Clinical trials: Valve Surgery
ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Atrial Fibrillation (AF)
Atrial Fibrillation TRIal of Left Atrial Appendage Closure Using Seralene Hemostatic Suture
Atrial fibrillation is a common heart rhythm disorder that increases the risk of stroke. In patients with atrial fibrillation, blood clots most often form in a small structure of the heart called the left atrial appendage.
- Conditions
- ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Atrial Fibrillation (AF), Mitral Valve Surgery, Stroke (in Patients With Atrial Fibrillation)
- Trial name
- ATRI-LASH (NCT07360899)
- Testing
- LAA closure using the AtriLASH
- Where
- Serbia
- Volunteers
- 200 people
- Sponsor
- Institute of Cardiovascular Diseases, Vojvodina
Cardiac Surgery, Heart Surgery
Safety and Performance Evaluation of CPB Venous and Arterial Cannulas
This is a two-phase study evaluating the Eurosets arterial and venous cannulas for use during cardiopulmonary bypass (CPB) procedures. Phase 1 is a pilot study focused on assessing cannula safety.
- Conditions
- Cardiac Surgery, Heart Surgery, Cardiopulmonary Bypass, Coronary Surgery
- Trial name
- NCT07354841
- Testing
- Eurosets Venous and Arterial Cannula, Control Arterial and Venous Cannulas
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Eurosets S.r.l.
Mitral Regurgitation (MR), Pediatric Cardiac Surgery
A Prospective Multicenter Cohort Study on Surgical Treatment Strategies for Pediatric Mitral Regurgitation
This prospective, multicenter cohort study aims to evaluate the outcomes of surgical repair for pediatric mitral regurgitation (MR) in China.
- Trial name
- NCT07284212
- Testing
- conventional mitral valve repair, standardized mitral valve repair
- Where
- China
- Volunteers
- 427 people
- Sponsor
- China National Center for Cardiovascular Diseases
Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation)
Demographic and Interpopulation Variations in Evaluation and Results of TAVI
The aim of the project is to evaluate demographic, clinical, and laboratory variations in patients with aortic stenosis treated with TAVI in different countries.
- Conditions
- Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation), Computed Tomography, Inflammatory Response During Cardiac Surgery
- Trial name
- DIVER-TAVI (NCT07258706)
- Testing
- laboratory biomarker analysis, Computed tomography of aortic root and aorta
- Where
- 5 sites in Italy, Poland and 3 more
- Volunteers
- 800 people
- Sponsor
- Poznan University of Medical Sciences
CABG, Cardiac Anesthesia
Impact of the Cardiopulmonary Bypass and Cross-Clamp Time Ratio on Postoperative Outcomes in Open Heart Surgery: A Prospective Observational Analysis
This study aims to investigate the relationship between the ratio of cardiopulmonary bypass (CPB) time to cross-clamp (CC) time and postoperative complications in open heart surgery.
- Conditions
- CABG, Cardiac Anesthesia, Cardiac Surgery Prognosis, Bypass Complication
- Trial name
- NCT06873620
- Where
- Turkey (Türkiye)
- Volunteers
- 348 people
- Sponsor
- Ahmet Yuksek
Anemia, Iron Deficiencies
Postoperative Intravenous Ferric Derisomaltose for Prevention of Long-term Anemia After Cardiac Surgery
Postoperative anemia is highly prevalent among patients undergoing cardiac surgery and is associated with delayed functional recovery, increased morbidity, and impaired long-term outcomes.
- Conditions
- Anemia, Iron Deficiencies, Iron Deficiency Anemia, Cardiac Surgery
- Trial name
- NCT07238972
- Testing
- Ferric derisomaltose
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Yonsei University
Surgery, Heart Diseases
Prescribed Sternal Precautions vs. Self-Guided Restrictive Care (PEEERC)
Our study aims to compare postoperative outcomes, postoperative pain and postoperative quality of lives in patients who receive the standard sternal precautions to those in patients who received self-managed sternal precautions…
- Conditions
- Surgery, Heart Diseases, Heart Failure, Cardiac Valve Disease
- Trial name
- NCT05206929
- Testing
- Self Managed Care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Cardiopulmonary Bypass Surgery, Aortic Valve Surgery
Methylene Blue-Enhanced Ultrafiltration Improves Outcomes After Cardiopulmonary Bypass
Introduction: Fluid overload and systemic inflammation are major contributors to postoperative complications in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Conditions
- Cardiopulmonary Bypass Surgery, Aortic Valve Surgery, Mitral Valve Surgery, Myocardial Revascularization Surgery With Extracorporeal Circulation
- Trial name
- NCT07212842
- Testing
- Methylene Blue, Conventional ultrafiltration, Zero-balance ultrafiltration
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- University of Sao Paulo
Valve Replacement Surgery
Phase One Cardiac Rehabilitation Outcomes Post Valve Replacement Surgery
Cardiac rehabilitation is a crucial component of postoperative recovery for patients who have received valve replacement surgery.
