Clinical trials: Valve Regurgitation, Mitral
Mitral Regurgitation
Safety and Efficacy of the HighLife Transcatherter Mitral Valve Replacement System in Patients With Moderate-severe or Severe Mitral Regurgitation in China
To observe and evaluate the safety and efficacy of the HighLife Transcatheter Mitral Valve Replacement System in patients with moderate-severe or severe mitral valve regurgitation through a prospective, multicenter clinical trial…
- Trial name
- NCT05610566
- Testing
- the HighLife Trans-Septal Transcatheter Mitral Valve Replacement System
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peijia Medical Technology (Suzhou) Co., Ltd.
Mitral Valve Regurgitation (Degenerative or Functional)
TVMR With the Innovalve System Trial - Pilot in Georgia
Study to evaluate the safety and performance of the Innovalve mitral valve replacement system
- Trial name
- TWIST-PILOT-GE (NCT05682066)
- Testing
- Innovalve MR system
- Where
- Georgia
- Volunteers
- 11 people
- Sponsor
- Edwards Lifesciences
Mitral Valve Regurgitation, Congestive Heart Failure
Effects of Mitral Valve Repair With the Geoform Ring on Cardiomyopathy
The primary aim of this study is to assess the changes on the shape and function of the left ventricle in patients with severe mitral valve regurgitation due to congestive heart failure and cardiomyopathy who undergo mitral valve…
- Conditions
- Mitral Valve Regurgitation, Congestive Heart Failure, Cardiomyopathy
- Trial name
- NCT00428103
- Testing
- 3 dimensional echocardiography
- Where
- United States
- Sponsor
- Juan Crestanello, MD
Mitral Valve (MV) Regurgitation
DragonFly M2 Pivotal Study
To confirm the effectiveness and safety of the DragonFly M2 Transcatheter Mitral Valve Repair System for the treatment of symptomatic moderate-to-severe (3+) or severe (4+) degenerative mitral regurgitation in high surgical risk…
- Trial name
- NCT07243197
- Testing
- DragonFly M2 Transcatheter Mitral Valve Repair System
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Hangzhou Valgen Medtech Co., Ltd
Mitral Valve Insufficiency
The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study
The study is a prospective, multi-center, single-arm, non-randomized, Early Feasibility Study (EFS) to evaluate the safety and performance of the Half Moon TMVr System in patients with severe, symptomatic mitral regurgitation…
- Trial name
- NCT04343313
- Testing
- Half Moon TMVr System
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Half Moon Medical
Mitral Regurgitation, Mitral Valve Disease
ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral
This study will establish the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects who are at high or greater surgical risk with a failing mitral surgical bioprosthetic valve or a failing…
- Conditions
- Mitral Regurgitation, Mitral Valve Disease, Mitral Stenosis
- Trial name
- NCT06167213
- Testing
- SAPIEN X4 THV
- Volunteers
- 125 people
- Sponsor
- Edwards Lifesciences
Mitral Regurgitation, Aortic Regurgitation
Comparison Study of Echocardiography and Cardiovascular Magnetic Resonance Imaging in the Assessment of Mitral and Aortic Regurgitation
The primary treatment for patients determined to have severe aortic or mitral regurgitation is surgical repair or replacement their valves.
- Trial name
- NCT04038879
- Testing
- MRI
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Mitral Regurgitation, Mitral Valve Disease
Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System
The objective of this study is to evaluate the 5-year outcomes of participants with degenerative mitral valve disease treated with the NeoChord Artificial Chordae System, Model DS1000 in a post-market setting.
- Conditions
- Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency, Mitral Valve Prolapse
- Trial name
- AcChord (NCT04190602)
- Testing
- NeoChord Artificial Chordae Delivery System, Model DS1000
- Where
- 5 sites in Germany, Greece and 1 more
- Volunteers
- 500 people
- Sponsor
- NeoChord
Mitral Valve Regurgitation, Mitral Valve Prolapse
CE Mark Study for the Harpoon Medical Device in Poland
The purpose of this study is to evaluate the safety and performance of the Harpoon Medical TSD-5. The Harpoon device will provide many significant advantages over current surgical interventions including: 1) a small minimally…
- Conditions
- Mitral Valve Regurgitation, Mitral Valve Prolapse, Mitral Valve Insufficiency
- Trial name
- NCT02432196
- Testing
- Harpoon Medical Device
- Where
- 2 sites in Poland
- Volunteers
- 26 people
- Sponsor
- Edwards Lifesciences
Degenerative Mitral Valve Disease
Commissural Closure to Treat Severe Mitral Regurgitation: Standing the Test of Time.
Mitral regurgitation (MR) for degenerative disease is nowadays routinely treated with valve repair with excellent short and long term results in experienced centers.
