal pacing configuration, including the possibility of biventricular or left ventricular pacing, in hypertrophic obstructive cardiomyopathy patients.
- Trial name
- CARDIO-HCM (NCT01332162)
- Testing
- Biventricular pacing, No Pacing
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Clinic of Barcelona
1- Primary (Sarcomeric) Hypertrophic Cardiomyopathy, 2- Obstructive Hypertrophic Cardiomyopathy
Neurohormonal Parameters in Hypertrophic Cardiomyopathies
The primary purpose of this study is to demonstrate that changes in plasma levels of circulating neurohormones (mainly BNP and NT-proBNP), measured at rest and post-exercise correlate with exercise functional limitation (assessed…
- Conditions
- 1- Primary (Sarcomeric) Hypertrophic Cardiomyopathy, 2- Obstructive Hypertrophic Cardiomyopathy, 3- Non Obstructive Hypertrophic Cardiomyopathy
- Trial name
- REEF-CMH (NCT01729702)
- Testing
- blood sample collection
- Where
- France
- Volunteers
- 131 people
- Sponsor
- French Cardiology Society
Aortic Stenosis
Multicenter Study for the Validation of Willem AI: Aortic StenoSis Early Diagnosis With AI-electrocardiogram Study
AoS-SEDAI study is an observational, multicenter, retrospective and prospective clinical study. This study aims to assess Willem Artificial Intelligence (AI) ability to distinguish between aortic stenosis (AS) and non-AS patients…
- Trial name
- AoS-SEDAI (NCT07479992)
- Testing
- Willem AI ECG assessment
- Where
- 2 sites in Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Idoven 1903 S.L.
Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy Symptom Release by BX1514M
Hypertrophic cardiomyopathy (HCM) is the most frequent genetic cardiac disease characterized by an asymmetric hypertrophic. In two third of patients, an obstruction to blood ejection is observed within the left ventricle which is…
- Trial name
- Light-CARMIDO (NCT02590809)
- Testing
- Treatment BX1514M, Walk distance test, Exercise echocardiography
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Bordeaux
Aortic Valve Stenosis
Measurement of Myocardial Stiffness Using Elastometry in Patients With Aortic Stenosis
Elastography is a new non-invasive medical technique for measuring the stiffness at a distance from a tissue. Recent advances in the development of elastography sequences for cardiac exploration suggest a more clinical approach…
- Trial name
- ELASTOP-AS (NCT04358692)
- Testing
- Aixplorer Mach30
- Where
- 2 sites in France
- Volunteers
- 98 people
- Sponsor
- University Hospital, Rouen
Aortic Stenosis, Cerebral Ischaemic Injury
Perioperative Intensive Statin Therapy for Neuroprotection in TAVR（PISTNT）
Transcatheter aortic valve replacement (TAVR) has become the most anticipated treatment method in the cardiovascular field in recent years, experiencing rapid development.
- Trial name
- PISTNT (NCT07087379)
- Testing
- Intensive statin treatment
- Volunteers
- 500 people
- Sponsor
- Pan Xiangbin
Ischemic Heart Disease, Coronary Artery Disease
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN)
Despite advancements in medical care, ischemic heart disease (IHD) remains the leading global cause of death. IHD develops through lipid accumulation into the coronary arteries with subsequent formation of larger atherogenic…
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Aortic Valve Stenosis, Acute Myocardial Infarction
- Trial name
- IHD-EPITRAN (NCT04533282)
- Testing
- Blood samples., Collection of right atrial appendage tissue sample., Health Survey, Clinical symptom scaling
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Hypertrophic Cardiomyopathy
Trimetazidine Therapy in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a common inherited heart condition that causes breathlessness, chest pain and fatigue. There are few treatments available.
- Trial name
- NCT01696370
- Testing
- Trimetazidine
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University College, London
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