- Trial name
- NCT07205393
- Testing
- Cardiac rehabilitation, Routine clinic care
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Valley University
Minimal Invasive Cardiac Surgery, Minimal Invasive Cardiac Surgery Mitral Valve Surgery
Serratus Plane Block After Minimally Invasive Mitral Valve Repair
Patients undergoing minimally invasive mitral valve reconstruction via small thoracotomy are randomized into two groups. The intervention group receives serratus anterior plane block after minimally invasive mitral-valve…
- Conditions
- Minimal Invasive Cardiac Surgery, Minimal Invasive Cardiac Surgery Mitral Valve Surgery, Serratus Anterior Plane Block
- Trial name
- NCT05648266
- Testing
- Continous SAPB (Ropivacain), institutional standard of care pain medication protocol
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Primary Valvular Heart Disease With Comorbid Coronary Artery Disease, Planned to Undergo Elective On-pump Valve Surgery Due to Primary Mitral and/or Aortic Valvular Heart Disease
Quantitative Flow Ratio (QFR) Guided Coronary Artery Bypass Grafting for Patients Undergoing Primary Valve Surgery With Concomitant Coronary Artery Disease
This is a multicenter, prospective, randomized, blinded, controlled clinical study in patients with planned primary valvular surgery and comorbid coronary artery lesions with diameter stenosis of ≥ 50%, to compare the…
- Trial name
- FAVOR IV-QVAS (NCT03977129)
- Testing
- QFR-guided strategy, CAG-guided strategy
- Where
- 12 sites in China
- Volunteers
- 792 people
- Sponsor
- Ruijin Hospital
Mitral Valve Failure, Surgery
Effects of Triflow and Deep Breathing and Cough Exercises on Respiration in Patients Undergoing Mitral Valve Replacement
The purpose of breathing exercises or the use of assistive devices is to provide deep breathing after surgery and to obtain a normal breathing pattern.
- Trial name
- NCT06997224
- Testing
- triflow application
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atlas University
AORTIC VALVE DISEASES, Aortic Valve Stenosis and Insufficiency
Post-market Safety and Performance Outcomes of the VIVERE® Bovine Pericardial Bioprosthetic Valve
This study aims to collect post-market safety and performance data related to the procedure and follow-up of the VIVERE Bovine Pericardial Bioprosthetic Valve, when used in accordance with the product's Instructions for Use (IFU).
- Conditions
- AORTIC VALVE DISEASES, Aortic Valve Stenosis and Insufficiency, Aortic Valve Surgery, Mitral Valve Regurgitation
- Trial name
- VITTA (NCT06959836)
- Testing
- VIVERE Bovine Pericardial Bioprosthetic Valve
- Where
- 3 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Braile Biomedica Ind. Com. e Repr. Ltda.
Use of Dexmedetomidine in Cardiac Surgery (CABG, Valve Replacement or Total Aortic Arch Replacement)
Effect of Dexmedetomidine on Hemodynamics in Cardiac Surgery
It is important to establish a stable haemodynamics in patients undergoing cardiac surgery. Haemodynamic depression is common during induction of anaesthesia [1].
- Trial name
- NCT06958913
- Testing
- Propofol group, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Pamukkale University
Ischemic Heart Disease, Valvular Heart Disease
Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)
In order to perform heart surgery, a machine called cardiopulmonary bypass (CPB), or more commonly known as a heart-lung machine, is used to maintain the circulation of oxygenated blood needed by the rest of the body and its…
- Conditions
- Ischemic Heart Disease, Valvular Heart Disease, Cardiovascular Diseases, Surgery-Complications
- Trial name
- THERMIC-4 (NCT05996120)
- Testing
- Hypothermic Cardiopulmonary Bypass, Normothermic Cardiopulmonary Bypass
- Where
- 11 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Leicester
Minimal Invasive Cardiac Surgery, Limited Right Anterior Thoracotomy for Mitral Valve Replacement
Efficacy of Limited Right Anterior Thoracotomy Versus Median Sternotomy for Mitral Valve Replacement
this study compare between two diffrent methods for approach mitral valve in mitral valve replacement throgh opening of the middle of the sternum by saw or through opening between 4th and 5th rib on the right side of the chest…
- Trial name
- NCT06869980
- Testing
- mitral valve replacement through limited right anterior thoractomy, mitral valve replacement through median sterntomy
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Zagazig University
Delirium - Postoperative, Sleep Problems
Effect of Preoperative Sleep Intervention on Postoperative Delirium in Adult Patients Undergoing Cardiac Surgery
This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in adult patients undergoing…
- Conditions
- Delirium - Postoperative, Sleep Problems, CABG, Valve Surgery
- Trial name
- NCT06777342
- Testing
- Cognitive behavioral therapy intervention, Melatonin intervention
- Volunteers
- 1,281 people
- Sponsor
- Yan Fuxia
Mitral Valve Repair Surgery
Safety and Effectiveness of Early Aspirin Administration After Mitral Valve Repair
This study compares the efficacy and safety of two different antithrombotic drugs, warfarin and aspirin, in early application after mitral valve repair (MVRep).
- Trial name
- NCT06738992
- Testing
- Aspirin, Warfarin
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Guangdong Provincial People's Hospital
Mitral Valve Disease, Mitral Valve Surgery
Registry for Mitral Valve Surgery at Department of Cardiac Surgery University Hospital of Basel/ Switzerland
A registry is installed to collect (pre-, intra- and postoperative) data on patients undergoing mitral valve surgery at the Department for Cardiac Surgery of Universitätsspital Basel/ Switzerland since 2009.
- Trial name
- NCT03587688
- Testing
- mitral valve surgery
- Where
- Switzerland
- Volunteers
- 701 people
- Sponsor
- University Hospital, Basel, Switzerland
Aortic Valve Disease, Surgery--Complications
Immune Responsiveness and Outcome After Aortic Valve Surgery (Measure)
There is considerable morbidity and mortality associated with cardiac surgery. Currently little effort is made to quantify how well the immune system of an individual can cope with inflammation or infection to which they are…
- Conditions
- Aortic Valve Disease, Surgery--Complications, Immune System Disorder
- Trial name
- Measure (NCT04430972)
- Testing
- Aortic valve replacement
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Barts & The London NHS Trust