- Trial name
- NCT05774769
- Testing
- Commissural edge to edge mitral valve repair
- Where
- Italy
- Volunteers
- 125 people
- Sponsor
- Michele De Bonis
Mitral Valve Prolapse, Mitral Regurgitation
Patient Specific Mitral Valve Modeling for Surgical Planning and Training
Mitral valve disease is a common pathologic problem occurring in approximately 2% of the general population but climbing to 10% in those over the age of 75 in Canada[1].
- Conditions
- Mitral Valve Prolapse, Mitral Regurgitation, Mitral Valve Disease
- Trial name
- NCT03609931
- Testing
- Mitral Valve Model
- Volunteers
- 65 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mitral Insufficiency, Pulmonary Arterial Hypertension
Surgical Valvuloplasty for Congenital Mitral Insufficiency
Congenital mitral insufficiency is one of the most common valvular diseases in the pediatric population worldwide, carrying a high morbidity and mortality risk if not treated immediately and properly.
- Trial name
- NCT03567668
- Testing
- mitral valvuloplasty
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hong Liu
Mitral Regurgitation
Outcomes of Patients tReated wIth Mitral Transcatheter Edge-to-edge Repair for Primary Mitral Regurgitation Registry
This multinational, non-interventional, investigator-initiated, retrospective study aims to investigate outcomes of patients, who underwent mitral valve transcatheter edge-to-edge repair (M-TEER) for primary mitral regurgitation…
- Trial name
- PRIME-MR (NCT05332782)
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 2,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Mitral Valve Insufficiency, Mitral Regurgitation
Acquisition of Objective Data During Transapical Neochordae Implantation
Mitral Valve repair (MVr) is the gold standard treatment for primary Mitral Regurgitation. Implantation of artificial Gore-Tex chordae (or neochordae implantation) is often used for MVr.
- Trial name
- TENSCHORD (NCT04709042)
- Testing
- Chordal tension measurement, Cardiac Magnetic Resonance Imaging (MRI)
- Sponsor
- Hospices Civils de Lyon
Mitral Regurgitation
Immediate Suboptimal Result of Mitral Valve Repair: Late Implications in a Matched Cohort Study
Mitral valve regurgitation is a pathology affecting the left atrioventricular valve, conditioning the loss of the normal unidirectionality of the atrioventricular flow and therefore volumetric and pressure overload of the left…
- Trial name
- NCT05836480
- Testing
- mitral valve repair
- Where
- Italy
- Volunteers
- 141 people
- Sponsor
- Michele De Bonis
Mitral Valve Insufficiency, Mitral Valve Annuloplasty
Study on Surgical Treatment Strategies for Moderate Ischemic Mitral Regurgitation
This study aimed to compare the efficacy of isolated coronary artery bypass grafting and coronary artery bypass grafting + mitral valve repair in moderate ischemic mitral regurgitation patients through a cohort and explore the…
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Annuloplasty, Coronary Artery Bypass
- Trial name
- NCT06408779
- Testing
- mitral valve repair
- Where
- China
- Volunteers
- 464 people
- Sponsor
- China National Center for Cardiovascular Diseases
Mitral Regurgitation
Flexible Band vs Rigid Ring for Degenerative Mitral Valve Disease
The study evaluates the results of mitral valve repair with flexible band in comparison with rigid ring in patients undergoing mitral valve repair for degenerative mitral valve disease
- Trial name
- NCT03278574
- Testing
- Mitral valve repair, Ring annuloplasty with posterior band, Ring annuloplasty with complete ring
- Volunteers
- 171 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Mitral Insufficiency, Transcatheter Aortic Valve Replacement
Transcatheter Mitral and Tricuspid Interventions: a Cardiac Magnetic Resonance Study
Mitral and tricuspid valve disease represents an increasing challenge in the management of patients with heart failure and other cardiovascular diseases.
- Trial name
- TEMATIC-MR (NCT07370467)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Centro Cardiologico Monzino
Heart Failure With Preserved Ejection Fraction, Functional Mitral Regurgitation
Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve Regurgitation
The main objective of this study is to assess the hemodynamic effects of sacubitril-valsartan in patients with heart failure with preserved ejection fraction and at least moderate atrial functional mitral regurgitation (AFMR)…
- Trial name
- PRAISE-MR (NCT05991284)
- Testing
- Sacubitril-valsartan, Standard of care
- Where
- Belgium
- Volunteers
- 84 people
- Sponsor
- Ziekenhuis Oost-Limburg
Tricuspid Disease, Mitral Regurgitation
Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM)
The surgical treatment of less than severe (≤2+/4+) functional tricuspid regurgitation (TR) in patient undergoing mitral valve surgery, is still controversial: some observational studies have suggested that performing tricuspid…
- Trial name
- NOSTRUM (NCT02996552)
- Testing
- M & T Repair Group, Mitral-Only Group
- Where
- 3 sites in Italy, Poland
- Volunteers
- 142 people
- Sponsor
- Ospedale San Raffaele